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LT3143011T - Deuterinti heterocikliniai junginiai ir jų naudojimas kaip vaizdinimo agentų - Google Patents

Deuterinti heterocikliniai junginiai ir jų naudojimas kaip vaizdinimo agentų

Info

Publication number
LT3143011T
LT3143011T LTEP15725253.7T LT15725253T LT3143011T LT 3143011 T LT3143011 T LT 3143011T LT 15725253 T LT15725253 T LT 15725253T LT 3143011 T LT3143011 T LT 3143011T
Authority
LT
Lithuania
Prior art keywords
heterocyclic compounds
deuterated
imagining agents
imagining
deuterated heterocyclic
Prior art date
Application number
LTEP15725253.7T
Other languages
English (en)
Inventor
Jan Marik
Joseph P. Lyssikatos
Simon Williams
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of LT3143011T publication Critical patent/LT3143011T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
LTEP15725253.7T 2014-05-13 2015-05-12 Deuterinti heterocikliniai junginiai ir jų naudojimas kaip vaizdinimo agentų LT3143011T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461992717P 2014-05-13 2014-05-13
PCT/EP2015/060447 WO2015173225A1 (en) 2014-05-13 2015-05-12 Deuterated heterocyclic compounds and their use as imaging agents

Publications (1)

Publication Number Publication Date
LT3143011T true LT3143011T (lt) 2021-05-10

Family

ID=53269446

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15725253.7T LT3143011T (lt) 2014-05-13 2015-05-12 Deuterinti heterocikliniai junginiai ir jų naudojimas kaip vaizdinimo agentų

Country Status (21)

Country Link
US (4) US10076581B2 (lt)
EP (2) EP3143011B1 (lt)
JP (2) JP6529986B2 (lt)
KR (2) KR102530129B1 (lt)
CN (2) CN106459059B (lt)
AU (2) AU2015261008B2 (lt)
CA (1) CA2948721C (lt)
DK (1) DK3143011T3 (lt)
ES (1) ES2867814T3 (lt)
HR (1) HRP20210641T1 (lt)
HU (1) HUE053939T2 (lt)
IL (3) IL280791B2 (lt)
LT (1) LT3143011T (lt)
MX (2) MX384604B (lt)
PL (1) PL3143011T3 (lt)
PT (1) PT3143011T (lt)
RS (1) RS61810B1 (lt)
RU (1) RU2696492C2 (lt)
SG (2) SG10201805628TA (lt)
SI (1) SI3143011T1 (lt)
WO (1) WO2015173225A1 (lt)

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CN106459059B (zh) 2014-05-13 2019-09-24 豪夫迈·罗氏有限公司 氘化杂环化合物和其作为成像剂的用途
WO2018015546A1 (en) 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
IL264239B (en) 2016-07-22 2022-08-01 Ac Immune Sa Compounds for imaging tau protein aggregates
EP3535265A4 (en) 2016-11-01 2020-07-08 Arvinas, Inc. PROTACS TARGETING ON TAU PROTEIN AND RELATED METHODS FOR USE
US11247987B2 (en) 2017-10-06 2022-02-15 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 30
US20210041447A1 (en) 2018-01-24 2021-02-11 Ac Immune Sa Azacarboline compounds for the detection of tau aggregates
US11306089B2 (en) 2018-01-24 2022-04-19 Life Molecular Imaging Limited Gamma-carboline compounds for the detection of Tau aggregates
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
ES2988920T3 (es) 2018-05-17 2024-11-22 Forma Therapeutics Inc Compuestos bicíclicos fusionados útiles como inhibidores de la peptidasa 30 específica de ubiquitina
JP7297053B2 (ja) 2018-08-20 2023-06-23 アルビナス・オペレーションズ・インコーポレイテッド 神経変性疾患を治療するためのe3ユビキチンリガーゼ結合活性を有するキメラ(protac)化合物を標的とし、アルファ-シヌクレインタンパク質を標的とするタンパク質分解
US20200115389A1 (en) 2018-09-18 2020-04-16 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
MX2021002981A (es) 2018-10-05 2021-05-14 Forma Therapeutics Inc Pirrolinas fusionadas que actuan como inhibidores de la proteasa 30 especifica de la ubiquitina (usp30).
TWI833819B (zh) 2018-10-05 2024-03-01 美商安尼波那生物公司 用於治療與apj受體活性相關的病狀的化合物及組成物
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
JP7119978B2 (ja) * 2018-12-20 2022-08-17 オムロン株式会社 制御装置およびプログラム
WO2020227576A1 (en) * 2019-05-09 2020-11-12 Genentech, Inc. Regio-selective synthesis of imidazo[1,2-a]pyrimidines
CN114867727B (zh) 2019-07-17 2025-02-21 阿尔维纳斯运营股份有限公司 Tau蛋白靶向化合物及相关使用方法
CN113526526A (zh) * 2021-07-12 2021-10-22 苏州大学 氘代氨制备方法及以其作为氘源参与的氘代反应
MX2024002295A (es) 2021-08-27 2024-03-07 Genentech Inc Metodos para tratar las patologias de tau.
EP4536358A1 (en) 2022-06-13 2025-04-16 Genentech Inc. Methods of delaying or preventing the onset of alzheimer's disease using crenezumab
WO2025155625A1 (en) * 2024-01-16 2025-07-24 Eli Lilly And Company Novel compounds for tau imaging
CN118957609B (zh) * 2024-07-23 2025-09-09 无锡绿能电合科技有限公司 一种氟代芳环的氘代方法

