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PA8853001A1 - 4-azentidinil-1-heteroaril-ciclohexanol antagonista del ccr2 - Google Patents

4-azentidinil-1-heteroaril-ciclohexanol antagonista del ccr2

Info

Publication number
PA8853001A1
PA8853001A1 PA20098853001A PA8853001A PA8853001A1 PA 8853001 A1 PA8853001 A1 PA 8853001A1 PA 20098853001 A PA20098853001 A PA 20098853001A PA 8853001 A PA8853001 A PA 8853001A PA 8853001 A1 PA8853001 A1 PA 8853001A1
Authority
PA
Panama
Prior art keywords
ccr2
ciclohexanol
azentidinil
heteroaril
antagonist
Prior art date
Application number
PA20098853001A
Other languages
English (en)
Inventor
Zhang Xuquing
Rae Hufnagel Heather
Hou Cuifen
L Johnson Dana
Sui Zhihua
Fegely Barry
Breslin David
Original Assignee
Janseen Pharmaceutica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41510894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8853001(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janseen Pharmaceutica N V filed Critical Janseen Pharmaceutica N V
Publication of PA8853001A1 publication Critical patent/PA8853001A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
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  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)

Abstract

LA PRESENTE INVENCIÓN COMPRENDE COMPUESTOS CON LA FÓRMULA(I).EN DONDE:R1,R2,R3,Y R4 SON COMO SE DEFINE EN LA ESPECIFICACIÓN.LA INVENCIÓN TAMBIÉN COMPRENDE COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS COMPUESTOS CON LA FÓRMULA(I)Y LOS MÉTODOS PARA PREVENIR,TRATAR O AMINORAR SÍNDROMES,TRASTORNOS O ENFERMEDADES MEDIADOS POR CCR2,POR EJEMPLO,DIABETES TIPO II.OBESIDAD O ASMA,ADMINISTRANDO LOS COMPUESTOS CON LA FÓRMULA(I).
PA20098853001A 2008-12-10 2009-12-09 4-azentidinil-1-heteroaril-ciclohexanol antagonista del ccr2 PA8853001A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12127208P 2008-12-10 2008-12-10
US16729509P 2009-04-07 2009-04-07

Publications (1)

Publication Number Publication Date
PA8853001A1 true PA8853001A1 (es) 2010-07-27

Family

ID=41510894

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098853001A PA8853001A1 (es) 2008-12-10 2009-12-09 4-azentidinil-1-heteroaril-ciclohexanol antagonista del ccr2

Country Status (28)

Country Link
US (1) US8450304B2 (es)
EP (1) EP2376475B1 (es)
JP (1) JP5782381B2 (es)
KR (1) KR20110094325A (es)
CN (1) CN102317278B (es)
AR (1) AR074583A1 (es)
AU (1) AU2009324723B2 (es)
BR (1) BRPI0923237A2 (es)
CA (1) CA2745969C (es)
CL (1) CL2011001427A1 (es)
CO (1) CO6331470A2 (es)
CR (1) CR20110381A (es)
EA (1) EA018997B1 (es)
EC (1) ECSP11011124A (es)
ES (1) ES2555004T3 (es)
HN (1) HN2011001606A (es)
IL (1) IL213250A0 (es)
MX (1) MX2011006226A (es)
NI (1) NI201100117A (es)
NZ (1) NZ593172A (es)
PA (1) PA8853001A1 (es)
PE (1) PE20110928A1 (es)
SG (1) SG171998A1 (es)
SV (1) SV2011003944A (es)
TW (1) TW201033204A (es)
UY (1) UY32312A (es)
WO (1) WO2010068663A1 (es)
ZA (1) ZA201105056B (es)

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WO2010121011A1 (en) * 2009-04-16 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
ES2541607T3 (es) * 2009-04-17 2015-07-22 Janssen Pharmaceutica Nv Antagonistas de CCR2 de ciclohexano unido a 4-azetidinilo-1-heteroátomo
AU2010236346B2 (en) 2009-04-17 2015-01-22 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of CCR2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
MX2012014934A (es) 2010-06-17 2013-05-20 Janssen Pharmaceutica Nv Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2.
EP2771484A1 (en) 2011-10-28 2014-09-03 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
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EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN107793404A (zh) * 2017-11-07 2018-03-13 全椒先奇医药科技有限公司 一种治疗缺血性脑损伤药物组合物及其应用
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