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PA8525001A1 - Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina - Google Patents

Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina

Info

Publication number
PA8525001A1
PA8525001A1 PA20018525001A PA8525001A PA8525001A1 PA 8525001 A1 PA8525001 A1 PA 8525001A1 PA 20018525001 A PA20018525001 A PA 20018525001A PA 8525001 A PA8525001 A PA 8525001A PA 8525001 A1 PA8525001 A1 PA 8525001A1
Authority
PA
Panama
Prior art keywords
compounds
rent
bradicinine
dihydropiridine
antagonists
Prior art date
Application number
PA20018525001A
Other languages
English (en)
Inventor
Takafumi Ikeda
Yasuhiro Katsu
Makoto Kawai
Mitsuhiro Kawamura
Yuji Shishido
Noriaki Murase
Tomoki Kato
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PA8525001A1 publication Critical patent/PA8525001A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA EN LA QUE CADA A ES INDEPENDIENTEMENTE HALO; Y ES -(CH2)m-, -C(O)- o -S (O)-; R1 y R2 SON INDEPENDIENTEMENTE ALQUILO C1-4; R3 ES AZACICLOALQUILO SUSTITUIDO, ETC.; R4 ES FENILO SUSTITUIDO EN LA POSICION 2 CON UN SUSTITUYENTE SELECCIONADO ENTRE ALQUILO C1-7 SUSTITUIDO, ALCOXI C1-7 SUSTITUIDO, AMINA, ETC.; R5 ES HIDROGENO O ALQUILO C1-4; m ES 0, 1 ó 2; Y n ES 0,1,2,3,4 ó 5. LA PRESENTE INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y AL USO DE TALES COMPUESTOS EN EL TRATAMIENTO Y PREVENCION DE LA INFLAMACION, ASMA, RINITIS ALERGICA, DOLOR Y OTROS TRASTORNOS.
PA20018525001A 2000-08-10 2001-08-10 Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina PA8525001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22455800P 2000-08-10 2000-08-10

Publications (1)

Publication Number Publication Date
PA8525001A1 true PA8525001A1 (es) 2002-08-26

Family

ID=22841188

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018525001A PA8525001A1 (es) 2000-08-10 2001-08-10 Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina

Country Status (21)

Country Link
US (1) US6653313B2 (es)
EP (1) EP1307449B1 (es)
JP (1) JP2004505973A (es)
AP (1) AP2001002238A0 (es)
AR (1) AR034555A1 (es)
AT (1) ATE312099T1 (es)
AU (1) AU2001270947A1 (es)
BR (1) BR0113071A (es)
CA (1) CA2418908C (es)
CR (1) CR6859A (es)
DE (1) DE60115661T2 (es)
ES (1) ES2257422T3 (es)
GT (1) GT200100153A (es)
IL (1) IL153224A0 (es)
IS (1) IS6639A (es)
MX (1) MXPA03001204A (es)
PA (1) PA8525001A1 (es)
PE (1) PE20020467A1 (es)
SV (1) SV2003000588A (es)
TN (1) TNSN01124A1 (es)
WO (1) WO2002012235A1 (es)

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US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3060560A1 (en) 2013-10-25 2016-08-31 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN114213390A (zh) 2014-02-07 2022-03-22 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
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US6048523A (en) 1996-02-13 2000-04-11 Global Art Co. Ltd. Polyester cyclic compounds, their complexes and bonded bodies
TNSN97037A1 (fr) * 1996-02-19 2005-03-15 Pfizer Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant.
MX9701245A (es) * 1996-02-19 1998-04-30 Pfizer Compuestos de 1,4 dihidropiridina.
JPH11106375A (ja) * 1997-08-18 1999-04-20 Pfizer Pharmaceut Inc ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
DE60001535T2 (de) 1999-12-10 2003-10-02 Pfizer Inc., New York Substituierte 1,4-Dihydropyridinverbindungen zur Verwendung als Bradykininantagonisten
PT1106614E (pt) 1999-12-10 2004-04-30 Pfizer Compostos de 1,4-dihidropiridina substituidos com heteroarilos de 5 membros como antagonistas de bradiquinina

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BR0113071A (pt) 2003-07-01
JP2004505973A (ja) 2004-02-26
WO2002012235A1 (en) 2002-02-14
US6653313B2 (en) 2003-11-25
TNSN01124A1 (fr) 2005-11-10
GT200100153A (es) 2002-07-03
ES2257422T3 (es) 2006-08-01
ATE312099T1 (de) 2005-12-15
CR6859A (es) 2003-11-25
CA2418908C (en) 2006-05-09
IL153224A0 (en) 2003-07-06
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DE60115661D1 (de) 2006-01-12
EP1307449A1 (en) 2003-05-07
CA2418908A1 (en) 2002-02-14
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US20020161006A1 (en) 2002-10-31
AR034555A1 (es) 2004-03-03
AP2001002238A0 (en) 2001-09-30

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