[go: up one dir, main page]

LT2015064A - Karboanhidrazės selektyvūs inhibitoriai - Google Patents

Karboanhidrazės selektyvūs inhibitoriai

Info

Publication number
LT2015064A
LT2015064A LT2015064A LT2015064A LT2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A
Authority
LT
Lithuania
Prior art keywords
carbonic anhydrase
selective inhibitors
compounds
benzenesulfonamides
biomedicine
Prior art date
Application number
LT2015064A
Other languages
English (en)
Other versions
LT6401B (lt
Inventor
Daumantas Matulis
Edita Čapkauskaitė
Audrius Zakšauskas
Vaida Morkūnaitė
Original Assignee
Vilniaus Universitetas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vilniaus Universitetas filed Critical Vilniaus Universitetas
Priority to LT2015064A priority Critical patent/LT6401B/lt
Priority to PCT/IB2015/056626 priority patent/WO2017017505A1/en
Priority to EP15766651.2A priority patent/EP3328833B1/en
Priority to US15/748,559 priority patent/US11312682B2/en
Publication of LT2015064A publication Critical patent/LT2015064A/lt
Publication of LT6401B publication Critical patent/LT6401B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Išradimas yra susijęs su naujais junginiais - benzensulfonamidais, kurių bendros formulės (I) ir (II). Junginiai gali būti naudojami biomedicinoje, kaip aktyvūs farmakologiniai ingredientai, nes jie slopina fermentus, dalyvaujančius ligos progresavime.
LT2015064A 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai LT6401B (lt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai
PCT/IB2015/056626 WO2017017505A1 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase
EP15766651.2A EP3328833B1 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase
US15/748,559 US11312682B2 (en) 2015-07-28 2015-09-01 Selective inhibitors of carbonic anhydrase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai

Publications (2)

Publication Number Publication Date
LT2015064A true LT2015064A (lt) 2017-02-27
LT6401B LT6401B (lt) 2017-06-12

Family

ID=54148589

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2015064A LT6401B (lt) 2015-07-28 2015-07-28 Karboanhidrazės selektyvūs inhibitoriai

Country Status (4)

Country Link
US (1) US11312682B2 (lt)
EP (1) EP3328833B1 (lt)
LT (1) LT6401B (lt)
WO (1) WO2017017505A1 (lt)

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2910488A (en) 1958-01-22 1959-10-27 Merck & Co Inc Aniline derivatives
US3291824A (en) 1962-04-06 1966-12-13 Hoffmann La Roche Nu-(2-halo-lower alkanoyl) anthranilic acid derivatives
DE1240873B (de) * 1964-12-08 1967-05-24 Hoechst Ag Verfahren zur Herstellung von 4-Halogen-5-sulfamylanthranilsaeure-hydroxamiden
NL139742B (nl) * 1965-06-05 1973-09-17 Hoechst Ag Werkwijze voor het bereiden van n-benzyl- en n-furfuryl-5sulfamylantranilzuren.
DE1806279C2 (de) * 1968-06-27 1970-10-29 Hoechst Ag Verfahren zur Herstellung von Sulfamyl-anthranilsaeuren
US3567746A (en) 1968-07-10 1971-03-02 Pennwalt Corp N-aryl benzamides
DE2031067A1 (de) 1970-02-18 1971-09-02 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt, Budapest Verfahren zur Herstellung von 2 Fur furylamino 4 chlor 5 sulfamoyl benzoe saure
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines
JPS58124767A (ja) * 1982-01-21 1983-07-25 Mitsui Toatsu Chem Inc スルファモイル安息香酸誘導体
FR2540870A1 (fr) 1983-02-15 1984-08-17 Provesan Sa Nouveaux derives de betaines n-iminopyridinium, leur preparation et leur application en tant que medicaments
DE4430212A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Ortho-substituierte Benzoesäure-Derivate
DE19742951A1 (de) * 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
PT1230243E (pt) 1999-11-12 2009-06-12 Biogen Idec Inc Policicloalquilpurinas como antagonistas dos receptores da adenosina
US7550424B2 (en) 2002-11-26 2009-06-23 Institute Of Virology Slovak Academy Of Sciences CA IX-specific inhibitors
CN1744899A (zh) 2002-12-13 2006-03-08 史密丝克莱恩比彻姆公司 作为ccr5拮抗剂的哌啶衍生物
EP1668008A4 (en) 2003-08-28 2009-02-25 Nitromed Inc NITROSED AND NITROSYLATED DIETETIC COMPOUNDS, COMPOSITIONS AND APPLICATION METHODS
CN1921845A (zh) 2004-02-20 2007-02-28 安万特药物公司 作为hm74调节剂的呋塞米衍生物以及它们用于治疗炎症的用途
WO2005107470A2 (en) 2004-04-29 2005-11-17 University Of Florida Research Foundation, Inc. Use of carbonic anhydrase inhibitors for insect control and malaria treatment
KR101242310B1 (ko) * 2004-05-17 2013-03-12 오츠카 세이야쿠 가부시키가이샤 티아졸 화합물 및 그의 용도
CA2574535A1 (en) 2004-11-15 2006-05-26 Nitromed, Inc. Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
WO2006137092A1 (en) 2005-06-23 2006-12-28 Supuran Claudiu T Fluorescent sulfonamide derivatives having carbonic anhydrase inhibiting activity and their use as theapeutic and diagnostic agents
US7763612B2 (en) 2006-01-03 2010-07-27 Algebra, Inc. Therapeutic amine-arylsulfonamide conjugate compounds
WO2008052190A2 (en) 2006-10-26 2008-05-02 Flynn Gary A Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance
WO2008071421A1 (en) 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
JP2010523599A (ja) 2007-04-05 2010-07-15 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド クリックケミストリーを使用した炭酸脱水酵素−ｉｘのための分子イメージングプローブの開発
EP2823826A3 (en) 2008-01-09 2015-03-25 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX
WO2010085352A2 (en) 2009-01-22 2010-07-29 Neurotherapeutics Pharma, Inc. Bumetanide, furosemide, piretanide, azosemide, and torsemide analogs, compositions and methods of use
EP2533775A1 (en) 2010-02-12 2012-12-19 Universita' Degli Studi di Firenze Carbonic anhydrase inhibitors
EP2598478A2 (en) 2010-07-26 2013-06-05 Neurotherapeutics Pharma, Inc. Arylsulfonamide derivatives, compositions, and methods of use
WO2012070024A1 (en) 2010-11-28 2012-05-31 Metasignal Therapeutics Inc. Carbonic anhydrase inhibitors with antimetastatic activity
NL1038473C2 (en) 2010-12-24 2012-06-27 Centre Nat Rech Scient Cancer targeting using carbonic anhydrase isoform ix inhibitors.
WO2012175654A1 (en) 2011-06-23 2012-12-27 Facultes Universitaires Notre-Dame De La Paix Tetraline sulfonamide derivatives for use in the treatment of proliferative disorders
CZ2011676A3 (cs) 2011-10-24 2013-05-02 Ústav organické chemie a biochemie Akademie ved CR, v.v.i. Inhibitory karbonické anhydrasy, zpusob jejich prípravy
EP2800471A4 (en) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE
LT6064B (lt) 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
WO2015025283A2 (en) 2013-08-20 2015-02-26 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Dual action carbonic anhydrase inhibitors

Also Published As

Publication number Publication date
WO2017017505A1 (en) 2017-02-02
US20180222856A1 (en) 2018-08-09
LT6401B (lt) 2017-06-12
EP3328833B1 (en) 2025-08-06
EP3328833A1 (en) 2018-06-06
US11312682B2 (en) 2022-04-26

Similar Documents

Publication Publication Date Title
MX2022009148A (es) Composiciones y metodos para el tratamiento de hemoglobinopatias.
EA201890204A1 (ru) Антибактериальные соединения
MX2018013983A (es) Inhibidores g12c de kras.
MX2018003353A (es) Terapias con celulas cart con una eficacia mejorada.
EA201990043A1 (ru) Антибактериальные соединения
EA201790273A1 (ru) Флагеллиновые композиции и их применение
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
EA201792205A1 (ru) Гетероциклические соединения как ингибиторы lsd1
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
EA201792535A1 (ru) Гетероциклические амиды в качестве ингибиторов киназ
EA201692425A1 (ru) Модифицированные биополимеры и способы их получения и использования
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
MX385082B (es) Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.
MX382624B (es) Compuestos farmacéuticos.
EA202091397A1 (ru) Бензохинолоновые ингибиторы vmat2
MX388301B (es) Il-23a y tnf-alfa orientados y compuesto y sus usos.
TR201908247T4 (tr) Sodyum glikoz birlikte taşıyıcı 1 inhibitörleri.
DK3127428T3 (da) Anvendelse af forgreningsenzym ec 2.4.1.18 til forbedring af sammenhængskraft i brød
MX373320B (es) Compuestos inhibidores de pde2.
EA201600124A1 (ru) Новые индолизиновые соединения, способ их получения и фармацевтические композиции, содержащие их
EA201692313A1 (ru) Производные индолизина в качестве ингибиторов фосфоинозитид-3-киназ
LT3288944T (lt) Imidazopirazinonai, kaip pde1 inhibitoriai
IL253619B (en) Encapsulation of high potency active agents
EA201890810A1 (ru) Соединения, эффективные для лечения гепатотоксичности и стеатоза печени, и их применение
EA201692548A1 (ru) Минеральные аминокислотные комплексы активных веществ

Legal Events

Date Code Title Description
BB1A Patent application published

Effective date: 20170227

FG9A Patent granted

Effective date: 20170612

MM9A Lapsed patents

Effective date: 20200728