LT4083038T - Piridazinilo tiazolkarboksamido junginys - Google Patents
Piridazinilo tiazolkarboksamido junginysInfo
- Publication number
- LT4083038T LT4083038T LTEPPCT/JP2020/048337T LTJP2020048337T LT4083038T LT 4083038 T LT4083038 T LT 4083038T LT JP2020048337 T LTJP2020048337 T LT JP2020048337T LT 4083038 T LT4083038 T LT 4083038T
- Authority
- LT
- Lithuania
- Prior art keywords
- pyridazinyl
- thiazolecarboxamide compound
- thiazolecarboxamide
- compound
- pyridazinyl thiazolecarboxamide
- Prior art date
Links
- -1 Pyridazinyl thiazolecarboxamide compound Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019233673 | 2019-12-25 | ||
| PCT/JP2020/048337 WO2021132422A1 (ja) | 2019-12-25 | 2020-12-24 | ピリダジニルチアアゾールカルボキシアミド化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT4083038T true LT4083038T (lt) | 2024-12-27 |
Family
ID=76574296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/JP2020/048337T LT4083038T (lt) | 2019-12-25 | 2020-12-24 | Piridazinilo tiazolkarboksamido junginys |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US12227517B2 (lt) |
| EP (1) | EP4083038B1 (lt) |
| JP (1) | JP6948659B1 (lt) |
| KR (1) | KR20220119702A (lt) |
| CN (3) | CN115626919B (lt) |
| AR (1) | AR120896A1 (lt) |
| AU (1) | AU2020413997A1 (lt) |
| BR (1) | BR112022012637A2 (lt) |
| CA (1) | CA3165889A1 (lt) |
| CL (1) | CL2022001752A1 (lt) |
| CO (1) | CO2022009124A2 (lt) |
| CR (1) | CR20220328A (lt) |
| DK (1) | DK4083038T3 (lt) |
| DO (1) | DOP2022000137A (lt) |
| EC (1) | ECSP22057324A (lt) |
| ES (1) | ES2995459T3 (lt) |
| FI (1) | FI4083038T3 (lt) |
| HR (1) | HRP20241588T1 (lt) |
| HU (1) | HUE069173T2 (lt) |
| IL (1) | IL294136B2 (lt) |
| JO (1) | JOP20220163A1 (lt) |
| LT (1) | LT4083038T (lt) |
| MX (1) | MX2022007993A (lt) |
| MY (1) | MY206825A (lt) |
| PE (1) | PE20230163A1 (lt) |
| PH (1) | PH12022551569A1 (lt) |
| PL (1) | PL4083038T3 (lt) |
| PT (1) | PT4083038T (lt) |
| SA (1) | SA522433129B1 (lt) |
| SI (1) | SI4083038T1 (lt) |
| TW (3) | TW202413375A (lt) |
| UA (1) | UA129628C2 (lt) |
| WO (1) | WO2021132422A1 (lt) |
| ZA (1) | ZA202207543B (lt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022007930A (es) | 2019-12-24 | 2022-08-08 | Carna Biosciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| ES3029140T3 (en) | 2020-04-24 | 2025-06-23 | Bayer Ag | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| AR124172A1 (es) | 2020-11-30 | 2023-02-22 | Astellas Pharma Inc | Compuesto de heteroarilcarboxamida |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| JP7686086B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリエルコール（ｄｉａｃｙｌｇｌｙｅｒｃｏｌ）キナーゼ調節化合物 |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271684A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN114621214B (zh) * | 2022-04-25 | 2024-04-26 | 宜春学院 | 一种抗菌席夫碱n-酰化物及其制备方法和应用 |
| US20240217989A1 (en) * | 2022-11-18 | 2024-07-04 | Incyte Corporation | Heteroaryl Fluoroalkenes As DGK Inhibitors |
| WO2024151346A1 (en) * | 2023-01-12 | 2024-07-18 | Incyte Corporation | Heteroaryl fluoroalkenes as dgk inhibitors |
| TW202436351A (zh) | 2023-02-06 | 2024-09-16 | 德商拜耳廠股份有限公司 | Ccr8抗體及dgk抑制劑之組合 |
| CN120826398A (zh) * | 2023-03-30 | 2025-10-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| WO2024208198A1 (zh) * | 2023-04-06 | 2024-10-10 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的噻唑类化合物 |
| WO2025067360A1 (zh) * | 2023-09-27 | 2025-04-03 | 海思科医药集团股份有限公司 | 一种DGKzeta拮抗剂及其在医药上的应用 |
