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PE11895A1 - Derivado de 5-arilindol - Google Patents

Derivado de 5-arilindol

Info

Publication number
PE11895A1
PE11895A1 PE1994247898A PE24789894A PE11895A1 PE 11895 A1 PE11895 A1 PE 11895A1 PE 1994247898 A PE1994247898 A PE 1994247898A PE 24789894 A PE24789894 A PE 24789894A PE 11895 A1 PE11895 A1 PE 11895A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
preference
nitrogen
carbon
Prior art date
Application number
PE1994247898A
Other languages
English (en)
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE11895A1 publication Critical patent/PE11895A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) A, B, D, E, F SON NITROGENO o CARBONO, SIENDO DE PREFERENCIA B o E ATOMOS DE NITROGENO y A o F ATOMOS DE CARBONO, FORMANDO UN ANILLO TAL COMO PIRIMIDINA, PIRIDINA, TRIAZINA Y OTROS; 2) R1 ES H, ALQUILO C1-C6, -(CH2)nR7, (ALQUILO C1-C3)-ARILO, DE PREFERENCIA ES H, ALQUILO C1-C3, -(CH2)2-OCH3; 3) R2, R3, R4, R5, R6 SON H, ALQUILO C1-C6, ARILO, (ALQUILO C1-C3)-ARILO, HALOGENO, CIANO, NITRO, -(CH2)m-NR8R9, -(CH2)m-OR9, -SR9 Y OTROS; 4) R7 ES OR10, SR10, -SO2NR10R11 Y OTROS; 5) R8, R9, R10, R11 SON H, ALQUILO C1-C6, (ALQUILO C1-C3)-ARILO; 5) m VARIA DE 0 A 2 Y n DE 2 A 4; DICHO COMPUESTO ES AGONISTA DE LA SEROTONINA (5-HT1) Y PUEDE SER UTIL EN EL TRATAMIENTO DE DEPRESION, ANSIEDAD, TRANSTORNOS DE LA ALIMENTACION, OBESIDAD, MIGRANA; Y COMO VASODILATADOR Y ANTIHIPERTENSOR QUE ACTUA CENTRALMENTE
PE1994247898A 1993-08-31 1994-08-03 Derivado de 5-arilindol PE11895A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11528293A 1993-08-31 1993-08-31

Publications (1)

Publication Number Publication Date
PE11895A1 true PE11895A1 (es) 1995-05-12

Family

ID=22360355

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994247898A PE11895A1 (es) 1993-08-31 1994-08-03 Derivado de 5-arilindol

Country Status (26)

Country Link
US (3) US5849739A (es)
EP (1) EP0716649B1 (es)
JP (1) JP2860603B2 (es)
KR (1) KR100191973B1 (es)
CN (1) CN1129933A (es)
AT (1) ATE170836T1 (es)
AU (1) AU686654B2 (es)
BR (1) BR9407402A (es)
CA (1) CA2169179C (es)
CO (1) CO4230238A1 (es)
CZ (1) CZ59996A3 (es)
DE (1) DE69413240T2 (es)
DK (1) DK0716649T3 (es)
EC (1) ECSP941122A (es)
EG (1) EG20547A (es)
ES (1) ES2122289T3 (es)
FI (1) FI113536B (es)
HU (1) HUT75646A (es)
IL (1) IL110773A (es)
MY (1) MY111127A (es)
NO (1) NO960818D0 (es)
NZ (1) NZ267487A (es)
PE (1) PE11895A1 (es)
PL (1) PL177604B1 (es)
WO (1) WO1995006636A1 (es)
ZA (1) ZA946608B (es)

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US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
WO1995006636A1 (en) * 1993-08-31 1995-03-09 Pfizer Inc. 5-arylindole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
EP0844996A1 (en) * 1995-08-07 1998-06-03 MERCK SHARP & DOHME LTD. Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
JP2001512727A (ja) 1997-08-09 2001-08-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ−１受容体のリガンドとしてのニ環式化合物
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
DE10159922A1 (de) * 2001-12-06 2003-06-26 Gruenenthal Gmbh Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate
ATE375980T1 (de) 2002-02-12 2007-11-15 Smithkline Beecham Corp Nicotinamide und deren verwendung als p38 inhibitoren
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
WO2005066157A1 (en) * 2004-01-02 2005-07-21 Suven Life Sciences 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators
US7223994B2 (en) * 2004-06-03 2007-05-29 International Business Machines Corporation Strained Si on multiple materials for bulk or SOI substrates
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US10590083B2 (en) 2017-08-10 2020-03-17 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (I) useful as EP3 receptor antagonists
US10399944B2 (en) 2017-08-10 2019-09-03 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (III) useful as EP3 receptor antagonists
US10336701B2 (en) 2017-08-10 2019-07-02 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists

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GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
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DK0695301T3 (da) * 1993-04-22 1996-12-09 Pfizer Ltd Indolderivater som 5-HT1-lignende agonister til anvendelse ved migræne
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WO1995006636A1 (en) * 1993-08-31 1995-03-09 Pfizer Inc. 5-arylindole derivatives

Also Published As

Publication number Publication date
AU6979694A (en) 1995-03-22
IL110773A (en) 2001-06-14
HUT75646A (en) 1997-05-28
US6093822A (en) 2000-07-25
JPH08511032A (ja) 1996-11-19
HU9600509D0 (en) 1996-04-29
EP0716649A1 (en) 1996-06-19
CA2169179C (en) 2000-02-29
PL313227A1 (en) 1996-06-10
NO960818L (no) 1996-02-28
EG20547A (en) 1999-07-31
CZ59996A3 (en) 1996-06-12
WO1995006636A1 (en) 1995-03-09
KR960704843A (ko) 1996-10-09
DE69413240D1 (en) 1998-10-15
AU686654B2 (en) 1998-02-12
DE69413240T2 (de) 1999-02-04
JP2860603B2 (ja) 1999-02-24
ATE170836T1 (de) 1998-09-15
ECSP941122A (es) 1994-12-15
CA2169179A1 (en) 1995-03-09
EP0716649B1 (en) 1998-09-09
FI943976A7 (fi) 1995-03-01
US5849739A (en) 1998-12-15
MY111127A (en) 1999-08-30
FI943976A0 (fi) 1994-08-30
IL110773A0 (en) 1999-04-11
NZ267487A (en) 1997-09-22
PL177604B1 (pl) 1999-12-31
BR9407402A (pt) 1996-11-05
ES2122289T3 (es) 1998-12-16
ZA946608B (en) 1996-02-28
CO4230238A1 (es) 1995-10-19
CN1129933A (zh) 1996-08-28
NO960818D0 (no) 1996-02-28
FI113536B (fi) 2004-05-14
KR100191973B1 (ko) 1999-06-15
DK0716649T3 (da) 1999-02-08
US5942524A (en) 1999-08-24

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