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LT3723815T - Psma ligandai, skirti vizualizavimui ir endoradioterapijai - Google Patents

Psma ligandai, skirti vizualizavimui ir endoradioterapijai

Info

Publication number
LT3723815T
LT3723815T LTEPPCT/EP2018/084399T LTEP2018084399T LT3723815T LT 3723815 T LT3723815 T LT 3723815T LT EP2018084399 T LTEP2018084399 T LT EP2018084399T LT 3723815 T LT3723815 T LT 3723815T
Authority
LT
Lithuania
Prior art keywords
endoradiotherapy
imaging
psma ligands
psma
ligands
Prior art date
Application number
LTEPPCT/EP2018/084399T
Other languages
English (en)
Inventor
Hans-Jürgen Wester
Alexander Schmidt
Mara PARZINGER
Original Assignee
Technische Universität München
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universität München filed Critical Technische Universität München
Publication of LT3723815T publication Critical patent/LT3723815T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nuclear Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEPPCT/EP2018/084399T 2017-12-11 2018-12-11 Psma ligandai, skirti vizualizavimui ir endoradioterapijai LT3723815T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17206510 2017-12-11
PCT/EP2018/084399 WO2019115547A1 (en) 2017-12-11 2018-12-11 Psma ligands for imaging and endoradiotherapy

Publications (1)

Publication Number Publication Date
LT3723815T true LT3723815T (lt) 2022-07-25

Family

ID=60654872

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2018/084399T LT3723815T (lt) 2017-12-11 2018-12-11 Psma ligandai, skirti vizualizavimui ir endoradioterapijai
LTEP21218180.4T LT4008359T (lt) 2017-12-11 2018-12-11 Psma ligandai, skirti vizualizavimui ir endoradioterapijai

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP21218180.4T LT4008359T (lt) 2017-12-11 2018-12-11 Psma ligandai, skirti vizualizavimui ir endoradioterapijai

Country Status (33)

Country Link
US (2) US11497819B2 (lt)
EP (3) EP4008359B1 (lt)
JP (3) JP7317375B2 (lt)
KR (1) KR102815791B1 (lt)
CN (2) CN111182927B (lt)
AU (2) AU2018382479B2 (lt)
BR (1) BR112020011727A2 (lt)
CA (1) CA3078104A1 (lt)
CL (1) CL2020001542A1 (lt)
CR (1) CR20200241A (lt)
CU (1) CU24677B1 (lt)
CY (1) CY1125376T1 (lt)
DK (2) DK4008359T3 (lt)
EC (1) ECSP20029142A (lt)
ES (2) ES2914832T3 (lt)
FI (1) FI4008359T3 (lt)
HR (2) HRP20241453T1 (lt)
HU (2) HUE069034T2 (lt)
IL (3) IL319022A (lt)
JO (1) JOP20200135A1 (lt)
LT (2) LT3723815T (lt)
MX (2) MX2020005430A (lt)
PE (1) PE20210456A1 (lt)
PL (1) PL3723815T3 (lt)
PT (2) PT3723815T (lt)
RS (2) RS66086B1 (lt)
SG (1) SG11202002965WA (lt)
SI (2) SI4008359T1 (lt)
SM (1) SMT202400439T1 (lt)
TN (1) TN2020000072A1 (lt)
UA (1) UA126413C2 (lt)
WO (1) WO2019115547A1 (lt)
ZA (1) ZA202003472B (lt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019020831A1 (en) * 2017-07-28 2019-01-31 Technische Universität München AGENTS WITH TWO RADIOTRATIVE AND THERAPEUTIC MODES
EP4008359B1 (en) * 2017-12-11 2024-09-11 Technische Universität München Psma ligands for imaging and endoradiotherapy
EA202192045A1 (ru) * 2019-01-30 2021-10-27 Технише Универзитет Мюнхен Средства для диагностической визуализации ракового заболевания
JP7528100B2 (ja) * 2019-01-30 2024-08-05 テクニシェ ユニバーシタット ミュンヘン Ｐｓｍａ結合デュアルモード放射性トレーサーおよび療法
CA3136979A1 (en) 2019-04-17 2020-10-22 Provincial Health Services Authority Radiolabelled compounds for diagnosis or treatment of prostate-spe cific membrane antigen-expressing cancer
CN119431260A (zh) 2019-06-21 2025-02-14 省卫生服务机构 靶向前列腺特异性膜抗原的放射性标记化合物
CN112321673B (zh) * 2020-11-04 2022-09-20 北京市肿瘤防治研究所 一种前列腺特异性膜抗原靶向抑制剂及应用和探针
CN113354707A (zh) * 2021-06-07 2021-09-07 苏州思萃同位素技术研究所有限公司 一种针对前列腺癌的三功能诊疗一体化药物前体的合成方法及其产品
WO2023173074A2 (en) * 2022-03-10 2023-09-14 The Research Foundation For The State University Of New York Immunostimulant-cytotoxic conjugate composition and methods for cancer treatment
CN115010629B (zh) * 2022-06-07 2024-02-23 西南医科大学附属医院 前列腺特异性膜抗原抑制剂、其核素标记物及制法和应用
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
WO2025022285A2 (en) 2023-07-21 2025-01-30 Novartis Ag Psma-targeting radioligand treatment regimen
JP2025538914A (ja) 2023-07-31 2025-12-03 キュリウム ユーエス エルエルシー ［１７７ｌｕ］ルテチウム－ｐｓｍａ ｉ＆ｔ組成物及び線量測定、キット、それを作製する方法、並びにそれを使用する方法
WO2025147677A1 (en) * 2024-01-05 2025-07-10 Point Biopharma, Inc. Preparation of psma-targeted radiopharmaceutical
CN119101006B (zh) * 2024-09-05 2025-11-07 西南医科大学附属医院 前列腺特异性膜抗原抑制剂、其放射性标记物及制法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200716632A (en) 2005-05-16 2007-05-01 Gilead Sciences Inc Integrase inhibitor compounds
HUE034027T2 (en) * 2008-08-01 2018-01-29 Univ Johns Hopkins Psma-binding agents and uses thereof
WO2010135431A2 (en) * 2009-05-19 2010-11-25 The Regents Of The University Of California Compositions, devices, and methods related to prostate-specific membrane antigen
SG11201602249RA (en) * 2013-10-18 2016-05-30 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN106660943B (zh) * 2014-05-06 2020-03-17 约翰霍普金斯大学 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物
US10688200B2 (en) 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
KR20220063298A (ko) * 2016-03-22 2022-05-17 더 존스 홉킨스 유니버시티 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제
TW201930265A (zh) 2017-12-11 2019-08-01 西班牙商阿爾米雷爾有限公司 作為acc抑制劑的吡咯衍生物
EP4008359B1 (en) * 2017-12-11 2024-09-11 Technische Universität München Psma ligands for imaging and endoradiotherapy
EP3724176B1 (en) 2017-12-11 2022-01-26 Helsinn Healthcare SA Fumarate salt of (r)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, methods of preparation, and uses thereof

