[go: up one dir, main page]

KR900016130A - 2-피리딜메틸티오 유도체 및 궤양 치료제 - Google Patents

2-피리딜메틸티오 유도체 및 궤양 치료제 Download PDF

Info

Publication number
KR900016130A
KR900016130A KR1019890004730A KR890004730A KR900016130A KR 900016130 A KR900016130 A KR 900016130A KR 1019890004730 A KR1019890004730 A KR 1019890004730A KR 890004730 A KR890004730 A KR 890004730A KR 900016130 A KR900016130 A KR 900016130A
Authority
KR
South Korea
Prior art keywords
compound
pyridylmethylthio
formula
dihydropyrido
phthalazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019890004730A
Other languages
English (en)
Inventor
다까하시 도시하루
하기와라 고이찌로
나까마루 고이찌
스즈끼 요시꾸니
Original Assignee
쇼오다 오사무
닛신 세이훈 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쇼오다 오사무, 닛신 세이훈 가부시끼가이샤 filed Critical 쇼오다 오사무
Publication of KR900016130A publication Critical patent/KR900016130A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음.

Description

2-피리딜메틸티오 유도체 및 궤양 치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 산 부가염.
    상기식에서, A는 4-메틸-2-퀴나졸리닐, 4-(2-피리딜메틸티오)-1-프탈아지닐 또는 4-옥소-3-페닐-3,4-디하이드로피리도[2,3-d]피리미딘-2-일이다.
  2. 제1항에 있어서, A가 4-메틸-2-퀴나졸리닐인 화합물.
  3. 제1항에 있어서, A가 4-(2-피리딜메틸티오)-1-프탈아지닐인 화합물.
  4. 제1항에 있어서, A가 4-옥소-3-페닐-3,4-디하이드로피리도[2,3-d]피리미딘-2-일인 화합물.
  5. 활성성분으로서 치료학적으로 유효한 양의 일반식(I) 화합물 또는 약제학적으로 허용되는 이의 산 부가염을 함유함을 특징으로 하는 궤양 치료제.
    상기식에서, A는 4-메틸-2-퀴나졸리닐, 4-(2-피리딜메틸티오)-1-프탈아지닐 또는 4-옥소-3-페닐-3,4-디하이드로피리도[2,3-d]피리미딘-2-일이다.
  6. 제5항에 있어서, 활성 성분이 A가 4-메틸-2-퀴나졸리닐인 일반식(I)의 화합물인 궤양 치료제.
  7. 제5항에 있어서, 활성 성분이 A가 4-(2-피리딜메틸디오)-1-프탈아지닐인 일반식(I)의 화합물인 궤양 치료제.
  8. 제5항에 있어서, 활성 성분이 A가 4-옥소-3-페닐-3,4-디하이드로피리도[2,3-d]피리미딘-2-일인 일반식(I)의 화합물인 궤양 치료제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890004730A 1988-04-11 1989-04-11 2-피리딜메틸티오 유도체 및 궤양 치료제 Withdrawn KR900016130A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-87271 1988-04-11
JP63087271A JPH01261386A (ja) 1988-04-11 1988-04-11 新規な２―ピリジルメチルチオ誘導体及びそれを含有する抗潰瘍剤

Publications (1)

Publication Number Publication Date
KR900016130A true KR900016130A (ko) 1990-11-12

Family

ID=13910100

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890004730A Withdrawn KR900016130A (ko) 1988-04-11 1989-04-11 2-피리딜메틸티오 유도체 및 궤양 치료제

Country Status (5)

Country Link
US (1) US4925843A (ko)
EP (1) EP0337308B1 (ko)
JP (1) JPH01261386A (ko)
KR (1) KR900016130A (ko)
DE (1) DE68919507T2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539805B1 (de) * 1991-10-31 1997-09-03 ASTA Medica Aktiengesellschaft Neue Phthalazine, die in 1-Stellung eine Ether-Gruppierung enthalten und Verfahren zu deren Herstellung
ES2167586T3 (es) * 1995-07-05 2002-05-16 Du Pont Pirimidinonas fungicidas.
CA2366857C (en) * 1999-03-30 2010-12-14 Novartis Ag Phthalazine derivatives for treating inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK585485A (da) * 1984-12-18 1986-08-08 Utsuka Pharm Co Ltd Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse
JPS62209062A (ja) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd ２−ピリジルメチルチオ−または２−ピリジルメチルスルフイニル−置換縮合環化合物
JPH07107056B2 (ja) * 1987-01-30 1995-11-15 日清製粉株式会社 ４（３ｈ）−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍剤
JPS646261A (en) * 1987-03-31 1989-01-10 Nisshin Flour Milling Co 4-thioquinazoline derivative, its production and antiulcer agent containing said derivative as active component

Also Published As

Publication number Publication date
JPH01261386A (ja) 1989-10-18
EP0337308A2 (en) 1989-10-18
EP0337308A3 (en) 1990-11-14
EP0337308B1 (en) 1994-11-30
DE68919507T2 (de) 1995-04-20
US4925843A (en) 1990-05-15
DE68919507D1 (de) 1995-01-12

Similar Documents

Publication Publication Date Title
KR920002144A (ko) 아연 l-카르노신 염 또는 이의 착화합물을 유효성분으로 함유하는 염증성 장질환 예방 및 치료제
DK0430045T3 (da) Ascorbinsyretocopherylphosphatdiestere til hæmning af Maillards reaktion
ATE133861T1 (de) Antihypertensive zubereitungen und deren verwendung
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
IE873125L (en) Benzimidazole derivatives
FI940696A0 (fi) Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö
ATE15596T1 (de) Pharmazeutische mittel.
KR910000158A (ko) 의약용 화합물 및 그것의 사용방법
DE69302646D1 (de) Benzimidazolverbindungen als Antibiotika gegen Campylobacter pylon
BG60101B2 (bg) Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол
KR890008136A (ko) 항균성 9-데옥소-9a-알릴 및 프로파길-9a-아자-9a-호모에리트로 마이신 A 유도체
KR900016130A (ko) 2-피리딜메틸티오 유도체 및 궤양 치료제
MY110092A (en) Butyric acid derivatives
KR900016156A (ko) 퀴녹살린 유도체 및 궤양치료제
AU7935887A (en) Therapeutic agent for the treatment of peptic ulcer disease
CA2038025A1 (en) Optically active alkylenedioxybenzene derivatives and their use in therapy
KR890003755A (ko) 7- (2- 메틸- 4- 아미노피롤리디닐)나프티리딘 및 퀴놀린 화합물
KR890001540A (ko) 심부전증 치료제
KR880009656A (ko) 국소 치근막 질환의 치료 또는 예방법
KR870001144A (ko) Nn-디메틸에틸옥사이드가 함유된 약제조성물 및 그의 생산방법
KR920019349A (ko) 불안을 치료하기 위한 r(+)-3-아미노-1-하이드록시-피롤리딘-2-온의 용도
KR890001543A (ko) 당뇨병 치료제
EP0413278A3 (en) Use of xanthine derivatives against peptic ulcers
KR940703656A (ko) 에이즈 바이러스 감염 저해용 조성물
KR890001555A (ko) 요산 배설용 조성물

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19890411

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid