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KR970703137A - 배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) - Google Patents

배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) Download PDF

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Publication number
KR970703137A
KR970703137A KR1019960706510A KR19960706510A KR970703137A KR 970703137 A KR970703137 A KR 970703137A KR 1019960706510 A KR1019960706510 A KR 1019960706510A KR 19960706510 A KR19960706510 A KR 19960706510A KR 970703137 A KR970703137 A KR 970703137A
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KR
South Korea
Prior art keywords
molecular weight
drug
transdermal
urination
agent
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Ceased
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KR1019960706510A
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English (en)
Inventor
가츠히로 나카무라
노부유키 고가
Original Assignee
나카토미 히로타카
히사미츠 세이야쿠 가부시키가이샤
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Publication of KR970703137A publication Critical patent/KR970703137A/ko
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

배뇨장해치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌 및 유지를 주기제로 함유하는 점착제 중에 함유시켜서 구성되는 배뇨장해치료용 경피투여제제이다. 또, 배뇨장해 치료약은 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌, 유지 및 스티렌이소프렌스티렌블록 공중합체를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 배뇨장해치료용 경피투여제제이다. 본 발명의 배뇨장해치료용 경피투여제제는 이와 같은 특정 기제성분을 사용함으로써 경시적 안정성이 우수하고, 피부에 대해여 저자극성이고, 게다가 경피흡수성에도 우수하다.

Description

배뇨장해 치료용 경피투여제제(PERCUTANEOUSLY ADMINISTRABLBLE PREPARATION FOR TREATING URINATION DISORDER)
[도면의 간단한 설명]
제1도는 래트에 의한 경피흡수시험결과를 도시한다,
제2도는 사람 피부에 의한 경피흡수시험결과를 도시한다,
제1도 및 제2도에 있어서, ○은 하기의 실시예 1의 제제, ●은 하기 실시예 2의 제제, □은 하기 실시예 3의 제제, ■은 하기 실시예 4의 제제, ◇은 하기 실시예 5의 제제, ×는 하기 실시예 6의 제제,은 하기 실시예 7의 제제, ◆은 하기 비교예 1의 제제, △은 하기 비교예 2의 제제, □은 하기 비교예 3의 제제, |은 하기 비교예 4의 제제,은 하기 비교예 19의 제제,비교예 20의 제제의 결과를 나타낸다.
제3도는 래트에 의한 시스토메트리법에 의한 약효 평가시험 결과를 도시한다.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 배뇨장해 치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌 및 유지를 주기제로서 함유하는 점착제중에 함유시켜서 구성되는 배뇨장해 치료용 경피투여제제.
  2. 제1항에 있어서, 상기 점착제의 전체중량에 의거하여, 상기 배뇨장해치료약 0.01∼50중량부를 상기 저분자량 폴리이소부틸렌 1∼60중량부, 상기 고분자량 폴리이소부틸렌 0.1∼40중량부 및 상기 유지 10∼60중량부를 주기제로서 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  3. 배뇨장해치료약을 저분자량 폴리이소부틸렌, 고분자량 폴리이소부틸렌, 유지 및 스티렌이소프렌스티렌블록 공중합체를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  4. 제3항에 있어서, 상기 점착제의 전체중량에 의거하여, 상기 배뇨장해치료약 0.01∼50중량부를 상기 저분자량 폴리이소부틸렌 1∼60중량부, 상기 고분자량 폴리이소부틸렌 0.1∼40중량부, 상기 유지 10∼60중량부 및 상기 스티렌이소프렌스티렌블록 공중합체 5∼50중량부를 주기제로 함유하는 점착제중에 함유시켜서 구성되는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 배뇨장해치료약이 요실금치료약, 배뇨곤란치료약, 빈뇨치료약 또는 배뇨통 치료약인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  6. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 배뇨장해치료약이 요실금치료약인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  7. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 저분자량 폴리이소부틸렌의 점도평균 분자량이 10,000∼100,000이고, 상기 고분자량 폴리이소부틸렌의 점도평균 분자량이 500,000∼2,500,000인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  8. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 유지가 점도 5∼100mm2/S의 유동 파라핀, 천연 및 합성 스쿠알렌 및 스쿠알란으로 이루어지는 군에서 선택된 적어도 1종인 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
  9. 제l항 내지 제8항 중 어느 한 항에 있어서, 경피흡수촉진제를 더 포함하는 것을 특징으로 하는 배뇨장해 치료용 경피투여제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960706510A 1994-05-18 1995-05-18 배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder) Ceased KR970703137A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12816294 1994-05-18
JP94-128162 1994-05-18
PCT/JP1995/000946 WO1995031190A1 (en) 1994-05-18 1995-05-18 Percutaneously administrable preparation for treating urination disorder

Publications (1)

Publication Number Publication Date
KR970703137A true KR970703137A (ko) 1997-07-03

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KR1019960706510A Ceased KR970703137A (ko) 1994-05-18 1995-05-18 배뇨장해 치료용 경피투여제제(percutaneously administrable preparation for treating urination disorder)

Country Status (8)

Country Link
US (1) US5770221A (ko)
EP (1) EP0760238B1 (ko)
KR (1) KR970703137A (ko)
AU (1) AU2454495A (ko)
DE (1) DE69526437T2 (ko)
DK (1) DK0760238T3 (ko)
ES (1) ES2172584T3 (ko)
WO (1) WO1995031190A1 (ko)

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Also Published As

Publication number Publication date
AU2454495A (en) 1995-12-05
EP0760238B1 (en) 2002-04-17
DK0760238T3 (da) 2002-07-22
EP0760238A1 (en) 1997-03-05
DE69526437T2 (de) 2002-10-31
WO1995031190A1 (en) 1995-11-23
EP0760238A4 (en) 1998-06-03
DE69526437D1 (de) 2002-05-23
ES2172584T3 (es) 2002-10-01
US5770221A (en) 1998-06-23

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