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PE20000127A1 - BENZENOSULFONAMIDE DERIVATIVE - Google Patents

BENZENOSULFONAMIDE DERIVATIVE

Info

Publication number
PE20000127A1
PE20000127A1 PE1998001240A PE00124098A PE20000127A1 PE 20000127 A1 PE20000127 A1 PE 20000127A1 PE 1998001240 A PE1998001240 A PE 1998001240A PE 00124098 A PE00124098 A PE 00124098A PE 20000127 A1 PE20000127 A1 PE 20000127A1
Authority
PE
Peru
Prior art keywords
alcoxy
alkyl
substituted
carbamoyl
carbonyl
Prior art date
Application number
PE1998001240A
Other languages
Spanish (es)
Inventor
Peter Buehlmayer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20000127A1 publication Critical patent/PE20000127A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE X ES S o NH, E "Y" y Z SON CADA UNO CH; o X ES NH Y UNA DE LAS VARIABLES Y y Z ES N, Y LA OTRA ES CH; R1 Y R2, EN FORMA INDEPENDIENTE, REPRESENTAN H, ALQUILO C1-C7, ALQUILO C1-C7 SUSTITUIDO POR HIDROXI, HALOGENO, ALCOXI C1-C7, CARBOXI, ALCOXI C1-C7-CARBONILO, CARBAMOILO, ALQUILO C1-C7 DE CARBONO-CARBOMOILO, DIALQUILO C1-C7-CARBAMOILO, CICLOALQUILO C3-C8, O POR CICLOALQUILO C3-C8 SUSTITUIDO POR ALCOXI C1-C7-CARBONILO, O REPRESENTA ALCANOILO C2-C7; MIENTRAS AL MENOS UNA DE LAS VARIABLES R1 o R2 SEA DIFERENTE DE HIDROGENO, EL GRUPO NR1R2 ES ALQUILENO C2-C6-AMINO LINEAL SUSTITUIDO O NO; EL ANILLO A, APARTE DE ESTAR SUSTITUIDO POR -SO2NR1R2 y -NH-, ESTA SUSTITUIDO o NO, UNA o MAS VECES POR ALQUILO C1-C7, ALCOXI C1-C7, ALCOXI C1-C7-ALCOXI DE C1-C7, HIDROXI, HALOGENO, Y CF3; EL ANILLO B ESTA SUSTITUIDO o NO, UNA o MAS VECES, MEDIANTE UNO DE SUS CARBONOS, POR HALOGENO, ALQUILO C1-C7, ALCOXI C1-C7, CARBOXI, ALCOXI C1-C7 DE CARBONO-CARBONILO, CARBAMOILO. TAMBIEN SE REFIERE AL USO DEL COMPUESTO DE FORMULA (I) PARA EL TRATAMIENTO DE LA OBESIDAD Y DESORDENES RELACIONADOS AL SER ANTAGONISTAS DEL SUBTIPO DE RECEPTOR DE NEUROPEPTIDO Y5REFERS TO A COMPOUND OF FORMULA (I), WHERE X IS S or NH, E "Y" AND Z ARE EACH CH; or X IS NH AND ONE OF THE VARIABLES Y and Z IS N, AND THE OTHER IS CH; R1 AND R2, INDEPENDENTLY, REPRESENT H, C1-C7 ALKYL, C1-C7 ALKYL SUBSTITUTED BY HYDROXY, HALOGEN, C1-C7 ALCOXY, CARBOXY, C1-C7-CARBONYL, CARBAMOYL-C7 CARBONYL, CARBAMOYL-C7 ALKYL , DIALKYL C1-C7-CARBAMOYL, CYCLOALKYL C3-C8, OR BY CYCLOALKYL C3-C8 SUBSTITUTED BY ALCOXY C1-C7-CARBONY, OR REPRESENTS ALKANOYL C2-C7; AS LONG AS AT LEAST ONE OF THE R1 or R2 VARIABLES IS DIFFERENT FROM HYDROGEN, THE NR1R2 GROUP IS C2-C6-LINEAR ALKYLENE SUBSTITUTED OR NOT; RING A, BESIDES BEING REPLACED BY -SO2NR1R2 and -NH-, IS SUBSTITUTED or NOT, ONE or MORE TIMES BY C1-C7 ALKYL, C1-C7 ALCOXY, C1-C7 ALCOXY-C1-C7 ALCOXY, HYDROXY, HALOGEN , And CF3; RING B IS SUBSTITUTED OR NOT, ONE OR MORE TIMES, THROUGH ONE OF ITS CARBONS, BY HALOGEN, C1-C7 ALKYL, C1-C7 ALCOXY, CARBOXI, CARBON-CARBONYL ALCOXY C1-C7, CARBAMOYL. IT ALSO REFERS TO THE USE OF THE FORMULA (I) COMPOUND FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS AS ANTAGONISTS OF THE Y5 NEUROPEPTIDE RECEPTOR SUBTYPE

