[go: up one dir, main page]

LV5748B4 - Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums - Google Patents

Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Info

Publication number
LV5748B4
LV5748B4 LV960221A LV960221A LV5748B4 LV 5748 B4 LV5748 B4 LV 5748B4 LV 960221 A LV960221 A LV 960221A LV 960221 A LV960221 A LV 960221A LV 5748 B4 LV5748 B4 LV 5748B4
Authority
LV
Latvia
Prior art keywords
agents
acquisition
morpholinoethyl ester
mycophenolate
mycophenolate morpholinoethyl
Prior art date
Application number
LV960221A
Other languages
English (en)
Latvian (lv)
Other versions
LV5748A4 (lv
Inventor
Peter H Nelson
Anthony C Allison
William A Lee
Chee-Liang Leo Gu
Elsie M Eugui
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5748(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of LV5748A4 publication Critical patent/LV5748A4/xx
Publication of LV5748B4 publication Critical patent/LV5748B4/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LV960221A 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums LV5748B4 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
EP87311021A EP0281713B1 (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
LV5748A4 LV5748A4 (lv) 1996-10-20
LV5748B4 true LV5748B4 (lv) 1997-02-20

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
LV960221A LV5748B4 (lv) 1987-01-30 1996-07-05 Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums

Country Status (26)

Country Link
US (7) US4753935A (xx)
EP (1) EP0281713B1 (xx)
JP (1) JPS63188672A (xx)
KR (1) KR940003758B1 (xx)
AT (1) ATE68180T1 (xx)
AU (1) AU599728B2 (xx)
CA (1) CA1333285C (xx)
DE (2) DE19675020I2 (xx)
DK (1) DK166675B1 (xx)
ES (1) ES2038190T3 (xx)
FI (1) FI85141C (xx)
GE (1) GEP20094816B (xx)
GR (1) GR3002866T3 (xx)
HK (1) HK125893A (xx)
HU (2) HU201927B (xx)
IE (1) IE60750B1 (xx)
IL (1) IL84833A (xx)
LU (1) LU88795I2 (xx)
LV (1) LV5748B4 (xx)
MX (1) MX9203163A (xx)
NL (1) NL960019I2 (xx)
NO (2) NO171680C (xx)
NZ (1) NZ222922A (xx)
PH (1) PH23819A (xx)
PT (1) PT86343B (xx)
ZA (1) ZA879414B (xx)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
ATE186302T1 (de) * 1989-02-23 1999-11-15 Univ North Carolina Etoposidanaloge
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ES2140541T3 (es) * 1993-06-25 2000-03-01 Main Camp Marketing Pty Ltd Agente terapeutico.
RO118427B1 (ro) * 1993-09-15 2003-05-30 Syntex Inc Procedeu de preparare a unei compozitii farmaceutice pe baza de sare de micofenolat de mofetil
ATE303143T1 (de) * 1993-10-01 2005-09-15 Roche Palo Alto Llc Hochdosierte oral anzuwendende suspensionen enthaltendmycophenolat mofetil
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
JP2002528533A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー 酵素ｉｍｐｄｈの新規なインヒビター
CA2348234A1 (en) 1998-10-29 2000-05-11 Chunjian Liu Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
IN188985B (xx) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
CA2407370A1 (en) * 2000-04-24 2001-11-01 Bristol-Myers Squibb Company Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
WO2004089946A1 (en) * 2003-04-07 2004-10-21 Biocon Limited Microwave synthesis of mycophenolate
JP4804353B2 (ja) * 2003-05-14 2011-11-02 ディーエスエム アイピー アセッツ ビー．ブイ． 糖尿病の治療及び予防のためのフタリド誘導体の使用
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
US20070032483A1 (en) * 2003-09-11 2007-02-08 Julia Greil Process for the production of mycophenolate mofetil
WO2005027661A1 (en) * 2003-09-23 2005-03-31 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
WO2005033089A1 (en) * 2003-10-07 2005-04-14 Biocon Limited Salt of 6-(1, 3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid with n, n-dimethyl-imidodicarbonimidic diamide
EP1740564A2 (en) * 2004-04-26 2007-01-10 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Process for preparation of mycophenolic acid and ester derivatives thereof
CA2555461A1 (en) * 2004-04-27 2005-11-10 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN101014584A (zh) * 2004-07-20 2007-08-08 特瓦药厂私人有限公司 结晶霉酚酸钠的制备方法
US7915255B2 (en) * 2004-08-16 2011-03-29 Verva Pharmaceuticals Pty Ltd Metabolism-modulating agents and uses therefor
WO2006076802A1 (en) * 2005-01-20 2006-07-27 Apotex Fermentation Inc. An improved process for the preparation of mycophenolate mofetil
US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
EP1917010A2 (en) * 2005-02-08 2008-05-07 Aspreva Pharmaceuticals SA Compositions and methods for treating vascular, autoimmune and inflammatory diseases
US20080281111A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
CN101378749A (zh) * 2006-02-13 2009-03-04 诺瓦提斯公司 高剂量的麦考酚酸(mpa)
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2310008A4 (en) * 2008-07-09 2014-03-05 Aspreva Internat Ltd MYCOPHENOLIC SODIUM ACID SOLUTIONS WITH PH SPECIFIC FOR THE TREATMENT OF OCULAR DISORDERS
CL2009002207A1 (es) * 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
CL2009002208A1 (es) * 2008-12-23 2010-10-29 Gilead Pharmasset Llc Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
PT2970101T (pt) 2013-03-14 2018-10-04 Alkermes Pharma Ireland Ltd Pró-fármacos de fumaratos e seu uso no tratamento de várias doenças
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
RU2672872C2 (ru) * 2014-01-10 2018-11-20 Фуджифилм Корпорэйшн Способ и устройство для прогнозирования эффективной дозы или восприимчивости к 5-гидрокси-1н-имидазол-4-карбоксамиду, способ определения количества ксантозинмонофосфата, а также средство и способ для лечения миелодиспластического синдрома
EP3110793B1 (en) 2014-02-24 2019-08-21 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2018167628A1 (en) 2017-03-13 2018-09-20 Ftf Pharma Private Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
GB2591396B (en) 2018-08-18 2023-06-07 Ftf Pharma Private Ltd Pharmaceutical suspension for oral dosage
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
CA3212370A1 (en) 2021-03-03 2022-09-09 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157100A (en) * 1966-09-27 1969-07-02 Ici Ltd Pharmaceutical Compositions
GB1173942A (en) * 1967-06-06 1969-12-10 Bellon Labor Sa Roger New 2,3-Dihydro-1,4-Benzoxazines
GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5542995B2 (xx) * 1972-02-24 1980-11-04
JPS5529994B2 (xx) * 1972-03-02 1980-08-07
JPS563353B2 (xx) * 1972-03-02 1981-01-24
US3868454A (en) * 1972-08-14 1975-02-25 Lilly Co Eli Psoriasis treatment with mycophenolic acid derivatives
US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
US3903071A (en) * 1973-05-22 1975-09-02 Lilly Co Eli Mycophenolic acid derivatives
US3905894A (en) * 1973-10-02 1975-09-16 Murskauskone Oy Apparatus for wet fine screening
JPS5724380A (en) * 1980-07-22 1982-02-08 Chugai Pharmaceut Co Ltd Preparation of mycophenolic acid derivative
JPS57183776A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
JPS57183777A (en) * 1981-05-01 1982-11-12 Ajinomoto Co Inc Preparation of mycophenolic acid derivative
IT1150194B (it) * 1982-02-23 1986-12-10 Chiesi Farma Spa Formulazioni farmaceutiche ad attivita'antiinfiammatoria, analgesica,antipiretica e gastroprotettiva

