LT4568B - Acetate antimicrobial threads - Google Patents

Abstract

This invention deals with acetate antimicrobial thread comprising 5-chlor-2-(2.4-dichlorophenoxy) phenol as antimicrobial additive into a spinning solution. The thread consists of (in mass percentage):acetyl cellulose 86.9-89.4antimicrobial additive 0.3- 2.5lubricant 2.7- 3.3acetone 0.3- 0.7water up to 100These threads are distinguished by the active antimicrobial effect on various micro-organisms, especially on those causing purulent infections, and may be used for textile products and in medicine.

Description

The present invention is about chemical yarns, more particularly acetate antimicrobial yarns, which can be used in the textile industry and medicine.

Acetyl cellulosic (acetate and triacetate) antimicrobial yarns, which are prepared by dissolving in a spinning solution antiseptic properties of 0.5 to 5 percent by weight of acetylcellulose compounds of the 5-nitrofuran group, are known. The production of these fibers was not assimilated because the synthesis of antiseptic compounds was expensive. (B. ilojinmyK h μρ. NojiyneHHe aHTHMHKpo6Hbix aueTaTHbix βοποκοη b onbiTHO-npoMbuujieHHbix ycnoBHHX. (XnMHHecKne BOJiOKHa): 2, 1972).

There is a known acetyl cellulose fiber that is used to make medical wounds for wounds. The acetate fiber is treated with triacetin (1,2,3-propanthryl triethanoate) and the resulting acetate fiber is used to make wounds for wounds. Because the fiber is soaked in an antiseptic solution, the tampons are disposable, which makes the antiseptic's longevity uncertain. (SU Invention 827629, Priority dated 09.11.1978, D 01 F 11/02, Published OB 17/1981).

The closest known technical solution is a wash-resistant chemical yarn which is blended with 0.1-5% by weight of an azole compound (Formula 1) and 0.1-5% by weight of a dihydroxydiphenylmethane derivative (Formula 2) to produce a synthetic polymer:

N - CH

Where n is 0 or 1; m = 0.1 or 2; R 1 -halo, halophenyl or phenyl; R? - COC (CH ₃ ) ₃ ; R ₃ and R 4 are halogens. Because this chemical fiber contains up to 10 percent of a mixture of two complex organic compounds, its production is complicated. (DE Application 0429665, AT Priority 08.11.1984, Applicant to BAYER AG, kboSpeTeHHii CTpaH Mnpa, BbinycK 70.10 / 1986, στρ. 13).

SUMMARY OF THE INVENTION It is an object of the present invention to provide an acetylcellulose yarn with long-lasting antimicrobial properties when worn and washed. Such yarns will be used to make underwear, outerwear, athletic clothing, linings, footwear liners, sheets, various liners, filters, wall hangings, elastic bands, napkins, dental masks, special purpose packs and so on.

This problem is solved by the patented acetate antimicrobial filaments of acetylcellulose and the organic antimicrobial additive, which contain (by weight):

acetylcellulose 86.9-89.4;

antimicrobial organic supplement 0.3 - 2.5;

grease 2.7-3 / 3;

acetone 0.3-0.7;

water up to 100.

Organic antimicrobial additive is 5-chloro-2- (2,4-dichlorophenoxy) phenol:

Cl

OH no — yy-o— / c)> - ci

It is a white, crystalline powder, freely soluble in organic solvents, but insoluble in water.

Acetate yarn is produced in accordance with technical specifications of AB “Artificial fiber” TS 3353911 - 01 - 96 “Twisted acetate yarn in packages”. The manufacturing process consists of the following technological operations: spinning solution production, spinning of threads, twisting and solvent regeneration.

The spinning solution is prepared as follows: the calculated amounts of acetylcellulose and the organic antimicrobial additive are mixed, loaded into a solvent, dissolved in a mixture of acetone and water and filtered.The composition of the spinning solution (in percentage by mass) is as follows:

acetylcellulose 23.3-25.5;

antimicrobial organic supplement 0.3 - 2.5;

acetone 70.6 - 71.0;

water up to 100.

The quality and composition of the spinning solution is checked after filtration (determination of viscosity, contamination constant, amount of antimicrobial additive).

Acetate yarns are spun dry, using an FFO spinning machine (acetone evaporation from the spinning solution), and the spun yarn is greased and welded onto metal spools. If you want to increase the compactness or structure of the antimicrobial thread, the twisted thread is rotated from 80 to 1200 revolutions per meter. From this ready-made yarn we produce fabrics, knitwear, non-woven materials for various applications.

TS 3353911 - 01-96 tests the following properties of yarns by the prescribed methods: longitudinal density, comparative breaking force, elongation at break and twist.

The invention is illustrated by the following examples.

example. Acetone spinning solutions are made from acetyl cellulose and an antimicrobial organic additive in the laboratory. Prepare solutions containing 0.3; 0.5; 0.7; 1.0; 1.5; 2.0 and 2.5 per cent by weight of the additive, based on the weight of the acetylcellulose. For the determination of the antimicrobial additive, the films of the solution are cast, dried and spectrophotometrically determined by the amount of additive.

example. Prepare 20 kg of spinning solution from acetylcellulose, antimicrobial additive and solvent and spin acetate acetate yarn with 0,3 on a laboratory bench; 0.5; 0.7; 1.0 and 2.5 percent of the supplement.

example. From acetyl cellulose and 0.3 percent antimicrobial additive, prepare a solution that produces 100 packs of 500 g of yarn under production conditions.

Example 1: Spinning acetate yarns without additives (control test) under the same conditions in the same technological process and from the same raw materials.

The properties of all these yarns are verified by the methods provided for in the technical specifications of TS “Artificial fiber” AB 3353911 -01 -96 “Twisted acetate yarn in packages”. The results of the studies are presented in Table 1.

Table of properties of acetate yarns

Example (% additive) Length density, tex Relative breaking force, mN / tex Elongation at break,% Twist, -i m Laboratory bench 0.3 16.4 114.0 27.9 82 0.3 16.4 115.0 27.6 136 05 16.4 114.0 32.6 92 0.7 16.4 115.0 30.9 89 1.0 .16.4 118.0 30.7 92 2.5 16.4 98.0 24.1 91 Production test 0.3 16.6 1055 295 91 Control example 16.4 106.8 29.8 90 TS 3353911-01-96 (Norm for Type I) 16.6 Not less than 98,0 24.0-32.0 95 ± 10

The data in the table show that the antimicrobial additive does not degrade the yarn properties, which is particularly important for low acetate yarns.

The antimicrobial properties of the selected antimicrobial organic additive 5-chloro-2- (2,4-dichlorophenoxy) phenol and the antimicrobial activity of the knitwear samples with various amounts of this additive, as well as the washing effect on these properties were determined by independent experts from Kaunas Medical Academy.

The antimicrobial activity of the additive is determined by assaying its minimum inhibition (inhibition) concentration (MIC) and its minimum bactericidal concentration (MBC). This accessory has a broad spectrum of antimicrobial activity. Gram-positive prokaryotes (staphylococci) are the most sensitive and gram-negative prokaryotes (pseudomonos) are the most resistant. For microorganisms, this additive acts microbocides (kills microbes) and microbostats (inhibits microbial growth).

The antimicrobial activity and washing effect of acetate knitwear with various amounts of the patented additive are investigated as follows: Knitwear knitwear is made from acetate yarn without additive (control sample) and with 0.3; 0.5; 0.7 and 1.0 percent of the supplement. The samples are washed according to LST EN 20105 - C01: 1998. Textile materials. Color fastness to washing. Test 1.

Prepare samples for one, five, ten and twenty washes each.

The antimicrobial activity of knit samples is determined by the cultures of standard microorganisms (prokaryotic cells, ie, non-spore bacteria (Gram-positive-Staphylococcus aureus ATCC 25923 and Gram-negative-Escherichiae coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), Bacterial spores as well as microscopic fungi (eukaryotic cells - Candida albicans ATCC 60193) and bacterial strains, which were isolated from patients with abscesses at Kaunas Academic Clinics.

