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PE20010459A1 - USE OF A CALCIOLITHIC COMPOUND WITH AN ANTI-RESORPTION AGENT - Google Patents

USE OF A CALCIOLITHIC COMPOUND WITH AN ANTI-RESORPTION AGENT

Info

Publication number
PE20010459A1
PE20010459A1 PE2000000756A PE0007562000A PE20010459A1 PE 20010459 A1 PE20010459 A1 PE 20010459A1 PE 2000000756 A PE2000000756 A PE 2000000756A PE 0007562000 A PE0007562000 A PE 0007562000A PE 20010459 A1 PE20010459 A1 PE 20010459A1
Authority
PE
Peru
Prior art keywords
phenoxy
propyl
hydroxy
dimethyl
amine
Prior art date
Application number
PE2000000756A
Other languages
Spanish (es)
Inventor
Maxine Gowen
Larry J Suva
Edward F Nemeth
John Fox
George B Stroup
Original Assignee
Smithkline Beecham Corp
Nps Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Nps Pharma Inc filed Critical Smithkline Beecham Corp
Publication of PE20010459A1 publication Critical patent/PE20010459A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE AL USO DE COMPUESTOS INHIBIDORES DE LA ACTIVIDAD DE LOS RECEPTORES DE CALCIO TAL COMO HIDROCLORURO DE N-[(2R-HIDROXI-3-[(3-CLORO-2-CIANO)FENOXI-PROPIL]-1,1-DIMETIL-2-(2-NAFTIL)-ETIL-AMINA, HIDROCLORURO DE N-[(2R-HIDROXI-3-[(3-CLORO-2-CIANO)FENOXI-PROPIL]-1,1-DIMETIL-2-(4-METOXIFENIL)ETIL-AMINA, HIDROCLORURO DE N-[(2R-HIDROXI-3-[(2,3-DICLORO)FENOXI-PROPIL]-1,1-DIMETIL-2-(4-METOXIFENIL)ETIL-AMINA, ENTRE OTROS; CON UN AGENTE DE ANTI-RESORCION TAL COMO ESTROGENOS, 1,25(OH)2-VITAMINA D3, CALCITONINA, MODULADORES SELECTIVOS DE LOS RECEPTORES DE ESTROGENOS, ANTAGONISTAS DEL RECEPTOR DE VITRONECTINA, INHIBIDORES DE LA V-H+-ADENOSINA-FOSFATASA, ANTAGONISTAS src DE SH2, BISFOSFONATOS Y LOS INHIBIDORES DE LA CATEPSINA K. EL AGENTE CALCIOLITICO PRODUCE UN AUMENTO EN LOS NIVELES DE LA HORMONA PARATIROIDEA EN SUERO DE TRES VECES O MAS. LA ADMINISTRACION CONJUNTA DE UN AGENTE CALCIOLITICO CON UN AGENTRE ANTI-RESORCION PUEDE SER UTIL PARA EL TRATAMIENTO DE UN TRASTORNO OSEO MINERAL TAL COMO ENFERMEDAD PERIODONTAL, CONSOLIDACION DE FRACTURAS, OSTEOARTRITIS, ARTRITIS REUMATOIDE, OSTEOPOROSIS, HIPERCALCEMIA HUMORAL MALIGNA, ENFERMEDAD METASTASICA DE LOS HUESOS, PROTESIS ARTICULARESREFERS TO THE USE OF COMPOUNDS INHIBITING THE ACTIVITY OF CALCIUM RECEPTORS SUCH AS N - [(2R-HYDROXY-3 - [(3-CHLORO-2-CYANE) PHENOXY-PROPYL] -1,1-DIMETHYL-HYDROCHLORIDE 2- (2-NAPHTHYL) -ETHYL-AMINE, N - [(2R-HYDROXY-3 - [(3-CHLORO-2-CYANE) PHENOXY-PROPYL] -1,1-DIMETHYL-2- (4- METHOXYPHENIL) ETHYL-AMINE, N - [(2R-HYDROXY-3 - [(2,3-DICHLORO) PHENOXY-PROPYL] -1,1-DIMETHYL-2- (4-METHOXYPHENYL) ETHYL-AMINE, BETWEEN OTHERS ; WITH AN ANTI-RESORPTION AGENT SUCH AS ESTROGENS, 1,25 (OH) 2-VITAMIN D3, CALCITONIN, SELECTIVE MODULATORS OF THE ESTROGEN RECEPTORS, VITRONECTIN RECEPTOR ANTAGONISTS, V-H + -ADEN PHASE INHIBITORS, SH2 src ANTAGONISTS, BISPHOSPHONATES AND INHIBITORS OF CATEPSIN K. THE CALCIOLYTIC AGENT PRODUCES AN INCREASE IN THE LEVELS OF PARATHYROID HORMONE IN SERUM THREE TIMES OR MORE. USEFUL FOR THE TREATMENT OF A MINERAL BONE DISORDER SUCH AS PERIODONTAL DISEASE, CONSOLIDATION OF FRACTURES, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, OSTEOPOROSIS, MALIGNANT HUMORAL HYPERCALCEMIA, BONE METASTASIC DISEASE, JOINT PROSTHESIS

PE2000000756A 1999-07-31 2000-07-31 USE OF A CALCIOLITHIC COMPOUND WITH AN ANTI-RESORPTION AGENT PE20010459A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14677899P 1999-07-31 1999-07-31

Publications (1)

Publication Number Publication Date
PE20010459A1 true PE20010459A1 (en) 2001-06-11

Family

ID=22518969

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000756A PE20010459A1 (en) 1999-07-31 2000-07-31 USE OF A CALCIOLITHIC COMPOUND WITH AN ANTI-RESORPTION AGENT

Country Status (21)

Country Link
EP (1) EP1200076A4 (en)
JP (1) JP2003505502A (en)
KR (1) KR20020016928A (en)
CN (1) CN1367687A (en)
AU (1) AU764716B2 (en)
BR (1) BR0012921A (en)
CA (1) CA2380081A1 (en)
CO (1) CO5180628A1 (en)
CZ (1) CZ2002360A3 (en)
EC (1) ECSP003590A (en)
HK (1) HK1046238A1 (en)
HU (1) HUP0202167A3 (en)
IL (1) IL147875A0 (en)
MX (1) MXPA02001204A (en)
NO (1) NO20020466L (en)
PE (1) PE20010459A1 (en)
PL (1) PL353318A1 (en)
TR (1) TR200200278T2 (en)
UY (1) UY26265A1 (en)
WO (1) WO2001008673A1 (en)
ZA (1) ZA200200784B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030684A1 (en) * 2000-01-24 2003-09-03 Smithkline Beecham Corp CALCILITICAL COMPOUNDS, USE OF SUCH COMPOUNDS IN THE MANUFACTURE OF MEDICINES, AND USEFUL INTERMEDIARIES IN THE PREPARATION OF SUCH COMPOUNDS
US20030018203A1 (en) 2002-07-17 2003-01-23 Largo Maria Amparo Calcilytic compounds
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
MY143244A (en) 2002-11-26 2011-04-15 Smithkline Beecham Corp Calcilytic compounds
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
US7265145B2 (en) 2003-05-28 2007-09-04 Bristol-Myers Squibb Company Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method
UY30801A1 (en) 2006-12-18 2008-07-03 Smithkline Beecham Corp CALCILITICAL COMPOUNDS
EP2797591A1 (en) * 2011-12-27 2014-11-05 Ubaldo Armato Use of calcilytic drugs as a pharmacological approach to the treatment and prevention of alzheimer's disease, alzheimer's disease-related disorders, and down's syndrome neuropathies
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
CN108420814A (en) * 2017-02-15 2018-08-21 四川大学 A kind of NPS-2143 is used for the new application of antibacterial
CN116173187B (en) * 2023-03-14 2024-05-10 哈尔滨医科大学 Application of calcitonin in the preparation of drugs for preventing and treating in-stent restenosis, drug-coated stent and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037967A1 (en) * 1996-04-09 1997-10-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
AR018177A1 (en) * 1998-04-08 2001-10-31 Smithkline Beecham Corp CALCILITICAL COMPOUNDS, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.
AR014975A1 (en) * 1998-04-08 2001-04-11 Nps Pharma Inc CALCILITICAL COMPOUNDS, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
ECSP003590A (en) 2002-02-25
HUP0202167A2 (en) 2002-10-28
AU6504100A (en) 2001-02-19
WO2001008673A1 (en) 2001-02-08
HK1046238A1 (en) 2003-01-03
CO5180628A1 (en) 2002-07-30
NO20020466L (en) 2002-03-20
NO20020466D0 (en) 2002-01-29
KR20020016928A (en) 2002-03-06
JP2003505502A (en) 2003-02-12
AU764716B2 (en) 2003-08-28
CN1367687A (en) 2002-09-04
BR0012921A (en) 2002-06-18
PL353318A1 (en) 2003-11-17
CA2380081A1 (en) 2001-02-08
EP1200076A1 (en) 2002-05-02
EP1200076A4 (en) 2005-02-09
MXPA02001204A (en) 2004-05-21
CZ2002360A3 (en) 2002-10-16
UY26265A1 (en) 2001-03-16
TR200200278T2 (en) 2002-06-21
HUP0202167A3 (en) 2006-07-28
IL147875A0 (en) 2002-08-14
ZA200200784B (en) 2003-01-29

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