| WO2025082460A1 (zh) * | 2023-10-20 | 2025-04-24 | 上海先祥医药科技有限公司 | 二酰基甘油激酶抑制剂化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381401B2 (en) | 2004-01-08 | 2008-06-03 | The University Of Chicago | T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase |
| KR101436161B1 (ko) | 2005-01-25 | 2014-09-01 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| US8455658B2 (en) * | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| CN101426774B (zh) * | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| AU2007314342B2 (en) * | 2006-10-31 | 2013-02-21 | Merck Sharp & Dohme Corp. | Anilinopiperazine Derivatives and methods of use thereof |
| MX2020002399A (es) | 2017-09-06 | 2020-07-22 | Propellon Therapeutics Inc | Inhibidores del enlace proteína-proteína de wdr5. |
| WO2020006018A1 (en) | 2018-06-27 | 2020-01-02 | Bristol-Myers Squibb Company | Substituted naphthyridinone compounds useful as t cell activators |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| ES3029140T3 (en) | 2020-04-24 | 2025-06-23 | Bayer Ag | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| AR124172A1 (es) | 2020-11-30 | 2023-02-22 | Astellas Pharma Inc | Compuesto de heteroarilcarboxamida |
-
2020
- 2020-12-23 AR ARP200103641A patent/AR120896A1/es unknown
- 2020-12-24 KR KR1020227025714A patent/KR20220119702A/ko active Pending
- 2020-12-24 CA CA3165889A patent/CA3165889A1/en active Pending
- 2020-12-24 SI SI202030542T patent/SI4083038T1/sl unknown
- 2020-12-24 EP EP20906466.6A patent/EP4083038B1/en active Active
- 2020-12-24 TW TW112145679A patent/TW202413375A/zh unknown
- 2020-12-24 TW TW112145680A patent/TW202413376A/zh unknown
- 2020-12-24 ES ES20906466T patent/ES2995459T3/es active Active
- 2020-12-24 DK DK20906466.6T patent/DK4083038T3/da active
- 2020-12-24 MY MYPI2022003381A patent/MY206825A/en unknown
- 2020-12-24 TW TW109146029A patent/TWI881008B/zh active
- 2020-12-24 CN CN202211308277.1A patent/CN115626919B/zh active Active
- 2020-12-24 JP JP2021531562A patent/JP6948659B1/ja active Active
- 2020-12-24 PT PT209064666T patent/PT4083038T/pt unknown
- 2020-12-24 LT LTEPPCT/JP2020/048337T patent/LT4083038T/lt unknown
- 2020-12-24 WO PCT/JP2020/048337 patent/WO2021132422A1/ja not_active Ceased
- 2020-12-24 PH PH1/2022/551569A patent/PH12022551569A1/en unknown
- 2020-12-24 CN CN202211308268.2A patent/CN115590854B/zh active Active
- 2020-12-24 IL IL294136A patent/IL294136B2/en unknown
- 2020-12-24 JO JOP/2022/0163A patent/JOP20220163A1/ar unknown
- 2020-12-24 MX MX2022007993A patent/MX2022007993A/es unknown
- 2020-12-24 US US17/427,426 patent/US12227517B2/en active Active
- 2020-12-24 CN CN202080011114.XA patent/CN113365994B/zh active Active
- 2020-12-24 CR CR20220328A patent/CR20220328A/es unknown
- 2020-12-24 HR HRP20241588TT patent/HRP20241588T1/hr unknown
- 2020-12-24 HU HUE20906466A patent/HUE069173T2/hu unknown
- 2020-12-24 UA UAA202202632A patent/UA129628C2/uk unknown
- 2020-12-24 BR BR112022012637A patent/BR112022012637A2/pt unknown
- 2020-12-24 PL PL20906466.6T patent/PL4083038T3/pl unknown
- 2020-12-24 PE PE2022001161A patent/PE20230163A1/es unknown
- 2020-12-24 AU AU2020413997A patent/AU2020413997A1/en active Pending
- 2020-12-24 FI FIEP20906466.6T patent/FI4083038T3/fi active
-
2022
- 2022-06-23 SA SA522433129A patent/SA522433129B1/ar unknown
- 2022-06-24 DO DO2022000137A patent/DOP2022000137A/es unknown
- 2022-06-24 CL CL2022001752A patent/CL2022001752A1/es unknown
- 2022-06-30 CO CONC2022/0009124A patent/CO2022009124A2/es unknown
- 2022-07-07 ZA ZA2022/07543A patent/ZA202207543B/en unknown
- 2022-07-21 EC ECSENADI202257324A patent/ECSP22057324A/es unknown
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