LV12072A - Panemiens 4-aizvietotu 1,4-dihidropiridinu iegusanai - Google Patents
Panemiens 4-aizvietotu 1,4-dihidropiridinu iegusanaiInfo
- Publication number
- LV12072A LV12072A LV980044A LV980044A LV12072A LV 12072 A LV12072 A LV 12072A LV 980044 A LV980044 A LV 980044A LV 980044 A LV980044 A LV 980044A LV 12072 A LV12072 A LV 12072A
- Authority
- LV
- Latvia
- Prior art keywords
- substituted
- reaction
- dihydropyridines
- saturation
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75902691A | 1991-09-13 | 1991-09-13 | |
| US07/920,701 US5310917A (en) | 1991-09-13 | 1992-07-28 | Process for the preparation of 4-substituted-1,4-dihydropydrines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV12072A true LV12072A (lv) | 1998-06-20 |
| LV12072B LV12072B (lv) | 1998-09-20 |
Family
ID=27116618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-98-44A LV12072B (lv) | 1991-09-13 | 1998-03-06 | Paņēmiens 4-aizvietotu 1,4-dihidropiridīnu iegūšanai |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0534520B1 (lv) |
| JP (1) | JPH0751562B2 (lv) |
| CN (1) | CN1070907A (lv) |
| AT (1) | ATE150456T1 (lv) |
| AU (1) | AU654387B2 (lv) |
| CA (1) | CA2077919A1 (lv) |
| DE (1) | DE69218330T2 (lv) |
| DK (1) | DK0534520T3 (lv) |
| ES (1) | ES2101027T3 (lv) |
| GR (1) | GR3022877T3 (lv) |
| IL (1) | IL103010A (lv) |
| LV (1) | LV12072B (lv) |
| MX (1) | MX9205215A (lv) |
| NZ (1) | NZ244130A (lv) |
| WO (1) | WO1993006082A1 (lv) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
| ATE234286T1 (de) | 1993-12-10 | 2003-03-15 | Bayer Ag | Phenyl-substituierte 1,4-dihydropyridine mit cerebraler aktivität |
| DE4423445A1 (de) * | 1994-07-05 | 1996-01-11 | Bayer Ag | Katalysatorverfahren zur Herstellung von Nifedipin |
| US5668151A (en) * | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
| US5554621A (en) * | 1995-06-07 | 1996-09-10 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives |
| US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
| IT1283793B1 (it) * | 1996-08-23 | 1998-04-30 | Lusochimica Spa | Processo per la preparazione di diidropiridine |
| US5889016A (en) * | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
| HUP9900353A3 (en) * | 1999-02-15 | 2002-01-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids |
| RU2161156C1 (ru) * | 1999-06-01 | 2000-12-27 | Джи.Б.Кемикалс Энд Фармасьютикалс Лтд | Способ получения 3-этил-5-метиловый эфир 2-[2-(n-фталимидо)-этоксиметил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5- пиридиндикарбоновой кислоты |
| AU764627B2 (en) | 1999-06-21 | 2003-08-28 | Bristol-Myers Squibb Company | Dihydropyrazine derivatives as NPY antagonists |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| CA2433181C (en) | 2000-12-29 | 2005-11-22 | Pfizer Limited | Amlodipine hemifumarate |
| MXPA03005884A (es) | 2000-12-29 | 2005-04-08 | Pfizer Ltd | Hemimaleato de amlodipina. |
| WO2002053540A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Aspartate derivative of amlodipine as calcium channel antagonist |
| GB2371862B (en) | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
| SI1309555T1 (sl) | 2000-12-29 | 2005-12-31 | Pfizer Ltd | Postopek izdelave amlodipin-maleata |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| WO2002053541A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| CN101613280B (zh) * | 2009-05-13 | 2012-10-17 | 合肥立方制药股份有限公司 | 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法 |
| CN103951608B (zh) * | 2009-08-04 | 2016-04-27 | 喜德生（苏州）医药科技有限公司 | 尼伐地平晶型及其制备方法 |
| WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
| CN102285911B (zh) * | 2011-07-12 | 2015-06-17 | 绍兴文理学院 | 非洛地平的制备方法 |
| CN102304079B (zh) * | 2011-09-29 | 2013-09-25 | 合肥立方制药股份有限公司 | 一种非洛地平环合反应液直接水析纯化方法 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA863578B (en) * | 1985-06-21 | 1987-02-25 | Hoffmann La Roche | Dihydropyridine derivatives |
| US4780538A (en) * | 1986-02-12 | 1988-10-25 | Merck & Co., Inc. | Process for 1,4-dihydropyridine compounds using a titanamine catalyst |
| FR2596760B1 (fr) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
| JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法 |
| JPH04211060A (ja) * | 1990-03-07 | 1992-08-03 | Tokawa Tetsuo | ２，６−ジメチル−４−（ｍ−ニトロフェニル）−１，４−ジヒドロピリジン−３，５−ジカルボン酸−３−メチルエステル−５−β−（Ｎ−ベンジル−Ｎ−メチルアミノ）エチルエステルの新規製造方法 |
| DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
-
1992
- 1992-08-26 WO PCT/US1992/007220 patent/WO1993006082A1/en not_active Ceased
- 1992-08-28 NZ NZ244130A patent/NZ244130A/en unknown
- 1992-09-01 IL IL10301092A patent/IL103010A/en not_active IP Right Cessation
- 1992-09-05 AT AT92202690T patent/ATE150456T1/de not_active IP Right Cessation
- 1992-09-05 DE DE69218330T patent/DE69218330T2/de not_active Expired - Fee Related
- 1992-09-05 DK DK92202690.1T patent/DK0534520T3/da active
- 1992-09-05 ES ES92202690T patent/ES2101027T3/es not_active Expired - Lifetime
- 1992-09-05 EP EP92202690A patent/EP0534520B1/en not_active Expired - Lifetime
- 1992-09-07 JP JP4238429A patent/JPH0751562B2/ja not_active Expired - Fee Related
- 1992-09-10 CA CA002077919A patent/CA2077919A1/en not_active Abandoned
- 1992-09-11 CN CN92110385.9A patent/CN1070907A/zh active Pending
- 1992-09-11 AU AU23552/92A patent/AU654387B2/en not_active Ceased
- 1992-09-11 MX MX9205215A patent/MX9205215A/es not_active IP Right Cessation
-
1997
- 1997-03-20 GR GR970400486T patent/GR3022877T3/el unknown
-
1998
- 1998-03-06 LV LVP-98-44A patent/LV12072B/lv unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05221984A (ja) | 1993-08-31 |
| WO1993006082A1 (en) | 1993-04-01 |
| DK0534520T3 (da) | 1997-09-08 |
| EP0534520B1 (en) | 1997-03-19 |
| NZ244130A (en) | 1994-10-26 |
| IL103010A (en) | 1996-10-31 |
| CA2077919A1 (en) | 1993-03-14 |
| ATE150456T1 (de) | 1997-04-15 |
| LV12072B (lv) | 1998-09-20 |
| CN1070907A (zh) | 1993-04-14 |
| DE69218330T2 (de) | 1997-09-18 |
| IL103010A0 (en) | 1993-02-21 |
| ES2101027T3 (es) | 1997-07-01 |
| AU2355292A (en) | 1993-03-18 |
| MX9205215A (es) | 1993-03-01 |
| AU654387B2 (en) | 1994-11-03 |
| DE69218330D1 (de) | 1997-04-24 |
| JPH0751562B2 (ja) | 1995-06-05 |
| EP0534520A2 (en) | 1993-03-31 |
| GR3022877T3 (en) | 1997-06-30 |
| EP0534520A3 (en) | 1993-05-05 |
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