[go: up one dir, main page]

PA8796801A1 - Sintesis quiral de diazepinoquinolinas - Google Patents

Sintesis quiral de diazepinoquinolinas

Info

Publication number
PA8796801A1
PA8796801A1 PA20088796801A PA8796801A PA8796801A1 PA 8796801 A1 PA8796801 A1 PA 8796801A1 PA 20088796801 A PA20088796801 A PA 20088796801A PA 8796801 A PA8796801 A PA 8796801A PA 8796801 A1 PA8796801 A1 PA 8796801A1
Authority
PA
Panama
Prior art keywords
diazepinoquinolins
chiral synthesis
agonists
syntheize
recristalization
Prior art date
Application number
PA20088796801A
Other languages
English (en)
Inventor
Sreenivasulu Megati
Shilpa Bhansali
Christoph Dehnhardt
Subodh Deshmukh
Peter Fung
Michael Macewan
Robert J Tinder
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40116648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8796801(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8796801A1 publication Critical patent/PA8796801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A MÉTODOS DE RESOLUCIÓN Y RECRISTALIZACIÓN MEJORADOS PARA SINTETIZAR COMPUESTOS ÚTILES COMO AGONISTAS O AGONISTAS PARCIALES 5HT2c,INCLUYENDO LOS INTERMEDIARIOS DE LOS MISMOS.
PA20088796801A 2007-09-21 2008-09-19 Sintesis quiral de diazepinoquinolinas PA8796801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97437207P 2007-09-21 2007-09-21

Publications (1)

Publication Number Publication Date
PA8796801A1 true PA8796801A1 (es) 2009-04-23

Family

ID=40116648

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088796801A PA8796801A1 (es) 2007-09-21 2008-09-19 Sintesis quiral de diazepinoquinolinas

Country Status (8)

Country Link
US (1) US20090093630A1 (es)
EP (1) EP2203450A2 (es)
JP (1) JP2010540450A (es)
CA (1) CA2700306A1 (es)
CL (1) CL2008002777A1 (es)
PA (1) PA8796801A1 (es)
TW (1) TW200918532A (es)
WO (1) WO2009039362A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
MX2008012105A (es) * 2006-03-24 2008-10-03 Wyeth Corp Metodos para modular la funcion de la vejiga.
BRPI0709146A2 (pt) * 2006-03-24 2011-06-28 Wyeth Corp métodos para tratar distúrbios cognitivos e outros distúrbios
WO2007112000A2 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain
MX2008012094A (es) * 2006-03-24 2008-10-03 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento de la depresion.

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3158619A (en) * 1962-06-14 1964-11-24 Searle & Co Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives
US3235564A (en) * 1964-03-27 1966-02-15 Searle & Co Intermediates to certain sulfur-containing ortho-fused polycyclic pyrazole derivatives
US3335134A (en) * 1964-04-02 1967-08-08 Sandoz Ag Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones
US3296252A (en) * 1964-04-02 1967-01-03 Sandoz Ag Tetracyclic diazepinone compounds
GB1120461A (en) * 1964-07-06 1968-07-17 Manuf Prod Pharma Derivatives of fluoreno-[1,9-ef]1,4-diazepine-1-oxide
US3417101A (en) * 1964-11-09 1968-12-17 American Home Prod Fused ring compounds
US3329676A (en) * 1964-11-09 1967-07-04 American Home Prod Fused 1, 4-diazepine ring systems
US3714149A (en) * 1969-11-03 1973-01-30 Upjohn Co Pyridobenzodiazepinones
US3914250A (en) * 1974-08-01 1975-10-21 American Home Prod 1,4-Diazepino{8 6,5,4-jk{9 carbazoles
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
US4948897A (en) * 1987-12-11 1990-08-14 Jet Research Center, Inc. Method of preparation of 2,6-bis(picrylamino)-3,5-dinitropyridine
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US4997831A (en) * 1988-09-01 1991-03-05 Glaxo Group Limited Lactam derivatives
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
CN100384825C (zh) * 1994-06-15 2008-04-30 大塚制药株式会社 苯并杂环衍生物
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6194407B1 (en) * 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
CO5210925A1 (es) * 1998-11-17 2002-10-30 Novartis Ag Derivados de diamino nitroguanidina tetrasustituidos
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US7141563B2 (en) * 2000-11-03 2006-11-28 Wyeth Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives
US6916922B2 (en) * 2000-11-03 2005-07-12 Wyeth Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives
AR031196A1 (es) * 2000-11-03 2003-09-10 Wyeth Corp Procedimiento para la preparacion de ciclopenta (b) (1,4)-diazepino (6,7,1-hi) indoles y derivados
AR031198A1 (es) * 2000-11-03 2003-09-10 Wyeth Corp Procedimiento para la preparacion de derivados de ciclopenta(b)diazepino(6,7,1)indol
AR031199A1 (es) * 2000-11-03 2003-09-10 Wyeth Corp Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
AR031201A1 (es) * 2000-11-03 2003-09-10 Wyeth Corp /1,4/diazepino/6,7,1-jk/carbazoles y derivados
US6777407B2 (en) * 2000-11-03 2004-08-17 Wyeth Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031200A1 (es) * 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
SE0004245D0 (sv) * 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
CA2432185C (en) * 2000-12-20 2011-11-08 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
WO2002059124A2 (en) * 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
US20020183395A1 (en) * 2001-04-04 2002-12-05 Wyeth Methods for treating hyperactive gastric motility
BR0211559A (pt) * 2001-08-06 2004-07-13 Upjohn Co Compostos, composições de ligantes tetracìclicos terapeuticamente úteis e seus usos
EP1436294A1 (en) * 2001-10-18 2004-07-14 PHARMACIA & UPJOHN COMPANY Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity
TW200307682A (en) * 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) * 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TWI312781B (en) * 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
SE0201544D0 (sv) * 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
US20040235856A1 (en) * 2003-04-25 2004-11-25 Pfizer Inc Treatment of incontinence
TW200635926A (en) * 2004-11-05 2006-10-16 Wyeth Corp Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR051946A1 (es) * 2004-11-05 2007-02-21 Wyeth Corp Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina
US20060281801A1 (en) * 2005-04-19 2006-12-14 Ashok Kumar Process for the preparation of valsartan and its intermediates
US20090076281A1 (en) * 2005-05-05 2009-03-19 Medichem, S.A. Process for the preparation of losartan and its salts
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
AR056695A1 (es) * 2005-10-17 2007-10-17 Wyeth Corp Tetrahidroquinolinas, su sintesis e intermediarios
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
BRPI0709146A2 (pt) * 2006-03-24 2011-06-28 Wyeth Corp métodos para tratar distúrbios cognitivos e outros distúrbios
MX2008012105A (es) * 2006-03-24 2008-10-03 Wyeth Corp Metodos para modular la funcion de la vejiga.
WO2007111983A2 (en) * 2006-03-24 2007-10-04 Wyeth New therapeutic combinations for the treatment or prevention of psychotic disorders
MX2008012094A (es) * 2006-03-24 2008-10-03 Wyeth Corp Nuevas combinaciones terapeuticas para el tratamiento de la depresion.
WO2007112000A2 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain

Also Published As

Publication number Publication date
WO2009039362A2 (en) 2009-03-26
WO2009039362A3 (en) 2009-04-30
TW200918532A (en) 2009-05-01
US20090093630A1 (en) 2009-04-09
CL2008002777A1 (es) 2010-01-22
CA2700306A1 (en) 2009-03-26
JP2010540450A (ja) 2010-12-24
EP2203450A2 (en) 2010-07-07

Similar Documents

Publication Publication Date Title
UY32292A (es) Agonistas de s1p1 y métodos de preparación y uso
DOP2010000328A (es) Inhibidores de bace
CR11861A (es) Compuestos organicos
ECSP109922A (es) Compuestos de pirazol y su uso como inhibidores raf
ECSP11011390A (es) Compuestos espiro-amidas sustituidas
CR20120011A (es) Inhibidores de bace
ECSP099818A (es) Procesos para la preparacion de pirazoles
ECSP12011654A (es) Derivados de 5-fluoropirimidinona
GT200600074A (es) 5-alcoxialquil-6-alquil-7-amino-azolopirimidinas, un procedimiento para su obtención y el uso de las mismas para combatir hongos nocivos, así como procuctos que las mismas contienen
UY31506A1 (es) Derivados de indolinona y procedimiento para su preparacion
NI201200020A (es) Derivados de n1 - sulfonil - 5 - fluoropirimidinona
CR20110135A (es) INHIBIDORES DE cMET
CR10662A (es) Compuestos de metilpiridopirimidinona
CL2009001686A1 (es) Procedimiento de preparacion de agomelatina; y los compuestos intermediarios considerados.
ECSP088383A (es) Tetrahidroquinolinas, su síntesis e intermediarios campo de la invención
SV2010003475A (es) Nuevos herbicidas
PA8796801A1 (es) Sintesis quiral de diazepinoquinolinas
EA200702464A1 (ru) Способы получения фенольных 4-бифенилилазетидин-2-онов
ECSP12011653A (es) Derivados de n1-acil-5-fluoropirimidinona
HN2012000261A (es) Derivados de 5-fluoro-2-oxopirimidina-1(2h)-carboxilato
ECSP088151A (es) Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
HN2006037713A (es) Compuestos utiles en terapia
CU23744B7 (es) Derivados de tetrahidronaftalina y procedimientos para prepararlos.
ECSP088251A (es) Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
CR20110208A (es) Proceso para la preparación de benzonorbornenos