[go: up one dir, main page]

PE20050254A1 - N-[3-(3-SUSTITUIDAS-PIRAZOLO [1,5-a]PIRIMIDIN-7-IL) FENIL]-SULFONAMIDAS Y COMPOSICIONES RELACIONADAS - Google Patents

N-[3-(3-SUSTITUIDAS-PIRAZOLO [1,5-a]PIRIMIDIN-7-IL) FENIL]-SULFONAMIDAS Y COMPOSICIONES RELACIONADAS

Info

Publication number
PE20050254A1
PE20050254A1 PE2004000710A PE2004000710A PE20050254A1 PE 20050254 A1 PE20050254 A1 PE 20050254A1 PE 2004000710 A PE2004000710 A PE 2004000710A PE 2004000710 A PE2004000710 A PE 2004000710A PE 20050254 A1 PE20050254 A1 PE 20050254A1
Authority
PE
Peru
Prior art keywords
pyrazolo
pyrimidin
phenyl
substituted
sulfonamides
Prior art date
Application number
PE2004000710A
Other languages
English (en)
Inventor
Luis Anglada Burniol
Albert Palomer Benet
Marta Princep Mota
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of PE20050254A1 publication Critical patent/PE20050254A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A N-[3-(3-SUSTITUIDAS-PIRAZOLO[1,5a] PIRIMIDIN-7-IL)FENIL]-SULFONAMIDAS DE FORMULA I DONDE R1 ES ALQUIL C1-C6, ALQUENIL C2-C6, ISOXAZOLIL, ENTRE OTROS; R2 ES H, ALQUIL C1-C6, ALQUINIL C2-C6, ENTRE OTROS; R3 ES H, HALOGENO, ALQUIL C1-C6, ENTRE OTROS. TAMBIEN REFERIDA A LA PREPARACION DE ESTOS COMPUESTOS QUE SON UTILES PARA TRATAR O PREVENIR LAS ENFERMEDADES MEDIADAS POR SUBUNIDADES a1 Y a2 DEL RECEPTOR GABAA
PE2004000710A 2003-07-24 2004-07-23 N-[3-(3-SUSTITUIDAS-PIRAZOLO [1,5-a]PIRIMIDIN-7-IL) FENIL]-SULFONAMIDAS Y COMPOSICIONES RELACIONADAS PE20050254A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301746A ES2222813B1 (es) 2003-07-24 2003-07-24 N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
ES200401697A ES2245894B1 (es) 2003-07-24 2004-07-12 Mejoras en el objeto de la patente de invencion n.p200301746 que se refiere a "n-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados".

Publications (1)

Publication Number Publication Date
PE20050254A1 true PE20050254A1 (es) 2005-04-11

Family

ID=34137682

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000710A PE20050254A1 (es) 2003-07-24 2004-07-23 N-[3-(3-SUSTITUIDAS-PIRAZOLO [1,5-a]PIRIMIDIN-7-IL) FENIL]-SULFONAMIDAS Y COMPOSICIONES RELACIONADAS

Country Status (29)

Country Link
US (1) US7947688B2 (es)
EP (1) EP1648897B1 (es)
JP (1) JP2006528608A (es)
KR (1) KR100840450B1 (es)
CN (1) CN100393721C (es)
AR (1) AR047017A1 (es)
AT (1) ATE417048T1 (es)
AU (1) AU2004263278B2 (es)
BR (1) BRPI0412826A (es)
CA (1) CA2532437C (es)
CL (1) CL2004001814A1 (es)
DE (1) DE602004018320D1 (es)
DK (1) DK1648897T3 (es)
EA (1) EA009519B1 (es)
ES (2) ES2222813B1 (es)
HR (1) HRP20060009A2 (es)
IL (1) IL173252A0 (es)
MA (1) MA27944A1 (es)
MX (1) MXPA06000754A (es)
NO (1) NO20060580L (es)
NZ (1) NZ544349A (es)
PA (1) PA8607501A1 (es)
PE (1) PE20050254A1 (es)
PL (1) PL1648897T3 (es)
PT (1) PT1648897E (es)
TW (1) TWI340140B (es)
UA (1) UA81959C2 (es)
UY (1) UY28440A1 (es)
WO (1) WO2005014597A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084835A1 (en) * 2005-02-10 2006-08-17 Ferrer Internacional, S. A. N-(3-(imidazo [1,5-a]pyrimidin-4-yl)phenyl]-sulfonamides and n-[3-(imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides and their use as gabaa receptor modulators
EP1736475A1 (en) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates
MX2008011853A (es) * 2006-03-17 2008-09-29 Wyeth Corp Derivados de pirazolo[1,5-a]pirimidina y sus metodos de uso.
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
EP1884516A1 (en) * 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions
EP1956021A1 (en) 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
EP1921079A1 (en) * 2006-11-08 2008-05-14 Ferrer Internacional, S.A. Amorphous form of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
AU2010205739B2 (en) * 2009-01-13 2015-12-10 Interquim S.A. Process for the preparation of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-acetamide
US9371307B2 (en) 2011-09-12 2016-06-21 The Johns Hopkins University Serine protease inhibitors
CN102807569B (zh) * 2012-08-21 2015-02-25 四川大学 一种镇静催眠的化合物及其制备方法和用途
CA2898294C (en) * 2013-02-21 2020-06-09 Calitor Sciences, Llc Heteroaromatic compounds as pi3 kinase modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
SG30590G (en) * 1985-05-13 1995-09-18 American Cyanamid Co D7-(3-disubstituted amino) phenylaepyrazolod 1,5-aaepyrimidines
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
AU4058000A (en) * 1999-04-02 2000-10-23 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulatorsof gabaa receptors
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Also Published As

