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LV10961B - Novel colon- or ileum-specific steroid derivatives - Google Patents

Novel colon- or ileum-specific steroid derivatives Download PDF

Info

Publication number
LV10961B
LV10961B LVP-95-207A LV950207A LV10961B LV 10961 B LV10961 B LV 10961B LV 950207 A LV950207 A LV 950207A LV 10961 B LV10961 B LV 10961B
Authority
LV
Latvia
Prior art keywords
compound according
epimer
gcs
sugar
formula
Prior art date
Application number
LVP-95-207A
Other languages
English (en)
Latvian (lv)
Other versions
LV10961A (lv
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hoegberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of LV10961A publication Critical patent/LV10961A/xx
Publication of LV10961B publication Critical patent/LV10961B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
LVP-95-207A 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives LV10961B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (fr) 1993-01-08 1993-12-17 Nouveaux derives steroidiens specifiques du colon ou de l'ileon

Publications (2)

Publication Number Publication Date
LV10961A LV10961A (lv) 1995-12-20
LV10961B true LV10961B (en) 1996-08-20

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-95-207A LV10961B (en) 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives

Country Status (22)

Country Link
US (2) US5908833A (fr)
EP (1) EP0678097B1 (fr)
JP (1) JP3366640B2 (fr)
KR (1) KR960700266A (fr)
AT (1) ATE183192T1 (fr)
BR (1) BR9307746A (fr)
CA (1) CA2152374A1 (fr)
CZ (1) CZ171095A3 (fr)
DK (1) DK0678097T3 (fr)
ES (1) ES2137353T3 (fr)
FI (1) FI953358L (fr)
GR (1) GR3031789T3 (fr)
HU (1) HU221584B (fr)
IS (1) IS4111A (fr)
LV (1) LV10961B (fr)
NO (1) NO305367B1 (fr)
NZ (1) NZ259596A (fr)
PL (1) PL178307B1 (fr)
RU (1) RU95115547A (fr)
SK (1) SK87295A3 (fr)
TW (1) TW261615B (fr)
WO (1) WO1994015947A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
DE69425439D1 (de) * 1993-09-29 2000-09-07 Nissin Food Products Ltd In stellung 21 substituierte steroide
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
HUP0200871A3 (en) 1999-05-04 2004-04-28 Strakan Int Ltd Androgen glycosides and androgenic activity thereof
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
RU2246293C2 (ru) 1999-06-14 2005-02-20 Космо С.П.А. Фармацевтические композиции для перорального введения с регулируемым высвобождением активного ингредиента и маскируемым вкусом
AU2001225363A1 (en) * 2000-01-14 2001-07-24 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
EP1625854B1 (fr) * 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Conjugés d'albumine contenant un lien glucuronique
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP7330101B2 (ja) 2016-11-08 2023-08-21 レゲネロン ファーマシューティカルス，インコーポレーテッド ステロイド及びそのタンパク質コンジュゲート
EP3604322B1 (fr) * 2017-03-30 2023-10-18 Fruithy Holdings Limited Composé de glycoside de lactulose, procédé de préparation et son utilisation
US11491237B2 (en) 2017-05-18 2022-11-08 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
MX2020004691A (es) 2017-11-07 2020-08-20 Regeneron Pharma Enlazadores hidrofilicos para conjugados anticuerpo-farmaco.
BR112020013492A2 (pt) 2018-01-08 2020-12-08 Regeneron Pharmaceuticals, Inc. Esteroides e conjugados de anticorpo dos mesmos
KR20210008008A (ko) 2018-05-09 2021-01-20 리제너론 파마슈티칼스 인코포레이티드 항-msr1 항체 및 이의 사용 방법

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378109B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
BG33735A3 (bg) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Метод за получаване на заместени в 17-та позиция стероиди от прегнановия ред
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (fr) * 1983-04-14 1984-10-25 Univ California Systeme d'administration de medicaments specifiques du colon
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
HU198216B (en) * 1986-05-12 1989-08-28 Kanto Ishi Pharma Co Ltd Process for producing sialosyl-cholesterin and pharmaceutical compositions containing them as active components
CA1299653C (fr) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Appareil de mesure des liquides biologiques
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (fr) * 1992-05-04 1993-11-11 Sri International Compositions pharmaceutiques et procedes pour l'apport de corticosteroides au colon
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo

Also Published As

Publication number Publication date
TW261615B (fr) 1995-11-01
DK0678097T3 (da) 2000-02-07
US5908833A (en) 1999-06-01
EP0678097A1 (fr) 1995-10-25
AU5844794A (en) 1994-08-15
IS4111A (is) 1994-07-09
WO1994015947A1 (fr) 1994-07-21
FI953358A7 (fi) 1995-07-07
JPH08505616A (ja) 1996-06-18
SK87295A3 (en) 1996-04-03
PL309777A1 (en) 1995-11-13
HU221584B (hu) 2002-11-28
ES2137353T3 (es) 1999-12-16
US6140308A (en) 2000-10-31
HU9502087D0 (en) 1995-09-28
FI953358A0 (fi) 1995-07-07
RU95115547A (ru) 1997-06-10
HUT73227A (en) 1996-07-29
NO952683L (no) 1995-07-06
NZ259596A (en) 1997-04-24
NO952683D0 (no) 1995-07-06
GR3031789T3 (en) 2000-02-29
PL178307B1 (pl) 2000-04-28
FI953358L (fi) 1995-07-07
ATE183192T1 (de) 1999-08-15
AU678803B2 (en) 1997-06-12
EP0678097B1 (fr) 1999-08-11
CZ171095A3 (en) 1996-01-17
NO305367B1 (no) 1999-05-18
BR9307746A (pt) 1995-11-14
JP3366640B2 (ja) 2003-01-14
LV10961A (lv) 1995-12-20
CA2152374A1 (fr) 1994-07-21
KR960700266A (ko) 1996-01-19

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