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DE76515C (de) F. MORA in Mailand Verfahren zur Herstellung imitirter Ledertapete aus Baumwollstoff
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EP1340759A1 (en) 2002-02-28 2003-09-03 Sanofi-Synthelabo 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
RS56171B1 (sr) 2006-03-30 2017-11-30 Univ Pennsylvania Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova
JP5647519B2 (ja) 2007-09-13 2014-12-24 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化カテコールおよびベンゾ[d][1,3]ジオキソールおよびその誘導体の合成
US8318132B2 (en) 2008-02-14 2012-11-27 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological dysfunction
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
US20100144657A1 (en) 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. PHENYLPIPERIDINE MODULATORS OF mu-OPIOID RECEPTORS
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
ES2797523T3 (es) 2009-03-23 2020-12-02 Lilly Co Eli Agentes de obtención de imagen para detectar trastornos neurológicos
EP2450332A1 (en) 2010-10-22 2012-05-09 Bayer Pharma Aktiengesellschaft Compounds for use in Imaging, diagnosing and/or treatment of diseases of the central nervous system (F-D2-Deprenyl)
BR112013011737A2 (pt) * 2010-11-15 2016-08-09 Univ Leuven Kath composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
CN107011342A (zh) * 2012-05-22 2017-08-04 伊莱利利公司 用于检测神经功能障碍的基于咔啉和咔唑的成像剂
SG11201602786UA (en) * 2013-10-08 2016-05-30 Hoffmann La Roche Diazacarbazole derivatives as tau-pet-ligands
CN106459059B (zh) 2014-05-13 2019-09-24 豪夫迈·罗氏有限公司 氘化杂环化合物和其作为成像剂的用途

Also Published As

Publication number Publication date
PT3143011T (pt) 2021-04-26
IL280791A (en) 2021-04-29
IL280791B2 (en) 2024-03-01
HUE053939T2 (hu) 2021-08-30
KR20230035445A (ko) 2023-03-13
US10076581B2 (en) 2018-09-18
JP2019147825A (ja) 2019-09-05
KR102530129B1 (ko) 2023-05-10
US20230218782A1 (en) 2023-07-13
IL248692B (en) 2020-01-30
US20200297875A1 (en) 2020-09-24
EP3143011A1 (en) 2017-03-22
NZ726208A (en) 2023-11-24
MX2016014615A (es) 2017-03-06
CN106459059B (zh) 2019-09-24
KR102618139B1 (ko) 2023-12-27
BR112016026443A2 (pt) 2017-08-15
IL271631B (en) 2021-05-31
IL248692A0 (en) 2017-01-31
US20190201561A1 (en) 2019-07-04
PL3143011T3 (pl) 2021-07-19
US20160250358A1 (en) 2016-09-01
RU2016147742A3 (lt) 2018-10-08
CN106459059A (zh) 2017-02-22
RU2696492C2 (ru) 2019-08-02
SG10201805628TA (en) 2018-08-30
ES2867814T3 (es) 2021-10-20
US11504440B2 (en) 2022-11-22
CA2948721C (en) 2023-03-28
US12214058B2 (en) 2025-02-04
AU2019203369B2 (en) 2020-06-04
MX376163B (es) 2025-03-07
SG11201609281UA (en) 2016-12-29
AU2019203369A1 (en) 2019-06-06
KR20170002639A (ko) 2017-01-06
WO2015173225A1 (en) 2015-11-19
RU2016147742A (ru) 2018-06-18
DK3143011T3 (da) 2021-05-03
MX384604B (es) 2025-03-14
CA2948721A1 (en) 2015-11-19
CN110483522A (zh) 2019-11-22
SI3143011T1 (sl) 2021-08-31
US10675367B2 (en) 2020-06-09
BR112016026443A8 (pt) 2021-07-06
AU2015261008A1 (en) 2016-11-17
NZ764181A (en) 2023-11-24
IL271631A (en) 2020-02-27
JP6681498B2 (ja) 2020-04-15
EP3901145A1 (en) 2021-10-27
CN110483522B (zh) 2022-05-03
JP2017515856A (ja) 2017-06-15
MX2020010847A (es) 2021-07-16
AU2015261008B2 (en) 2019-02-14
JP6529986B2 (ja) 2019-06-12
EP3143011B1 (en) 2021-03-03
RS61810B1 (sr) 2021-06-30
IL280791B1 (en) 2023-11-01
HRP20210641T1 (hr) 2021-05-28

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