PE20050582A1 - QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS - Google Patents
QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTSInfo
- Publication number
- PE20050582A1 PE20050582A1 PE2004001119A PE2004001119A PE20050582A1 PE 20050582 A1 PE20050582 A1 PE 20050582A1 PE 2004001119 A PE2004001119 A PE 2004001119A PE 2004001119 A PE2004001119 A PE 2004001119A PE 20050582 A1 PE20050582 A1 PE 20050582A1
- Authority
- PE
- Peru
- Prior art keywords
- cyane
- pyrrolidin
- cyclopropyl
- dihydro
- oxo
- Prior art date
Links
- 150000007660 quinolones Chemical class 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A DERIVADOS DE QUINOLONA DE FORMULA I DONDE X ES N, C CON LA CONDICION DE QUE CUANDO X SEA N, R5 ESTE AUSENTE EN ESA POSICION; R1 ES ALQUILO (C1-C6), HALO-ALQUILO (C1-C6), CICLOALQUILO (C1-C6), HALO-CICLOALQUILO (C3-C6), HETEROCICLILO, ARILO, HETEROARILO, ENTRE OTROS; R2 ES OH, OBF2, O-ALQUILO (C1-C6), O-CICLOALQUILO (C3-C6), ENTRE OTROS; R3, R4 Y R5 SON H, OH, HALO, NRyRz DONDE CADA UNO DE Ry Y Rz ES INDEPENDIENTEMENTE H O ALQUILO (C1-C6); R1 Y R5 TOMADOS JUNTO CON LOS CARBONOS A LOS QUE ESTAN UNIDOS FORMAN UN ANILLO DE 5 O 6 MIEMBROS SUSTITUIDO O NO SUSTITUIDO QUE CONTIENEN 0 A 2 HETEROATOMOS SELECCIONADOS ENTRE O, S, SO, SO2, NRx DONDE Rx ES H, ALQUILO (C1-C6). SON COMPUESTOS PREFERIDOS:ACIDO 7- [3- (2-CIANO-ETILAMINO)-PIRROLIDIN-1-IL]-1-CICLOPROPIL-6-FLUORO-8-METOXI-4- OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7- [3- (2-CIANO-ETILAMINO)-PIRROLIDIN-1-IL]-1-CICLOPROPIL-6-FLUORO-8-METIL-4-OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7- {3-[(2-CIANO-ETIL)-METIL-AMINO]-PIRROLIDIN-1-IL}-1-CICLOPROPIL-6-FLUORO-8- METOXI-4-OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7-{3-[(2-CIANO-ETIL)-METIL-AMINO]-PIRROLIDIN-L-IL}-1-CICLOPROPIL-6-FLUORO-8- METIL-4-OXO-1,4-DIHIDRO-QUINOLIN-3-CARBOXILICO , ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE UNA INFECCION BACTERIANAREFERS TO QUINOLONE DERIVATIVES OF FORMULA I WHERE X IS N, C WITH THE CONDITION THAT WHEN X IS N, R5 IS ABSENT IN THAT POSITION; R1 IS ALKYL (C1-C6), HALO-ALKYL (C1-C6), CYCLOALKYL (C1-C6), HALO-CYCLOALKYL (C3-C6), HETEROCYCLYL, ARYL, HETEROARYL, AMONG OTHERS; R2 IS OH, OBF2, O-ALKYL (C1-C6), O-CYCLOALKYL (C3-C6), AMONG OTHERS; R3, R4 AND R5 ARE H, OH, HALO, NRyRz WHERE EACH OF Ry AND Rz IS INDEPENDENTLY H OR ALKYL (C1-C6); R1 AND R5 TAKEN TOGETHER WITH THE CARBONS TO WHICH THEY ARE UNITED FORM A SUBSTITUTED OR NON-SUBSTITUTED RING OF 5 OR 6 MEMBERS CONTAINING 0 TO 2 HETEROATOMS SELECTED FROM O, S, SO, SO2, NRx WHERE Rx IS H, RENT (C1 -C6). PREFERRED COMPOUNDS ARE: ACID 7- [3- (2-CYANE-ETHYLAMINE) -PYRROLIDIN-1-IL] -1-CYCLOPROPYL-6-FLUORO-8-METOXY-4-OXO-1, 4-DIHYDRO-QUINOLIN-3 -CARBOXYL; 7- [3- (2-CYANE-ETHYLAMINE) -PYRROLIDIN-1-IL] -1-CYCLOPROPYL-6-FLUORO-8-METHYL-4-OXO-1,4-DIHYDRO-QUINOLIN-3-CARBOXYL ACID; ACID 7- {3 - [(2-CYANE-ETHYL) -METHYL-AMINO] -PYRROLIDIN-1-IL} -1-CYCLOPROPYL-6-FLUORO-8-METOXY-4-OXO-1, 4-DIHYDRO-QUINOLIN -3-CARBOXYL; ACID 7- {3 - [(2-CYANE-ETHYL) -METHYL-AMINO] -PYRROLIDIN-L-IL} -1-CYCLOPROPYL-6-FLUORO-8-METHYL-4-OXO-1,4-DIHYDRO-QUINOLINE -3-CARBOXYL, AMONG OTHERS. ALSO REFERS TO A USEFUL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF A BACTERIAL INFECTION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52307103P | 2003-11-18 | 2003-11-18 | |
| US60549604P | 2004-08-31 | 2004-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050582A1 true PE20050582A1 (en) | 2005-08-25 |
Family
ID=34623167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004001119A PE20050582A1 (en) | 2003-11-18 | 2004-11-16 | QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR046638A1 (en) |
| NL (1) | NL1027545C2 (en) |
| PE (1) | PE20050582A1 (en) |
| TW (1) | TW200524930A (en) |
| UY (1) | UY28622A1 (en) |
| WO (1) | WO2005049602A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4639149B2 (en) | 2003-09-10 | 2011-02-23 | 杏林製薬株式会社 | 7- (4-Substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivatives |
| EP2468752A1 (en) | 2005-08-04 | 2012-06-27 | Sirtris Pharmaceuticals, Inc. | Thiazolopyridine derivatives as sirtuin-modulators |
| DE102006005861A1 (en) * | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituted quinolones III |
| DK2097400T3 (en) * | 2007-01-05 | 2013-10-14 | Daiichi Sankyo Co Ltd | CONDENSED, SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE |
| CN101622240B (en) * | 2007-01-05 | 2014-07-23 | 第一三共株式会社 | Fused Substituted Aminopyrrolidine Derivatives |
| JP5322927B2 (en) | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | A mutilin derivative having a heteroaromatic carboxylic acid structure at the 14-position substituent. |
| DE102007036068A1 (en) | 2007-08-01 | 2009-02-05 | Wacker Chemie Ag | Process for the preparation of alkylmethoxymethyltrimethylsilanylmethylamines |
| EP2295406B1 (en) | 2008-05-30 | 2014-04-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US8673891B2 (en) | 2009-02-06 | 2014-03-18 | Nippon Shinyaku Co., Ltd. | Aminopyrazine derivative and medicine |
| AR091858A1 (en) * | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | CISTATIONIN-g-LIASA INHIBITORS (CSE) |
| EA035465B1 (en) | 2015-06-09 | 2020-06-22 | Байер Фарма Акциенгезельшафт | 7-substituted 1-arylnaphthyridine-3-carboxamides as positive allosteric modulators of muscarinic m2 receptor, process for preparation thereof, use thereof for treatment and/or prevention of diseases and medicament comprising these compounds |
| CN109689654A (en) * | 2016-07-11 | 2019-04-26 | 拜耳医药股份有限公司 | 7-Substituted 1-pyridyl-naphthyridine-3-carboxamides and their uses |
| JOP20190045A1 (en) | 2016-09-14 | 2019-03-14 | Bayer Ag | Amide-1-aryl-naphthridine-3-carboxylic acid amide compounds are substituted at position 7 and used. |
| EP3296298A1 (en) | 2016-09-14 | 2018-03-21 | Bayer Pharma Aktiengesellschaft | 7-substituted 1-aryl-naphthyridin-3-carboxamides and their use |
| WO2018060073A1 (en) | 2016-09-29 | 2018-04-05 | Bayer Cropscience Aktiengesellschaft | Novel 5-substituted imidazole derivatives |
-
2004
- 2004-11-05 WO PCT/IB2004/003666 patent/WO2005049602A1/en not_active Ceased
- 2004-11-16 PE PE2004001119A patent/PE20050582A1/en not_active Application Discontinuation
- 2004-11-17 UY UY28622A patent/UY28622A1/en not_active Application Discontinuation
- 2004-11-17 TW TW093135213A patent/TW200524930A/en unknown
- 2004-11-18 AR ARP040104261A patent/AR046638A1/en unknown
- 2004-11-18 NL NL1027545A patent/NL1027545C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| UY28622A1 (en) | 2005-06-30 |
| AR046638A1 (en) | 2005-12-14 |
| WO2005049602A1 (en) | 2005-06-02 |
| TW200524930A (en) | 2005-08-01 |
| NL1027545C2 (en) | 2006-01-17 |
| NL1027545A1 (en) | 2005-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |