PE20020261A1 - Sistemas auto-emulsionantes de administracion de medicinas para drogas lipofilicas extremadamente insolubles en agua - Google Patents
Sistemas auto-emulsionantes de administracion de medicinas para drogas lipofilicas extremadamente insolubles en aguaInfo
- Publication number
- PE20020261A1 PE20020261A1 PE2001000747A PE2001000747A PE20020261A1 PE 20020261 A1 PE20020261 A1 PE 20020261A1 PE 2001000747 A PE2001000747 A PE 2001000747A PE 2001000747 A PE2001000747 A PE 2001000747A PE 20020261 A1 PE20020261 A1 PE 20020261A1
- Authority
- PE
- Peru
- Prior art keywords
- polyvinylpyrrolidone
- emulsing
- self
- extremely insoluble
- water
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- -1 METROXYPROGESTERONE Chemical compound 0.000 abstract 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 abstract 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 abstract 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 230000000416 anti-micotic effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001647 drug administration Methods 0.000 abstract 1
- 239000010685 fatty oil Substances 0.000 abstract 1
- 238000005187 foaming Methods 0.000 abstract 1
- 239000004088 foaming agent Substances 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 1
- VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 abstract 1
- 229960004130 itraconazole Drugs 0.000 abstract 1
- 229960004125 ketoconazole Drugs 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN SISTEMA AUTOEMULSIONANTE DE ADMINISTRACION DE DROGAS QUE COMPRENDE UNA MEZCLA DE a)UN AGENTE ACTIVO LIPOFILICO EXTREMADAMENTE INSOLUBLE EN AGUA, QUE TIENE UN COEFICIENTE DE PARTICION DE LA DROGA ENTRE 2 FASES INMISCIBLES (LOG p) IGUAL O MAYOR A 2, CON UNA SOLUBILIDAD MENOR DE 100µg/ml EN AGUA; TAL COMO ESTEROIDE, ANTICANCERIGENO, ANTIMICOTICO, ANTIINFECCIOSO SELECCIOADNO DE PROGESTERONA, KETOCONAZOL, ITRACONAZOL, METROXIPROGESTERONA, PACLITAXEL, COMPUESTO DE INDOLINONA DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES O, S; R3, R4, R5, R6 SON H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS; A ES TIOFENO, PIRROL, PIRAZOL, IMIDAZOL, ENTRE OTROS; n ES 0-3; R Y R1 SON H, ALQUILO, ARILO SON COMPUESTOS PREFERIDOS 3-[(2,4-DIMETILPIRROL-5-IL)METILENO]-2-INDOLINONA; 3-[2,4-DIMETIL-5-(2-OXO-1,2-DIHIDROINDOL-3-ILIDENEMETIL)-1H-PIRROL-3-IL]PROPIONICO; b)DE 5% A 40% DE POLIVINILPIRROLIDONA CON UN PESO DE 2500 A 100000; QUE AYUDA A LA DISOLUCION DE LA DROGA EXTREMADAMENTE INSOLUBLE; c)5% A 35% DE ACIDO GRASO C6-C18 SELECCIONADO DE ACIDO HEXANOICO, OCTANOICO, NONANOICO, ENTRE OTROS; d)DE 20% A 70% DE ESPUMANTE COMO ACEITE DE CASTOR POLIOXILATADO, GLICERIDOS POLIOXILATADOS DE ACEITES GRASOS; f)SOLVENTE ORGANICO COMO ETANOL, GLICOL POLIETILENO, GLICOLPROPILENO, ENTRE OTROS; SIENDO LA PROPORCION EN PESO DEL ACIDO GRASO A POLIVINILPIRROLIDONA DE 2:1 HASTA 3:1 Y DEL ESPUMANTE A POLIVINILPIRROLIDONA DE 10:1 HASTA 1:1; e)UN ANTIOXIDANTE COMO ACIDO ASCORBICO, PALMITATO DE ASCORBIL, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22037600P | 2000-07-24 | 2000-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020261A1 true PE20020261A1 (es) | 2002-04-18 |
Family
ID=22823309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000747A PE20020261A1 (es) | 2000-07-24 | 2001-07-24 | Sistemas auto-emulsionantes de administracion de medicinas para drogas lipofilicas extremadamente insolubles en agua |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20020119198A1 (es) |
| EP (1) | EP1303261B1 (es) |
| JP (1) | JP2004504342A (es) |
| AR (1) | AR030253A1 (es) |
| AT (1) | ATE290372T1 (es) |
| AU (2) | AU2001277099B2 (es) |
| CA (1) | CA2410683A1 (es) |
| DE (1) | DE60109295T2 (es) |
| DK (1) | DK1303261T3 (es) |
| ES (1) | ES2238050T3 (es) |
| MX (1) | MXPA03000720A (es) |
| PE (1) | PE20020261A1 (es) |
| PT (1) | PT1303261E (es) |
| WO (1) | WO2002007712A2 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2002364212B2 (en) * | 2001-12-21 | 2007-09-20 | Shire Laboratories Inc. | Oral capsule formulation with increased physical stability |
| UY28057A1 (es) * | 2002-10-31 | 2003-12-31 | Alza Corp | Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrófobos |
| ITRM20030074A1 (it) * | 2003-02-21 | 2004-08-22 | Pharmacia Italia Spa | Formulazioni semisolide a rilascio immediato intese |
| CA2550866A1 (en) * | 2003-12-23 | 2005-07-14 | Alza Corporation | Methods and dosage forms for increasing solubility of drug compositions for controlled delivery |
| JP2007515458A (ja) * | 2003-12-23 | 2007-06-14 | テイボテク・フアーマシユーチカルズ・リミテツド | Ｈｉｖプロテアーゼ阻害剤の自己ミクロ乳化性薬剤送達システム |
| US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
| US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
