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PE20001237A1 - PROTEASE INHIBITORS - Google Patents

PROTEASE INHIBITORS

Info

Publication number
PE20001237A1
PE20001237A1 PE1999001145A PE00114599A PE20001237A1 PE 20001237 A1 PE20001237 A1 PE 20001237A1 PE 1999001145 A PE1999001145 A PE 1999001145A PE 00114599 A PE00114599 A PE 00114599A PE 20001237 A1 PE20001237 A1 PE 20001237A1
Authority
PE
Peru
Prior art keywords
compound
protease inhibitors
disease
morpholinoetoxi
ilcarbonil
Prior art date
Application number
PE1999001145A
Other languages
Spanish (es)
Inventor
Andrew D Gribble
Jason Witherington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE20001237A1 publication Critical patent/PE20001237A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO MORFOLINO ETOXI BENZOFURANO DE FORMULA I, DONDE n ES 1-2, SIENDO UN COMPUESTO PREFERIDO: 4-(R)-AMINO-N-[[5-(2-N-MORFOLINOETOXI)-BENZO[b]FURAN-2-ILCARBONIL]-S-LEUCINA]-TETRAHIDROPIRAN-3-ONA. EL COMPUESTO I INHIBE A LA CISTEINA PROTEASA COMO CATEPSINA K; POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE LA OSTEOPOROSIS, ENFERMEDAD GINGIVAL, PERIODONTAL O ENFERMEDAD CARACTERIZADA POR UNA EXCESIVA DEGRADACION DE LOS CARTILAGOS O LAS MATRICES, OSTEOARTRITIS, ARTRITIS REUMATOIDEREFERS TO A MORPHOLINE ETOXY BENZOFURAN COMPOUND OF FORMULA I, WHERE n IS 1-2, A PREFERRED COMPOUND BEING: 4- (R) -AMINO-N - [[5- (2-N-MORPHOLINOETOXI) -BENZO [b] FURAN-2-ILCARBONIL] -S-LEUCINE] -TETRAHYDROPYRAN-3-ONA. COMPOUND I INHIBITS CYSTEINE PROTEASE AS CATEPSIN K; SO IT MAY BE USEFUL FOR THE TREATMENT OF OSTEOPOROSIS, GINGIVAL DISEASE, PERIODONTAL OR DISEASE CHARACTERIZED BY EXCESSIVE DEGRADATION OF THE CARTILAGES OR MATRICES, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS

PE1999001145A 1998-11-13 1999-11-12 PROTEASE INHIBITORS PE20001237A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10841098P 1998-11-13 1998-11-13

Publications (1)

Publication Number Publication Date
PE20001237A1 true PE20001237A1 (en) 2000-12-23

Family

ID=22322023

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001145A PE20001237A1 (en) 1998-11-13 1999-11-12 PROTEASE INHIBITORS

Country Status (5)

Country Link
AR (1) AR021241A1 (en)
AU (1) AU1393900A (en)
CO (1) CO5150165A1 (en)
PE (1) PE20001237A1 (en)
WO (1) WO2000029408A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
JP2003513924A (en) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション Protease inhibitor
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1232155A4 (en) 1999-11-10 2002-11-20 Smithkline Beecham Corp Protease inhibitors
CZ20023168A3 (en) 2000-03-21 2003-02-12 Smithkline Beecham Corporation Protease inhibitors
IL155958A0 (en) * 2000-11-17 2003-12-23 Medivir Ab Cysteine protease inhibitors
US7132449B2 (en) * 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
IL156775A0 (en) * 2001-01-17 2004-02-08 Amura Therapeutics Ltd Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases
US6958358B2 (en) 2001-01-17 2005-10-25 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
PT1362052E (en) 2001-01-17 2007-04-30 Amura Therapeutics Ltd Inhibitors of cruzipain and other cysteine proteases
JP2005515254A (en) 2002-01-17 2005-05-26 スミスクライン ビーチャム コーポレーション Cycloalkylketoamide derivatives useful as cathepsin K inhibitors
JP5587790B2 (en) 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド Compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
CA2111930A1 (en) * 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
MA26487A1 (en) * 1997-04-29 2004-12-20 Smithkline Beecham Corp PROTEASE INHIBITOR HETEROCYCLECETOHYDRAZIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AR013079A1 (en) * 1997-05-06 2000-12-13 Smithkline Beecham Corp SUBSTITUTED DERIVATIVES OF TETRAHIDROFURANO-3-ONAS, TETRAHIDROPIRANO-3- ONAS AND TETRAHIDROTIOFEN-3-ONAS, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION OF A MEDICINAL PRODUCT USEFUL AS INTERMEDIATE PROTEIN INHIBITORS
WO1998050534A1 (en) * 1997-05-08 1998-11-12 Smithkline Beecham Corporation Protease inhibitors
CN1255119A (en) * 1997-05-08 2000-05-31 史密丝克莱恩比彻姆公司 Protease inhibitors
MA26618A1 (en) * 1998-04-09 2004-12-20 Smithkline Beecham Corp PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MALARIA
DZ2796A1 (en) * 1998-05-21 2003-12-01 Smithkline Beecham Corp New bis-aminomethyl-carbonyl compounds, process for their preparation and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
CO5150165A1 (en) 2002-04-29
AR021241A1 (en) 2002-07-03
WO2000029408A1 (en) 2000-05-25
AU1393900A (en) 2000-06-05

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Legal Events

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