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PE20030061A1 - 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4 - Google Patents

1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4

Info

Publication number
PE20030061A1
PE20030061A1 PE2002000434A PE2002000434A PE20030061A1 PE 20030061 A1 PE20030061 A1 PE 20030061A1 PE 2002000434 A PE2002000434 A PE 2002000434A PE 2002000434 A PE2002000434 A PE 2002000434A PE 20030061 A1 PE20030061 A1 PE 20030061A1
Authority
PE
Peru
Prior art keywords
inhibitors
biaril
naphthyridin
ona
phosphodiesterase
Prior art date
Application number
PE2002000434A
Other languages
English (en)
Inventor
Richard Friesen
Mario Girard
Ives Girard
Chu Li
Pierre Hamel
Sebastien Laliberte
Daniel Guay
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of PE20030061A1 publication Critical patent/PE20030061A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE 1-BIARIL-1,8-NAFTIRIDIN-4-ONA DE FORMULA I DONDE Ar ES FENILO, PIRIDILO, PIRIMIDILO, INDOLILO, ENTRE OTROS; R ES H, ALQUILO C1-C6; R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ALCOXI C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; n ES 0-2; R3 ES H, OH, AMINA, HALOGENO, ENTRE OTROS; R4, R5, R6, R7 SON H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-ISOPROPIL-1-[3-(3-ACETILFENIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA, N-(2,6-DICLOROPIRIDIN-4-IL)-1-[3-(3-ACETILFENIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA, N-ISOPROPIL-1-[3-(4-n-PROPILFENIL)FENIL]-1,4-DIHIDRO[1,8]NAFTIRIDIN-4-ONA-3-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FOSFODIESTERASA-4 Y SON UTILES PARA EL TRATAMIENTO Y SON UTILES PARA EL TRATAMIENTO DE ASMA, BRONQUITIS CRONICA, EPOC
PE2002000434A 2001-05-24 2002-05-23 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4 PE20030061A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29324701P 2001-05-24 2001-05-24

Publications (1)

Publication Number Publication Date
PE20030061A1 true PE20030061A1 (es) 2003-02-08

Family

ID=23128314

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000434A PE20030061A1 (es) 2001-05-24 2002-05-23 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4

Country Status (10)

Country Link
US (1) US6677351B2 (es)
EP (1) EP1397359B1 (es)
JP (1) JP4460221B2 (es)
AT (1) ATE303384T1 (es)
AU (1) AU2002257459B2 (es)
CA (1) CA2447765C (es)
DE (1) DE60205899T2 (es)
ES (1) ES2247325T3 (es)
PE (1) PE20030061A1 (es)
WO (1) WO2002094823A1 (es)

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US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
AR042194A1 (es) * 2002-11-22 2005-06-15 Merck & Co Inc Metodo para preparar inhibidores de fosfodiesterasa - 4
WO2004047836A1 (en) * 2002-11-22 2004-06-10 Merck Frosst Canada & Co. Use of phosphodiesterase-4 inhibitors as enhancers of cognition
IS7839A (is) * 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
CN100441185C (zh) * 2003-04-30 2008-12-10 麦克弗罗斯特加拿大有限公司 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂
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DK1954274T3 (da) * 2005-11-10 2011-01-31 Chemocentryx Inc Substituerede quinoloner og fremgangsmåder til anvendelse
JP5349302B2 (ja) * 2006-07-05 2013-11-20 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性肺疾患の治療のためのＨＭＧ−ＣｏＡレダクターゼインヒビターとホスホジエステラーゼ４インヒビターとの組合せ物
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AU2009252938B2 (en) 2008-05-27 2012-04-26 Astrazeneca Ab Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states
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Also Published As

Publication number Publication date
CA2447765A1 (en) 2002-11-28
DE60205899D1 (en) 2005-10-06
WO2002094823A1 (en) 2002-11-28
ATE303384T1 (de) 2005-09-15
US20030096829A1 (en) 2003-05-22
ES2247325T3 (es) 2006-03-01
JP4460221B2 (ja) 2010-05-12
US6677351B2 (en) 2004-01-13
AU2002257459B2 (en) 2006-12-14
EP1397359B1 (en) 2005-08-31
EP1397359A1 (en) 2004-03-17
DE60205899T2 (de) 2006-06-29
CA2447765C (en) 2011-01-25
JP2004534773A (ja) 2004-11-18

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