Also Published As

Publication number Publication date
ECSP20029142A (es) 2020-09-30
ES2997266T3 (en) 2025-02-14
PT4008359T (pt) 2024-10-25
BR112020011727A2 (pt) 2020-11-17
RS66086B1 (sr) 2024-11-29
CN111182927A (zh) 2020-05-19
KR20200097690A (ko) 2020-08-19
FI4008359T3 (fi) 2024-11-11
JOP20200135A1 (ar) 2020-06-02
DK3723815T3 (da) 2022-07-11
AU2018382479A1 (en) 2020-04-16
NZ763033A (en) 2025-02-28
ZA202003472B (en) 2022-06-29
EP4464341A2 (en) 2024-11-20
CN116617421A (zh) 2023-08-22
HRP20241453T1 (hr) 2024-12-20
IL313103B2 (en) 2025-07-01
HRP20220764T1 (hr) 2022-09-16
IL313103B1 (en) 2025-03-01
JP2021505532A (ja) 2021-02-18
RS63279B1 (sr) 2022-06-30
UA126413C2 (uk) 2022-09-28
CU20200052A7 (es) 2021-03-11
IL274072B1 (en) 2024-07-01
CU24677B1 (es) 2023-09-07
MX2020005430A (es) 2020-08-27
AU2018382479B2 (en) 2024-11-07
MX2023005053A (es) 2023-05-17
PT3723815T (pt) 2022-05-30
JP7317375B2 (ja) 2023-07-31
EP3723815A1 (en) 2020-10-21
CY1125376T1 (el) 2025-05-09
US20200297876A1 (en) 2020-09-24
IL274072A (en) 2020-06-30
EP4008359B1 (en) 2024-09-11
PL3723815T3 (pl) 2022-07-18
EP4464341A3 (en) 2025-01-22
JP2023139063A (ja) 2023-10-03
EP3723815B1 (en) 2022-04-20
DK4008359T3 (da) 2024-10-14
LT4008359T (lt) 2024-12-27
CA3078104A1 (en) 2019-06-20
IL313103A (en) 2024-07-01
US20230122957A1 (en) 2023-04-20
SI3723815T1 (sl) 2022-07-29
JP2025011169A (ja) 2025-01-23
ES2914832T3 (es) 2022-06-16
EP4008359A1 (en) 2022-06-08
AU2025200837A1 (en) 2025-02-27
SMT202400439T1 (it) 2024-11-15
CN111182927B (zh) 2023-07-21
SI4008359T1 (sl) 2025-03-31
WO2019115547A1 (en) 2019-06-20
HUE069034T2 (hu) 2025-02-28
SG11202002965WA (en) 2020-04-29
IL319022A (en) 2025-04-01
TN2020000072A1 (en) 2022-01-06
CL2020001542A1 (es) 2020-10-02
JP7572080B2 (ja) 2024-10-23
IL274072B2 (en) 2024-11-01
US11497819B2 (en) 2022-11-15
RU2020116158A (ru) 2022-01-13
PE20210456A1 (es) 2021-03-08
HUE059083T2 (hu) 2022-10-28
CR20200241A (es) 2020-09-21
KR102815791B1 (ko) 2025-05-30

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