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PE20030850A1 - Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon - Google Patents

Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon

Info

Publication number
PE20030850A1
PE20030850A1 PE2002000981A PE2002000981A PE20030850A1 PE 20030850 A1 PE20030850 A1 PE 20030850A1 PE 2002000981 A PE2002000981 A PE 2002000981A PE 2002000981 A PE2002000981 A PE 2002000981A PE 20030850 A1 PE20030850 A1 PE 20030850A1
Authority
PE
Peru
Prior art keywords
glp
refers
polypeptide
peptides
act
Prior art date
Application number
PE2002000981A
Other languages
English (en)
Inventor
Clark Pan
James Whelan
Kevin B Clairmont
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of PE20030850A1 publication Critical patent/PE20030850A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO AGONISTA DEL RECEPTOR DEL GLP-1 Y ANTAGONISTA DEL RECEPTOR DEL GLUCAGON QUE PUEDE SER UTIL EN LA ESTIMULACION DE LIBERACION DE INSULINA DE LAS CELULAS BETA PANCREATICAS EN RESPUESTA A LA GLUCOSA Y EN LA REDUCCION DE LA SECRECION GLUCAGON MEDIADA DE LA GLUCOSA DEL HIGADO; SELECCIONADO DE LAS SECUENCIAS SECIDNOS:6-32 Y SUS FRAGMENTOS, DERIVADOS Y VARIANTES FUNCIONALMENTE EQUIVALENTES. TAMBIEN SE REFIERE AL POLINUCLEOTIDO QUE CODIFICA EL POLIPEPTIDO O UNA VARIANTE DEGENERADA DEL MISMO, VECTOR , CELULA HUESPED. TAMBIEN SE REFIERE A UN METODO PARA LA PRODUCCION DEL POLIPEPTIDO
PE2002000981A 2001-10-05 2002-10-03 Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon PE20030850A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32773001P 2001-10-05 2001-10-05

Publications (1)

Publication Number Publication Date
PE20030850A1 true PE20030850A1 (es) 2003-10-31

Family

ID=23277790

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000981A PE20030850A1 (es) 2001-10-05 2002-10-03 Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon

Country Status (27)

Country Link
US (6) US7399745B2 (es)
EP (1) EP1436330A4 (es)
JP (1) JP2005508639A (es)
KR (1) KR20050034580A (es)
CN (1) CN1326876C (es)
AR (1) AR036711A1 (es)
BR (1) BR0213132A (es)
CA (1) CA2462462A1 (es)
CO (1) CO5570710A2 (es)
DO (1) DOP2002000475A (es)
EC (2) ECSP024346A (es)
HN (1) HN2002000282A (es)
HR (1) HRP20040327A2 (es)
HU (1) HUP0401797A2 (es)
IL (1) IL160706A0 (es)
MA (1) MA26228A1 (es)
MX (1) MXPA04002140A (es)
MY (1) MY138267A (es)
NO (1) NO20041792L (es)
NZ (1) NZ532685A (es)
PE (1) PE20030850A1 (es)
PL (1) PL368760A1 (es)
RU (1) RU2334761C2 (es)
SG (2) SG158736A1 (es)
UY (1) UY27469A1 (es)
WO (1) WO2003040309A2 (es)
ZA (1) ZA200403322B (es)

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EP2512503A4 (en) 2009-12-18 2013-08-21 Univ Indiana Res & Tech Corp COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR
EP2460527A1 (en) 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
EP2525833A2 (en) 2010-01-22 2012-11-28 Novo Nordisk Health Care AG Stable growth hormone compounds
SI2525834T1 (sl) 2010-01-22 2019-10-30 Novo Nordisk Healthcare Ag Rastni hormoni s podaljšano in vivo učinkovitostjo
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US8691763B2 (en) 2010-05-04 2014-04-08 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
MX2012013005A (es) 2010-05-13 2013-02-26 Univ Indiana Res & Tech Corp Peptidos de la superfamilia de glucagon que presentan actividad del receptor acoplado a proteinas g.
RU2604067C2 (ru) 2010-05-13 2016-12-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Пептиды глюкагонового суперсемейства, обладающие активностью относительно ядерных гормональных рецепторов
JP2013540102A (ja) 2010-06-24 2013-10-31 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション アミド結合を介して修飾されたグルカゴンスーパーファミリーのペプチドプロドラッグ
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Also Published As

Publication number Publication date
US20050153890A1 (en) 2005-07-14
CA2462462A1 (en) 2003-05-15
IL160706A0 (en) 2004-08-31
NZ532685A (en) 2006-02-24
ECSP024346A (es) 2003-05-26
RU2334761C2 (ru) 2008-09-27
EP1436330A4 (en) 2006-01-18
MY138267A (en) 2009-05-29
DOP2002000475A (es) 2003-06-30
US7488716B2 (en) 2009-02-10
WO2003040309A2 (en) 2003-05-15
SG158736A1 (en) 2010-02-26
US20060003934A1 (en) 2006-01-05
WO2003040309A3 (en) 2003-12-18
KR20050034580A (ko) 2005-04-14
CO5570710A2 (es) 2005-10-31
ECSP045094A (es) 2004-06-28
NO20041792L (no) 2004-07-02
US20060003417A1 (en) 2006-01-05
CN1326876C (zh) 2007-07-18
PL368760A1 (en) 2005-04-04
US7488715B2 (en) 2009-02-10
CN1564828A (zh) 2005-01-12
RU2004114243A (ru) 2005-05-10
UY27469A1 (es) 2003-04-30
US20060003419A1 (en) 2006-01-05
US7494978B2 (en) 2009-02-24
AR036711A1 (es) 2004-09-29
MA26228A1 (fr) 2004-07-01
JP2005508639A (ja) 2005-04-07
US20050288248A1 (en) 2005-12-29
HRP20040327A2 (en) 2007-11-30
US7399745B2 (en) 2008-07-15
EP1436330A2 (en) 2004-07-14
BR0213132A (pt) 2004-10-19
US7488714B2 (en) 2009-02-10
HUP0401797A2 (en) 2006-08-28
MXPA04002140A (es) 2005-03-07
HK1073117A1 (zh) 2005-09-23
HN2002000282A (es) 2002-12-12
ZA200403322B (en) 2005-05-03
SG149693A1 (en) 2009-02-27
US20060003418A1 (en) 2006-01-05

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