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KR900006318A - 피페리디닐 벤즈이미다졸 - Google Patents

피페리디닐 벤즈이미다졸 Download PDF

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Publication number
KR900006318A
KR900006318A KR1019890014536A KR890014536A KR900006318A KR 900006318 A KR900006318 A KR 900006318A KR 1019890014536 A KR1019890014536 A KR 1019890014536A KR 890014536 A KR890014536 A KR 890014536A KR 900006318 A KR900006318 A KR 900006318A
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KR
South Korea
Prior art keywords
compound
choh
alkyl
hydrogen
alkoxy
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KR1019890014536A
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KR0157046B1 (ko
Inventor
안토니 카 알버트
마이클 케인 존
쳉 지엔창
Original Assignee
게리 디.스트리트
메렐 다우 파마슈티칼스 인코포레이티드
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Publication of KR900006318A publication Critical patent/KR900006318A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

피페리디닐 벤즈이미다졸
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(I)의 화합물 또는 약제학적으로 허용되는 이의 산부가염.
    상기식에서, Y는 CO 또는 CHOH이고, m은 1 또는 2 이고, R은 C1-4알킬, C1-4알콕시, 할로겐, 하이드록시 또는 수소이고, X 는 수소, COOR2또는 일반식
    의 알킬렌 페닐 라디칼이고, R3는 C1-4알킬이고, T는 CHOH, CO, 산소 또는 직접 결합이고, R1은 C1-4알킬, C1-4알콕시, 할로겐, 하이드록시, 2,2-디메틸 에타노산 또는 수소이고, n은 1 내지 5의 정수이다.
  2. 제 1 항에 있어서, X가 일반식
    (여기에서, T는 CHOH, CO, 산소 또는 직접 결합이고, R1은 C1-4알킬, C1-4알콕시, 할로겐, 하이드록시, 2,2-디메틸 에타노산 또는 수소이고, n은 1 내지 5의 정수이다) 의 알킬렌 페닐 라디칼인 화합물.
  3. 제 2 항에 있어서, T가 CO인 화합물.
  4. 제 3 항에 있어서, Y가 CO인 화합물.
  5. 제 3 항에 있어서, Y가 CHOH인 화합물.
  6. 제 2 항에 있어서, T가 CHOH인 화합물.
  7. 제 6 항에 있어서, Y가 CO인 화합물.
  8. 제 6 항에 있어서, Y가 CHOH인 화합물.
  9. 제 1 항에 따른 화합물을 항히스타민적 양으로 이를 필요로 하는 환자에게 투여함을 특징으로 하여, 알러지성 질병을 치료하는 방법.
  10. 하기 일반식(Ⅱ)의 화합물.
    상기식에서, Y는 CO 또는 CHOH이고, m은 1 또는 2 이고, R은 C1-4알킬, C1-4알콕시, 할로겐, 하이드록시 또는 수소이고, Z는 아미노 보호그룹이다.
  11. 일반식(Ⅲ)의 벤즈이미다졸을 일반식(Ⅳ)의 피페리디닐 화합물과 반응시킴을 특징으로 하여, 제 1 항의 피페리디닐 벤즈이미다졸을 제조하는 방법.
    상기식에서, m 및 R은 제 1 항에서 정의된 바와 같고, X는 제 1 항에서 정의된 바와 같거나 아미노 보호그룹이고, E는 C1-4알킬이다.
  12. 항히스타민적 양의 제 1 항에 따른 화합물과 약제학적으로 허용되는 담체와의 혼합물을 포함하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890014536A 1988-10-13 1989-10-11 피페리디닐 벤즈이미다졸 Expired - Fee Related KR0157046B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/256,959 US4908372A (en) 1988-10-13 1988-10-13 Antihistaminic piperidinyl benzimidazoles
US256,959 1988-10-13

Publications (2)

Publication Number Publication Date
KR900006318A true KR900006318A (ko) 1990-05-07
KR0157046B1 KR0157046B1 (ko) 1998-11-16

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KR1019890014536A Expired - Fee Related KR0157046B1 (ko) 1988-10-13 1989-10-11 피페리디닐 벤즈이미다졸

Country Status (20)

Country Link
US (1) US4908372A (ko)
EP (1) EP0363963B1 (ko)
JP (1) JP2867151B2 (ko)
KR (1) KR0157046B1 (ko)
CN (1) CN1028103C (ko)
AR (1) AR248018A1 (ko)
AT (1) ATE121741T1 (ko)
AU (1) AU619601B2 (ko)
CA (1) CA2000468C (ko)
DE (1) DE68922366T2 (ko)
DK (1) DK506189A (ko)
ES (1) ES2074067T3 (ko)
FI (1) FI894834A7 (ko)
HU (1) HU203340B (ko)
IE (1) IE66112B1 (ko)
IL (1) IL91952A (ko)
NO (1) NO894086L (ko)
NZ (1) NZ230956A (ko)
PT (1) PT91968B (ko)
ZA (1) ZA897676B (ko)

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CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds
AU8506791A (en) * 1990-10-01 1992-04-28 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
HUT64320A (en) * 1990-12-14 1993-12-28 Merrell Dow Pharma Process for production antiallergic imidazole derivatives and pharmaceutical preparations containing these compounds
TW263504B (ko) * 1991-10-03 1995-11-21 Pfizer
WO1993014083A1 (en) * 1992-01-09 1993-07-22 Janssen Pharmaceutica N.V. Pharmaceutically active substituted benzimidazole derivatives
ES2163407T3 (es) * 1992-02-13 2002-02-01 Merrell Pharma Inc Derivados piperidinilos tiaciclicos.
HU221434B (en) 1994-08-25 2002-10-28 Merrell Pharma Inc Substituted piperidines, pharmaceutical compositions containing them and their use
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
BR9708146A (pt) * 1996-03-15 1999-07-27 Lilly Co Eli Processo de tratamento de resfriado comum ou de rinite alérgica
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
PT1260512E (pt) * 2000-02-29 2007-10-10 Mitsubishi Pharma Corp ''novos derivados de amida cíclicos''
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
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US20070225217A1 (en) 2005-11-09 2007-09-27 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
TWI411607B (zh) * 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
CL2007002689A1 (es) * 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
EP2081927B1 (en) * 2006-09-18 2011-08-17 Vitae Pharmaceuticals, Inc. Piperidine derivatives as renin inhibitors
WO2009096996A1 (en) * 2007-06-20 2009-08-06 Smithkline Beecham Corporation Renin inhibitors
US20100160424A1 (en) * 2007-06-20 2010-06-24 Baldwin John J Renin inhibitors
US20110160300A1 (en) * 2008-06-20 2011-06-30 Marlys Hammond Renin Inhibitors and Methods of Use Thereof
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US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
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Also Published As

Publication number Publication date
NO894086L (no) 1990-04-17
CN1041940A (zh) 1990-05-09
IL91952A0 (en) 1990-06-10
HU203340B (en) 1991-07-29
CN1028103C (zh) 1995-04-05
ZA897676B (en) 1990-07-25
PT91968A (pt) 1990-04-30
EP0363963A1 (en) 1990-04-18
JP2867151B2 (ja) 1999-03-08
IL91952A (en) 1994-06-24
DK506189A (da) 1990-04-14
HU895305D0 (en) 1990-01-28
KR0157046B1 (ko) 1998-11-16
AU619601B2 (en) 1992-01-30
US4908372A (en) 1990-03-13
CA2000468A1 (en) 1990-04-13
HUT51613A (en) 1990-05-28
CA2000468C (en) 2000-03-21
AR248018A1 (es) 1995-05-31
PT91968B (pt) 1995-05-31
ATE121741T1 (de) 1995-05-15
NZ230956A (en) 1991-03-26
DE68922366D1 (de) 1995-06-01
FI894834A0 (fi) 1989-10-12
NO894086D0 (no) 1989-10-12
DK506189D0 (da) 1989-10-12
JPH02134377A (ja) 1990-05-23
DE68922366T2 (de) 1995-09-28
IE66112B1 (en) 1995-12-13
ES2074067T3 (es) 1995-09-01
EP0363963B1 (en) 1995-04-26
IE893294L (en) 1990-04-13
FI894834A7 (fi) 1990-04-14
AU4273589A (en) 1990-04-26

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