KR920700626A - 톡소플라스마병의 치료용 약제 - Google Patents
톡소플라스마병의 치료용 약제Info
- Publication number
- KR920700626A KR920700626A KR1019910700523A KR910700523A KR920700626A KR 920700626 A KR920700626 A KR 920700626A KR 1019910700523 A KR1019910700523 A KR 1019910700523A KR 910700523 A KR910700523 A KR 910700523A KR 920700626 A KR920700626 A KR 920700626A
- Authority
- KR
- South Korea
- Prior art keywords
- naphthoquinone
- chlorophenyl
- cyclohexyl
- acceptable salt
- physiologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 241000223996 Toxoplasma Species 0.000 title claims 5
- 201000010099 disease Diseases 0.000 title claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 5
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000000034 method Methods 0.000 claims 14
- 241001465754 Metazoa Species 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- BSJMWHQBCZFXBR-UHFFFAOYSA-N 3-[4-(p-chlorophenyl)cyclohexyl]-4-hydroxy-1,2-naphthoquinone Chemical compound O=C1C(=O)C2=CC=CC=C2C(O)=C1C(CC1)CCC1C1=CC=C(Cl)C=C1 BSJMWHQBCZFXBR-UHFFFAOYSA-N 0.000 claims 7
- 201000005485 Toxoplasmosis Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical group NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (18)
- 2-[4-(4-클로로페닐)시클로헥실]-3히드록시-1,4-나프토퀴논 또는 그것의 생리적허용염 또는 생리적작용성 유도체를 동물의 톡소플라스마병의 치료 및/또는 예방용 약제의 제조에 사용하는 방법
- 제1항에 있어서, 상기 2-[4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논이 그것의 트랜스이성체 형태로 또는 적어도 95%의 트랜스 이성체를 함유하는 시스 이성체와 트랜스이성체의 혼합물형태로 사용되는 방법
- 제1항 또는 제2항에 있어서, 상기 동물이 사람인 방법
- 활성성분인 2-[4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논 또는 그것의 생리적허용염 또는 생리적작용성 유도체와 약학적 허용담체를 포함하는 동물의 톡소플라스마병의 치료 및 또는 예방용 약학체제
- 톡소플라스마병이 걸린 동물에 치료적 유료량의 2-[4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논 또는 그것의 생리적 허용염 또는 생리적 작용성 유도체를 투여하는 것을 포함하는 동물의 톡소플라스마병의 치료방법
- 제5항에있어서,화합물 2-[트랜스-4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논이 투여되는 방법
- 제5항에 또는 제6항에 있어서, 상기 화합물 또는 그것의 생리적허용염 또는 생리적작용성 유도체가 25내지 100㎎/㎏(체중)/일의 양으로 투여되는 방법
- 제5항에 있어서, 상기 동물이 사람인 방법
- 제8항에 있어서, 상기 사람이 면역손상된 자인 방법
- 제9항에 있어서, 상기 사람이 HIV에 감염된자인 방법
- 톡소플라스마병이 걸린 동물에 예방적 유효량의 2-[4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논 또는 그것의 생리적허용염 또는 생리적작용성 유도체를 투여하는것을 포함하는, 톡소플라스마병에 걸릴수 있는 동물의 톡소플라스마병 예방방법
- 제11항에 있어서, 화합물 2-[트랜스-4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논이 투여되는 방법
- 제11항또는 제12항에 있어서, 상기 동물이 사람인 방법
- 제13항에 있어서, 상기 사람이 면역손상된 자인 방법
- 제14항에 있어서, 상기 사람이 HIV에 감염된자인 방법.
- 제11항 또는 제12항에 있어서, 상기 화합물 또는 그것의 생리적허용염또는 생리적작용성 유도체가 5내지 50mg/kg(체중)/주의 양으로 투여되는 방법.
- 톡소플라스마병의 치료 및/또는 예방에 사용하기 위한 2-[4-(4-클로로페닐)시클로헥실]-3히드록시-1,4-나프토퀴논 또는 그것의 생리적허용염 또는 생리적작용성 유도체.
- 활성성분으로서 50mg 내지 3g분량의 2-[4-(4-클로로페닐)시클로헥실]-3-히드록시-1,4-나프토퀴논 또는 생리적 허용염 또는 생리적작용성 유도체를 포함하는 단위투여형태.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB89215164 | 1989-09-22 | ||
| GB898921516A GB8921516D0 (en) | 1989-09-22 | 1989-09-22 | Medicaments |
| PCT/GB1989/001286 WO1991004021A1 (en) | 1989-09-22 | 1989-10-26 | Medicaments for the treatment of toxoplasmosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920700626A true KR920700626A (ko) | 1992-08-10 |
Family
ID=10663513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910700523A Ceased KR920700626A (ko) | 1989-09-22 | 1989-10-26 | 톡소플라스마병의 치료용 약제 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0445141B1 (ko) |
| JP (1) | JP2810746B2 (ko) |
| KR (1) | KR920700626A (ko) |
| AT (1) | ATE108063T1 (ko) |
| AU (1) | AU628422B2 (ko) |
| CA (1) | CA2001568C (ko) |
| DE (1) | DE68916651T2 (ko) |
| DK (1) | DK175716B1 (ko) |
| GB (1) | GB8921516D0 (ko) |
| HU (1) | HU207942B (ko) |
| IE (1) | IE66153B1 (ko) |
| MC (1) | MC2142A1 (ko) |
| MW (1) | MW1291A1 (ko) |
| PH (1) | PH27250A (ko) |
| SG (1) | SG28346G (ko) |
| WO (1) | WO1991004021A1 (ko) |
| ZA (1) | ZA898146B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9126874D0 (en) * | 1991-12-18 | 1992-02-19 | Wellcome Found | Medicaments |
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| GB9226905D0 (en) * | 1992-12-24 | 1993-02-17 | Wellcome Found | Pharmaceutical preparation |
| WO2010023686A2 (en) * | 2008-08-29 | 2010-03-04 | Matrix Laboratories Limited | Crystalline form of 2-chloro-3-[4-(4-chlorophenyl) cyclohexyl] [1,4]naphthoquinone, process for the same and use for producing 2-[4-(4-chlorophenyl)cyclohexyl]-3- hydroxy- 1,4- naphthoquinone |
| WO2013093937A2 (en) * | 2011-09-16 | 2013-06-27 | Alkem Laboratories Ltd. | ''3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2- trans-[(4-chloro phenyl) cyclohexyl] [1,4]naphthaquinone"-atovaquone prodrug |
| CN104474416A (zh) * | 2014-11-03 | 2015-04-01 | 青岛绿曼生物工程有限公司 | 治疗猪弓形体病的复方蜂胶组合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8310141D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Naphthoquinone derivatives |
| GB8310140D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Antiprotozoal agents |
| ES2052012T3 (es) * | 1988-08-16 | 1994-07-01 | Wellcome Found | Naftoquinonas para el tratamiento y profilaxis de infecciones por pneumocystis carinii. |
-
1989
- 1989-09-22 GB GB898921516A patent/GB8921516D0/en active Pending
- 1989-10-26 WO PCT/GB1989/001286 patent/WO1991004021A1/en not_active Ceased
- 1989-10-26 AU AU45191/89A patent/AU628422B2/en not_active Expired
- 1989-10-26 CA CA002001568A patent/CA2001568C/en not_active Expired - Lifetime
- 1989-10-26 HU HU896916A patent/HU207942B/hu not_active IP Right Cessation
- 1989-10-26 EP EP89912648A patent/EP0445141B1/en not_active Expired - Lifetime
- 1989-10-26 KR KR1019910700523A patent/KR920700626A/ko not_active Ceased
- 1989-10-26 ZA ZA898146A patent/ZA898146B/xx unknown
- 1989-10-26 DE DE68916651T patent/DE68916651T2/de not_active Expired - Lifetime
- 1989-10-26 MC MC@@@@D patent/MC2142A1/xx unknown
- 1989-10-26 AT AT89912648T patent/ATE108063T1/de not_active IP Right Cessation
- 1989-10-26 JP JP1511680A patent/JP2810746B2/ja not_active Expired - Lifetime
- 1989-10-26 SG SG1995904215A patent/SG28346G/en unknown
- 1989-10-26 IE IE345189A patent/IE66153B1/en not_active IP Right Cessation
-
1991
- 1991-05-16 DK DK199100930A patent/DK175716B1/da not_active IP Right Cessation
- 1991-05-20 MW MW12/91A patent/MW1291A1/xx unknown
- 1991-10-26 PH PH39415A patent/PH27250A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE66153B1 (en) | 1995-12-13 |
| MC2142A1 (fr) | 1992-02-18 |
| MW1291A1 (en) | 1991-11-13 |
| HU896916D0 (en) | 1991-08-28 |
| EP0445141A1 (en) | 1991-09-11 |
| JP2810746B2 (ja) | 1998-10-15 |
| WO1991004021A1 (en) | 1991-04-04 |
| AU628422B2 (en) | 1992-09-17 |
| DE68916651D1 (de) | 1994-08-11 |
| HUT57040A (en) | 1991-11-28 |
| HU207942B (en) | 1993-07-28 |
| CA2001568C (en) | 1998-05-12 |
| ATE108063T1 (de) | 1994-07-15 |
| JPH04504107A (ja) | 1992-07-23 |
| AU4519189A (en) | 1991-04-18 |
| EP0445141B1 (en) | 1994-07-06 |
| DK175716B1 (da) | 2005-01-31 |
| IE893451A1 (en) | 1991-03-27 |
| DK93091D0 (da) | 1991-05-16 |
| PH27250A (en) | 1993-05-04 |
| DK93091A (da) | 1991-06-28 |
| CA2001568A1 (en) | 1991-03-22 |
| GB8921516D0 (en) | 1989-11-08 |
| SG28346G (en) | 1995-09-18 |
| DE68916651T2 (de) | 1995-02-16 |
| ZA898146B (en) | 1991-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19910522 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19941019 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19910522 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19971118 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19980421 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19971118 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |