KR900007845A - 에토포시드-2-디메틸아미노 화합물 염산염의 2수염결정 및 그 제조방법 - Google Patents
에토포시드-2-디메틸아미노 화합물 염산염의 2수염결정 및 그 제조방법 Download PDFInfo
- Publication number
- KR900007845A KR900007845A KR1019890016615A KR890016615A KR900007845A KR 900007845 A KR900007845 A KR 900007845A KR 1019890016615 A KR1019890016615 A KR 1019890016615A KR 890016615 A KR890016615 A KR 890016615A KR 900007845 A KR900007845 A KR 900007845A
- Authority
- KR
- South Korea
- Prior art keywords
- etoposide
- hydrochloride
- dimethylamino
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 Compound Hydrochloride Chemical class 0.000 title claims description 8
- 239000013078 crystal Substances 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- 150000004683 dihydrates Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는형 에토포시드-2-디메틸아미노 화합물 염산염 2수염 결정의 X선 회절모양이고,
제2도는 β형 에토포시드-2-디메틸아미노 화합물 염산염 2수염 결정의 X선 회절모양이고,
제3도는 무수(anhydrous)에토포시드-2-디메틸아미노 화합물 염산염의 X선 회절모양이다.
Claims (3)
- 일반식(Ⅰ)의 4'-디메틸 에피포도필로톡신 9-(4,6-0-에틸리덴-2-디메틸아미노-2-디옥시-β-D-글루코피라노시드(이하, 에토포시드-2-디메틸아미노 화합물이라 함)염산염의 2수염 결정.
- 에토포시드-2-디메틸 아미노 화합물 염산염을 수중에 현탁시켜, 에토포시드-2-디메틸아미노 화합물 염산염의 2수염 결정을 제조하는 방법.
- 구조식(Ⅱ)의 4'-디메틸 에피포도필로톡신-β-D-2-아미노-2-디옥시-4,6-0-에틸리덴-글루코피라노시드 또는 그 염을 구조식(Ⅲ)의 알데히드와 반응시키고, 생성물을 금속 촉매존재하에 수소 첨가 반응시켜 에트포시드-2-디메틸아미노 화합물 또는 그 염을 생성시키고, (a) 생성된 에토포시드-2-디메틸아미노 화합물이 염산염이외의 염일 경우는 그 염을 유리시킨 후에, 생성된 에토포시드-2-디메틸 아미노화합물이 유리상태의 화합물일 경우는 이를 그대로, 유기 용매중에서 염산염으로 전환시키고, (b) 생성된 염산염을 수중에 현탁시켜, 에토포시드-2-디메틸아미노 화합물 염산염의 2수염 결정을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28781288A JPH0631302B2 (ja) | 1988-11-16 | 1988-11-16 | エトポシド−２−ジメチルアミノ体塩酸二水和結晶及びその製造法 |
| JP88-287812 | 1988-11-16 | ||
| JP88-287811 | 1988-11-16 | ||
| JP28781188A JP2639709B2 (ja) | 1988-11-16 | 1988-11-16 | ４’−デメチルエピポドフィロトキシン誘導体の新規製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR900007845A true KR900007845A (ko) | 1990-06-02 |
Family
ID=26556892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890016615A Ceased KR900007845A (ko) | 1988-11-16 | 1989-11-16 | 에토포시드-2-디메틸아미노 화합물 염산염의 2수염결정 및 그 제조방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4997923A (ko) |
| EP (1) | EP0369369B1 (ko) |
| KR (1) | KR900007845A (ko) |
| CN (2) | CN1023121C (ko) |
| AU (1) | AU613536B2 (ko) |
| CA (1) | CA2003028A1 (ko) |
| DE (1) | DE68912721T2 (ko) |
| ES (1) | ES2061891T3 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2745059B2 (ja) * | 1989-03-08 | 1998-04-28 | メクト株式会社 | Ｎ―アセチルノイラミン酸ナトリウム・三水和物 |
| KR910014122A (ko) * | 1990-01-19 | 1991-08-31 | 디께다 가즈히꼬 | 에토포시드-2-디메틸아미노 화합물의 동결건조 제제 |
| US5648474A (en) * | 1991-10-08 | 1997-07-15 | Bristol-Myers Squibb | Crystalline etoposide 4'-phosphate diethanolate |
| JPH07632B2 (ja) * | 1991-12-23 | 1995-01-11 | ブリストル−マイヤーズ スクイブ カンパニー | エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物 |
| EP1762299B1 (en) | 2004-03-31 | 2018-05-30 | China Petroleum & Chemical Corporation | A catalyst containing zeolite for hydrocarbon converting and preparation thereof, and a hydrocarbon oil converting method using said catalyst |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2579206B1 (fr) * | 1985-03-22 | 1987-05-07 | Sanofi Sa | Nouvelles 5-h pyrido (3', 4' : 4,5) (pyrrolo 3,2-c) pyridones, leur procede de preparation et leur application en tant qu'intermediaires de synthese |
| JPS61227590A (ja) * | 1985-04-02 | 1986-10-09 | Microbial Chem Res Found | 新規４′−デメチル−４−エピポドフイロトキシン誘導体 |
-
1989
- 1989-11-11 ES ES89120987T patent/ES2061891T3/es not_active Expired - Lifetime
- 1989-11-11 EP EP89120987A patent/EP0369369B1/en not_active Expired - Lifetime
- 1989-11-11 DE DE89120987T patent/DE68912721T2/de not_active Expired - Fee Related
- 1989-11-13 US US07/434,777 patent/US4997923A/en not_active Expired - Fee Related
- 1989-11-15 CA CA002003028A patent/CA2003028A1/en not_active Abandoned
- 1989-11-15 AU AU44672/89A patent/AU613536B2/en not_active Ceased
- 1989-11-16 CN CN89108575A patent/CN1023121C/zh not_active Expired - Fee Related
- 1989-11-16 KR KR1019890016615A patent/KR900007845A/ko not_active Ceased
-
1992
- 1992-11-20 CN CN92112450A patent/CN1025622C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0369369A3 (en) | 1990-08-22 |
| DE68912721D1 (de) | 1994-03-10 |
| ES2061891T3 (es) | 1994-12-16 |
| DE68912721T2 (de) | 1994-05-11 |
| EP0369369A2 (en) | 1990-05-23 |
| CN1072181A (zh) | 1993-05-19 |
| CN1025622C (zh) | 1994-08-10 |
| CN1023121C (zh) | 1993-12-15 |
| AU613536B2 (en) | 1991-08-01 |
| CN1043502A (zh) | 1990-07-04 |
| EP0369369B1 (en) | 1994-01-26 |
| CA2003028A1 (en) | 1990-05-16 |
| US4997923A (en) | 1991-03-05 |
| AU4467289A (en) | 1990-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19891116 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19940622 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19891116 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19970826 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19971118 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19970826 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |