PE20000879A1 - METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO - Google Patents

METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO

Info

Publication number: PE20000879A1
Authority: PE; Peru
Prior art keywords: acid; lactam; crystallize; alcoxy; glycin
Prior art date: 1998-04-29

Application number

PE1999000315A

Other languages

English (en)

Spanish (es)

Inventor

Der Does Thomas Van

Rienk Hendrik Kuipers

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-29

Filing date

1999-04-16

Publication date

2000-09-23

1999-04-16 Application filed by Dsm Nv filed Critical Dsm Nv

2000-09-23 Publication of PE20000879A1 publication Critical patent/PE20000879A1/es

Links

238000000034 method Methods 0.000 title abstract 2
230000003115 biocidal effect Effects 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
150000003952 β-lactams Chemical class 0.000 abstract 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
WDLWHQDACQUCJR-ZAMMOSSLSA-N (6r,7r)-7-[[(2r)-2-azaniumyl-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(e)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)/C=C/C)C(O)=O)=CC=C(O)C=C1 WDLWHQDACQUCJR-ZAMMOSSLSA-N 0.000 abstract 1
ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
229960003022 amoxicillin Drugs 0.000 abstract 1
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
229960000723 ampicillin Drugs 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 abstract 1
229960005361 cefaclor Drugs 0.000 abstract 1
OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 abstract 1
229960003012 cefamandole Drugs 0.000 abstract 1
RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 abstract 1
229960003719 cefdinir Drugs 0.000 abstract 1
GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 abstract 1
229960004261 cefotaxime Drugs 0.000 abstract 1
229960002580 cefprozil Drugs 0.000 abstract 1
229960001668 cefuroxime Drugs 0.000 abstract 1
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 abstract 1
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
229940106164 cephalexin Drugs 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
RPBAFSBGYDKNRG-NJBDSQKTSA-N epicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CCC=CC1 RPBAFSBGYDKNRG-NJBDSQKTSA-N 0.000 abstract 1
229960002457 epicillin Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000004679 hydroxides Chemical class 0.000 abstract 1
229910017604 nitric acid Inorganic materials 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
239000012266 salt solution Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PE1999000315A 1998-04-29 1999-04-16 METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO PE20000879A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98201398		1998-04-29

Publications (1)

Publication Number	Publication Date
PE20000879A1 true PE20000879A1 (es)	2000-09-23

Family

ID=8233663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1999000315A PE20000879A1 (es)	1998-04-29	1999-04-16	METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO

Country Status (9)

Country	Link
EP (1)	EP1075479A1 (fr)
KR (1)	KR20010043038A (fr)
CN (1)	CN1298408A (fr)
AU (1)	AU3539599A (fr)
BR (1)	BR9910085A (fr)
ID (1)	ID26418A (fr)
PE (1)	PE20000879A1 (fr)
TR (1)	TR200003131T2 (fr)
WO (1)	WO1999055710A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1554289B1 (fr)	2002-08-13	2011-03-09	Sandoz Ag	Intermediaire de cefdinir
US7534781B2 (en) *	2003-03-21	2009-05-19	Dsm Ip Assets B.V.	Crystalline amoxicillin trihydrate powder
CN100357294C (zh) *	2003-03-24	2007-12-26	桑多斯股份公司	7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
MX2007006018A (es)	2004-11-30	2007-06-07	Astellas Pharma Inc	Suspension farmaceutica oral novedosa de cristal de cefdinir.
EP2024374A1 (fr) *	2006-05-19	2009-02-18	DSMIP Assets B.V.	Procédé de cristallisation du céfadroxil
CN103145733B (zh) *	2013-03-20	2014-02-26	四川省惠达药业有限公司	一种阿莫西林化合物及该化合物和克拉维酸钾的药物组合物
CN104059086B (zh) *	2014-06-19	2016-04-13	河南牧翔动物药业有限公司	一种阿莫西林晶体及其制备方法
CN104830523B (zh) *	2015-05-15	2018-01-09	湖北民族学院	一种高品质植物油的无公害生产装置及生产植物油的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE465649A (fr) *	1944-06-19
JPS6379888A (ja) *	1986-09-24	1988-04-09	Tanabe Seiyaku Co Ltd	ペニシリン誘導体の安定型水和物
RU2024851C1 (ru) *	1992-07-22	1994-12-15	Шорманов Владимир Камбулатович	СПОСОБ ОПРЕДЕЛЕНИЯ 6-(D-α -АМИНОФЕНИЛАЦЕТАМИДО)-ПЕНИЦИЛЛАНОВОЙ КИСЛОТЫ НАТРИЕВОЙ СОЛИ
BE1009264A3 (nl) *	1995-03-31	1997-01-07	Dsm Nv	Werkwijze voor de winning van ampicilline.
AU1234999A (en) *	1997-11-10	1999-05-31	Gist-Brocades B.V.	Crystallization of beta-lactam compounds

1999
- 1999-04-16 PE PE1999000315A patent/PE20000879A1/es not_active Application Discontinuation
- 1999-04-27 ID IDW20002187A patent/ID26418A/id unknown
- 1999-04-27 CN CN99805572A patent/CN1298408A/zh active Pending
- 1999-04-27 AU AU35395/99A patent/AU3539599A/en not_active Abandoned
- 1999-04-27 KR KR1020007011901A patent/KR20010043038A/ko not_active Withdrawn
- 1999-04-27 EP EP99917236A patent/EP1075479A1/fr not_active Withdrawn
- 1999-04-27 WO PCT/NL1999/000246 patent/WO1999055710A1/fr not_active Ceased
- 1999-04-27 BR BR9910085-1A patent/BR9910085A/pt not_active Application Discontinuation
- 1999-04-27 TR TR2000/03131T patent/TR200003131T2/xx unknown

Also Published As

Publication number	Publication date
CN1298408A (zh)	2001-06-06
KR20010043038A (ko)	2001-05-25
BR9910085A (pt)	2000-12-26
ID26418A (id)	2000-12-21
EP1075479A1 (fr)	2001-02-14
WO1999055710A1 (fr)	1999-11-04
AU3539599A (en)	1999-11-16
TR200003131T2 (tr)	2001-01-22

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Legal Events

Date	Code	Title	Description
2002-03-19	FC	Refusal