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PE20030307A1 - 1-PENETHYLPIPERIDINE COMPOUNDS SUBSTITUTED WITH EDERIVATES OF PHENYL-ACETAMIDE-THIAZOLE AND PROCESS FOR THEIR PREPARATION ANALGESIC FECT - Google Patents

1-PENETHYLPIPERIDINE COMPOUNDS SUBSTITUTED WITH EDERIVATES OF PHENYL-ACETAMIDE-THIAZOLE AND PROCESS FOR THEIR PREPARATION ANALGESIC FECT

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Publication number
PE20030307A1
PE20030307A1 PE20020006112002000599A PE2002000599A PE20030307A1 PE 20030307 A1 PE20030307 A1 PE 20030307A1 PE 20020006112002000599 A PE20020006112002000599 A PE 20020006112002000599A PE 2002000599 A PE2002000599 A PE 2002000599A PE 20030307 A1 PE20030307 A1 PE 20030307A1
Authority
PE
Peru
Prior art keywords
phenyl
acetamide
isopropyl
refers
compounds
Prior art date
Application number
PE20020006112002000599A
Other languages
Spanish (es)
Inventor
Bernd Pevarello Paolo Sundermann
Raffaella Hoenen Lambert Amici
Helmut Salom Barbara Buschmann
Anna Koegel Babette-Yvonne Vulpetti
Elmar Villa Manuela Friderichs
Mario Varasi
Maria Gabriella Brasca
Gabriella Traquandi
Marcella Nesi
Original Assignee
Pharmacia Italia S P A Grunenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10132746A external-priority patent/DE10132746A1/en
Application filed by Pharmacia Italia S P A Grunenthal Gmbh filed Critical Pharmacia Italia S P A Grunenthal Gmbh
Publication of PE20030307A1 publication Critical patent/PE20030307A1/en

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Abstract

SE REFIERE A COMPUESTOS DE FENETILPIPERIDINA SUSTISE REFIERE A DERIVADOS DE FENILACETAMIDO-TIAZOL DE FORMULA I DONDE R ES H, ALQUILO C1-C4, GRUPO IIa,TUIDA DE FORMULA I DONDE X ES METILENO-(CH2), CARBONILO-CO; R1 ES ARILO, HETEROARILO; R2 ES H, COR5, IIb, IIc, IId, IIe; R2 ES H, ALQUILO C1-C6; R3 ES SO2R5, RADICAL ALIFATICO C1-C10, ENTRE OTROS; R3 AMINO, AMINOMETILO, HIDROXIMETILO, ALQUILO C1-C4, HETEROCICLO DE 5-6 MIEMBROS, CUANDO R ES H, R3 ESY R4 SON H, UN ENLACE; R5 ES UN RADICAL ALIFATICO C1-C10, CICLOALIFATICO C3-C8, ARILO, HETEROARILO. DIFERENTE DE METILO, PIRIDIL-3-ILO. SON COMPUESTOSON COMPUESTOS PREFERIDOS 2-(1-FENETILPIPERIDIN-4-S PREFERIDOS N-(5-ISOPROPIL-1,3-TIAZOL-2-IL)-2-[4-IL)-N-FENILACETAMIDA; [2-(1-FENETILPIPERIDIN-4-IL)(2-OXO-1-PIRROLIDINIL)-FENIL]-ACETAMIDA; (2S)-2-[4ETIL]FENILAMINA; 2-(1-FENETILPIPERIDIN-4-ILIDEN)-N-(ACETILAMINO)FENIL]-N-(5-ISOPROPIL-1,3-TIAZOL-2-IL)-PROPANAMIDA; N-(4-{(1S)-2-[(5-ISOPROPIL-1,3-TIA-FENIL-ACETAMIDA, N-(4-METOXIFENIL)-2-(1-FENETILPIZOL-2-IL)-AMINO-1-METIL-2-OXOETIL}-FENIL)-NICOTINAPERIDIN-4-IL)ACETAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS MIDA; N-(4-{(1S)-2-[(5-ISOPROPIL-1,3-TIAZOL-2-IL-AMINO]-1-METIL-2-OXOETIL}-FENIL)ISONICOTINAMIDA; ENCOMPUESTOS TIENEN EFECTO ANALGESICO Y PUEDEN SER UTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PTILES PARA EL TRATAMIENTO DE DOLOR, MIGRANA, DIARREA, INCONTINENCIA URINARIA, PRURITO, REACCIONES INARA LA PREPARACION; Y A UNA COMPOSICION QUE COMPREFLAMATORIAS, ALERGICAS, ABUSO DE ALCOHOL, DROGAS, NDE ADEMAS OTROS AGENTES QUIMIOTERAPEUTICOS. LOS CMEDICAMENTOS, INFLAMACION, ANESTESIA LOCAL OMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE QUINASA cdk CICLINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE CANCER, CARCINOMAREFERS TO PENETHYLPIPERIDINE COMPOUNDS, SUBSTISE REFERS TO Phenylacetamide-Thiazole Derivatives OF FORMULA I WHERE R IS H, C1-C4 ALKYL, GROUP IIa, FORMULA I TUIDA WHERE X IS METHYLENE- (CH2), CARBONYL; R1 IS ARYL, HETEROARYL; R2 IS H, COR5, IIb, IIc, IId, IIe; R2 IS H, C1-C6 ALKYL; R3 IS SO2R5, C1-C10 ALIPHATIC RADICAL, AMONG OTHERS; R3 AMINO, AMINOMETHYL, HYDROXIMETHYL, C1-C4 ALKYL, 5-6 MEMBER HETEROCICLE, WHEN R IS H, R3 IS AND R4 ARE H, A LINK; R5 IS AN ALIPHATIC C1-C10, CYCLOALIPHATIC C3-C8, ARYL, HETEROARYL RADICAL. DIFFERENT FROM METHYL, PIRIDIL-3-ILO. COMPOUNDS ARE PREFERRED COMPOUNDS 2- (1-PENETHYLPIPERIDIN-4-S N- (5-ISOPROPYL-1,3-THIAZOL-2-IL) -2- [4-IL) -N-PHENYLACETAMIDE; [2- (1-PENETHYLPIPERIDIN-4-IL) (2-OXO-1-PYRROLIDINYL) -PHENYL] -ACETAMIDE; (2S) -2- [4ETHYL] PHENYLAMINE; 2- (1-PENETHYLPIPERIDIN-4-ILIDEN) -N- (ACETYLAMINE) PHENYL] -N- (5-ISOPROPYL-1,3-THIAZOL-2-IL) -PROPANAMIDE; N- (4 - {(1S) -2 - [(5-ISOPROPYL-1,3-THIA-PHENYL-ACETAMIDE, N- (4-METOXYPHENYL) -2- (1-PENETHYLPIZOL-2-IL) -AMINO- 1-METHYL-2-OXOETHYL} -PHENYL) -NICOTINAPERIDIN-4-IL) ACETAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. MEASURE THEM; N- (4 - {(1S) -2 - [(5-ISOPROPYL-1,3-THIAZOL-2-IL-AMINO] -1-METHYL-2-OXOETHYL} -PHENYL) ISONICOTINAMIDE; COMPOUNDS HAVE ANALGESIC EFFECT AND MAY BEING ANOTHER OTHERS ALSO REFERS TO A PTILES PROCEDURE FOR THE TREATMENT OF PAIN, MIGRANE, DIARRHEA, URINARY INCONTINENCE, PRURIT, REACTIONS IN THE PREPARATION; AND TO A COMPOSITION THAT COMPREFLAMATORY, ALLERGIC, ABUSE OF ALCEMOSIMOSTROSYM, ADDOTHYMOSTROSYM . MEDICINES, INFLAMMATION, LOCAL ANESTHESIA ORMPOSITE ARE INHIBITORS OF KINASE cdk CYCLINE ACTIVITY AND MAY BE USEFUL FOR THE TREATMENT OF CANCER, CARCINOMA

PE20020006112002000599A 2001-07-05 2002-07-04 1-PENETHYLPIPERIDINE COMPOUNDS SUBSTITUTED WITH EDERIVATES OF PHENYL-ACETAMIDE-THIAZOLE AND PROCESS FOR THEIR PREPARATION ANALGESIC FECT PE20030307A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10132746A DE10132746A1 (en) 2001-07-05 2001-07-05 Substituted 1-phenethylpiperidine compounds
US90794701A 2001-07-19 2001-07-19
US35764202P 2002-02-20 2002-02-20

Publications (1)

Publication Number Publication Date
PE20030307A1 true PE20030307A1 (en) 2003-04-26

Family

ID=43602604

Family Applications (1)

Application Number Title Priority Date Filing Date
PE20020006112002000599A PE20030307A1 (en) 2001-07-05 2002-07-04 1-PENETHYLPIPERIDINE COMPOUNDS SUBSTITUTED WITH EDERIVATES OF PHENYL-ACETAMIDE-THIAZOLE AND PROCESS FOR THEIR PREPARATION ANALGESIC FECT

Country Status (1)

Country Link
PE (1) PE20030307A1 (en)

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