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PE20001297A1 - Antibioticos cetolidos carbamato y carbazato - Google Patents

Antibioticos cetolidos carbamato y carbazato

Info

Publication number
PE20001297A1
PE20001297A1 PE1999001153A PE00115399A PE20001297A1 PE 20001297 A1 PE20001297 A1 PE 20001297A1 PE 1999001153 A PE1999001153 A PE 1999001153A PE 00115399 A PE00115399 A PE 00115399A PE 20001297 A1 PE20001297 A1 PE 20001297A1
Authority
PE
Peru
Prior art keywords
compounds
formula
cetolides
carbazate
carbamate
Prior art date
Application number
PE1999001153A
Other languages
English (en)
Inventor
Yong-Jin Wu
Takushi Kaneko
Wei-Guo Su
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001297A1 publication Critical patent/PE20001297A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A MACROLIDOS DE FORMULA I, DONDE: X1 ES O, CR13R14, NR4; X2 ES =O, =NOR1; R1 ES H, METILO, ETILO; R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), ENTRE OTROS; R3 ES HALO, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, AZIDO, -C(O)R5, -C(O)OR5, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6; R6 ES H, -C(O)(ALQUILO C1-C6); R7, R8, R9, R10, R11, R12, R13, R14 SON H, HALO, ALQUILO C1-C6 CON LA CONDICION: CUANDO X1 ES CR13R14 Y R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), AL MENOS UNO DE R7, R8. R9, R10, R11, R12, R13, R14 ES HALO O ALQUILO C1-C6; CUANDO X1 ES NR4 Y R2 ES C(R7)(R8)C(R9)(R10)C(R11)(R12)(HETEROCICLO DE 4-10 MIEMBROS), AL MENOS UNO DE R7, R8, R9 R10, R11, R12 ES HALO, ALQUILO C1-C6; ENTRE OTROS; R15 ES ALQUILO C1-C6; R16 ES H, ALQUILO C1-C10. SON COMPUESTOS PREFERIDOS: 11-DESOXI-5-O-DESOXAMINIL-11-(3,3-DIMETIL-3-(4-PIRIDIN-3-IL-IMIDAZOL-1-IL-PROPIL))HIDRAZO-6-O-METIL-3-OXOERITRONOLIDA A, 11,12-CARBAMATO, 9-E-(O-METIL)OXIMA; 11-DESOXI-5-O-DESOXAMINIL-11-(3(R)-METIL-3-(4-PIRIDIN-3-IL-IMIDAZOL-1-IL-PROPIL))HIDRAZO-6-O-METIL-3-OXOERITRONOLIDA A, 11,12-CARBAMATO, 9-E-(O-METIL)OXIMA, ENTRE OTROS. LOS MACROLIDOS SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
PE1999001153A 1998-12-10 1999-11-15 Antibioticos cetolidos carbamato y carbazato PE20001297A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11172898P 1998-12-10 1998-12-10

Publications (1)

Publication Number Publication Date
PE20001297A1 true PE20001297A1 (es) 2000-12-04

Family

ID=22340138

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001153A PE20001297A1 (es) 1998-12-10 1999-11-15 Antibioticos cetolidos carbamato y carbazato

Country Status (13)

Country Link
US (1) US6664238B1 (es)
EP (1) EP1137654A1 (es)
AT (1) ATE344269T1 (es)
AU (1) AU6484199A (es)
DE (1) DE69933897T2 (es)
ES (1) ES2273964T3 (es)
GT (1) GT199900208A (es)
MA (1) MA26711A1 (es)
PA (1) PA8486401A1 (es)
PE (1) PE20001297A1 (es)
TN (1) TNSN99227A1 (es)
TR (1) TR200102129T2 (es)
WO (1) WO2000034297A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
SI1147121T1 (en) * 1999-01-27 2004-04-30 Pfizer Products Inc. Ketolide antibiotics
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
CN1373767A (zh) 1999-04-16 2002-10-09 奥索-麦克尼尔药品公司 酮式大环内酯抗菌剂
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
KR20020007374A (ko) 1999-04-16 2002-01-26 추후제출 매크롤라이드 항감염제
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ES2552682T3 (es) * 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
US7419962B2 (en) * 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
DE602005019786D1 (de) * 2004-12-21 2010-04-15 Pfizer Prod Inc Makrolide
CN1318441C (zh) * 2005-04-25 2007-05-30 中国医学科学院医药生物技术研究所 大环内酯类抗生素的酮内酯化合物及其制备方法和用途
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
AU2009308181B2 (en) 2008-10-24 2015-12-03 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
SI2571506T1 (sl) 2010-05-20 2017-12-29 Cempra Pharmaceuticals, Inc. Postopki za pripravo makrolidov in ketolidov ter njihovih intermediatov
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN105163785A (zh) 2013-03-14 2015-12-16 森普拉制药公司 用于治疗呼吸道疾病的方法及其制剂
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
CN114437154B (zh) * 2022-01-30 2024-03-01 北京理工大学 一种含有喹诺酮的酮内酯衍生物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE19626036A1 (de) 1996-06-28 1998-01-02 Whitaker Corp Optischer Steckverbinder
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CN1238777A (zh) 1996-11-27 1999-12-15 大正制药株式会社 红霉素a衍生物
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5794778A (en) 1997-02-26 1998-08-18 Riverwood International Corporation Article carrier with strap-type handle and top panel access
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
TR200102129T2 (tr) 2002-01-21
ES2273964T3 (es) 2007-05-16
MA26711A1 (fr) 2004-12-20
WO2000034297A1 (en) 2000-06-15
PA8486401A1 (es) 2003-01-24
ATE344269T1 (de) 2006-11-15
DE69933897D1 (de) 2006-12-14
EP1137654A1 (en) 2001-10-04
AU6484199A (en) 2000-06-26
TNSN99227A1 (fr) 2005-11-10
GT199900208A (es) 2001-05-31
US6664238B1 (en) 2003-12-16
DE69933897T2 (de) 2007-03-15

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