Also Published As

Publication number Publication date
GEP20094816B (en) 2009-11-10
HK125893A (en) 1993-11-19
FI85141B (fi) 1991-11-29
AU599728B2 (en) 1990-07-26
HU210350A9 (en) 1995-03-28
NZ222922A (en) 1990-09-26
NO171680C (no) 1993-04-21
EP0281713B1 (en) 1991-10-09
ZA879414B (en) 1989-08-30
NO875240D0 (no) 1987-12-15
US4948793A (en) 1990-08-14
DE19675020I2 (de) 2002-11-07
FI875502L (fi) 1988-07-31
DK658787D0 (da) 1987-12-15
HU201927B (en) 1991-01-28
JPS63188672A (ja) 1988-08-04
IL84833A0 (en) 1988-06-30
US4992467A (en) 1991-02-12
PT86343B (pt) 1991-02-08
US4868153A (en) 1989-09-19
EP0281713A1 (en) 1988-09-14
DE3773660D1 (de) 1991-11-14
DK658787A (da) 1988-07-31
PT86343A (en) 1988-01-01
ATE68180T1 (de) 1991-10-15
US4808592A (en) 1989-02-28
US4952579A (en) 1990-08-28
KR940003758B1 (ko) 1994-04-30
DK166675B1 (da) 1993-06-28
NO875240L (no) 1988-08-01
IE60750B1 (en) 1994-08-10
ES2038190T3 (es) 1993-07-16
KR880009016A (ko) 1988-09-13
MX9203163A (es) 1992-07-31
NO1997007I1 (no) 1997-07-01
GR3002866T3 (en) 1993-01-25
NL960019I2 (nl) 1997-06-02
US4753935A (en) 1988-06-28
NL960019I1 (nl) 1996-10-01
FI875502A0 (fi) 1987-12-15
PH23819A (en) 1989-11-23
US4786637A (en) 1988-11-22
LU88795I2 (fr) 1996-11-05
HUT47567A (en) 1989-03-28
LV5748A4 (lv) 1996-10-20
FI85141C (fi) 1992-03-10
NO171680B (no) 1993-01-11
CA1333285C (en) 1994-11-29
AU8254087A (en) 1988-08-04
IE873397L (en) 1988-07-30
IL84833A (en) 1992-03-29
JPH0571591B2 (xx) 1993-10-07

Similar Documents

Publication Publication Date Title
LV5748A4 (lv) Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums
NO173867C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzamider
GR3020848T3 (en) 1,8-Naphthyridin-2-one derivatives
FI902850A0 (fi) N-heteroarylpurin-6-aminer, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.
FI900461A0 (fi) Imidazopyridaziner, deras framstaellning och anvaendning.
FI881816A0 (fi) Nya bicykliska foereningar, foerfarane foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
ATE96446T1 (de) Estramustin-ester.
ES2055235T3 (es) Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
DK451389D0 (da) 2-substituerede 4,5-diaryl-thioimidazoler samt farmaceutisk praeparat indeholdende saadanne forbindelser
DK424888D0 (da) Naphthothiazepinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende saadanne derivater
SE8204791D0 (sv) Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters