PE20040569A1 - Uso de n-(indolcarbonil-)piperazinas como antagonistas de los receptores 5-ht2a - Google Patents
Uso de n-(indolcarbonil-)piperazinas como antagonistas de los receptores 5-ht2aInfo
- Publication number
- PE20040569A1 PE20040569A1 PE2003000995A PE2003000995A PE20040569A1 PE 20040569 A1 PE20040569 A1 PE 20040569A1 PE 2003000995 A PE2003000995 A PE 2003000995A PE 2003000995 A PE2003000995 A PE 2003000995A PE 20040569 A1 PE20040569 A1 PE 20040569A1
- Authority
- PE
- Peru
- Prior art keywords
- well
- piperazines
- antagonists
- indolcarbonyl
- fluorophenethyl
- Prior art date
Links
- -1 INDOLCARBONYL- Chemical class 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 101150104779 HTR2A gene Proteins 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
- 108091005479 5-HT2 receptors Proteins 0.000 abstract 1
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 abstract 1
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 abstract 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000008452 non REM sleep Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE AL USO DE DERIVADOS DE N-(INDOLCARBONIL-) PIPERAZINAS COMO ANTAGONISTAS DE LOS RECEPTORES 5-HT2 EN ESPECIAL DEL SUBTIPO 5-HT2A DONDE LOS COMPUESTOS PREFERIDOS SON: (3-AMINOCARBONIL-1H-INDOL-7-IL)-[4-(4-FLUOROFENETIL)-PIPERAZIN-1-IL]-METANONA, (3-CIAN-1H-INDOL-7-IL)-[4-(4-FLUOROFENETIL)-PIPERAZIN-1-IL]-METANONA, ENTRE OTROS. ASI COMO SUS SALES Y SOLVATOS PARA SU UTILIZACION EN LA PEPRARACION DE UN MEDICAMENTO PARA PROLONGAR EL SUENO REM, ASI COMO TAMBIEN EL SUENO NO REM, PARA EL TRATAMIENTO DE TRANSTORNOS DE CONCILIACION Y CONTINUIDAD DEL SUENO, ASI COMO UN DESPERTAR ANTICIPADO EN LAS MANANAS, TAMBIEN SE REFIERE A UNA PREPARACION FARMACEUTICA QUE CONTIENE EL INGREDIENTE ACTIVO ASI COMO EVENTUALMENTE VEHICULOS Y/O EXCIPIENTES, ESTOS COMPUESTOS PUEDEN ADMINISTRARSE CON OTROS INGREDIENTES ACTIVOS COMO EL GRUPO DE LOS SOMNIFEROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10246357A DE10246357A1 (de) | 2002-10-04 | 2002-10-04 | Verwendung von 5-HT2Rezeptorantagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040569A1 true PE20040569A1 (es) | 2004-08-30 |
Family
ID=32010223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000995A PE20040569A1 (es) | 2002-10-04 | 2003-10-01 | Uso de n-(indolcarbonil-)piperazinas como antagonistas de los receptores 5-ht2a |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060040951A1 (es) |
| EP (1) | EP1545531A1 (es) |
| JP (1) | JP2006503870A (es) |
| KR (1) | KR20050054996A (es) |
| CN (1) | CN1688309A (es) |
| AR (1) | AR041476A1 (es) |
| AU (1) | AU2003283237A1 (es) |
| BR (1) | BR0314945A (es) |
| CA (1) | CA2501082A1 (es) |
| DE (1) | DE10246357A1 (es) |
| MX (1) | MXPA05003437A (es) |
| PE (1) | PE20040569A1 (es) |
| PL (1) | PL374077A1 (es) |
| RU (1) | RU2005113712A (es) |
| TW (1) | TW200410691A (es) |
| UA (1) | UA79993C2 (es) |
| WO (1) | WO2004032932A1 (es) |
| ZA (1) | ZA200503520B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004047517A1 (de) * | 2004-09-28 | 2006-03-30 | Merck Patent Gmbh | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865939A (en) * | 1973-02-23 | 1975-02-11 | Procter & Gamble | Edible oils having hypocholesterolemic properties |
| DE3119383A1 (de) * | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten |
| US5244887A (en) * | 1992-02-14 | 1993-09-14 | Straub Carl D | Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof |
| PT1148793E (pt) * | 1999-02-03 | 2003-12-31 | Forbes Medi Tech Inc | Metodo para a preparacao de microparticulas de fitoesterois ou fitoestanois |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
| US6391370B1 (en) * | 1999-11-12 | 2002-05-21 | Kraft Foods, Inc. | Micromilling plant sterols and emulsifiers |
| US6576285B1 (en) * | 2000-11-14 | 2003-06-10 | Sunpure Ltd. | Cholesterol lowering beverage |
| DE10102944A1 (de) * | 2001-01-23 | 2002-07-25 | Merck Patent Gmbh | Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen |
| DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
-
2002
- 2002-10-04 DE DE10246357A patent/DE10246357A1/de not_active Withdrawn
-
2003
- 2003-03-09 UA UAA200504236A patent/UA79993C2/uk unknown
- 2003-09-03 BR BR0314945-5A patent/BR0314945A/pt not_active IP Right Cessation
- 2003-09-03 EP EP03775144A patent/EP1545531A1/de not_active Withdrawn
- 2003-09-03 RU RU2005113712/15A patent/RU2005113712A/ru not_active Application Discontinuation
- 2003-09-03 US US10/530,051 patent/US20060040951A1/en not_active Abandoned
- 2003-09-03 CN CNA038235668A patent/CN1688309A/zh active Pending
- 2003-09-03 KR KR1020057005858A patent/KR20050054996A/ko not_active Withdrawn
