[go: up one dir, main page]

PE20021085A1 - PIRROLO (2.1-a) DIHIDROISOQUINOLINAS - Google Patents

PIRROLO (2.1-a) DIHIDROISOQUINOLINAS

Info

Publication number
PE20021085A1
PE20021085A1 PE2002000338A PE2002000338A PE20021085A1 PE 20021085 A1 PE20021085 A1 PE 20021085A1 PE 2002000338 A PE2002000338 A PE 2002000338A PE 2002000338 A PE2002000338 A PE 2002000338A PE 20021085 A1 PE20021085 A1 PE 20021085A1
Authority
PE
Peru
Prior art keywords
alkyl
pirrolo
compounds
dimetoxy
isoquinoline
Prior art date
Application number
PE2002000338A
Other languages
English (en)
Inventor
Marcus Bauser
Stephen Boyer
Nils Burkhardt
Jens-Kerim Erguden
Dietmar Flubacher
Mark Miglarese
Olaf Weber
Ulrich Niewohner
Thorsten-Oliver Reep
Michael Schauer
Karl-Heinz Schlemmer
Andrea Sewing
Juergen Stoltefub
Paul Naab
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20021085A1 publication Critical patent/PE20021085A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS PIRROLO (2.1-a) DIHIDROISOQUINOLINAS DONDE x E y SON 0-1 CON LA CONDICION x + y ES IGUAL A 1-2; R1 Y R2 SON H, ALQUILO C1-C4, CR3; R1 Y R2 JUNTOS FORMAN UN ENLACE ALQUILENO C1-C4; R3 Y R4 SON ALQUILO C1-C4; R5 ES ARILO C6-C14 CON 1-3 SUSTITUYENTES ADICIONALES SELECCIONADOS DE HALOGENO, ALQUILO C1-C6, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. SON COMPUESTOS PREFERIDOS 2-(4-HIDROXI-3,5-DIMETILFENIL)-8,9-DIMETOXI-3-METIL-5,6-DIHIDRO-PIRROLO[3,1-a]ISOQUINOLINA-1-CARBOXILATO DE ETILO, 2-(3-AMINOFENIL)-8,9-DIMETOXI-3-METIL-5,6-DIHIDROPIRROLO[2,1-a]ISOQUINOLINA-1-CARBOXILATO DE ETILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FOSFODIESTERASA 10a Y SON UTILES PARA EL TRATAMIENTO DEL CANCER
PE2002000338A 2000-12-13 2002-04-23 PIRROLO (2.1-a) DIHIDROISOQUINOLINAS PE20021085A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25520600P 2000-12-13 2000-12-13
US31031201P 2001-08-06 2001-08-06

Publications (1)

Publication Number Publication Date
PE20021085A1 true PE20021085A1 (es) 2003-05-16

Family

ID=26944520

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000338A PE20021085A1 (es) 2000-12-13 2002-04-23 PIRROLO (2.1-a) DIHIDROISOQUINOLINAS

Country Status (10)

Country Link
US (1) US6930114B2 (es)
EP (1) EP1347973A1 (es)
JP (1) JP2004517843A (es)
AU (1) AU2002227985A1 (es)
CA (1) CA2431326A1 (es)
HN (1) HN2001000277A (es)
PE (1) PE20021085A1 (es)
SV (1) SV2002000761A (es)
UY (1) UY27067A1 (es)
WO (1) WO2002048144A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236276A1 (en) * 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
AU2002366362A1 (en) * 2001-12-18 2003-06-30 Bayer Aktiengesellschaft 2-substituted pyrrolo(2.1-a)isoquinolines against cancer
DE10230604A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
US8338420B1 (en) 2002-12-04 2012-12-25 Mitsubishi Tanabe Pharma Corporation Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor
EP1578424A4 (en) * 2002-12-12 2007-08-08 Cytovia Inc SUBSTITUTED 1-BENZOYL-3-CYANOPYRROLO1,2-A | CHINOLINES AND THEIR ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCTORS OF APOPTOSIS
US20060148838A1 (en) * 2003-06-30 2006-07-06 Altana Pharma Ag Novel pyrrolodihydroisoquinolines useful in the treatment of cancer
US20070105840A1 (en) * 2003-06-30 2007-05-10 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
ES2326337T3 (es) * 2005-01-12 2009-10-07 Nycomed Gmbh Nuevas pirrolodihidroisoquinolinas como inhibidores de pde10.
US20080064714A1 (en) * 2005-01-12 2008-03-13 Nycomed Gmbh Novel Pyrrolodihydroisoquinolines
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008001182A1 (en) * 2006-06-26 2008-01-03 Pfizer Products Inc. Tricyclic heteroaryl compounds as pde10 inhibitors
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
ES2527363T3 (es) 2009-12-04 2015-01-22 Nerviano Medical Sciences S.R.L. Derivados de triciclopirazol
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US10039764B2 (en) 2013-07-12 2018-08-07 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression
GB202002926D0 (en) * 2020-02-28 2020-04-15 Benevolentai Tech Limited Compositions and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE690792A (es) * 1966-12-07 1967-05-16
FR7348M (es) * 1967-12-07 1969-10-13
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
DE3401018A1 (de) * 1984-01-13 1985-07-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
IT1292092B1 (it) 1997-06-05 1999-01-25 Geange Ltd Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali
US6673564B2 (en) 1999-10-18 2004-01-06 Millennium Pharmaceuticals, Inc. Methods for using 22045, a human cyclic nucleotide phosphodiesterase

