PA8777501A1 - COMBINATION OF PROGESTERONE RECEIVER ANTAGONIST WITH NON-STEROID ANTI-TROGENS FOR USE IN BRCA MEDIUMED DISEASES - Google Patents
COMBINATION OF PROGESTERONE RECEIVER ANTAGONIST WITH NON-STEROID ANTI-TROGENS FOR USE IN BRCA MEDIUMED DISEASESInfo
- Publication number
- PA8777501A1 PA8777501A1 PA20088777501A PA8777501A PA8777501A1 PA 8777501 A1 PA8777501 A1 PA 8777501A1 PA 20088777501 A PA20088777501 A PA 20088777501A PA 8777501 A PA8777501 A PA 8777501A PA 8777501 A1 PA8777501 A1 PA 8777501A1
- Authority
- PA
- Panama
- Prior art keywords
- combination
- diseases
- mediumed
- trogens
- brca
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 6
- 229960003387 progesterone Drugs 0.000 title abstract 3
- 239000000186 progesterone Substances 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 abstract 2
- -1 ARZOXIFENO Chemical compound 0.000 abstract 1
- 102000052609 BRCA2 Human genes 0.000 abstract 1
- 108700020462 BRCA2 Proteins 0.000 abstract 1
- 101150008921 Brca2 gene Proteins 0.000 abstract 1
- ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 abstract 1
- AUYLVPGDOVEOML-UHFFFAOYSA-N [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(piperidin-1-ylmethoxy)phenyl]methanone Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 AUYLVPGDOVEOML-UHFFFAOYSA-N 0.000 abstract 1
- GXESHMAMLJKROZ-IAPPQJPRSA-N lasofoxifene Chemical compound C1([C@@H]2[C@@H](C3=CC=C(C=C3CC2)O)C=2C=CC(OCCN3CCCC3)=CC=2)=CC=CC=C1 GXESHMAMLJKROZ-IAPPQJPRSA-N 0.000 abstract 1
- 229960001603 tamoxifen Drugs 0.000 abstract 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCIÓN SE RELACIONA CON LA COMBINACIÓN DEL ANTAGONISTA DEL RECEPTOR DE PROGESTERONA 11ß- ( 4-ACETILFENIL ) -17ß-HIDROXI -17ALFA- ( 1,1,2,2,2-PENTAFLUOROETIL ) -ESTRA-4,9-DIEN-3-ONA, O UN DERIVADO O UN ANÁLOGO DE ÉSTE ACEPTABLE PARA USO FARMACÉUTICO, CON AL MENOS UN ANTIESTRÓGENO NO ESTEROIDAL, Y CON EL USO DE DICHA COMBINACIÓN PARA LA PROFILAXIS Y EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR BRCAL O BRCA2 . LOS ANTIESTRÓGENOS NO ESTEROIDALES QUE PUEDEN COMBINARSE CON EL ANTAGONISTA DEL RECEPTOR DE PROGESTERONA 11ß- ( 4-ACETILFENIL ) -17ß-HIDROXI-17ALFA- (1,1,2,2,2-PENTAFLUOROETIL ) - ESTRA -4, 9-DIEN-3-ONA SON, POR EJEMPLO, TAMOXIFENO, RALOXIFENO, DROLOXIFENO, TOREMIFENO, LASOFOXIFENO, ARZOXIFENO, GW5638, EM-800, IDOXIFENO Y BASEDOXIFENO .THIS INVENTION IS RELATED TO THE COMBINATION OF THE PROGESTERONE RECEIVER ANTAGONIST 11ß- (4-ACETILFENIL) -17ß-HIDROXI -17ALFA- (1,1,2,2,2-PENTAFLUOROETIL) -ESTRA-4,9-DIEN- 3-ONA, OR A DERIVATIVE OR AN ANALOG OF THIS ACCEPTABLE FOR PHARMACEUTICAL USE, WITH AT LEAST ONE NON-STEROID ANTI-TROGEN, AND WITH THE USE OF SUCH COMBINATION FOR PROFILAXIS AND THE TREATMENT OF DISEASES MEDIATIONED BY BRCAL OR BRCA2. NON-STEROID ANTISTROGENS THAT CAN COMBINE WITH THE PROGESTERONE RECEIVER ANTIGONIST 11ß- (4-ACETILFENIL) -17ß-HYDROXI-17ALFA- (1,1,2,2,2-PENTAFLUOROETIL) - ESTRA -4, 9-DIEN- 3-ONA ARE, FOR EXAMPLE, TAMOXIFEN, RALOXIFEN, DROLOXIFENO, TOREMIFENO, LASOFOXIFENO, ARZOXIFENO, GW5638, EM-800, IDOXIFENO AND BASEDOXIFENO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07090081 | 2007-04-23 | ||
| US91438507P | 2007-04-27 | 2007-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8777501A1 true PA8777501A1 (en) | 2008-11-19 |
Family
ID=39872870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20088777501A PA8777501A1 (en) | 2007-04-23 | 2008-04-22 | COMBINATION OF PROGESTERONE RECEIVER ANTAGONIST WITH NON-STEROID ANTI-TROGENS FOR USE IN BRCA MEDIUMED DISEASES |
| PA20088777401A PA8777401A1 (en) | 2007-04-23 | 2008-04-22 | COMBINATION OF PROGESTERONE RECEIVER ANTAGONIST WITH AN AROMATASE INHIBITOR FOR USE IN BRCA MEDIUMED DISEASES |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20088777401A PA8777401A1 (en) | 2007-04-23 | 2008-04-22 | COMBINATION OF PROGESTERONE RECEIVER ANTAGONIST WITH AN AROMATASE INHIBITOR FOR USE IN BRCA MEDIUMED DISEASES |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080261929A1 (en) |
| EP (1) | EP2136842A1 (en) |
| JP (1) | JP2010524994A (en) |
| AR (1) | AR066232A1 (en) |
| CA (1) | CA2684806A1 (en) |
| CL (1) | CL2008001150A1 (en) |
| PA (2) | PA8777501A1 (en) |
| PE (1) | PE20090233A1 (en) |
| TW (1) | TW200902028A (en) |
| UY (1) | UY31043A1 (en) |
| WO (1) | WO2008128784A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9603856B2 (en) | 2013-11-03 | 2017-03-28 | Flamina Holding Ag | Pharmaceutical composition or group of compositions for inhibiting autocrine HCG production in adult human cells |
| TWI639430B (en) * | 2016-08-27 | 2018-11-01 | 中國醫藥大學 | Use of pharmaceutical composition for manufacturing drug of treating gastric cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
| DE60115274T2 (en) * | 2000-10-18 | 2006-07-27 | Schering Ag | USE OF ANTIPROGESTINES FOR PROPHYLAXIS AND TREATMENT OF HORMONE-RELATED DISEASES |
| US20040242551A1 (en) * | 2003-05-28 | 2004-12-02 | Schering Ag | Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases |
-
2008
- 2008-04-18 US US12/105,356 patent/US20080261929A1/en not_active Abandoned
- 2008-04-21 CA CA002684806A patent/CA2684806A1/en not_active Abandoned
- 2008-04-21 JP JP2010504546A patent/JP2010524994A/en not_active Withdrawn
- 2008-04-21 WO PCT/EP2008/003324 patent/WO2008128784A1/en not_active Ceased
- 2008-04-21 EP EP08735383A patent/EP2136842A1/en not_active Withdrawn
- 2008-04-22 UY UY31043A patent/UY31043A1/en not_active Application Discontinuation
- 2008-04-22 AR ARP080101668A patent/AR066232A1/en unknown
- 2008-04-22 PE PE2008000688A patent/PE20090233A1/en not_active Application Discontinuation
- 2008-04-22 PA PA20088777501A patent/PA8777501A1/en unknown
- 2008-04-22 TW TW097114709A patent/TW200902028A/en unknown
- 2008-04-22 CL CL2008001150A patent/CL2008001150A1/en unknown
- 2008-04-22 PA PA20088777401A patent/PA8777401A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2136842A1 (en) | 2009-12-30 |
| CL2008001150A1 (en) | 2008-11-03 |
| PE20090233A1 (en) | 2009-04-08 |
| JP2010524994A (en) | 2010-07-22 |
| CA2684806A1 (en) | 2008-10-30 |
| AR066232A1 (en) | 2009-08-05 |
| TW200902028A (en) | 2009-01-16 |
| US20080261929A1 (en) | 2008-10-23 |
| PA8777401A1 (en) | 2008-11-19 |
| WO2008128784A1 (en) | 2008-10-30 |
| UY31043A1 (en) | 2008-11-28 |
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