PE20021099A1 - Derivados de c-furano-2-il-metilamina sustituidos - Google Patents
Derivados de c-furano-2-il-metilamina sustituidosInfo
- Publication number
- PE20021099A1 PE20021099A1 PE2002000428A PE2002000428A PE20021099A1 PE 20021099 A1 PE20021099 A1 PE 20021099A1 PE 2002000428 A PE2002000428 A PE 2002000428A PE 2002000428 A PE2002000428 A PE 2002000428A PE 20021099 A1 PE20021099 A1 PE 20021099A1
- Authority
- PE
- Peru
- Prior art keywords
- ethyl
- phenylamine
- aryl
- alkyl
- methyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- AKCRQHGQIJBRMN-UHFFFAOYSA-N 2-chloroaniline Chemical compound NC1=CC=CC=C1Cl AKCRQHGQIJBRMN-UHFFFAOYSA-N 0.000 abstract 1
- KMYNSRFDYFGKLR-UHFFFAOYSA-N 4-chloro-2-ethyl-N-methylaniline Chemical compound CCC1=CC(Cl)=CC=C1NC KMYNSRFDYFGKLR-UHFFFAOYSA-N 0.000 abstract 1
- -1 N- (CYCLOPROPYL-2-THENYLMEthyl) -4,5-DIHYDRO-2-OXAZOLAMINE Chemical compound 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 229940035674 anesthetics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A DERIVADOS DE C-FURANO-2-IL-METILAMINA Y C-TIOFENO-2-IL-METILAMINA SUSTITUIDOS DE FORMULA I DONDE A ES O, S; R1 ES ARILO, HETEROCICLILO, -(C1-6-ALQUIL)-ARILO, ENTRE OTROS; R2 ES -C(=O)R6, ALQUILO C3-C8; R3, R4, R5 SON H, F, Cl, Br, I, CN, OR7, ENTRE OTROS; R6 ES ARILO, HETEROCICLILO, ENTRE OTROS; R7 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8. SON COMPUESTOS PREFERIDOS 5-[1-(2-CLORO-FENILAMINO)-2-OXO-2-FENIL-ETIL]-2-METIL-FURAN-3-CARBOXILATO DE ETILO, 5-[1-(4-CLORO-2-METIL-FENILAMINO)-2-OXO-2-FENIL-ETIL]-2-METIL-FURAN-3-CARBOXILATO DE ETILO EXCEPTO N-(CICLOPROPIL-2-TIENILMETIL)-4,5-DIHIDRO-2-OXAZOLAMINA, N-(CICLOPROPIL-2-FURANILMETIL)-4,5-DIHIDRO-2-OXAZOLAMINA, 1,2-DI-2-FURANIL-2-(FENILAMINO)-ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON ANALGESICOS, ANESTESICOS, ANTIARRITMICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10125145A DE10125145A1 (de) | 2001-05-22 | 2001-05-22 | Substituierte C-Furan-2-yl-methylamin- und C-Thiophen-2-yl-methylamin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021099A1 true PE20021099A1 (es) | 2003-01-25 |
Family
ID=7685874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000428A PE20021099A1 (es) | 2001-05-22 | 2002-05-21 | Derivados de c-furano-2-il-metilamina sustituidos |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6878740B2 (es) |
| EP (1) | EP1392670B1 (es) |
| JP (1) | JP2004532246A (es) |
| AR (1) | AR035982A1 (es) |
| AT (1) | ATE299873T1 (es) |
| AU (1) | AU2002338989B2 (es) |
| CA (1) | CA2448038C (es) |
| DE (2) | DE10125145A1 (es) |
| DK (1) | DK1392670T3 (es) |
| ES (1) | ES2242869T3 (es) |
| HU (1) | HUP0401162A3 (es) |
| MX (1) | MXPA03010601A (es) |
| PE (1) | PE20021099A1 (es) |
| PL (1) | PL367535A1 (es) |
| PT (1) | PT1392670E (es) |
| SI (1) | SI1392670T1 (es) |
| WO (1) | WO2002094802A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0302094D0 (en) * | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| KR100553398B1 (ko) | 2004-03-12 | 2006-02-16 | 한미약품 주식회사 | 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체 |
| KR101722289B1 (ko) | 2009-07-08 | 2017-03-31 | 데르미라 (캐나다), 인코포레이티드 | 피부과 질환 또는 증상의 치료에 유용한 ｔｏｆａ 유사체 |
| TR201802607T4 (tr) * | 2013-11-22 | 2018-03-21 | Teva Branded Pharmaceutical Prod R & D Inc | Bir solunabilir ilaç. |
| KR101844984B1 (ko) * | 2016-05-31 | 2018-04-03 | 한림대학교 산학협력단 | 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| CN112521357B (zh) * | 2020-08-31 | 2021-10-08 | 深圳瑞健生物科技有限公司 | 一种长效低成瘾性hnk衍生物及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816457A (en) * | 1973-01-05 | 1974-06-11 | Richardson Merrell Inc | Lactamimide derivatives |
| US3890445A (en) * | 1973-01-05 | 1975-06-17 | Richardson Merrell Inc | Lactamimide derivatives useful as hypoglycemic agents |
| WO2001068816A1 (en) | 2000-03-13 | 2001-09-20 | Smithkline Beecham Corporation | Human histamine h3 gene variant-3 |
| DE10012820A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Substituierte 1-Aryl-cyclopropylmethylamino-1,3,5-triazine |
| DE10059864A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Substituierte Amino-furan-2-yl-essigsäure- und Amino-thien-2-yl-essigsäure-Derivate |
-
2001
- 2001-05-22 DE DE10125145A patent/DE10125145A1/de not_active Withdrawn
-
2002
- 2002-05-17 AR ARP020101843A patent/AR035982A1/es not_active Application Discontinuation
- 2002-05-21 PE PE2002000428A patent/PE20021099A1/es not_active Application Discontinuation
- 2002-05-21 PL PL02367535A patent/PL367535A1/xx not_active Application Discontinuation
- 2002-05-21 SI SI200230178T patent/SI1392670T1/sl unknown
- 2002-05-21 EP EP02743057A patent/EP1392670B1/de not_active Expired - Lifetime
- 2002-05-21 PT PT02743057T patent/PT1392670E/pt unknown
- 2002-05-21 MX MXPA03010601A patent/MXPA03010601A/es active IP Right Grant
- 2002-05-21 JP JP2002591475A patent/JP2004532246A/ja active Pending
- 2002-05-21 WO PCT/EP2002/005542 patent/WO2002094802A1/de not_active Ceased
- 2002-05-21 DE DE50203686T patent/DE50203686D1/de not_active Expired - Lifetime
- 2002-05-21 ES ES02743057T patent/ES2242869T3/es not_active Expired - Lifetime
- 2002-05-21 CA CA2448038A patent/CA2448038C/en not_active Expired - Fee Related
- 2002-05-21 AT AT02743057T patent/ATE299873T1/de not_active IP Right Cessation
- 2002-05-21 HU HU0401162A patent/HUP0401162A3/hu unknown
- 2002-05-21 AU AU2002338989A patent/AU2002338989B2/en not_active Ceased
- 2002-05-21 DK DK02743057T patent/DK1392670T3/da active
-
2003
- 2003-11-21 US US10/717,932 patent/US6878740B2/en not_active Expired - Fee Related
-
2005
- 2005-03-07 US US11/072,962 patent/US7317034B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1392670B1 (de) | 2005-07-20 |
| US20050148550A1 (en) | 2005-07-07 |
| PL367535A1 (en) | 2005-02-21 |
| CA2448038C (en) | 2010-09-28 |
| HUP0401162A3 (en) | 2007-05-02 |
| ATE299873T1 (de) | 2005-08-15 |
| HUP0401162A2 (hu) | 2004-10-28 |
| US6878740B2 (en) | 2005-04-12 |
| DE10125145A1 (de) | 2002-11-28 |
| EP1392670A1 (de) | 2004-03-03 |
| AR035982A1 (es) | 2004-07-28 |
| DE50203686D1 (en) | 2005-08-25 |
| WO2002094802A1 (de) | 2002-11-28 |
| MXPA03010601A (es) | 2004-03-09 |
| JP2004532246A (ja) | 2004-10-21 |
| PT1392670E (pt) | 2005-10-31 |
| SI1392670T1 (sl) | 2005-12-31 |
| US7317034B2 (en) | 2008-01-08 |
| AU2002338989B2 (en) | 2007-06-07 |
| US20040152734A1 (en) | 2004-08-05 |
| CA2448038A1 (en) | 2002-11-28 |
| DK1392670T3 (da) | 2005-08-08 |
| ES2242869T3 (es) | 2005-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |