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PA8806901A1 - SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES - Google Patents

SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES

Info

Publication number
PA8806901A1
PA8806901A1 PA20088806901A PA8806901A PA8806901A1 PA 8806901 A1 PA8806901 A1 PA 8806901A1 PA 20088806901 A PA20088806901 A PA 20088806901A PA 8806901 A PA8806901 A PA 8806901A PA 8806901 A1 PA8806901 A1 PA 8806901A1
Authority
PA
Panama
Prior art keywords
substances
epotilones
functioned
solid
polymer nanoparticles
Prior art date
Application number
PA20088806901A
Other languages
Spanish (es)
Inventor
Katrin Fisher
Sascha General
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PA8806901A1 publication Critical patent/PA8806901A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN NANOPARTÍCULAS POLIMÉRICAS CON POTENCIAL SUPERFICIAL CATIÓNICO EN LAS CUALES PUEDEN ENCAPSULARSE SUSTANCIAS NEUTRAS, HIDROFÓBICAS E HIDROFÍLICAS CON ACTIVIDAD FARMACÉUTICA. LAS SUSTANCIAS HIDROFÍLICAS, Y POR LO TANTO, SOLUBLES EN AGUA, SE ENCAPSULAN EN LA PARTÍCULA QUE CONSTITUYE EL NÚCLEO POR CO-PRECIPITACIÓN, MEDIANTE LA COMPLEJIZACIÓN IÓNICA CON UN POLÍMERO CARGADO. COMO SUSTANCIAS CON ACTIVIDAD FARMACÉUTICA PARA LA ENCAPSULACIÓN PUEDEN USARSE AGENTES TERAPÉUTICA Y AGENTES DE DIAGNÓSTICO. LA SUPERFICIE CATIÓNICA DE LA PARTÍCULA PERMITE REALIZAR UNA MODIFICACIÓN ELECTROSTÁTICA ESTABLE DE LA SUPERFICIE CON COMPUESTOS CON CARGAS PARCIALMENTE OPUESTAS, LOS CUALES PUEDEN CONTENER LIGANDOS CON ESPECIFICIDAD POR EL BLANCO PARA MEJORAR EL DIRECCIONAMIENTO PASIVO Y ACTIVO.POLYMERIC NANOPARTICLES WITH CATIONIC SURFACE POTENTIAL ARE DESCRIBED IN WHICH NEUTRAL, HYDROPHOBIC AND HYDROPHYTIC SUBSTANCES WITH PHARMACEUTICAL ACTIVITY CAN BE ENCLOSED. THE HYDROPHYLIC SUBSTANCES, AND THEREFORE, SOLUBLE IN WATER, ARE ENCAPSULATED IN THE PARTICLE THAT CONSTITUTES THE CORE BY CO-PRECIPITATION, THROUGH IONIC COMPLEXIZATION WITH A LOADED POLYMER. AS SUBSTANCES WITH PHARMACEUTICAL ACTIVITY FOR ENCAPSULATION THERAPEUTIC AGENTS AND DIAGNOSTIC AGENTS CAN BE USED. THE CATIÓNICA SURFACE OF THE PARTICLE ALLOWS TO PERFORM A STABLE ELECTROSTATIC MODIFICATION OF THE SURFACE WITH COMPOUNDS WITH PARTIALLY OPPOSED CHARGES, WHICH MAY CONTAIN SPECIFICITY LINKS BY THE WHITE TO IMPROVE THE PASSIVE AND ACTIVE ADDRESS.

PA20088806901A 2007-12-10 2008-12-09 SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES PA8806901A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007059752A DE102007059752A1 (en) 2007-12-10 2007-12-10 Functionalized solid polymer nanoparticles containing epothilones

Publications (1)

Publication Number Publication Date
PA8806901A1 true PA8806901A1 (en) 2009-07-23

Family

ID=40409013

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088806901A PA8806901A1 (en) 2007-12-10 2008-12-09 SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES

Country Status (7)

Country Link
AR (1) AR069638A1 (en)
DE (1) DE102007059752A1 (en)
PA (1) PA8806901A1 (en)
PE (1) PE20091107A1 (en)
TW (1) TW200932220A (en)
UY (1) UY31521A1 (en)
WO (1) WO2009074274A1 (en)

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Also Published As

Publication number Publication date
AR069638A1 (en) 2010-02-10
TW200932220A (en) 2009-08-01
UY31521A1 (en) 2009-08-03
PE20091107A1 (en) 2009-08-29
WO2009074274A1 (en) 2009-06-18
DE102007059752A1 (en) 2009-06-18

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