PE20010319A1 - ANTAGONISTS OF IL-8 RECEPTORS - Google Patents
ANTAGONISTS OF IL-8 RECEPTORSInfo
- Publication number
- PE20010319A1 PE20010319A1 PE2000000589A PE0005892000A PE20010319A1 PE 20010319 A1 PE20010319 A1 PE 20010319A1 PE 2000000589 A PE2000000589 A PE 2000000589A PE 0005892000 A PE0005892000 A PE 0005892000A PE 20010319 A1 PE20010319 A1 PE 20010319A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- group
- ring
- halosustituted
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 102000010681 interleukin-8 receptors Human genes 0.000 title 1
- 108010038415 interleukin-8 receptors Proteins 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 abstract 1
- 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 102100036154 Platelet basic protein Human genes 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE AL USO COMPUESTOS QUE CONTIENEN GUANIDINA DE FORMULA I, DONDE: Z ES CN, OR11, C(O)NR15R16, R18, C(O)R11, S(O)2R17; R ES UN GRUPO CON UN H IONIZABLE Y UN pKa MENOR A 10; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10 HALOSUSTITUIDO, (CR8R8)qS(O)tR4, OH, (CR8R8)qNR4R5, ENTRE OTROS; q ES 0-10, t ES 0-2; v ES 0-4; R4 Y R5 SON H, ALQUILO C1-C4, ARILO, (ARIL)-ALQUILO C1-C4, HETEROARILO, HETEROCICLICO,ENTRE OTROS; O JUNTO CON N FORMAN UN ANILLO DE 5 A 7 MIEMBROS; Y ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10 HALOSUSTITUIDO, ALQUENILO C2-C10, ALCOXI C1-C10, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C4; R6 Y R7 JUNTO A N FORMAN UN ANILLO DE 5 A 7 MIEMBROS; R8 ES H, ALQUILO C1-C4; R11 ES H, ALQUILO C1-C4, ENTRE OTROS; R15 Y R16 SON H, ALQUILO C1-C4, ARILO, ENTRE OTROS; R17 ES ALQUILO C1-C4, NR15R16, OR11, ARILO, ENTRE OTROS; R18 ES ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS; W ES UN GRUPO a, ENTRE OTROS; E` ES UN GRUPO b, ENTRE OTROS; W1 ES UN GRUPO c, ENTRE OTROS; E ES UN GRUPO d; * ES EL PUNTO DE UNION DEL ANILLO. LOS COMPUESTOS DE GUANIDINA INHIBE LA UNION DE QUIMIOQUINAS GROO, GROß, GROÛ, NAP-2 AL RECEPTOR O, ß DE INTERLEUQUINA IL-8 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE MALARIA, RESTENOSIS, ANGIOGENESIS, ATEROSCLEROSIS, OSTEOPOROSIS, GINGIVITIS, ENFERMEDADES CAUSADAS POR VIRUS DE LA HEPATITIS ßREFERS TO THE USE OF COMPOUNDS CONTAINING GUANIDINE OF FORMULA I, WHERE: Z IS CN, OR11, C (O) NR15R16, R18, C (O) R11, S (O) 2R17; R IS A GROUP WITH A H IONIZABLE AND A pKa LESS THAN 10; R1 IS H, HALOGEN, NITRO, CYANE, C1-C10 HALOSUSTITUTED ALKYL, (CR8R8) qS (O) tR4, OH, (CR8R8) qNR4R5, AMONG OTHERS; q IS 0-10, t IS 0-2; v ES 0-4; R4 AND R5 ARE H, C1-C4 ALKYL, ARYL, (ARYL) -C1-C4 ALKYL, HETEROARYL, HETEROCYCLIC, AMONG OTHERS; OR TOGETHER WITH N, THEY FORM A RING OF 5 TO 7 MEMBERS; AND IT IS H, HALOGEN, NITRO, CYANE, C1-C10 HALOSUSTITUTED ALKYL, C2-C10 ALKYL, C1-C10 ALCOXY, AMONG OTHERS; R6 AND R7 ARE H, C1-C4 ALKYL; R6 AND R7 TOGETHER WITH N FORM A RING OF 5 TO 7 MEMBERS; R8 IS H, C1-C4 ALKYL; R11 IS H, C1-C4 ALKYL, AMONG OTHERS; R15 AND R16 ARE H, C1-C4 ALKYL, ARYL, AMONG OTHERS; R17 IS C1-C4 ALKYL, NR15R16, OR11, ARYL, AMONG OTHERS; R18 IS C1-C4 ALKYL, ARYL, ARYL-C1-C4 ALKYL, AMONG OTHERS; W IS A GROUP a, AMONG OTHERS; E` IS A GROUP b, AMONG OTHERS; W1 IS A GROUP c, AMONG OTHERS; E IS A GROUP d; * IS THE JOINT POINT OF THE RING. GUANIDINE COMPOUNDS INHIBIT THE BINDING OF CHEMOKINES GROO, GROß, GROÛ, NAP-2 TO THE IL-8 INTERLEUQUIN O, ß RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF MALARIA, RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROMEDOSIS, CABINETS FOR HEPATITIS VIRUS ß
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13967499P | 1999-06-16 | 1999-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010319A1 true PE20010319A1 (en) | 2001-05-24 |
Family
ID=22487784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000589A PE20010319A1 (en) | 1999-06-16 | 2000-06-14 | ANTAGONISTS OF IL-8 RECEPTORS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1191934A4 (en) |
| JP (1) | JP2003501471A (en) |
| KR (1) | KR20020009635A (en) |
| CN (1) | CN1494424A (en) |
| AR (1) | AR029368A1 (en) |
| AU (1) | AU766086B2 (en) |
| BR (1) | BR0010985A (en) |
| CA (1) | CA2377397A1 (en) |
| CZ (1) | CZ20014490A3 (en) |
| EC (2) | ECSP003525A (en) |
| HK (1) | HK1044716A1 (en) |
| HU (1) | HUP0202019A3 (en) |
| IL (1) | IL146214A0 (en) |
| MX (1) | MXPA01013287A (en) |
| NO (1) | NO20016065D0 (en) |
| NZ (1) | NZ515232A (en) |
| PE (1) | PE20010319A1 (en) |
| PL (1) | PL352218A1 (en) |
| TR (1) | TR200103690T2 (en) |
| UY (1) | UY26209A1 (en) |
| WO (1) | WO2000076516A1 (en) |
| ZA (1) | ZA200110203B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642215B2 (en) * | 2001-05-24 | 2003-11-04 | Leo Pharma A/S | Method of modulating NF-kB activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| AR008290A1 (en) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | NEW COMPOUNDS CONTAINING GUANIDINE USEFUL AS ANTAGONISTS OF IL-8 RECEPTORS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND PROCEDURE FOR THE PREPARATION OF INTERMEDIARIES. |
-
2000
- 2000-06-12 EC EC2000003525A patent/ECSP003525A/en unknown
- 2000-06-14 UY UY26209A patent/UY26209A1/en not_active Application Discontinuation
- 2000-06-14 AR ARP000102925A patent/AR029368A1/en not_active Application Discontinuation
- 2000-06-14 PE PE2000000589A patent/PE20010319A1/en not_active Application Discontinuation
- 2000-06-16 JP JP2001502849A patent/JP2003501471A/en not_active Withdrawn
- 2000-06-16 EP EP00942933A patent/EP1191934A4/en not_active Withdrawn
- 2000-06-16 MX MXPA01013287A patent/MXPA01013287A/en unknown
- 2000-06-16 BR BR0010985-1A patent/BR0010985A/en not_active IP Right Cessation
- 2000-06-16 CN CNA008089205A patent/CN1494424A/en active Pending
- 2000-06-16 PL PL00352218A patent/PL352218A1/en not_active Application Discontinuation
- 2000-06-16 NZ NZ515232A patent/NZ515232A/en unknown
- 2000-06-16 WO PCT/US2000/016813 patent/WO2000076516A1/en not_active Ceased
- 2000-06-16 HK HK02106332.2A patent/HK1044716A1/en unknown
- 2000-06-16 CZ CZ20014490A patent/CZ20014490A3/en unknown
- 2000-06-16 TR TR2001/03690T patent/TR200103690T2/en unknown
- 2000-06-16 KR KR1020017016140A patent/KR20020009635A/en not_active Withdrawn
- 2000-06-16 CA CA002377397A patent/CA2377397A1/en not_active Abandoned
- 2000-06-16 AU AU57482/00A patent/AU766086B2/en not_active Ceased
- 2000-06-16 HU HU0202019A patent/HUP0202019A3/en unknown
- 2000-06-16 IL IL14621400A patent/IL146214A0/en unknown
- 2000-08-14 EC EC2000003528A patent/ECSP003528A/en unknown
- 2000-12-12 ZA ZA200110203A patent/ZA200110203B/en unknown
-
2001
- 2001-12-12 NO NO20016065A patent/NO20016065D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20016065L (en) | 2001-12-12 |
| MXPA01013287A (en) | 2002-06-04 |
| CA2377397A1 (en) | 2000-12-21 |
| JP2003501471A (en) | 2003-01-14 |
| EP1191934A1 (en) | 2002-04-03 |
| AU5748200A (en) | 2001-01-02 |
| ECSP003525A (en) | 2002-01-25 |
| IL146214A0 (en) | 2002-07-25 |
| HUP0202019A2 (en) | 2002-10-28 |
| AR029368A1 (en) | 2003-06-25 |
| TR200103690T2 (en) | 2002-05-21 |
| EP1191934A4 (en) | 2004-02-04 |
| AU766086B2 (en) | 2003-10-09 |
| KR20020009635A (en) | 2002-02-01 |
| HUP0202019A3 (en) | 2003-03-28 |
| ECSP003528A (en) | 2002-01-25 |
| ZA200110203B (en) | 2002-09-11 |
| BR0010985A (en) | 2002-03-26 |
| PL352218A1 (en) | 2003-08-11 |
| NO20016065D0 (en) | 2001-12-12 |
| WO2000076516A1 (en) | 2000-12-21 |
| NZ515232A (en) | 2004-02-27 |
| UY26209A1 (en) | 2000-12-29 |
| CN1494424A (en) | 2004-05-05 |
| HK1044716A1 (en) | 2002-11-01 |
| CZ20014490A3 (en) | 2002-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |