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PE20030360A1 - Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion - Google Patents

Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion

Info

Publication number
PE20030360A1
PE20030360A1 PE2002000806A PE2002000806A PE20030360A1 PE 20030360 A1 PE20030360 A1 PE 20030360A1 PE 2002000806 A PE2002000806 A PE 2002000806A PE 2002000806 A PE2002000806 A PE 2002000806A PE 20030360 A1 PE20030360 A1 PE 20030360A1
Authority
PE
Peru
Prior art keywords
indan
alkyl
onas
derivatives
substituted
Prior art date
Application number
PE2002000806A
Other languages
English (en)
Inventor
Martin Bickel
Volker Krone
Gerhard Jaehne
Matthias Gossel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE20030360A1 publication Critical patent/PE20030360A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE INDAN-1-ONAS SUSTITUIDAS EN C2 Y SUS DERIVADOS DE FORMULA I DONDE: a) R1-R4 SON H; X ES S, SO, SO2; Y ES (CH2)p DONDE p PUEDE SER 0-3; R5 ES CF3, ALQUILO C2-C18, CICLOALQUILO C3-C4, CICLOALQUILO C6-C8, DONDE LOS GRUPOS ALQUILO PUEDEN ESTAR REEMPLAZADOS CON F; b) R1 Y R4 SON H, F, Cl, Br, I, CH, N3, NO2, OH, ENTRE OTROS, R2 Y R3 SON H, F, Cl, Br, I, CH, N3, OALQUILO C1-C8, OCICLOALQUILO C3-C8, O-CO-ALQUILO C1-C8, ENTRE OTROS, R2 Y R3 JUNTOS FORMAN EL GRUPO -O-CH2-O-, ENTRE OTROS, R4 ES DIFERENTE DE H, X ES S, SO, SO2, R5 ES ALQUILO C1-C18, CICLAOLQUILO C3-C4 Y C6-C8 , ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. SON COMPUESTOS PREFERIDOS 5-CLORO-2-METILSULFANIL-INDAN-1-ONA, 5-CLORO-2-METANOSULFONIL-INDAN-1-ONA, 5-CLORO-2-FENILSULFANIL-INDAN-1-ONA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO O PROFILAXIS DE OBESIDAD, DIABETES TIPO II
PE2002000806A 2001-08-31 2002-08-22 Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion PE20030360A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10142722A DE10142722A1 (de) 2001-08-31 2001-08-31 C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20030360A1 true PE20030360A1 (es) 2003-05-16

Family

ID=7697277

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000806A PE20030360A1 (es) 2001-08-31 2002-08-22 Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion

Country Status (12)

Country Link
US (1) US6762326B2 (es)
EP (1) EP1425267B1 (es)
JP (1) JP4280164B2 (es)
AR (1) AR036675A1 (es)
AT (1) ATE472525T1 (es)
AU (1) AU2002336085B2 (es)
CA (1) CA2458528C (es)
DE (2) DE10142722A1 (es)
IL (1) IL160608A0 (es)
MX (1) MXPA04001846A (es)
PE (1) PE20030360A1 (es)
WO (1) WO2003020677A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920393D0 (en) 1999-08-27 1999-11-03 Medix Scient Uk Limited Plant extract mixtures and their uses
US7659313B2 (en) 2007-09-13 2010-02-09 Gateway Health Alliances, Inc. Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7700500L (sv) * 1976-01-20 1977-07-21 Hoechst Ag Tiazolidinderivat och forfarande for deras framstellning
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE2965279D1 (en) * 1978-07-27 1983-06-01 Schering Ag Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds
MX13484A (es) * 1987-10-19 1993-05-01 Pfizer Procedimiento para la obtencion de tetralinas, cromanos y compuestos relacionados, sustituidos
DK0608568T3 (da) * 1993-01-29 1998-09-28 American Cyanamid Co Aminocycloalkanobenzodioxoler som beta 3-selektiveadrenerge midler
AU1169397A (en) * 1995-12-06 1997-06-27 Venantius Limited Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity
WO1997026265A1 (en) 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Ｇｌｐ―１誘導体
PT958296E (pt) 1996-12-31 2003-11-28 Reddys Lab Ltd Dr Compostos heterociclicos processo para a sua preparacao composicoes farmaceuticas contendo-os e sua utilizacao no tratamento da diabetes e doencas relacionadas
KR20010021936A (ko) 1997-07-16 2001-03-15 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 융합된 1,2,4-티아디아진 유도체, 그의 제조와 사용
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2796070B1 (fr) * 1999-07-06 2003-02-21 Lipha Derives de benzodiazepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation
EP1078632A1 (en) 1999-08-16 2001-02-28 Sanofi-Synthelabo Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity

Also Published As

Publication number Publication date
CA2458528C (en) 2011-01-25
WO2003020677A2 (de) 2003-03-13
CA2458528A1 (en) 2003-03-13
JP4280164B2 (ja) 2009-06-17
US20030130345A1 (en) 2003-07-10
ATE472525T1 (de) 2010-07-15
AR036675A1 (es) 2004-09-29
MXPA04001846A (es) 2004-06-15
EP1425267A2 (de) 2004-06-09
JP2005525295A (ja) 2005-08-25
EP1425267B1 (de) 2010-06-30
IL160608A0 (en) 2004-07-25
DE50214511D1 (de) 2010-08-12
WO2003020677A3 (de) 2003-07-31
US6762326B2 (en) 2004-07-13
AU2002336085B2 (en) 2007-10-11
DE10142722A1 (de) 2003-03-27

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