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PE20030361A1 - Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas - Google Patents

Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas

Info

Publication number
PE20030361A1
PE20030361A1 PE2002000742A PE2002000742A PE20030361A1 PE 20030361 A1 PE20030361 A1 PE 20030361A1 PE 2002000742 A PE2002000742 A PE 2002000742A PE 2002000742 A PE2002000742 A PE 2002000742A PE 20030361 A1 PE20030361 A1 PE 20030361A1
Authority
PE
Peru
Prior art keywords
agents
butyl
alkyl
methyl
inhibiting agents
Prior art date
Application number
PE2002000742A
Other languages
English (en)
Inventor
Wendelin Frick
Hans-Ludwig Schafer
Werner Kramer
Heiner Glombik
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10140169A external-priority patent/DE10140169A1/de
Priority claimed from DE10142456A external-priority patent/DE10142456A1/de
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20030361A1 publication Critical patent/PE20030361A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

SE REFIERE FORMULACIONES EN COMBINACION DE DERIVADOS DE 1,4-BENZOTIEPINA-1,1-DIOXIDO DE FORMULA I DONDE R1 ES METILO, ETILO PROPILO, BUTILO; R2 ES H, OH, NH2, NH-ALQUILO(C1-C6); R3 ES UN RADICAL AZUCAR, UNA RADICAL AMINOACIDO, UN DIAMINOACIDO, CON GRUPOS PROTECTORES DE AZUCARES Y AMINOACIDOS; R4 ES METILO, ETILO, PROPILO, BUTILO; R5 ES METILO, ETILO, PROPILO, BUTILO; Z ES -(C=O)n-ALQUILO C0-C16, -(C=O)n-ALQUIL C0-C16-NH-, ENTRE OTROS; n ES 0-1; m ES 0-1. SE REFIERE TAMBIEN A UNA MEZCLA DE SUSTANCIAS QUE COMPRENDE LA SUSTANCIA ACTIVA JUNTO A AGENTES ANTIDIABETICOS , SUSTANCIAS ACTIVAS HIPOGLUCEMICAS, AGENTES INHIBIDORES DE HMG-CoA-REDUCTASA, AGENTES INHIBIDORES DE LA RESORCION DEL COLESTEROL (EZETIMIBE, TIQUESIDE, PAMAQUESIDE), AGENTES INHIBIDORES DE MTP, ANTIOXIDANTES, INHIBIDORES DE SINTETASA ESCUALENO. LA FORMULACION ES UTIL PARA EL TRATAMIENTO DE HIPERLIPIDEMIA, TRASTORNOS DEL METABOLISMO DE LIPIDOS, ARTERIOESCLEROSIS
PE2002000742A 2001-08-22 2002-08-16 Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas PE20030361A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10140169A DE10140169A1 (de) 2001-08-22 2001-08-22 Kombinationspräparate von 1,4-Benzothiepin-1,1-dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung
DE10142456A DE10142456A1 (de) 2001-08-31 2001-08-31 Kombinationspräparate von 1,4-Benzothiepin-1,1dioxidderivaten mit weiteren Wirkstoffen und deren Verwendung

Publications (1)

Publication Number Publication Date
PE20030361A1 true PE20030361A1 (es) 2003-05-27

Family

ID=26009944

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000742A PE20030361A1 (es) 2001-08-22 2002-08-16 Formulaciones en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas

Country Status (29)

Country Link
US (2) US20030158119A1 (es)
EP (1) EP1425018B1 (es)
JP (1) JP2005501861A (es)
KR (1) KR20040032937A (es)
CN (1) CN1655792A (es)
AR (1) AR035285A1 (es)
AT (1) ATE411802T1 (es)
AU (1) AU2002333373B2 (es)
BR (1) BR0212031A (es)
CA (1) CA2457976A1 (es)
CO (1) CO5560550A2 (es)
DE (1) DE50212937D1 (es)
HN (1) HN2002000235A (es)
HR (1) HRP20040171A2 (es)
HU (1) HUP0401318A3 (es)
IL (1) IL160474A0 (es)
MA (1) MA26317A1 (es)
MX (1) MXPA04001328A (es)
NO (1) NO20040702L (es)
NZ (1) NZ531293A (es)
OA (1) OA12654A (es)
PA (1) PA8553201A1 (es)
PE (1) PE20030361A1 (es)
PL (1) PL366851A1 (es)
RS (1) RS11104A (es)
RU (1) RU2297222C2 (es)
TN (1) TNSN04034A1 (es)
UY (1) UY27419A1 (es)
WO (1) WO2003018024A1 (es)

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ME00145B (me) 2001-01-26 2010-10-10 Merck Sharp & Dohme Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
DE60216300T2 (de) 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
ATE406364T1 (de) 2003-03-07 2008-09-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
WO2004081003A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia
CA2517573C (en) 2003-03-07 2011-12-06 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
DE102006053637B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE102006053635B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
JP2010509252A (ja) 2006-11-14 2010-03-25 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 改善された特性を有する新規な1,4−ベンゾチエピン−1,1−ジオキシド誘導体、それらの製造方法、上記化合物を含有する薬物、及びそれらの使用
DE102006053636B4 (de) * 2006-11-14 2008-09-18 Sanofi-Aventis Deutschland Gmbh Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
CN102316872B (zh) 2008-11-26 2016-12-21 萨蒂奥根制药公司 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂
EP2575821B1 (en) * 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
EP2765855A4 (en) 2011-10-12 2015-03-25 Merck Sharp & Dohme PHARMACEUTICAL COMPOSITIONS FOR DISPERSION INHIBITION
EP3278796A1 (en) 2011-10-28 2018-02-07 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
EP3266457A1 (en) 2011-10-28 2018-01-10 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
JP2016514684A (ja) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤
MX2015013196A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
KR20150079373A (ko) 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
AU2020221239A1 (en) 2019-02-12 2021-09-16 Mirum Pharmaceuticals, Inc. Methods for treating cholestasis

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Also Published As

Publication number Publication date
IL160474A0 (en) 2004-07-25
CN1655792A (zh) 2005-08-17
CO5560550A2 (es) 2005-09-30
NZ531293A (en) 2005-08-26
HN2002000235A (es) 2003-02-18
NO20040702L (no) 2004-05-19
OA12654A (en) 2006-06-15
HUP0401318A2 (hu) 2004-10-28
RU2004108119A (ru) 2005-04-10
PA8553201A1 (es) 2004-08-31
EP1425018A1 (de) 2004-06-09
MA26317A1 (fr) 2004-10-01
JP2005501861A (ja) 2005-01-20
ATE411802T1 (de) 2008-11-15
PL366851A1 (en) 2005-02-07
AR035285A1 (es) 2004-05-05
WO2003018024A1 (de) 2003-03-06
AU2002333373B2 (en) 2006-12-14
US7179792B2 (en) 2007-02-20
TNSN04034A1 (en) 2006-06-01
UY27419A1 (es) 2003-04-30
RU2297222C2 (ru) 2007-04-20
HUP0401318A3 (en) 2008-03-28
US20030158119A1 (en) 2003-08-21
HRP20040171A2 (en) 2004-10-31
US20040097424A1 (en) 2004-05-20
EP1425018B1 (de) 2008-10-22
DE50212937D1 (de) 2008-12-04
MXPA04001328A (es) 2004-05-05
KR20040032937A (ko) 2004-04-17
RS11104A (sr) 2006-12-15
BR0212031A (pt) 2004-08-03
CA2457976A1 (en) 2003-03-06

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