Also Published As

Publication number Publication date
SV2002000761A (es) 2002-12-02
HN2001000277A (es) 2002-01-30
CA2431326A1 (en) 2002-06-20
UY27067A1 (es) 2002-07-31
WO2002048144A1 (en) 2002-06-20
US6930114B2 (en) 2005-08-16
JP2004517843A (ja) 2004-06-17
US20040138249A1 (en) 2004-07-15
AU2002227985A1 (en) 2002-06-24
EP1347973A1 (en) 2003-10-01

Similar Documents

Publication Publication Date Title
PE20021085A1 (es) PIRROLO (2.1-a) DIHIDROISOQUINOLINAS
FR21C1010I2 (fr) 2,4,di-(hetero-) arylamino (-oxy)-5 pyrimidines substitutees utilisees comme agents antineoplasiques
PA8495101A1 (es) Derivados de 13-metileritromicina
DE60039125D1 (de) 9-(piperazinylalkyl)carbazole als bax-modulatoren
AR030959A1 (es) Derivados de aminoalcoholes, procedimiento para prepararlos, el uso de los mismos para preparar medicamentos y las composiciones farmaceuticas que las contienen
CY1106087T1 (el) Παραγωγα τετραϋδροκινολινης
PE20030129A1 (es) Imidazotriazinas
AR041739A1 (es) Compuestos derivados -3,4-dihidro-1h-pirimido[4,5-d]pirimidin-2-ona y con actividad antiproliferativa.
TR200003429T2 (tr) Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.
DOP2004000949A (es) Derivados de pirrolo [3,4-c]pirazol activos como inhibidores de cinasa, proceso para su preparacion y composiciones farmaceuticas que comprenden los mismos
UY24206A1 (es) Feniliminoimidazolinas agonistas de alfa 1l útiles en el tratamiento de la incontinencia urinaria.
PA8451801A1 (es) Derivados de la 9-oxima eritromicina
AU2002249890A1 (en) Carboline derivatives
SE9903997D0 (sv) New compounds
ATE273281T1 (de) Heterozyklische cytotoxische wirkstoffe
EA200400475A1 (ru) Замещенные производные бензимидазола и их применение для лечения злокачественной опухоли
AR029347A1 (es) Compuesto de adenina, compuesto de isognanina y 2,6-ditioxantina como precursor del mismo, uso de dichos compuestos para preparar una composicion farmaceutica y dicha composicion farmaceutica
CY1106257T1 (el) ΧΡΗΣΗ ΠΑΡΑΓΩΓΩΝ ΠΥΡΙΔΑΖΙΝΟ [4,5-(b)]-ΙΝΔΟΛΗ -1-ΑΚΕΤΑΜΙΔΗ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΣΚΕΥΑΣΜΑΤΩΝ ΠΟΥ ΠΡΟΟΡΙΖΟΝΤΑΙ ΓΙΑ ΝΟΣΟΥΣ ΠΟΥ ΣΥΝΔΕΟΝΤΑΙ ΜΕ ΤΗ ΔΥΣΛΕΙΤΟΥΡΓΙΑ ΤΩΝ ΥΠΟΔΟΧΕΩΝ ΠEPΙΦEPΙΚΟΥ ΤΥΠΟΥ ΣΤΙΣ ΒΕΝΖΟΔΙΑΖΕΠΙΝΕΣ
HUP0401588A2 (hu) Rákellenes és proliferáció elleni hatású indeno[1,2-c]pirazol-4-on-származékok és ezeket tartalmazó gyógyszerkészítmények
MX2024013019A (es) Compuestos de heteroarilo para el tratamiento del dolor
AR018162A1 (es) Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica
SE0003476D0 (sv) Compounds
ES2010284A6 (es) Procedimiento para preparar derivados de tiourea.
DK1109560T3 (da) Som AICARFT-inhibitorer anvendelige forbindelser
PE20040782A1 (es) DERIVADOS DE [6,7-DIHIDRO-5H-IMIDAZO[1,2-a]IMIDAZOL-3-SULFONILAMINO]-PROPIONAMIDA

Legal Events

Date Code Title Description
FA Abandonment or withdrawal