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KR970703112A - 조직을 모니터하는 방법(tissue monitor) - Google Patents

조직을 모니터하는 방법(tissue monitor) Download PDF

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KR970703112A
KR970703112A KR1019960706916A KR19960706916A KR970703112A KR 970703112 A KR970703112 A KR 970703112A KR 1019960706916 A KR1019960706916 A KR 1019960706916A KR 19960706916 A KR19960706916 A KR 19960706916A KR 970703112 A KR970703112 A KR 970703112A
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signal
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마예프스키 아브라함
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

본 발명은 체조직의 동일 부피 엘리먼트의 다양한 변수를 모니터하기 위하 단일 시그날-단일 프로브 다중변수 분석 장치로서, 입력 시그날 발생기, 입력 시그날을 전달시키고, 출력 시그날을 전달시키며, 단일 시그날-시그날 프로브로 구성된 단일 시그날 가이드, 출력 시그날이 2 부분 이상으로 분할시키는 시그날 스플릿터, 출력 시그날의 다양한 성분을 분리시키는 2개 이상의 필터, 출력 시그날의 상이한 성분들을 측정하는 2개 이상의 검출기, 컴퓨터 및 아날로그 대 디지탈 변환기, 및 자료 평가용 알고리즘으로 이루어지는 장치에 관한 것이다.

Description

조직을 모니터하는 방법(TISSUE MONITOR)
[도면의 간단한 설명]
제7도는 뇌 기능 분석기의 개략도이다.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (21)

  1. 동일 부피의 체조직 엘리먼트에 대한 다양한 변수를 모니터하기 위한 단일 시그날-단일 프로브 방식의 다중변수 분석 장치로서, (a) 입력 시그날 발생기; (b) 단일 시그날-단일 프로브로 구성되고, 입력 시그날 및 출력 시그날을 내외로 전달시키는 단일 시그날 가이드; (c) 출력 시그날을 2개 이상의 부분들로 분할시키는 시그날 스플릿터; (d) 출력 시그날의 다양한 성분을 분리시키는 2개 이상의 필터; (e) 출력 시그날의 상이한 성분들을 측정하는 2개 이상의 검출기; (f) 컴퓨터 및 아날로그 대 디지탈 변환기; 및 (g) 자료 평가용 알고리즘으로 이루어지는 분석 장치.
  2. 제1항에 있어서, (i) 입력 시그날 발생기가 광원이고; (ii) 시그날 가이드가 Y형의 광섬유로서, Y의 한가지로부터 입력 시그날을 전달시키고, Y의 다른 가지로부터 출력 시그날을 전달시키며; (iii) 시그날 스플릿터가 광 스플릿터이고; (iv) 시그날 필터가 광 필터이고; (v) 검출기는 반사광이나 또는 형광으로부터 입사되는 방사선의 다양한 특징을 측정하는 분석 장치인 것을 특징으로 하는, 동일 부피 조직 엘리먼트의 산화 환원 상태(NADH) 및 미소순환 혈류(MBF)를 동시에 모니터하는 분석 장치.
  3. 제2항에 있어서, 시그날 가이드가 시그날 입력을 위한 제1그룹, 및 시그날 출력을 위한 제2그룹으로 이루어지는 다양한 그룹의 광섬유를 포함하는 것을 특징으로 하는 분석 장치.
  4. 제2항에 있어서, 상기 광원이 수은 램프(366nm)인 것을 특징으로 하는 분석 장치.
  5. 제2항에 있어서, 상기 광원이 He-Cd 레이저(324nm)인 것을 특징으로 하는 분석 장치.
  6. 제2항에 있어서, 제1검출기는 450nm 형광을 투과시키는 필터를 구비한 포토멀티플리어 튜브를 통해 입사방사선을 측정하고, 제2검출기는 반사광(324 또는 366nm)을 투과시키는 필터를 구비한 도플러 분석기인 것을 특징으로 하는 분석 장치.
  7. 제2항에 있어서, 방사선을 측정하는 제3장치는 도플러 분석기 및 450nm 방사선을 모니터하는 포토멀티플리어와 조합 상태로 사용되는 또다른 포토멀티플리어내로 반사광(324 또는 366nm)을 투과시키는 필터를 구비한 반사계인 것을 특징으로 하는 분석 장치.
  8. 동일 부피 조직 엘리먼트의 산화환원 상태(NADH) 및 혈류(MBF), 그리고 상기 영역에서의 전기피질 활성도(ECoG)를 동시에 모니터하기 위한 2중 시그날-2중 프로브 다중변수 분석 장치로서, 광원; 광 시그날 입력 및 출력 전달용 광섬유의 광 가이드, 및 전기시그날 전달용 절연된 2개의 백금 와이어를 함께 탑재하고, 2중 시그날-2중 프로브를 포함하는 프로브; 전기시그날을 증폭시키는 증폭기; 출력 시그날을 다양한 검출기 및 분석기에 분할시키는 광 스플릿터; 선택된 파장만을 통과시키는 광 필터; 목적 파장의 입사되는 방사선을 측정하는 포트멀티플리어 튜브; 도플러 분석기; 아날로그 대 디지탈 변환기 및 컴퓨터; 및 자료 평가용 알고리즘으로 이루어지는 분석 장치.
  9. 제8항에 있어서, 2중 시그날 단일 프로브가 절연된 2개의 백금 와이어와 함께 불규칙하게 혼합된 (NADH) 및 MBF 모니터용 광 가이드로서의 2그룹의 광섬유로 이루어지는 것을 특징으로 하는 분석 장치.
  10. 제8항에 있어서, 상기 광섬유 광 가이드가 Y자 형인 것을 특징으로 하는 분석 장치.
  11. 제8항에 있어서, 상기 광 가이드가 광섬유의 많은 그룹, 시그날 입력을 의한 한 그룹, 및 시그날 출력을 위한 다른 그룹으로 이루어지는 것을 특징으로 하는 분석 장치.
  12. 제8항에 있어서, 상기 광원이 수은 램프(366nm)인 것을 특징으로 하는 분석 장치.
  13. 제8항에 있어서, 상기 광원이 He-Cd 레이저(324nm)인 것을 특징으로 하는 분석 장치.
  14. 제8항에 있어서, 제1포토멀티플리어 튜브가 450nm 방사선을 측정하고, 제2포토멀티플리어 튜브가 324 또는 366nm 방사선을 측정하는 것을 특징으로 하는 분석 장치.
  15. 동일 부피 조직 엘리먼트의 산화환원 상태(NADH), 혈액 부피 및 혈류(MBF), 및 상기 영역에서 상기 엘리먼트의 ECoG, 유조직압, 세포의 K+및 국소 온도를 동시에 모니터하기 위한 다중 시그날-다중 프로브 다중변수 분석 장치로서, 제8항의 2중 시그날-단일 프로브; 섬유 광학 프로브; K+미니 전극 및 기준 전극; 단일 하우징내에 어셈블링된 더미스터; 2개의 광 스플릿터; 450nm 형광에 대한 광 필터 및 광전자중배기; 366 또는 324nm 반사광에 대한 광 필터 및 광진자중배기; 366 또는 324nm 반사광에 대한 도플러 분석기 및 필터; ECoG를 모니터하기 위해 백금 와이어에 연결된 증폭기; [K+]를 모니터하기 위해 미니 전극에 연결된 전위계; 온도를 모니터하기 위해 더미스터 프로브에 연결된 원격 온도계; 아날로그 대 디지탈 변환기; 컴퓨터; 및 자료 평가용 알고리즘을 포함하는 다중 프로브 어셈블리로 이루어지는 분석 장치.
  16. 동일 부피 조직 엘리먼트의 산화환원 상태(NADH), 혈액 부피 및 혈류(MBF), 및 상기 엘리먼트의 영역에서 세포의 K+, Ca2+, H+, Na+이온 농도, ECoG, 유조직압 및 국소 온도를 동시에 모니터하기 위한 다중 시그날-다중 프로브 다중변수 분석 장치로서, -아날로그 대 디지탈 변환기; -컴퓨터; 및 -자료 평가용 알고리즘과 조합상태로, 각각 -형광계 반사계 도플러 분석기(FRDA); -증폭기; -압력 트랜스듀서; 및 -온도 측정기에 연결된 캐뉼러가 설치되어 있는 단일 하우징내에, -동일 부피의 조직 엘리먼트를 측정하기 위해, 240μ 여자(excitation) 광섬유로 이루어진 레이저 도플러 유량 측정용 및 NADH 모니터링용 광섬유 다발/광 가이드; 및 주변의 dc 정전위 전극과 결합된 상태로 에폭시 접착제에 의해 캐뉼러에 부착된 이온 특이적 전극을 포함하는 다중 프로브 어셈블리; -전기피질 전극; -기준 전극; -유조직압을 모니터하기 위한 섬유 광학 프로브; 및 -열전쌍 전극으로 이루어지는 분석 장치.
  17. 제16항에 있어서, 동물 조직의 생존력을 모니터하는 분석 장치.
  18. 제1항에 따른 단일 시그날-단일 프로브 다중변수 분석 장치 및 조직의 에너지 상태에 관련된 지표의 계산 수단을 포함하는 전문가 시스템.
  19. 제8항에 따른 2중 시그날-2중 프로브 다중변수 분석 장치 및 뇌의 생존력과 관련된 지표의 계산 수단을 포함하는 전문가 시스템.
  20. 제15항에 따른 다중 시그날-다중 프로브 다중변수 분석 장치 및 뇌의 작용과 관련된 지표의 계산 수단을 포함하는 전문가 시스템.
  21. 제16항에 따른 다중 시그날-다중 프로브 다중변수 분석 장치 및 뇌의 작용과 관련된 지표의 계산 수단을 포함하는 전문가 시스템.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960706916A 1994-05-31 1995-05-26 조직을모니터링하는방법 Expired - Fee Related KR100383476B1 (ko)

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US08/251,765 1994-05-31
US08/251,765 US5685313A (en) 1994-05-31 1994-05-31 Tissue monitor

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KR100383476B1 KR100383476B1 (ko) 2003-10-11

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EP (1) EP0763998A4 (ko)
JP (1) JPH10508763A (ko)
KR (1) KR100383476B1 (ko)
CN (1) CN1149821A (ko)
AU (1) AU697741B2 (ko)
CA (1) CA2191699A1 (ko)
IL (1) IL113872A (ko)
WO (1) WO1995032664A1 (ko)

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