- 2003-09-03 MX MXPA05003437A patent/MXPA05003437A/es not_active Application Discontinuation
- 2003-09-03 AU AU2003283237A patent/AU2003283237A1/en not_active Abandoned
- 2003-09-03 CA CA002501082A patent/CA2501082A1/en not_active Abandoned
- 2003-09-03 PL PL03374077A patent/PL374077A1/xx not_active Application Discontinuation
- 2003-09-03 WO PCT/EP2003/009738 patent/WO2004032932A1/de not_active Ceased
- 2003-09-03 JP JP2004542340A patent/JP2006503870A/ja active Pending
- 2003-09-30 TW TW092127070A patent/TW200410691A/zh unknown
- 2003-10-01 PE PE2003000995A patent/PE20040569A1/es not_active Application Discontinuation
- 2003-10-03 AR ARP030103600A patent/AR041476A1/es not_active Application Discontinuation
-
2005
- 2005-05-03 ZA ZA200503520A patent/ZA200503520B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003283237A1 (en) | 2004-05-04 |
| TW200410691A (en) | 2004-07-01 |
| RU2005113712A (ru) | 2005-11-20 |
| BR0314945A (pt) | 2005-08-02 |
| CN1688309A (zh) | 2005-10-26 |
| KR20050054996A (ko) | 2005-06-10 |
| PL374077A1 (en) | 2005-09-19 |
| DE10246357A1 (de) | 2004-04-15 |
| AR041476A1 (es) | 2005-05-18 |
| UA79993C2 (en) | 2007-08-10 |
| EP1545531A1 (de) | 2005-06-29 |
| WO2004032932A1 (de) | 2004-04-22 |
| JP2006503870A (ja) | 2006-02-02 |
| MXPA05003437A (es) | 2005-07-05 |
| ZA200503520B (en) | 2006-02-22 |
| US20060040951A1 (en) | 2006-02-23 |
| CA2501082A1 (en) | 2004-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2167061T3 (es) | Formas de dosificacion para mejorar la disfuncion erectil en pacientes de sexo masculino. | |
| PA8587101A1 (es) | Nuevos derivados de dihidropirimido [4,5-d] pirimidinona sustituida por amiino, fabricacion y uso de los mismos como agentes farmaceuticos | |
| EE200300033A (et) | Tsüklopentanoindoolid, nende kasutamine ravimi valmistamiseks ning neid sisaldav farmatseutiline kompositsioon | |
| CO5011096A1 (es) | Medicamentos que contienen antagonistas del receptor 5-ht3 para el tratamiento de la ibs | |
| UY28231A1 (es) | Metodos y composiciones farmacéuticas para la obtención confiable de niveles aceptables de testosterona en suero. | |
| DK1526839T3 (da) | Orale farmaceutiske former for flydende lægemidler med forbedret biotilgængelighed | |
| AR020001A1 (es) | COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO | |
| BR0315547A (pt) | Derivados de quinolina como antagonistas de crth2 | |
| NO20080670L (no) | Substituerte piperaziner som metabotrofiske glutamatreseptorantagonister | |
| CU23423B7 (es) | Oxazolidinonas sustituidas y su uso en el campo de la coagulación sanguínea | |
| ATE390135T1 (de) | Verfahren zur verwendung von und zusammensetzungen mit immunomodulatorischen verbindungen zur behandlung und versorgung von myelodysplastischen syndromen | |
| CO2021006482A2 (es) | Ureas cíclicas | |
| UY26291A1 (es) | Compuestos químicos xxii | |
| AR026916A1 (es) | Combinaciones farmaceuticas y su uso en el tratamiento de desordenes gastrointestinales | |
| ECSP055701A (es) | Nuevos derivados de pirimidinamida y el uso de los mismos | |
| ES2052603T3 (es) | Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen. | |
| EA200300183A1 (ru) | Новое сочетание агониста (5-th2) и антагониста (5-ht6) серотонина в качестве фармацевтической композиции | |
| BRPI0511224A (pt) | método para preparar uma composição contendo antagonistas de opióides, produto contendo antagonistas de opióides, composição contendo antagonistas de opióides, formulação de dosagem injetável, kit, método para prevenir ou tratar um efeito colateral associado com um opióide num paciente, e para tratar ou impedir dor num paciente | |
| AR035603A1 (es) | Derivados de piperazina, composicion farmaceutica que los comprende y el uso de los mismos para la fabricacion de un medicamento como agentes serotonergicos | |
| AR029373A1 (es) | Metodo para el tratamiento de migranas, utilizando compuestos antagonistas selectivos de los receptores iglur5, uso de dichos compuestos antagonistas selectivos en la manufactura de medicamentos para el tratamiento de migranas y dichos compuestos antagonistas | |
| ATE364044T1 (de) | 5ht2c rezeptor agonisten zur behandlung von diabetes und fettleibigkeit | |
| EE200100104A (et) | 5-HT4 agonisti või antagonisti uus peroraalne ravimvorm | |
| PE20040973A1 (es) | Composiciones de anti-histaminicos, descongestivos y drogas anti-inflamatorias no esteroidales | |
| BRPI0413013A (pt) | composto, seus sais, solvatos, e derivados farmaceuticamente funcionais, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou profilaxia de condições ou distúrbios, e de doenças | |
| AR046036A1 (es) | Composiciones de risedronato y metodos para su uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |