[go: up one dir, main page]

PA8587801A1 - Isomeros posicionales de interferon alfa 2-a monopegilado - Google Patents

Isomeros posicionales de interferon alfa 2-a monopegilado

Info

Publication number
PA8587801A1
PA8587801A1 PA20038587801A PA8587801A PA8587801A1 PA 8587801 A1 PA8587801 A1 PA 8587801A1 PA 20038587801 A PA20038587801 A PA 20038587801A PA 8587801 A PA8587801 A PA 8587801A PA 8587801 A1 PA8587801 A1 PA 8587801A1
Authority
PA
Panama
Prior art keywords
monopegilado
isomeros
positional
interferon alfa
treatment
Prior art date
Application number
PA20038587801A
Other languages
English (en)
Inventor
Doris Brugger
Stefan Foser
Alfred Schacher
Karl Weyer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8587801A1 publication Critical patent/PA8587801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION CONCIERNE CON ISOMEROS POSICIONALES DEL INTERFERON ALFA 2a MONOPEGILADO, CON UN METODO PARA SU AISLAMIENTO Y PARA SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES, ESPECIALMENTE PARA EL TRATAMIENTO DE ENFERMEDADES VIRALES.
PA20038587801A 2002-11-15 2003-11-12 Isomeros posicionales de interferon alfa 2-a monopegilado PA8587801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02025585 2002-11-15

Publications (1)

Publication Number Publication Date
PA8587801A1 true PA8587801A1 (es) 2004-09-16

Family

ID=32319537

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038587801A PA8587801A1 (es) 2002-11-15 2003-11-12 Isomeros posicionales de interferon alfa 2-a monopegilado

Country Status (23)

Country Link
US (1) US20040223950A1 (es)
EP (1) EP1562634B1 (es)
JP (1) JP4279258B2 (es)
KR (1) KR20050065677A (es)
CN (1) CN1323722C (es)
AR (1) AR042039A1 (es)
AT (1) ATE337017T1 (es)
AU (1) AU2003293668A1 (es)
BR (1) BR0316227A (es)
CA (1) CA2503594C (es)
DE (1) DE60307881T2 (es)
ES (1) ES2270152T3 (es)
GT (1) GT200300244A (es)
MX (1) MXPA05005178A (es)
NO (1) NO20052310L (es)
PA (1) PA8587801A1 (es)
PE (1) PE20040834A1 (es)
PL (1) PL376883A1 (es)
RU (1) RU2005118752A (es)
TW (1) TW200413404A (es)
UY (1) UY28080A1 (es)
WO (1) WO2004045648A1 (es)
ZA (1) ZA200503756B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506097A (ja) * 2002-11-18 2006-02-23 マキシジェン， インコーポレイテッド インターフェロン−αのポリペプチドおよび結合体
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
NZ548255A (en) 2004-02-02 2010-10-29 Ambrx Inc Modified human interferon polypeptides and their uses
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
AU2005245918A1 (en) * 2004-05-19 2005-12-01 F. Hoffmann-La Roche Ag Interferon-alpha polypeptides and conjugates
AU2006299901A1 (en) 2005-05-18 2007-04-19 Maxygen, Inc. Evolved interferon-alpha polypeptides
KR20080037656A (ko) * 2005-06-20 2008-04-30 펩젠 코포레이션 저독성의 장시간 순환하는 사람 인터페론-알파 유사체 및인터페론 타우의 키메라
US7695710B2 (en) 2005-06-20 2010-04-13 Pepgen Corporation Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
CN101002944B (zh) * 2006-01-17 2012-07-25 中国科学院过程工程研究所 支链聚乙二醇-干扰素结合物及其制备方法
AR078117A1 (es) * 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
US8597635B2 (en) * 2007-09-04 2013-12-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof
KR101483814B1 (ko) * 2007-09-04 2015-01-16 바이오스티드 진 익스프레션 테크. 컴파니 리미티드 폴리에틸렌 글리콜에 의해 변형된 인터페론 알파 2ａ, 이의 합성 방법 및 용도
JP5458416B2 (ja) * 2008-04-03 2014-04-02 バイオスティード ジーン エクスプレッション テック． カンパニー リミテッド 二本鎖ポリエチレングリコール化成長ホルモン、その製造方法およびその使用
EP2113256A1 (en) 2008-04-29 2009-11-04 Ascendis Pharma AS PEGylated rhGH compounds
PT3050576T (pt) 2008-04-29 2021-06-01 Ascendis Pharma Growth Disorders Div A/S Compostos recombinantes e peguilados da hormona de crescimento humana
DE102009009344B4 (de) * 2009-02-05 2018-01-04 Helmholtz-Zentrum Dresden - Rossendorf E.V. Verfahren und Anordnung zur Reinigung des Reaktionsgemisches bei der Herstellung von Radiopharmaka
US8623348B2 (en) * 2009-03-27 2014-01-07 Jw Pharmaceutical Corporation Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP)
CN101514229B (zh) * 2009-04-03 2012-05-09 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物
LT2512450T (lt) 2009-12-15 2018-04-25 Ascendis Pharma Endocrinology Division A/S Sausa augimo hormono kompozicija, laikinai prijungta prie polimero nešiklio
CA2968282A1 (en) 2014-11-18 2016-05-26 Thomas Kurpiers Polymeric hgh prodrugs
PL3220892T3 (pl) 2014-11-21 2022-01-31 Ascendis Pharma Endocrinology Division A/S Postacie dawkowane długo działającego hormonu wzrostu
CN106749608B (zh) * 2015-11-18 2021-10-15 石药集团中奇制药技术（石家庄）有限公司 干扰素α缀合物
AU2020233198B2 (en) 2019-03-04 2025-05-15 Ascendis Pharma Endocrinology Division A/S Long-acting growth hormone dosage forms with superior efficacy to daily somatropin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
AU2003270341A1 (en) * 2002-09-05 2004-03-29 The General Hospital Corporation Modified asialo-interferons and uses thereof

Also Published As

Publication number Publication date
JP2006515571A (ja) 2006-06-01
US20040223950A1 (en) 2004-11-11
ZA200503756B (en) 2008-02-27
CN1323722C (zh) 2007-07-04
NO20052310D0 (no) 2005-05-11
PE20040834A1 (es) 2004-11-17
BR0316227A (pt) 2005-10-04
CA2503594A1 (en) 2004-06-03
NO20052310L (no) 2005-08-09
ES2270152T3 (es) 2007-04-01
TW200413404A (en) 2004-08-01
UY28080A1 (es) 2004-05-31
CA2503594C (en) 2011-05-10
AR042039A1 (es) 2005-06-08
EP1562634B1 (en) 2006-08-23
GT200300244A (es) 2004-06-03
AU2003293668A1 (en) 2004-06-15
EP1562634A1 (en) 2005-08-17
ATE337017T1 (de) 2006-09-15
CN1711109A (zh) 2005-12-21
DE60307881D1 (de) 2006-10-05
WO2004045648A1 (en) 2004-06-03
PL376883A1 (pl) 2006-01-09
MXPA05005178A (es) 2005-07-22
KR20050065677A (ko) 2005-06-29
JP4279258B2 (ja) 2009-06-17
RU2005118752A (ru) 2006-02-10
DE60307881T2 (de) 2007-03-08

Similar Documents

Publication Publication Date Title
PA8587801A1 (es) Isomeros posicionales de interferon alfa 2-a monopegilado
ATE461217T1 (de) Glp-1-verbindungen
DOP2002000429A (es) Imidazotriazinas
EG25011A (en) Amino-piperidin-1-yl-xanthines, the production thereof and the use of the same as medicaments.
CA100209S (en) Handle
CA106187S (en) Luminaire
CA106186S (en) Luminaire
DE60311272D1 (de) Neue purin- oder pyrrolol(2,3-d)pyrimidin-2-carbonsäurenitrile zur behandlung von mit cysteinproteaseaktivität assoziierten krankheiten
IS7814A (is) Fenetanólamín afleiða í meðhöndlun á öndunarfærasjúkdómum.
CA105223S (en) Sponge
CA106188S (en) Luminaire
EP1589981A4 (en) INTERFERON ANTAGONISTS FOR THE TREATMENT OF DISEASES RELATED TO INTERFERON
CA102775S (en) Sponge
UY28313A1 (es) Nonadepsipeptidos acilados
RU2002107079A (ru) Вещество, обладающее седативным действием
UY27451A1 (es) 2,5-diamidoindoles sustituidos y su utilización
AU2002319296A1 (en) Use of 2-alkoxyphenyl-substituted imidazotriazinones for the treatment of diseases associated with CGMP regulated processes
SV2003001061A (es) Nuevos heterociclos 3 ref.lea 35361-sv
CA101967S (en) Pacifier
IS7868A (is) Notkun á kortkólíberín-úrókortín kerfi í meðferð á bólguvaldandi sjúkdómum.
CA102620S (en) Sphygmomanometer
NL1023797A1 (nl) Farmaceutische doseringsvorm die zwangerschapsvriendelijke onderscheidingstekens draagt.
AR035274A1 (es) Uso de inhibidores de il-18 en desordenes de hipersensibilidad
UY26945A1 (es) Alcanosulfonatos de fenoxifenilo
CA101943S (en) Plate