PE1998001240A 1997-12-22 1998-12-17 BENZENOSULFONAMIDE DERIVATIVE PE20000127A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19757248 1997-12-22

Publications (1)

Publication Number Publication Date
PE20000127A1 true PE20000127A1 (en) 2000-03-14

Family

ID=7853006

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001240A PE20000127A1 (en) 1997-12-22 1998-12-17 BENZENOSULFONAMIDE DERIVATIVE

Country Status (6)

Country Link
AR (1) AR014406A1 (en)
AU (1) AU2415299A (en)
CO (1) CO5011105A1 (en)
PE (1) PE20000127A1 (en)
WO (1) WO1999032466A1 (en)
ZA (1) ZA9811705B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191160B1 (en) 1998-11-10 2001-02-20 Merck & Co., Inc. Spiro-indolines as Y5 receptor antagonists
FR2792314B1 (en) * 1999-04-15 2001-06-01 Adir NOVEL AMINOTRIAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
US6218408B1 (en) 1999-06-30 2001-04-17 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6340683B1 (en) 1999-04-22 2002-01-22 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
EP1816127A1 (en) 1999-04-22 2007-08-08 H. Lundbeck A/S Triazine derivatives for use as selective npy (y5) antagonists
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
US6225330B1 (en) 1999-06-30 2001-05-01 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US6222040B1 (en) 1999-06-30 2001-04-24 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
ATE466573T1 (en) * 1999-11-26 2010-05-15 Shionogi & Co NPYY5 ANTAGONISTS
WO2001064674A1 (en) 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
FR2815346B1 (en) * 2000-10-13 2004-02-20 Servier Lab NOVEL AMINOTRIAZOLONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
JP2005508841A (en) * 2001-03-29 2005-04-07 スミスクライン・ビーチャム・コーポレイション Compounds and methods
CA2403307A1 (en) 2001-10-23 2003-04-23 Neurogen Corporation Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
ATE384526T1 (en) * 2003-04-14 2008-02-15 Inst For Pharm Discovery Inc N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULPHONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES
CA2523714A1 (en) 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Substituted carboxylic acids
MX2007004155A (en) 2004-10-08 2007-09-11 Johnson & Johnson 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives.
GB0526257D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US9353078B2 (en) * 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
JP2023508909A (en) * 2019-12-20 2023-03-06 イケナ オンコロジー， インコーポレイテッド 4-Phenyl-N-(phenyl)thiazol-2-amine Derivatives and Related Compounds as Aryl Hydrocarbon Receptor (AHR) Agonists, For example, for the Treatment of Angiogenesis-Related Disorders or Inflammatory Diseases
WO2025017207A1 (en) * 2023-07-20 2025-01-23 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Inhibitors of smndc1 and their therapeutic use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776765A (en) * 1972-02-28 1973-12-04 Cities Service Co Process for protecting a substrate with an n{11 substituted aminoarylsulfonamide intumescent agent
FR2701480B1 (en) * 1993-02-15 1995-05-24 Sanofi Elf Compounds with a sulfamoyl and amidino group, process for their preparation and pharmaceutical compositions containing them.
JPH10504542A (en) * 1994-07-27 1998-05-06 ジー．ディー．サール アンド カンパニー Substituted thiazole compounds for treating inflammation

Also Published As

Publication number Publication date
AR014406A1 (en) 2001-02-28
ZA9811705B (en) 1999-09-07
CO5011105A1 (en) 2001-02-28
WO1999032466A1 (en) 1999-07-01
AU2415299A (en) 1999-07-12

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