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LT3204378T - N-piridinilo acetamido dariniai kaip wnt signalinio kelio inhibitoriai - Google Patents

N-piridinilo acetamido dariniai kaip wnt signalinio kelio inhibitoriai

Info

Publication number
LT3204378T
LT3204378T LT15782041T LT15782041T LT3204378T LT 3204378 T LT3204378 T LT 3204378T LT 15782041 T LT15782041 T LT 15782041T LT 15782041 T LT15782041 T LT 15782041T LT 3204378 T LT3204378 T LT 3204378T
Authority
LT
Lithuania
Prior art keywords
inhibitors
wnt signal
signal road
acetamide derivatives
pyridinyl
Prior art date
Application number
LT15782041T
Other languages
English (en)
Inventor
Inder Bhamra
Matilda Bingham
Richard Testar
Louise Sargent
Craig Donoghue
Original Assignee
Redx Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1417829.7A external-priority patent/GB201417829D0/en
Priority claimed from GBGB1511387.1A external-priority patent/GB201511387D0/en
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of LT3204378T publication Critical patent/LT3204378T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
LT15782041T 2014-10-08 2015-10-08 N-piridinilo acetamido dariniai kaip wnt signalinio kelio inhibitoriai LT3204378T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417829.7A GB201417829D0 (en) 2014-10-08 2014-10-08 Compounds
GBGB1511387.1A GB201511387D0 (en) 2015-06-29 2015-06-29 Compounds
PCT/GB2015/052939 WO2016055786A1 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as inhibitors of the wnt signalling pathway

Publications (1)

Publication Number Publication Date
LT3204378T true LT3204378T (lt) 2019-10-25

Family

ID=54337304

Family Applications (1)

Application Number Title Priority Date Filing Date
LT15782041T LT3204378T (lt) 2014-10-08 2015-10-08 N-piridinilo acetamido dariniai kaip wnt signalinio kelio inhibitoriai

Country Status (24)

Country Link
US (4) US10047079B2 (lt)
EP (1) EP3204378B3 (lt)
JP (2) JP6722178B2 (lt)
KR (1) KR102525131B1 (lt)
CN (1) CN107108565B (lt)
AU (1) AU2015329784C1 (lt)
CA (1) CA2960446C (lt)
CY (1) CY1122243T1 (lt)
DK (1) DK3204378T6 (lt)
EA (1) EA034822B9 (lt)
ES (1) ES2754349T7 (lt)
HR (1) HRP20191826T4 (lt)
HU (1) HUE046914T2 (lt)
IL (1) IL251131B (lt)
LT (1) LT3204378T (lt)
MX (1) MX373651B (lt)
PH (1) PH12017500611A1 (lt)
PL (1) PL3204378T6 (lt)
PT (1) PT3204378T (lt)
SG (1) SG11201701837UA (lt)
SI (1) SI3204378T1 (lt)
SM (1) SMT201900615T1 (lt)
WO (1) WO2016055786A1 (lt)
ZA (1) ZA201701842B (lt)

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BR112017007218B1 (pt) 2014-10-08 2023-10-10 Redx Pharma Plc Derivados de n-piridil acetamida como inibidores da via de sinalização de wnt, formulações farmacêuticas compreendendo os mesmos e seus usos
MX373651B (es) 2014-10-08 2020-03-31 Redx Pharma Plc Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt.
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2018045182A1 (en) 2016-09-01 2018-03-08 The Board Of Regents Of Hte University Of Texas System Disubstituted and trisubtituted 1,2,3-triazoles as wnt inhibitors
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
JP2019064975A (ja) * 2017-10-03 2019-04-25 国立大学法人 熊本大学 抗がん剤
EP3717465A1 (en) 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
EP3746422A4 (en) * 2018-02-01 2021-06-09 The University Of Sydney ANTI-CANCER COMPOUNDS
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
US10961534B2 (en) 2018-07-13 2021-03-30 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating porphyria
ES3044436T3 (en) 2019-06-04 2025-11-26 Step Pharma S A S N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(ethylsulfonamido)pyrimidin-4-yl)tetrahydro-2h-pyran-4-carboxamide as a human ctps1 inhibitor for the treatment of proliferative diseases
CR20220325A (es) 2019-12-20 2022-08-19 Tenaya Therapeutics Inc Fluoroalquil-oxadiazoles y sus usos
US20230404985A1 (en) * 2020-11-02 2023-12-21 Icahn School Of Medicine At Mount Sinai Methods of treating tumors and cancers having dysregulated wnt signaling pathways
GB202100526D0 (en) * 2021-01-15 2021-03-03 Redx Pharma Plc Pharmaceutical formulation
KR20240016950A (ko) 2021-05-04 2024-02-06 테나야 테라퓨틱스, 인코포레이티드 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제
TW202434564A (zh) * 2022-12-27 2024-09-01 大陸商南京聖和藥業股份有限公司 選擇性cdk12/13抑制劑及其應用

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BR112017007218B1 (pt) 2014-10-08 2023-10-10 Redx Pharma Plc Derivados de n-piridil acetamida como inibidores da via de sinalização de wnt, formulações farmacêuticas compreendendo os mesmos e seus usos
MX373651B (es) 2014-10-08 2020-03-31 Redx Pharma Plc Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt.

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Publication number Publication date
AU2015329784C1 (en) 2020-10-15
PL3204378T4 (pl) 2020-03-31
WO2016055786A1 (en) 2016-04-14
SMT201900615T1 (it) 2020-01-14
HUE046914T2 (hu) 2020-04-28
EA034822B1 (ru) 2020-03-25
PL3204378T3 (pl) 2020-03-31
JP2020090542A (ja) 2020-06-11
EA034822B9 (ru) 2020-10-23
EP3204378B1 (en) 2019-07-10
US20180319788A1 (en) 2018-11-08
EP3204378B3 (en) 2022-05-25
PH12017500611A1 (en) 2017-09-25
HRP20191826T1 (hr) 2020-01-10
JP2017530183A (ja) 2017-10-12
CN107108565A (zh) 2017-08-29
US10793560B2 (en) 2020-10-06
US12202826B2 (en) 2025-01-21
CY1122243T1 (el) 2020-11-25
AU2015329784A1 (en) 2017-03-30
EA201790637A1 (ru) 2017-10-31
SG11201701837UA (en) 2017-04-27
MX373651B (es) 2020-03-31
KR102525131B1 (ko) 2023-04-24
US20230365549A1 (en) 2023-11-16
CN107108565B (zh) 2019-08-23
JP6722178B2 (ja) 2020-07-15
BR112017006476A2 (pt) 2017-12-19
DK3204378T3 (da) 2019-10-21
ES2754349T3 (es) 2020-04-17
US20170275276A1 (en) 2017-09-28
KR20170063906A (ko) 2017-06-08
PL3204378T6 (pl) 2022-09-12
MX2017004637A (es) 2017-06-30
CA2960446C (en) 2023-09-19
US20210046076A1 (en) 2021-02-18
US11643408B2 (en) 2023-05-09
US10047079B2 (en) 2018-08-14
NZ729820A (en) 2023-09-29
IL251131A0 (en) 2017-04-30
ZA201701842B (en) 2022-05-25
ES2754349T7 (es) 2022-09-19
HRP20191826T4 (hr) 2022-08-05
SI3204378T1 (sl) 2019-12-31
EP3204378A1 (en) 2017-08-16
CA2960446A1 (en) 2016-04-14
DK3204378T6 (da) 2022-07-18
IL251131B (en) 2020-07-30
AU2015329784B2 (en) 2019-08-22
PT3204378T (pt) 2019-11-12

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