[go: up one dir, main page]

LT2523669T - Akispūdžio mažinimo būdas, derinys ir rinkinys - Google Patents

Akispūdžio mažinimo būdas, derinys ir rinkinys

Info

Publication number
LT2523669T
LT2523669T LTEP11732309.7T LT11732309T LT2523669T LT 2523669 T LT2523669 T LT 2523669T LT 11732309 T LT11732309 T LT 11732309T LT 2523669 T LT2523669 T LT 2523669T
Authority
LT
Lithuania
Prior art keywords
kit
combination
intraocular pressure
reducing intraocular
reducing
Prior art date
Application number
LTEP11732309.7T
Other languages
English (en)
Inventor
Norman N. Kim
William K. Mcvicar
Thomas Mccauley
Rudolf A. Baumgartner
Original Assignee
Inotek Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44258984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2523669(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inotek Pharmaceuticals Corporation filed Critical Inotek Pharmaceuticals Corporation
Publication of LT2523669T publication Critical patent/LT2523669T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
LTEP11732309.7T 2010-01-11 2011-01-11 Akispūdžio mažinimo būdas, derinys ir rinkinys LT2523669T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29380610P 2010-01-11 2010-01-11
PCT/US2011/020808 WO2011085361A1 (en) 2010-01-11 2011-01-11 Combination, kit and method of reducing intraocular pressure

Publications (1)

Publication Number Publication Date
LT2523669T true LT2523669T (lt) 2017-04-25

Family

ID=44258984

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11732309.7T LT2523669T (lt) 2010-01-11 2011-01-11 Akispūdžio mažinimo būdas, derinys ir rinkinys

Country Status (29)

Country Link
US (3) US8877732B2 (lt)
EP (1) EP2523669B1 (lt)
JP (2) JP2013516495A (lt)
KR (1) KR20120115344A (lt)
CN (1) CN102711771B (lt)
AU (1) AU2011203897B2 (lt)
BR (1) BR112012017106A2 (lt)
CA (1) CA2784908A1 (lt)
CL (1) CL2012001912A1 (lt)
CO (1) CO6571924A2 (lt)
CY (1) CY1118510T1 (lt)
DK (1) DK2523669T3 (lt)
EA (1) EA025415B1 (lt)
ES (1) ES2613698T3 (lt)
HR (1) HRP20170007T1 (lt)
HU (1) HUE030566T2 (lt)
IL (1) IL220604A (lt)
IN (1) IN2012DN06592A (lt)
LT (1) LT2523669T (lt)
ME (1) ME02608B (lt)
MX (1) MX2012007661A (lt)
PH (1) PH12012501320A1 (lt)
PL (1) PL2523669T3 (lt)
PT (1) PT2523669T (lt)
RS (1) RS55615B1 (lt)
SG (2) SG10201502588UA (lt)
SI (1) SI2523669T1 (lt)
SM (2) SMT201700017T1 (lt)
WO (1) WO2011085361A1 (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5778663B2 (ja) * 2009-05-01 2015-09-16 イノテック ファーマシューティカルズ コーポレイション ヒトの眼圧を低下させるための医薬組成物
AU2011203897B2 (en) * 2010-01-11 2016-11-17 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
KR20130029050A (ko) 2010-03-26 2013-03-21 이노텍 파마슈티컬스 코포레이션 Ｎ6-시클로펜틸아데노신(ｃｐａ), ｃｐａ 유도체 또는 이의 전구 약물을 사용하여 사람의 안압을 감소시키는 방법
US9278991B2 (en) * 2012-01-26 2016-03-08 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
JP2016513706A (ja) 2013-03-15 2016-05-16 イノテック ファーマシューティカルズ コーポレイション 点眼用製剤
EA201591434A1 (ru) * 2013-03-15 2016-03-31 Инотек Фармасьютикалс Корпорейшн Способ обеспечения глазной нейропротекции
KR20170076673A (ko) 2014-10-24 2017-07-04 오노 야꾸힝 고교 가부시키가이샤 Kcnq2∼5 채널 활성화제
AU2015358576A1 (en) * 2014-12-03 2017-06-22 Inotek Pharmaceuticals Corporation Methods of preventing, reducing or treating macular degeneration