Prepare discs 2 cm in diameter from all the knitted samples submitted for examination. They are placed on a sterile surface of tryptose agar in Petri dishes. Subsequently, 5 ml of reconstituted tryptose agar (50-55) ° C mixed with a suspension of culture or bacterial strain of culture for one day is added to the sample with agar. One ml should contain 100000 bacterial cells. When the medium is frozen on the agar surface, Petri dishes are incubated for 24 hours. At 37 ° C. The cultures are incubated for 3 days at 25 ° C in Saburo agar with Candida albikans. The antimicrobial activity of the knitwear is evaluated by the diameter of the sterile zone, which proves that the bacteria does not grow, on the discs of the knitwear samples. The results of the microbiological tests are shown in Tables 2 and 3. We can see that staphylococci causing purulent infections are particularly sensitive. The anti-staphylococcal effect of hosiery gradually diminishes during washing, but does not disappear even after 20 washes. The antimicrobial activity of knitwear samples against Escherichiae coli, Bacillus subtilis is also negligible when washed. However, Pseudomonas aeruginosa ATCC 27853, Bacillus cereus ATCC 8035 and Candida albicans ATCC were found not to be active in the test samples and were resistant to these bacteria. Antibacterial activity against clinical strains of bacteria has been shown to be low susceptible to Klebsiella pneumoniae, although higher concentrations of antimicrobial additive in the suture already inhibit the growth of these bacteria.

Table of antimicrobial activity of knitwear samples against standard cultures of microorganisms

Standard Attached Diameter of sterile zone around knit discs, mm microorganic concentric Laundries nism cultures tation% 1 5 10th 20th 1 2 3 4 5 6th Staphylocu- 0.3 25.0 33.25 31.0 32.75 ccus aureus 03 45.0 44.0 45.0 44.0 ATCC 0.7 44.05 44.25 443 43.0 25923 1.0 493 45.75 45.75 44.25 Escherichiae 0.3 22.75 22.25 213 22.25 coli 03 27.0 263 24.0 23.75 ATCC 0.7 27.25 263 26.75 24.75 25922 1.0 29.75 27.75 26.75 25.75 Bacillus 0.3 27.0 26.0 24.75 24.75 subtilis 03 28.75 32.0 30.0 28.75 ATCC 0.7 33.75 33.75 323 29.25 6633 1.0 35.25 34.25 333 32.25 Bacillus cereus ATCC 8035 In all Concentrate cations 0 0 0 0 Pseudomonas aeruginosa ATCC27853 In all Concentrate cations 0 0 0 0 Candida albican ATCC 60193 In all Concentrate cations 0 0 0 0

Table of antimicrobial activity of knitwear samples against bacterial clinical strains

Standard cultures of microorganisms Concentration of additive,% Diameter of sterile zone around knit discs, mm Laundries 1 5 10th 20th Staphylococcus aureus 0.3 24.7 33.43 32.0 32.0 0.5 45.0 44.3 44.4 44.0 0.7 44.3 44.1 44.1 43.0 1.0 49.9 45.43 45.3 44.1 Staphylococcus epidermis 0.3 24.8 33.6 32.0 31.8 0.5 45.0 44.2 44.4 43.6 0.7 44.4 44.0 43.6 42.8 1.0 50.2 45.6 45.2 44.2 Klebsiella pneumonia 0.3 0 0 0 0 0.5 0 0 0 0 0.7 20.4 0 0 0 1.0 22.6 21.8 20.0

All control crops with knitwear samples without additives showed no signs of antimicrobial activity.

and Table 3 show that acetate yarns with an antimicrobial organic additive exhibit active antimicrobial activity against a variety of microorganisms, and these properties are retained after multiple washes.

Claims (1)

DEFINITION OF INVENTION Acetate antimicrobial yarn of acetylcellulose and of antimicrobial organic additive, characterized in that the antimicrobial organic additive is 5-chloro-2- (2,4-dichlorophenoxy) phenol and the composition by weight of these yarns is as follows: acetylcellulose 86.9-89.4; antimicrobial organic supplement 0.3-2.5; grease 2.7-3.3; acetone 0.3-0.7; water up to 100.