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PE20050669A1 - Biaril sulfonamidas - Google Patents

Biaril sulfonamidas

Info

Publication number
PE20050669A1
PE20050669A1 PE2004001190A PE2004001190A PE20050669A1 PE 20050669 A1 PE20050669 A1 PE 20050669A1 PE 2004001190 A PE2004001190 A PE 2004001190A PE 2004001190 A PE2004001190 A PE 2004001190A PE 20050669 A1 PE20050669 A1 PE 20050669A1
Authority
PE
Peru
Prior art keywords
biaryl
benzofuran
biphenyl
amino
sulphonamides
Prior art date
Application number
PE2004001190A
Other languages
English (en)
Inventor
Jeremy Ian Levin
Thomas Saltmarsh Rush Iii
Frank Lovering
Yonghan Hu
Jun Jun Wu
Rejeev Hotchandani
Jason Shaoyun Xiang
Xuemei Du
Derek Cecil Cole
Jianchang Li
Wei Li
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20050669A1 publication Critical patent/PE20050669A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
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    • C07D495/04—Ortho-condensed systems

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Abstract

REFERIDA A UN METODO DE MODULACION (INHIBICION) DE UNA METALOPROTEINA DONDE SE UNE UNA METALOPROTEINASA TAL COMO GELATINASA A, METALOELASTASA DE MACROFAGO, COLAGENASA-3, ENTRE OTRAS; CON UNA CANTIDAD DE BIARIL SULFONAMIDA UNIDA A UN GRUPO HETEROARILO TAL COMO FURANO, 1,2,4-OXADIAZOL, IMIDAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-({4'[1-BENZOFURAN-2-ILCARBONIL)-AMINO]-1,1'-BIFENIL-4-IL}-SULFONIL)-GLICINA, ACIDO L-2-{4'-[(BENZOFURAN-2-CARBONIL)-AMINO]-BIFENIL-4-SULFONILAMINO}-3-METIL-BUTIRICO, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA, ENTRE OTRAS
PE2004001190A 2003-12-04 2004-12-03 Biaril sulfonamidas PE20050669A1 (es)

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PCT/US2003/040835 WO2005061477A1 (en) 2003-12-04 2003-12-22 Biaryl sulfonamides as mmp inhibitors

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525406A (ja) * 2003-12-04 2007-09-06 ワイス ビアリールスルホンアミドおよびその使用方法
US20080119513A1 (en) * 2004-09-06 2008-05-22 Fumihiko Watanabe Sulfonamide Derivative Selectively Inhibiting Mmp-13
CA2617055A1 (en) * 2005-07-29 2007-02-08 Bayer Healthcare Llc Preparation and use of biphenyl amino acid derivatives for the treatment of obesity
US7615363B2 (en) * 2005-08-25 2009-11-10 Wyeth Aggrecanase structure
US7625731B2 (en) * 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
EP1981505A4 (en) * 2006-02-08 2009-05-13 Wyeth Corp PREPARATION OF 7-ALKENYL-3-QUINOLINECARBONITRILES THROUGH PALLADIUM INDUCED COUPLING REACTION
CN101415683B (zh) 2006-03-31 2013-07-17 诺瓦提斯公司 新化合物
WO2008147763A1 (en) * 2007-05-23 2008-12-04 Array Biopharma Inc. Mmp inhibitors and methods of use thereof
CN102149677A (zh) * 2008-08-15 2011-08-10 霍夫曼-拉罗奇有限公司 联芳基氨基四氢化萘类
US8716312B2 (en) * 2008-11-19 2014-05-06 Merck Sharp & Dohme Corporation Inhibitors of diacylglycerol acyltransferase
WO2011031628A1 (en) * 2009-09-14 2011-03-17 Schering Corporation Inhibitors of diacylglycerol acyltransferase
US8530453B2 (en) * 2009-09-28 2013-09-10 Aquilus Pharmaceuticals, Inc. Compounds and methods for the treatment of pain and other diseases
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
PH12013500105A1 (en) 2010-07-16 2013-02-25 Abbvie Bahamas Ltd Process for preparing antiviral compounds
EA030228B1 (ru) 2010-07-16 2018-07-31 ЭббВи Айэленд Анлимитед Компани Фосфиновые лиганды для каталитических реакций
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
JP2014514259A (ja) * 2011-03-02 2014-06-19 アクイラス ファーマシューティカルズ， インコーポレイテッド 疼痛および他の障害の処置のための化合物および方法
CN104244939A (zh) 2012-04-05 2014-12-24 Chdi基金会股份有限公司 犬尿氨酸-3-单加氧酶抑制剂、其药物组合物及其使用方法
CN103333144B (zh) * 2013-06-17 2014-12-10 温州大学 一种2-硫基-3-卤代苯并呋喃化合物及其合成方法和用途
US9938252B2 (en) 2013-09-26 2018-04-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9884853B2 (en) 2013-09-26 2018-02-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
US10301324B2 (en) 2016-04-12 2019-05-28 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (ATR) inhibitors and methods of their use
CN106905348B (zh) * 2017-02-13 2018-12-04 牡丹江医学院 一种预防和治疗急性肾损伤的药物及其制备方法和用途
CN112480020B (zh) * 2020-12-11 2023-10-10 东华理工大学 一种2-取代苯并恶唑化合物
CN113527152B (zh) * 2021-08-09 2023-07-28 西北农林科技大学 一种联苯磺酰胺类化合物及其防治农作物害虫的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69737605T2 (de) * 1996-01-23 2008-04-03 Shionogi & Co., Ltd. Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
RU2001126719A (ru) * 1999-03-03 2004-02-20 Дзе Проктер Энд Гэмбл Компани (US) Дигетерозамещенные ингибиторы металлопротеазы
TR200200977T2 (tr) * 1999-10-14 2002-08-21 The Procter & Gamble Company Beta konumunda iki kere sübstitüe edilmiş metaloproteaz engelleyiciler
JP2007525406A (ja) * 2003-12-04 2007-09-06 ワイス ビアリールスルホンアミドおよびその使用方法

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ATE411306T1 (de) 2008-10-15
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CR8418A (es) 2007-08-28
US20100137298A1 (en) 2010-06-03
AR046859A1 (es) 2005-12-28
DE60324208D1 (de) 2008-11-27
AU2003299789A1 (en) 2005-07-14
US7420001B2 (en) 2008-09-02
ZA200604551B (en) 2008-11-26
JP2007524567A (ja) 2007-08-30
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CA2548518A1 (en) 2005-07-07
IL159679A0 (en) 2004-06-20
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CN1623537A (zh) 2005-06-08
TW200519100A (en) 2005-06-16
US20050143422A1 (en) 2005-06-30
RU2006123559A (ru) 2008-01-10
NO20062649L (no) 2006-09-01
PA8618901A1 (es) 2005-11-25
KR20060093735A (ko) 2006-08-25

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