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4935635B1 (lt) 1970-12-28 1974-09-25
CH563405A5 (lt) 1971-09-10 1975-06-30 Duschinsky Robert Dr Schweiz I
DE2226295A1 (de) 1972-05-30 1973-12-20 Henning Berlin Gmbh Salpetersaeureester von purinnucleosiden und verfahren zur herstellung derselben
DE2342479A1 (de) 1973-08-23 1975-03-13 Merck Patent Gmbh Ribonucleosid-5'-nitrate und verfahren zu ihrer herstellung
GB2001976B (en) 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
US4849311A (en) 1986-09-24 1989-07-18 Toa Nenryo Kogyo Kabushiki Kaisha Immobilized electrolyte membrane
US4968697A (en) 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5219840A (en) 1987-04-06 1993-06-15 Sandoz Ltd. Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
DE1300150T1 (de) 1988-09-06 2003-09-18 Pharmacia Ab, Stockholm Prostaglandin-Derivate zur Behandlung von Glaukom oder Augenüberdruck
US5140015A (en) 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5280015A (en) 1990-09-05 1994-01-18 The United States Of America As Represented By The Department Of Health And Human Services 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides
JP3020580B2 (ja) 1990-09-28 2000-03-15 株式会社日立製作所 マイクロ波プラズマ処理装置
US5206222A (en) 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
US5278150A (en) 1992-04-24 1994-01-11 Whitby Research, Inc. 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions
DK62692D0 (lt) 1992-05-14 1992-05-14 Novo Nordisk As
AU4772493A (en) 1992-07-15 1994-02-14 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Sulfo-derivatives of adenosine
US5972991A (en) * 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5338430A (en) 1992-12-23 1994-08-16 Minnesota Mining And Manufacturing Company Nanostructured electrode membranes
US5443836A (en) 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5773423A (en) 1993-07-13 1998-06-30 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
US5589467A (en) 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
WO1995011681A1 (en) 1993-10-29 1995-05-04 Merck & Co., Inc. Human adenosine receptor antagonists
US5620676A (en) 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
EP0704215A3 (en) 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Inhibitor of vascular permeability enhancer
GB9414193D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
US5801159A (en) 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
CN1164122A (zh) 1996-03-01 1997-11-05 株式会社日立制作所 等离子处理机及其处理方法
WO1997033590A1 (en) 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033879A1 (en) 1996-03-15 1997-09-18 Merck & Co., Inc. Compounds and methods for selectively inhibiting activation of the human a3 adenosine receptor
US5789416B1 (en) 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
CA2289731A1 (en) 1997-05-09 1998-11-12 The United States Of America, Represented By The Secretary, Department O F Health And Human Services Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
CA2306096A1 (en) 1997-10-15 1999-04-22 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
WO1999020284A1 (en) 1997-10-23 1999-04-29 Trustees Of The University Of Pennsylvania Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid a and adenosine receptor agents
GB9723590D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
GB9723566D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
FR2775901B1 (fr) 1998-03-13 2000-07-21 Logeais Labor Jacques Sels de cetoacides et de derives amines, et leur utilisation pour la preparation de medicaments
GB9813535D0 (en) 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
AU765423B2 (en) 1998-07-16 2003-09-18 Government Of The United States Of America, The Methods for reducing intraocular pressure
ATE331726T1 (de) 1998-10-16 2006-07-15 Pfizer Adenine-derivate
IL127947A0 (en) 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US6180615B1 (en) 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
DE60006116T2 (de) 1999-06-22 2004-07-08 CV Therapeutics, Inc., Palo Alto A2a rezeptor agonisten
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives
US6368573B1 (en) 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6258793B1 (en) 1999-12-03 2001-07-10 Cv Therapeutics, Inc. N6 heterocyclic 5′ modified adenosine derivatives
GB9930071D0 (en) 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB0003960D0 (en) 2000-02-18 2000-04-12 Pfizer Ltd Purine derivatives
US20010051612A1 (en) 2000-02-23 2001-12-13 Gloria Cristalli 2-Thioether A2A receptor agonists
US20030010454A1 (en) 2000-03-27 2003-01-16 Bailey Andrew D. Method and apparatus for varying a magnetic field to control a volume of a plasma
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US6753322B2 (en) 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
JP2004518612A (ja) 2000-07-28 2004-06-24 インスパイアー ファーマシューティカルズ，インコーポレイティド インドール誘導体を用いて眼圧を下降させる方法
AU2002219497B2 (en) 2001-01-16 2004-08-26 Can-Fite Biopharma Ltd. Use of an adenosine A3 receptor agonist for inhibition of viral replication
GB2372742A (en) 2001-03-03 2002-09-04 Univ Leiden C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
US20040204481A1 (en) 2001-04-12 2004-10-14 Pnina Fishman Activation of natural killer cells by adenosine A3 receptor agonists
US20030013675A1 (en) 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
WO2003013683A1 (en) 2001-08-08 2003-02-20 Brown University Research Foundation Methods for micronization of hydrophobic drugs
NZ532062A (en) 2001-10-01 2006-09-29 Univ Virginia 2-propynyl adenosine analogues having A2 adenosine recepter agonist activity and compositions thereof to treat inflammatory responses
CA2482928A1 (en) 2002-04-18 2003-10-30 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside
BR0309623A (pt) 2002-04-30 2005-02-09 Alcon Inc Agentes que regulam. inibem ou modulam a atividade e/ou a expressão do fator de crescimento de tecido conjuntivo (ctgf) como um único meio de diminuir a pressão intraocular e tratar retinopatias glaucomatosas/neuropatias ópticas
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
CA2551169A1 (en) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
GB2436255B (en) 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
US8008338B2 (en) 2003-06-03 2011-08-30 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
AU2005207037A1 (en) 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
ME01072B (me) 2004-05-26 2012-10-20 Inotek Pharmaceuticals Corp Derivati purina kao agonisti receptora adenozina a1 i postupci za njihovu upotrebu
CN101010085B (zh) 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
EP1768991A1 (en) 2004-07-12 2007-04-04 Cv Therapeutics, Inc. Process for the preparation of a1-adenosine receptor agonists
KR101289917B1 (ko) * 2004-10-18 2013-07-25 폴리문 사이언티픽 임무노이비오로기쉐 포르슝 게엠베하 평활근을 이완시키기 위한 활성 성분을 함유하는 리포좀조성물, 이런 조성물의 생산 및 이의 치료적 용도
WO2007002139A2 (en) 2005-06-22 2007-01-04 The Trustees Of The University Of Pennsylvania Neuroprotection of retinal ganglion cells
NZ568392A (en) * 2005-11-30 2011-07-29 Inotek Pharmaceuticals Corp Purine derivatives and methods of use thereof
EP2397148A3 (en) 2006-02-02 2012-04-25 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
US8784886B2 (en) 2006-03-09 2014-07-22 GlaxoSmithKline, LLC Coating capsules with active pharmaceutical ingredients
WO2007111954A2 (en) 2006-03-23 2007-10-04 Inotek Phamaceuticals Corporation Purine compounds and methods of use thereof
US8163737B2 (en) 2006-06-13 2012-04-24 Vertex Pharmaceuticals Incorporated CGRP receptor antagonists
AR062046A1 (es) 2006-07-25 2008-08-10 Osmotica Pharmaceutical Argentina S A Soluciones oftalmicas
JP2010505848A (ja) 2006-10-06 2010-02-25 ザ トラスティーズ オヴ ザ ユニヴァーシティー オヴ ペンシルバニア 眼内圧を低下させるための種交差性ａ３アデノシン受容体アンタゴニストの効果的送達
MX2009004316A (es) 2006-11-10 2009-05-05 Basf Se Nueva modificacion cristalina.
US8648169B2 (en) 2006-12-05 2014-02-11 The Royal Institution For The Advancement Of Learning/Mcgill University Methods of use of Trk receptor modulators
JP2008266143A (ja) 2007-04-16 2008-11-06 Santen Pharmaceut Co Ltd アデノシン誘導体を有効成分として含有する緑内障治療剤
CN101980603A (zh) 2007-10-11 2011-02-23 比奥根艾迪克Ma公司 LINGO-1和TrkB拮抗剂的用途
WO2009076580A2 (en) 2007-12-12 2009-06-18 Thomas Jefferson University Compositions and methods for the treatment and prevention of cardiovascular diseases
CN101983062A (zh) 2008-02-07 2011-03-02 吉利德帕洛阿尔托股份有限公司 提高abca-1的化合物及其用途
CA3019967A1 (en) 2008-11-13 2010-05-20 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation of bmp-6
JP5778663B2 (ja) 2009-05-01 2015-09-16 イノテック ファーマシューティカルズ コーポレイション ヒトの眼圧を低下させるための医薬組成物
EP2493480A4 (en) 2009-10-26 2013-04-10 Inotek Pharmaceuticals Corp OPHTHALMIC FORMULATION AND MANUFACTURING METHOD THEREFOR
WO2011077435A1 (en) 2009-12-22 2011-06-30 Bar-Ilan University Compositions and methods for reducing intraocular pressure
AU2011203897B2 (en) 2010-01-11 2016-11-17 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US20110217262A1 (en) 2010-03-05 2011-09-08 Kornfield Julia A Treatment of Ocular Surface Disorders by Increasing Conjunctival Vascular Permeability
SMT201700020T1 (it) * 2010-03-19 2017-03-08 Inotek Pharmaceuticals Corp Combinazione di composizioni di antagonisti di adenosina a1 e bloccanti di recettori non selettivi beta-adrenergici per ridurre la pressione intraoculare
ME02593B (me) 2010-03-19 2017-06-20 Inotek Pharmaceuticals Corp Kombinovane kompozicije adenozinskih a1 agonista i inhibitora ugljene anhidraze za snižavanje intraokularnog pritiska
KR20130029050A (ko) * 2010-03-26 2013-03-21 이노텍 파마슈티컬스 코포레이션 Ｎ6-시클로펜틸아데노신(ｃｐａ), ｃｐａ 유도체 또는 이의 전구 약물을 사용하여 사람의 안압을 감소시키는 방법
MX2012010723A (es) 2010-03-26 2012-11-12 Inotek Pharmaceuticals Corp Compuestos de adenosina y uso de los mismos.

Also Published As

Publication number Publication date
US20160367586A1 (en) 2016-12-22
BR112012017106A2 (pt) 2018-05-29
EP2523669A4 (en) 2013-08-28
HRP20170007T1 (hr) 2017-03-10
EA025415B1 (ru) 2016-12-30
CA2784908A1 (en) 2011-07-14
RS55615B1 (sr) 2017-06-30
AU2011203897A1 (en) 2012-08-09
US20150038448A1 (en) 2015-02-05
HUE030566T2 (en) 2017-05-29
CY1118510T1 (el) 2017-07-12
EP2523669B1 (en) 2016-12-07
SMT201700017T1 (it) 2017-03-08
IN2012DN06592A (lt) 2015-10-23
JP2016040320A (ja) 2016-03-24
SG182285A1 (en) 2012-08-30
US8877732B2 (en) 2014-11-04
ME02608B (me) 2017-06-20
CN102711771B (zh) 2016-05-18
SMT201700017B (it) 2017-03-08
JP2013516495A (ja) 2013-05-13
CO6571924A2 (es) 2012-11-30
EP2523669A1 (en) 2012-11-21
US20110172177A1 (en) 2011-07-14
CN102711771A (zh) 2012-10-03
IL220604A0 (en) 2012-08-30
PT2523669T (pt) 2017-01-31
KR20120115344A (ko) 2012-10-17
PH12012501320A1 (en) 2013-01-21
WO2011085361A1 (en) 2011-07-14
CL2012001912A1 (es) 2013-04-19
DK2523669T3 (en) 2017-02-06
MX2012007661A (es) 2012-08-01
AU2011203897B2 (en) 2016-11-17
IL220604A (en) 2017-01-31
EA201201011A1 (ru) 2012-12-28
SG10201502588UA (en) 2015-05-28
US9370530B2 (en) 2016-06-21
ES2613698T3 (es) 2017-05-25
SI2523669T1 (sl) 2017-05-31
PL2523669T3 (pl) 2017-06-30

Similar Documents

Publication Publication Date Title
SI2408337T1 (sl) Blazina, komplet in postopek izdelave
IL248530A0 (en) Biomarkers and treatment methods
SMT202200371T1 (it) Determinate triazolopirazine, loro composizioni e loro metodi d'uso
IL220261A0 (en) Intraocular devices and associated methods
PL2397069T3 (pl) Analiza ciśnienia wewnątrzgałkowego
ZA201208578B (en) Composition,method and use
GB2481911B (en) Hard face structure, body comprising same and method for making same
EP2437602A4 (en) OPHTHALMIC FORMULATIONS, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE
WO2011075731A3 (en) Tissue expanders and methods of use
IL220604A0 (en) Combination, kit and method of reducing intraocular pressure
IL216081A0 (en) Method of reducing intraocular pressure in humans
GB201117106D0 (en) Prosthesis and methods and uses involving said prosthesis
ZA201203025B (en) Connector, and methods of use
EP2592069A4 (en) PROCESS FOR THE PREPARATION OF TOLUENEDICARBAMATE, METHOD FOR THE PRODUCTION OF TOLUENEDIISOCYANATE AND TOLUENEDICARBAMATE
GB2488494B (en) Solution, use and method of preparation thereof
GB0912744D0 (en) Methods and uses
GB0909380D0 (en) Method and use
PL390250A1 (pl) Zawór oraz sposób modyfikacji zaworu
HK1187109A (zh) 生物標記物和處理方法
HK1179148A (en) Inflatable prostheses and methods of making same
GB201118217D0 (en) Carrier, kit and method of use
PL391368A1 (pl) Nowy 3β, 11α-dihydroksy-17a-oxa-D-homo-androst-5-en-17-on oraz sposób jego wytwarzania
PL387345A1 (pl) Fotokatalizatory hybrydowe, sposób ich otrzymywania oraz ich zastosowanie
ZA201301175B (en) Biomarkers and methods of treatment
GB0920904D0 (en) Uses and methods