Publication number Publication date
JP2006528608A (ja) 2006-12-21
CL2004001814A1 (es) 2005-06-03
BRPI0412826A (pt) 2006-09-26
KR100840450B1 (ko) 2008-06-20
AR047017A1 (es) 2006-01-04
TWI340140B (en) 2011-04-11
MA27944A1 (fr) 2006-06-01
DE602004018320D1 (de) 2009-01-22
IL173252A0 (en) 2006-06-11
US7947688B2 (en) 2011-05-24
NZ544349A (en) 2009-05-31
TW200510422A (en) 2005-03-16
CA2532437A1 (en) 2005-02-17
WO2005014597A1 (en) 2005-02-17
ES2245894A1 (es) 2006-01-16
UA81959C2 (en) 2008-02-25
PT1648897E (pt) 2009-03-17
MXPA06000754A (es) 2006-03-30
EA009519B1 (ru) 2008-02-28
PA8607501A1 (es) 2005-09-28
HK1083844A1 (en) 2006-07-14
UY28440A1 (es) 2004-11-08
CN100393721C (zh) 2008-06-11
EA200600316A1 (ru) 2006-06-30
CN1829719A (zh) 2006-09-06
AU2004263278B2 (en) 2009-03-12
CA2532437C (en) 2010-01-26
ES2222813A1 (es) 2005-02-01
PL1648897T3 (pl) 2009-07-31
NO20060580L (no) 2006-02-03
ES2222813B1 (es) 2005-12-16
ES2245894B1 (es) 2006-12-01
AU2004263278A1 (en) 2005-02-17
HRP20060009A2 (en) 2006-08-31
DK1648897T3 (da) 2009-04-06
ATE417048T1 (de) 2008-12-15
EP1648897B1 (en) 2008-12-10
KR20060030908A (ko) 2006-04-11
US20060270690A1 (en) 2006-11-30
EP1648897A1 (en) 2006-04-26

Similar Documents

Publication Publication Date Title
PE20011371A1 (es) Derivados de 3-(3-isopropil-5-metil-4h-1,2,4-triazol-4-il)-exo-8-azabiciclo[3.2.1]octano como antagonistas de los receptores de quimiocina ccr5
MA31419B1 (fr) Derives de pyridine
EA200700099A1 (ru) Производные пиридина
DE60229530D1 (de) Substituierte piperazine als modulatoren des melanocortinrezeptors
UY28150A1 (es) Agentes terapeuticos
EA200700047A1 (ru) Новые алкильные производные в качестве метаботропных рецепторов глутамата
ECSP056097A (es) Antagonistas del receptor cgrp
DK1474406T3 (da) Disubstituerede thiazolylcarboxanilider samt deres anvendelse som mikrobicider
ECSP088590A (es) Derivados de aminoácido multicíclicos y sus métodos de uso
UY30025A1 (es) Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones.
PE20050254A1 (es) N-[3-(3-SUSTITUIDAS-PIRAZOLO [1,5-a]PIRIMIDIN-7-IL) FENIL]-SULFONAMIDAS Y COMPOSICIONES RELACIONADAS
CY1109808T1 (el) Αρυλινδενο-πυριδινες και αρυλινδενο-πυριμιδινες και η χρηση τους ως ανταγωνιστων των υποδοχεων αδενοσινης α2α
DE602006006850D1 (de) Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate
ES2186550B2 (es) Nuevos derivados de oxazolidinonas como antibacterianos.
PE20060590A1 (es) COMPUESTOS ESTEROIDALES 15ß-SUSTITUIDOS CON ACTIVIDAD SELECTIVA DEL RECEPTOR DE ESTROGENOS
EA200600071A1 (ru) Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором
UY29412A1 (es) Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos.
PE20030944A1 (es) Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso
EA200601895A1 (ru) 3-(4-гетероарилциклогексиламино)циклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
EA200600694A1 (ru) Дисульфидные, сульфидные, сульфоксидные и сульфоновые производные циклических сахаров и их применение
DK1448562T3 (da) Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer
DK1373220T3 (da) Benzimidazoler, som er nyttige ved behandling af seksuel dysfunktion
ATE420859T1 (de) Azabicycloä3.1.0ühexylphenylderivate als modulatoren von dopamin-d3-rezeptoren
PE20080941A1 (es) Compuestos triciclicos como agonistas del receptor de melatonina
EA200702612A1 (ru) Соединения бензимидазолкарбоксамида в качестве агонистов рецепторов 5-нт

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed