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KR930701436A - 비스헤테로환 화합물 - Google Patents

비스헤테로환 화합물

Info

Publication number
KR930701436A
KR930701436A KR1019920703427A KR920703427A KR930701436A KR 930701436 A KR930701436 A KR 930701436A KR 1019920703427 A KR1019920703427 A KR 1019920703427A KR 920703427 A KR920703427 A KR 920703427A KR 930701436 A KR930701436 A KR 930701436A
Authority
KR
South Korea
Prior art keywords
group
same
different
atom
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019920703427A
Other languages
English (en)
Inventor
구니히로 니이가타
다쿠미 다카하시
기요시 이와오카
다카시 요네다
오사무 노시로
레이코 고이케
Original Assignee
오노다 마사아이
야마노우치세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오노다 마사아이, 야마노우치세이야쿠 가부시키가이샤 filed Critical 오노다 마사아이
Publication of KR930701436A publication Critical patent/KR930701436A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 하기 일반식의 혈당 저하제로서 유용한 신규 비스헤테로환 화합물 및 신규한 혈당 저하제에 관한 것이다.
상기식에서 R1및 R2는 동일하거나 상이하며
R3은 수소원자 또는 아세킬아미노기이거나, 카복시기 또는 설폭시기에 의해 치환될 수 있는 저급 알킬기이며, X 및 Y는 동일하거나 상이하며, 산소원자, 황원자 및 NH기이며, B1및 B2는 저급 알킬기에 의해 치환될수 있는 벤젠환 또는 나프탈렌환이며, L1및 L2는 동일하거나 상이하며, 단일결합, 산소원자, 황 원자, 설피닐기 또는 설포닐기이며, A는 단일결합, 직쇄 또는 측쇄의 알킬렌기, (C2내지 C6) 저급 알케닐렌기 또는 알키닐렌기이며, n은 0 또는 1이다.

Description

비스헤테로환 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식의 화합물.
  3. 상기식에서, R1및 R2는 동일하거나 상이하며
  5. R3은 수소원자 또는 아세킬아미노기이거나, 카복시기 또는 설폭시기에 의해 치환될 수 있는 저급 알킬기이며, X 및 Y는 동일하거나 상이하며, 산소원자, 황원자 및 NH기이며, B1및 B2는 저급 알킬기에 의해 치환될수 있는 벤젠환 또는 나프탈렌환이며, L1및 L2는 동일하거나 상이하며, 단일결합, 산소원자, 황 원자, 설피닐기 또는 설포닐기비며, A는 단일결합, 직쇄 또는 측쇄의 알킬렌기, (C2내지 C6) 저급 알케닐렌기 또는 알키닐렌기이며, n은 0 또는 1이다.(단, n이 1이고 R1및 R2가
  7. L1및 L2가 동시에 산소원자이고, A가 직쇄의 C2내지 C6알킬기인 화합물은 제외된다).
  8. 4,4'-비스[(2,4-디옥소-5-티아졸리디닐)메틸]디페닐메탄.
  9. 시스-1,4-비스(p-[(2,4-디옥소-5-티아졸리디닐)메틸]페녹시]-2-부텐.
  10. 트랜스-1,4-비스[p-[(2,4-디옥소-5-티아졸리디닐)메틸]페녹시]-2-부텐.
  11. 명세서에 기재한 바와 같은 제1항의 화합물을 제조하는 방법.
  12. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920703427A 1990-07-03 1991-07-01 비스헤테로환 화합물 Withdrawn KR930701436A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP17655090 1990-07-03
JP90-176,550 1990-07-03
JP91-114,184 1991-02-22
JP11418491 1991-02-22
PCT/JP1991/000887 WO1992000967A1 (en) 1990-07-03 1991-07-01 Bisheterocyclic compound

Publications (1)

Publication Number Publication Date
KR930701436A true KR930701436A (ko) 1993-06-11

Family

ID=26453004

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703427A Withdrawn KR930701436A (ko) 1990-07-03 1991-07-01 비스헤테로환 화합물

Country Status (8)

Country Link
EP (1) EP0533933A4 (ko)
KR (1) KR930701436A (ko)
AU (1) AU650465B2 (ko)
CA (1) CA2086606A1 (ko)
FI (1) FI925980A7 (ko)
HU (1) HUT65619A (ko)
PL (1) PL296945A1 (ko)
WO (1) WO1992000967A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69228122T2 (de) * 1991-07-30 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd., Tokio/Tokyo Neues bisheterocyclisches derivat und salz und hypoglykämische zusammensetzung
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
IT1265209B1 (it) * 1993-11-22 1996-10-31 Pierrel Spa Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
ATE353654T1 (de) 1997-06-18 2007-03-15 Smithkline Beecham Plc Behandlung der diabetes mit thiazolidindione und sulphonylurea
ES2154551B1 (es) * 1998-08-03 2001-10-16 Vita Invest Sa Nuevos derivados de tetrazol como agentes antidiabeticos.
AR023699A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
IL143002A0 (en) 1998-11-12 2002-04-21 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
AU2003282920A1 (en) 2002-10-04 2004-05-04 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5661366A (en) * 1979-10-23 1981-05-26 Doujin Kagaku Kenkyusho:Kk Bistetrazolium salt compound
US4338452A (en) * 1980-09-17 1982-07-06 Eli Lilly And Company 1-and 2-(1-Alkyl-1H-tetrazol-5-yl-methyl)-1H-tetrazol-5-thiols and 1-cyanomethyl tetrazole-5-thiol
US4659801A (en) * 1985-12-10 1987-04-21 Minnesota Mining And Manufacturing Company Thiazolinethione-containing polymer
GB8910639D0 (en) * 1989-05-09 1989-06-21 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
FI925980A0 (fi) 1992-12-31
AU8079591A (en) 1992-02-04
PL296945A1 (ko) 1992-07-13
AU650465B2 (en) 1994-06-23
CA2086606A1 (en) 1992-01-04
HUT65619A (en) 1994-07-28
HU9204176D0 (en) 1993-04-28
EP0533933A1 (en) 1993-03-31
FI925980A7 (fi) 1992-12-31
EP0533933A4 (en) 1993-05-05
WO1992000967A1 (en) 1992-01-23

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Legal Events

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19921231

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid