PE20001486A1 - Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas - Google Patents
Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasasInfo
- Publication number
- PE20001486A1 PE20001486A1 PE2000000128A PE0001282000A PE20001486A1 PE 20001486 A1 PE20001486 A1 PE 20001486A1 PE 2000000128 A PE2000000128 A PE 2000000128A PE 0001282000 A PE0001282000 A PE 0001282000A PE 20001486 A1 PE20001486 A1 PE 20001486A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- het
- compounds
- cycloalkyl
- etereo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/18—Eight-membered rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS ETER ANULAR DE 7-14 MIEMBROS DE FORMULA I, DONDE A ES CO, CH(OH); R1 ES R3-N(R`)-C(R2)-C(=O)-; R' ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R'' ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R''' ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R2 ES H, ALQUENILO C2-C6, ALQUINILO C2-C6, HET, Ar, ALQUILO C1-C6 CON OR6, R6NC(O)OR5, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6, R4C(O)-, R4R7NC(O)-, ENTRE OTROS; R4 ES ALQUILO C1-C6, CICLOALQUIL C3-C6-ALQUILO C0-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R5 ES H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; R6 Y R7 SON H, ALQUILO C1-C6, Ar-ALQUILO C0-C6, HET-ALQUILO C0-C6; M ES HC=CH, H2C-CH2, H(OR2)C-C(OR2)H, H(OR2)C-CH2, H(NR2H)C-C(NR2H)H, ENTRE OTROS; n ES 1-7; l ES 0-1. SON COMPUESTOS PREFERIDOS [(S)-3-METIL-1-(3-OXO-3,4,5,8-TETRAHIDRO-2H-OXOCIN-4-ILCARBAMOIL)-BUTIL]-AMIDA DE ACIDO NAFTILENO-2-CARBOXILICO; [(S)-3-METIL-1((S)-3-OXO-3,4,5,8-TETRAHIDRO-2H-OXOCIN-4-ILCARBAMOIL)-BUTIL]-AMIDA DE ACIDO BENZO[b]TIOFEN-2-CARBOXILICO, ENTRE OTROS. EL COMPUESTO DE FORMULA I ES UN INHIBIDOR DE CISTEINA Y SERINA PROTEASA Y PUEDE SER UTIL PARA EL TRATAMIENTO OSTEOPOROSIS, PERIODONTITIS, ARTRITIS, GINGIVITIS, OSTEOARTRITIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12069999P | 1999-02-19 | 1999-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001486A1 true PE20001486A1 (es) | 2001-02-08 |
Family
ID=22392011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000128A PE20001486A1 (es) | 1999-02-19 | 2000-02-18 | Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1153022A4 (es) |
| JP (1) | JP2002537297A (es) |
| AU (1) | AU3235100A (es) |
| CO (1) | CO5271679A1 (es) |
| DZ (1) | DZ3083A1 (es) |
| HK (1) | HK1042695A1 (es) |
| PE (1) | PE20001486A1 (es) |
| WO (1) | WO2000049011A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7168084B1 (en) | 1992-12-09 | 2007-01-23 | Sedna Patent Services, Llc | Method and apparatus for targeting virtual objects |
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2003513924A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| EP1232155A4 (en) | 1999-11-10 | 2002-11-20 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
| CZ20023168A3 (cs) | 2000-03-21 | 2003-02-12 | Smithkline Beecham Corporation | Inhibitory proteázy |
| IL155958A0 (en) * | 2000-11-17 | 2003-12-23 | Medivir Ab | Cysteine protease inhibitors |
| IL155961A0 (en) * | 2000-11-17 | 2003-12-23 | Medivir Uk Ltd | Cysteine protease inhibitors |
| DE502004001386D1 (de) * | 2003-05-27 | 2006-10-19 | Merck Patent Gmbh | Pyranderivative mit exocyclischer Doppelbindung |
| DE502004001563D1 (de) | 2003-05-27 | 2006-11-09 | Merck Patent Gmbh | Pyranderivate |
| EP1757284A1 (en) | 2005-08-25 | 2007-02-28 | Santhera Pharmaceuticals (Schweiz) AG | Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
| CA2157412A1 (en) * | 1993-03-03 | 1994-09-15 | Julia Marie Heerding | Balanoids |
| US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
-
2000
- 2000-02-16 DZ DZ000030A patent/DZ3083A1/xx active
- 2000-02-17 HK HK02102419.7A patent/HK1042695A1/zh unknown
- 2000-02-17 JP JP2000599751A patent/JP2002537297A/ja not_active Withdrawn
- 2000-02-17 EP EP00910222A patent/EP1153022A4/en not_active Withdrawn
- 2000-02-17 WO PCT/US2000/004133 patent/WO2000049011A1/en not_active Ceased
- 2000-02-17 AU AU32351/00A patent/AU3235100A/en not_active Abandoned
- 2000-02-18 CO CO00011383A patent/CO5271679A1/es not_active Application Discontinuation
- 2000-02-18 PE PE2000000128A patent/PE20001486A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DZ3083A1 (fr) | 2004-06-02 |
| AU3235100A (en) | 2000-09-04 |
| WO2000049011A1 (en) | 2000-08-24 |
| EP1153022A4 (en) | 2002-03-27 |
| HK1042695A1 (zh) | 2002-08-23 |
| CO5271679A1 (es) | 2003-04-30 |
| EP1153022A1 (en) | 2001-11-14 |
| JP2002537297A (ja) | 2002-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |