[go: up one dir, main page]

PE20001429A1 - Derivados de higromicina como agentes antibacterianos - Google Patents

Derivados de higromicina como agentes antibacterianos

Info

Publication number
PE20001429A1
PE20001429A1 PE1999001195A PE00119599A PE20001429A1 PE 20001429 A1 PE20001429 A1 PE 20001429A1 PE 1999001195 A PE1999001195 A PE 1999001195A PE 00119599 A PE00119599 A PE 00119599A PE 20001429 A1 PE20001429 A1 PE 20001429A1
Authority
PE
Peru
Prior art keywords
cr6r7
alkyl
aryl
link
antibacterial agents
Prior art date
Application number
PE1999001195A
Other languages
English (en)
Inventor
Matthew Merrill Hayward
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001429A1 publication Critical patent/PE20001429A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A HIGROMICINA A DE FORMULA I, DONDE X1 ES CR6R7, SOn, NR6, ENLACE; n ES 0-2; X2 ES CR6R7, SOn, NR6, O, ENLACE; SI X1 o X2 ES S, SO EL OTRO ES CR6R7, ENLACE; SI X1 o X2 ES SO2 EL OTRO ES NR6, CR6R7, ENLACE, SI X1 ES NR6, X2 ES SO2, CO; SI X2 ES O, X1 ES CR6R7; R1 ES H, OH; R2 ES H, ALQUILO C1-C6, HALO, CUANDO X2 ES NR6; R3 Y X2 JUNTOS FORMAN UN ANILLO DE 5-12 MIEMBROS OPCIONALMENTE SUSTITUIDO CON 1-3 R4; R3 ES H, ALQUILO C1-C10, (CR6R7)t(ARILO C6-C10), (CR6R7)t(HETEROCICLO DE 4-10 MIEMBROS), CO(CR6R7)t(ARILO C6-C10), ENTRE OTROS; t ES 0-5; R4 ES ALQUILO C1-C10, ALQUENILO C2-C10, ALQUINILO C2-C10, HALO, CIANO, COR5, NR6COOR8, SOj(CR6R7)m(ARILO C6-C10), ENTRE OTROS; R5 ES H, ALQUILO C1-C10, (CR6R7)m(ARILO C6-C10), CR6R7)m(HETEROCICLO DE 4-10 MIEMBROS), ENTRE OTROS; m ES 0-4; R6 Y R7 SON H, CO-ALQUILO C1-C6, F; R8 ES R5 EXCEPTO H. UN COMPUESTO PREFERIDO ES 3-(4-((2S,3S,4S,5R)-3,4-DIHIDROXI-5-(3-HIDROXI-1-METIL-(1E)-PROPENIL)-TETRAHIDRO-FURAN-2-ILOXI)-3-HIDROXI-FENIL)-2-METIL-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-TRIHIDROXI-BENZO(1,3)DIOXOL-5-IL)-(2E))ACRILAMIDA, ENTRE OTROS; TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIETNO DE INFECCIONES BACTERIANAS, PROTOZOARIAS
PE1999001195A 1998-12-02 1999-11-29 Derivados de higromicina como agentes antibacterianos PE20001429A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11061898P 1998-12-02 1998-12-02

Publications (1)

Publication Number Publication Date
PE20001429A1 true PE20001429A1 (es) 2000-12-18

Family

ID=22334003

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001195A PE20001429A1 (es) 1998-12-02 1999-11-29 Derivados de higromicina como agentes antibacterianos

Country Status (38)

Country Link
US (1) US6245745B1 (es)
EP (1) EP1135400A1 (es)
JP (1) JP3393189B2 (es)
KR (1) KR100418167B1 (es)
CN (1) CN1329617A (es)
AP (1) AP2001002154A0 (es)
AR (1) AR019784A1 (es)
AU (1) AU6362799A (es)
BG (1) BG105645A (es)
BR (1) BR9915813A (es)
CA (1) CA2352332C (es)
CO (1) CO5150171A1 (es)
CZ (1) CZ20011904A3 (es)
DZ (1) DZ2932A1 (es)
EA (1) EA004303B1 (es)
EE (1) EE200100301A (es)
GE (1) GEP20033144B (es)
GT (1) GT199900205A (es)
HN (1) HN1999000202A (es)
HR (1) HRP20010413A2 (es)
HU (1) HUP0104949A3 (es)
ID (1) ID28848A (es)
IL (1) IL142882A0 (es)
IS (1) IS5930A (es)
MA (1) MA26705A1 (es)
NO (1) NO20012687L (es)
NZ (1) NZ511424A (es)
OA (1) OA11721A (es)
PA (1) PA8486101A1 (es)
PE (1) PE20001429A1 (es)
PL (1) PL348063A1 (es)
SK (1) SK7302001A3 (es)
TN (1) TNSN99211A1 (es)
TR (1) TR200101540T2 (es)
UY (1) UY25827A1 (es)
WO (1) WO2000032616A1 (es)
YU (1) YU32601A (es)
ZA (1) ZA200104434B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382149A (zh) * 1999-10-29 2002-11-27 辉瑞产品公司 潮霉素a前药
PL357083A1 (en) * 1999-10-29 2004-07-12 Pfizer Products Inc. Hygromycin derivatives
OA12277A (en) * 2000-06-02 2006-05-11 Pfizer Prod Inc Hygromycin A derivatives for the treatment of bacterial and protozoal infections.
EP1643901A4 (en) * 2003-06-19 2008-10-29 Compumed Inc METHOD AND SYSTEM FOR ANALYZING BONE CONDITIONS USING A RADIOGRAPHIC IMAGE OF COMPATIBLE DICOM OS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20000478A1 (es) * 1998-05-04 2000-05-31 Pfizer Prod Inc Derivados de higromicina a
DE69908936T2 (de) * 1998-05-04 2004-05-19 Pfizer Products Inc., Groton 2''-deoxyhygromycinderivate

Also Published As

Publication number Publication date
SK7302001A3 (en) 2001-12-03
HUP0104949A2 (hu) 2002-04-29
TR200101540T2 (tr) 2001-10-22
EP1135400A1 (en) 2001-09-26
HUP0104949A3 (en) 2003-12-29
ZA200104434B (en) 2002-05-30
PL348063A1 (en) 2002-05-06
EA004303B1 (ru) 2004-02-26
EA200100444A1 (ru) 2001-10-22
IS5930A (is) 2001-04-27
ID28848A (id) 2001-07-05
EE200100301A (et) 2002-08-15
TNSN99211A1 (fr) 2005-11-10
JP2002531463A (ja) 2002-09-24
AR019784A1 (es) 2002-03-13
AP2001002154A0 (en) 2001-05-09
CZ20011904A3 (cs) 2001-10-17
UY25827A1 (es) 2001-08-27
KR20010093136A (ko) 2001-10-27
CN1329617A (zh) 2002-01-02
CA2352332A1 (en) 2000-06-08
HRP20010413A2 (en) 2002-06-30
BR9915813A (pt) 2001-08-21
JP3393189B2 (ja) 2003-04-07
NZ511424A (en) 2003-08-29
KR100418167B1 (ko) 2004-02-11
NO20012687D0 (no) 2001-05-31
OA11721A (en) 2005-01-25
MA26705A1 (fr) 2004-12-20
YU32601A (sh) 2004-05-12
PA8486101A1 (es) 2000-09-29
DZ2932A1 (fr) 2004-03-15
IL142882A0 (en) 2002-03-10
BG105645A (bg) 2002-02-28
AU6362799A (en) 2000-06-19
GEP20033144B (en) 2003-12-25
HN1999000202A (es) 2000-06-13
US6245745B1 (en) 2001-06-12
GT199900205A (es) 2001-05-24
CA2352332C (en) 2004-12-07
NO20012687L (no) 2001-05-31
WO2000032616A1 (en) 2000-06-08
CO5150171A1 (es) 2002-04-29

Similar Documents

Publication Publication Date Title
PT1178045E (pt) Derivados de azaindole-etilamina como agentes de ligacao de receptores de acetilcolina nicotinicos
PE20040071A1 (es) Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion
DE69724777D1 (de) Pentafluorobenzensulfonamiden und analoge
AU1676200A (en) Polyhydroxylated heterocyclic derivatives as anti-coagulants
DE60017115D1 (de) Amid-derivate und deren medizinische verwendung
ES2088537T3 (es) Derivados de piranil cianoguanidina.
MXPA03010432A (es) Inmunoconjugados del anticuerpo cd44 citotoxico.
PE20040772A1 (es) Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos
NO902394L (no) Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
KR900006331A (ko) 항미생물성 퀴놀로닐 락탐
DK0903347T3 (da) Hidtil ukendte cyclodepsipeptid PF1022-derivater
PE20020144A1 (es) Derivados de pleuromutilinas como agentes antibacterianos
ES2166046T3 (es) Derivados de arilacrilamida como agonistas o antagonistas de 5ht1.
AR017221A1 (es) Compuestos abridores de los canales de potasio, y el uso de los mismos para la manufactura de un medicamento
ES2055867T3 (es) Derivados de dibenzotiazepina utiles como agentes antiespasmodicos.
PE20001429A1 (es) Derivados de higromicina como agentes antibacterianos
ES2161417T3 (es) Compuestos de 2-aril-3-aminoariloxinaftilo, intermediarios, composiciones y procedimientos.
ATE199717T1 (de) Benzothiophenverbindungen, ihre anwendungen und zusammensetzungen
EA200101180A1 (ru) Производные тио-оксиндола
EA200001157A2 (ru) Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
ATE147376T1 (de) Heterocyclische derivate
ATE85056T1 (de) Tetracyclische indolderivate.
BR0014303A (pt) Sultam e sultona derivados de oxazolidinonas
FI903950A0 (fi) Ny komposition.
BR9902049A (pt) Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.

Legal Events

Date Code Title Description
FC Refusal