| DK1748759T3 (da) * | 2004-04-27 | 2013-04-22 | Javeri Indu | Fremgangsmåder til at forøge hydrofobe forbindelsers opløselighed i vand af ved micellære dispersioner |
| CN100361656C (zh) * | 2004-08-27 | 2008-01-16 | 石药集团中奇制药技术（石家庄）有限公司 | 丁苯酞自乳化释药体系及其制备方法和应用 |
| CN101137395B (zh) * | 2005-03-14 | 2012-10-31 | 株式会社大塚制药工场 | 含有水难溶性药物的医药组合物 |
| US20160184258A1 (en) * | 2005-11-07 | 2016-06-30 | Murty Pharmaceuticals, Inc. | Oral gastrointestinal dosage form delivery system of cannabinoids and/or standardized marijuana extracts |
| US20140357708A1 (en) * | 2005-11-07 | 2014-12-04 | Murty Pharmaceuticals, Inc. | Oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery |
| MY153288A (en) * | 2006-06-28 | 2015-01-29 | Hovid Berhad | An effective pharmaceutical carrier for poorly bioavailable drugs |
| CN101809024A (zh) * | 2007-07-16 | 2010-08-18 | 铂雅制药公司 | 吡铂的口服制剂 |
| EP2200613B1 (en) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
| WO2010123564A1 (en) * | 2009-04-22 | 2010-10-28 | Agency For Science, Technology And Research | Emulsions for transdermal delivery |
| WO2011038073A1 (en) | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes comprising docetaxel |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| JP5951489B2 (ja) | 2009-10-16 | 2016-07-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 組成物 |
| WO2012039768A2 (en) * | 2010-09-24 | 2012-03-29 | Texas Southern University | Itraconazole formulations |
| US20120302954A1 (en) * | 2011-05-25 | 2012-11-29 | Zhao Jonathon Z | Expandable devices coated with a paclitaxel composition |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| CN102415995B (zh) * | 2011-12-09 | 2013-11-13 | 广东众生药业股份有限公司 | 一种黄体酮过饱和自微乳组合物及其制备方法 |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| KR20160137597A (ko) * | 2014-03-28 | 2016-11-30 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 프로게스테론 제형 |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
| US20160346219A1 (en) | 2015-06-01 | 2016-12-01 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| TW201718598A (zh) * | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| JP6871542B2 (ja) * | 2017-02-28 | 2021-05-12 | 国立大学法人横浜国立大学 | 無機物成形体およびその製造方法 |
| WO2019051437A1 (en) * | 2017-09-11 | 2019-03-14 | Board Of Regents, The University Of Texas System | COMPOSITIONS FOR ENHANCED MEDICATION DELIVERY |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| WO2025153584A1 (en) * | 2024-01-17 | 2025-07-24 | Basf Se | Solid self-emulsifying dosage form |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| NZ510991A (en) * | 1997-03-05 | 2002-11-26 | Sugen Inc | Use of formulations for hydrophobic pharmaceutical agents in treatment or prevention of cell proliferative disorders |
| KR100661879B1 (ko) * | 1998-04-01 | 2006-12-27 | 스키에파마 캐나다 인코포레이티드 | 항암 조성물 |
| US6221391B1 (en) * | 1998-11-23 | 2001-04-24 | Accucaps Industries Limited | Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith |
| US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
| DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
-
2001
- 2001-07-20 DE DE60109295T patent/DE60109295T2/de not_active Expired - Fee Related
- 2001-07-20 JP JP2002513448A patent/JP2004504342A/ja not_active Withdrawn
- 2001-07-20 EP EP01954879A patent/EP1303261B1/en not_active Expired - Lifetime
- 2001-07-20 AU AU2001277099A patent/AU2001277099B2/en not_active Ceased
- 2001-07-20 US US09/909,691 patent/US20020119198A1/en not_active Abandoned
- 2001-07-20 DK DK01954879T patent/DK1303261T3/da active
- 2001-07-20 AU AU7709901A patent/AU7709901A/xx active Pending
- 2001-07-20 CA CA002410683A patent/CA2410683A1/en not_active Abandoned
- 2001-07-20 WO PCT/US2001/023140 patent/WO2002007712A2/en not_active Ceased
- 2001-07-20 MX MXPA03000720A patent/MXPA03000720A/es active IP Right Grant
- 2001-07-20 PT PT01954879T patent/PT1303261E/pt unknown
- 2001-07-20 ES ES01954879T patent/ES2238050T3/es not_active Expired - Lifetime
- 2001-07-20 AT AT01954879T patent/ATE290372T1/de not_active IP Right Cessation
- 2001-07-24 AR ARP010103528A patent/AR030253A1/es unknown
- 2001-07-24 PE PE2001000747A patent/PE20020261A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004504342A (ja) | 2004-02-12 |
| ATE290372T1 (de) | 2005-03-15 |
| AU2001277099B2 (en) | 2006-08-31 |
| ES2238050T3 (es) | 2005-08-16 |
| PT1303261E (pt) | 2005-06-30 |
| DK1303261T3 (da) | 2005-05-23 |
| US20020119198A1 (en) | 2002-08-29 |
| DE60109295T2 (de) | 2006-04-13 |
| EP1303261A2 (en) | 2003-04-23 |
| WO2002007712A3 (en) | 2002-06-13 |
| WO2002007712A2 (en) | 2002-01-31 |
| EP1303261B1 (en) | 2005-03-09 |
| DE60109295D1 (de) | 2005-04-14 |
| CA2410683A1 (en) | 2002-01-31 |
| AR030253A1 (es) | 2003-08-13 |
| AU7709901A (en) | 2002-02-05 |
| MXPA03000720A (es) | 2004-11-01 |
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