PE20020373A1 - FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONS - Google Patents
FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONSInfo
- Publication number
- PE20020373A1 PE20020373A1 PE2001000889A PE2001000889A PE20020373A1 PE 20020373 A1 PE20020373 A1 PE 20020373A1 PE 2001000889 A PE2001000889 A PE 2001000889A PE 2001000889 A PE2001000889 A PE 2001000889A PE 20020373 A1 PE20020373 A1 PE 20020373A1
- Authority
- PE
- Peru
- Prior art keywords
- flavor
- compositions
- lopinavir
- flavoring
- water
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 abstract 2
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 235000009508 confectionery Nutrition 0.000 abstract 2
- 239000000796 flavoring agent Substances 0.000 abstract 2
- 235000019634 flavors Nutrition 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229960004525 lopinavir Drugs 0.000 abstract 2
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 abstract 2
- 229960000311 ritonavir Drugs 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 abstract 1
- 229920000742 Cotton Polymers 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 244000290333 Vanilla fragrans Species 0.000 abstract 1
- 235000009499 Vanilla fragrans Nutrition 0.000 abstract 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 235000019636 bitter flavor Nutrition 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- 235000019534 high fructose corn syrup Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
SE REFIERE UNA COMPOSICION LIQUIDA QUE COMPRENDE a)SISTEMA SABORIZANTE QUE COMPRENDE: i)DE 20% A 67% DE EDULCORANTES COMO JARABE DE MAIZ DE ALTA FRUCTOSA; ii)DE 1,4% A 3,5% DE INGREDIENTES SABORIZADOS COMO CRISTALES DE MENTOL, ACEITE DE MENTA, VAINILLA, SABOR A ALGODON DE AZUCAR, CARAMELO, iii)MODIFICADORES DEL SABOR COMO CITRATO DE SODIO, CLORURO DE SODIO, ACIDO CITRICO, b)AGENTES FARMACEUTICOS ACTIVOS COMO LOPINAVIR, RITONAVIR c)UN SISTEMA DE SOLVENTES QUE COMPRENDE SOLUBILIZANTES COMO AGUA, ALCOHOLES ALQUILICOS (ETANOL), ALQUILENGLICOLES (PROPILENGLICOL); d)UN AGENTE ESPESANTE COMO POLIVINILPIRROLIDONA; e)MEJORADOR DE LA BIODISPONIBILIDAD COMO DERIVADO DE ACEITE DE CASTOR. TAMBIEN SE REFIERE A UN PROCESO PARA LA PREPARACION. LOS SISTEMAS SABORIZANTES PUEDEN MEJORAR LAS COMPOSICIONES LIQUIDAS QUE CONTIENEN RITONAVIR O LOPINAVIR QUE SON PRACTICAMENTE INSOLUBLES EN AGUA Y TIENDEN A TENER UN SABOR AMARGOREFERRED TO A LIQUID COMPOSITION THAT INCLUDES a) FLAVORING SYSTEM THAT INCLUDES: i) FROM 20% TO 67% OF SWEETENERS AS HIGH FRUCTOSE CORN SYRUP; ii) FROM 1.4% TO 3.5% OF FLAVORED INGREDIENTS LIKE MENTHOL CRYSTALS, MINT OIL, VANILLA, COTTON CANDY FLAVOR, CANDY, iii) FLAVOR MODIFIERS LIKE SODIUM CITRATE, SODIUM CHLORIDE, CITRIC ACID , b) ACTIVE PHARMACEUTICAL AGENTS SUCH AS LOPINAVIR, RITONAVIR c) A SOLVENT SYSTEM THAT INCLUDES SOLUBILIZERS SUCH AS WATER, ALKYL ALCOHOLS (ETHANOL), ALKYLENE GLYCOLS (PROPYLENE GLYCOL); d) A THICKENING AGENT SUCH AS POLYVINYLPYRROLIDONE; e) BIOAVAILABILITY IMPROVER AS A DERIVATIVE FROM CASTOR OIL. IT ALSO REFERS TO A PROCESS FOR PREPARATION. FLAVORING SYSTEMS CAN IMPROVE LIQUID COMPOSITIONS CONTAINING RITONAVIR OR LOPINAVIR WHICH ARE PRACTICALLY INSOLUBLE IN WATER AND TEND TO HAVE A BITTER FLAVOR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65519200A | 2000-09-05 | 2000-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020373A1 true PE20020373A1 (en) | 2002-05-13 |
Family
ID=24627898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000889A PE20020373A1 (en) | 2000-09-05 | 2001-09-04 | FLAVORING SYSTEMS FOR PHARMACEUTICAL COMPOSITIONS AND METHODS TO MAKE SUCH COMPOSITIONS |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1315487A2 (en) |
| JP (1) | JP2004522698A (en) |
| AR (1) | AR030715A1 (en) |
| AU (1) | AU2001288695A1 (en) |
| BR (1) | BR0108433A (en) |
| CA (1) | CA2417258A1 (en) |
| MX (1) | MXPA03001952A (en) |
| PE (1) | PE20020373A1 (en) |
| UY (1) | UY26925A1 (en) |
| WO (1) | WO2002020057A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| JP5767429B2 (en) | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | Crystallization inhibitors in solid dispersants |
| KR20050061604A (en) * | 2002-11-22 | 2005-06-22 | 피르메니히 에스아 | Oral compositions which mask the salty taste of salts |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| GB2423711B (en) * | 2005-10-24 | 2007-02-14 | Fortune Apex Dev Ltd | Method for preparing a pharmaceutical composition with enhanced mucoadhesion |
| WO2013129436A1 (en) * | 2012-02-29 | 2013-09-06 | 武田薬品工業株式会社 | Oral agent |
| US8771651B2 (en) * | 2012-09-10 | 2014-07-08 | Johnson & Johnson Consumer Companies, Inc. | Mouth rinses and tooth sensitivity treatment compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111991A (en) * | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
| WO1997046222A1 (en) * | 1996-06-03 | 1997-12-11 | Merck & Co., Inc. | Pediatric formulation for hiv protease inhibitors |
-
2001
- 2001-09-04 EP EP01968449A patent/EP1315487A2/en not_active Withdrawn
- 2001-09-04 PE PE2001000889A patent/PE20020373A1/en not_active Application Discontinuation
- 2001-09-04 AR ARP010104207A patent/AR030715A1/en unknown
- 2001-09-04 AU AU2001288695A patent/AU2001288695A1/en not_active Abandoned
- 2001-09-04 BR BRPI0108433-0A patent/BR0108433A/en not_active IP Right Cessation
- 2001-09-04 WO PCT/US2001/027415 patent/WO2002020057A2/en not_active Ceased
- 2001-09-04 JP JP2002524540A patent/JP2004522698A/en not_active Withdrawn
- 2001-09-04 MX MXPA03001952A patent/MXPA03001952A/en unknown
- 2001-09-04 CA CA002417258A patent/CA2417258A1/en not_active Abandoned
- 2001-09-04 UY UY26925A patent/UY26925A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002020057A2 (en) | 2002-03-14 |
| UY26925A1 (en) | 2002-04-26 |
| JP2004522698A (en) | 2004-07-29 |
| AU2001288695A1 (en) | 2002-03-22 |
| CA2417258A1 (en) | 2002-03-14 |
| WO2002020057A3 (en) | 2002-05-10 |
| EP1315487A2 (en) | 2003-06-04 |
| AR030715A1 (en) | 2003-09-03 |
| BR0108433A (en) | 2006-06-06 |
| MXPA03001952A (en) | 2003-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |