KR20190114921A - Ph-sensitive cosmetic composition for improving acne and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a pH-sensitive cosmetic composition for acne improvement and a method for producing the same. The present invention provides the cosmetic composition having excellent acne improving effect and stable formulation and being hypoallergenic, by including a pH-sensitive complex for discharging salicylic acid to the outside only in a specific pH range, wherein the core carries salicylic acid and tea tree oil, and at least one or more of the plurality of through holes carries a pH-sensitive material; and the method for producing the same.

Description

PH sensitive cosmetic composition for improving acne and its manufacturing method {PH-SENSITIVE COSMETIC COMPOSITION FOR IMPROVING ACNE AND MANUFACTURING METHOD THEREOF}

The present invention relates to a pH sensitive cosmetic composition for acne improvement and a method for producing the same.

Acne is an inflammatory skin disease that occurs in hair follicles and sebaceous glands, and is caused by excessive secretion of sebum, keratinization of hair follicles, and growth of acne bacteria. In particular, the excessive secretion of sebum and keratinization of the hair follicles may promote the growth of propionibacterium acnes, an acne bacterium present in hair follicles.

At this time, propionabacterium acnes eat triglycerides and release fatty acids or free fatty acids, which irritate skin or promote acne production, cause inflammatory reactions, as well as weak acidity. There was a problem of alkalizing healthy skin. In addition, the pH 4.0 ~ 6.0 weakly acidic skin maintains its own homeostasis and antibacterial activity, but the alkaline skin above pH 7.0 is difficult to maintain homeostasis and antibacterial action, the skin itself There was a problem of deterioration.

Accordingly, various compositions for improving acne using antibiotics and drugs that sterilize acne bacteria and reduce inflammation while restoring alkaline skin to weakly acidic healthy skin have been developed.

Among them, salicylic acid has a very good acne improving effect and is mainly used as an acne improving or therapeutic substance. For example, the Republic of Korea Patent Publication No. 10-2013-0055182 discloses a composition and kit that can improve acne, including sulfur, calamine, salicylic acid.

On the other hand, salicylic acid is a type of strong acid, effective in improving acne, but has a problem of irritating the skin and destabilizing the formulation of the cosmetic composition. However, the prior art including the above-mentioned patent discloses that salicylic acid is effective in improving acne, and there is a problem not considering skin irritation, formulation stability, etc. of the cosmetic composition using salicylic acid.

Accordingly, there is a need for development of a cosmetic composition that contains salicylic acid effective for improving acne but is hypoallergenic to the skin and whose formulation is stable.

Republic of Korea Patent Publication No. 10-2013-0055182

The first object of the present invention includes a hollow porous silica, salicylic acid, tea tree oil and pH sensitive material, the hollow porous silica is a hollow core and the core and the outer Is formed in the structure of a shell formed with a plurality of through holes connecting the, the core is supported salicylic acid and tea tree oil, at least one or more of the plurality of through holes is supported by a pH sensitive material, in a specific pH region It is to provide a pH sensitive complex that can release salicylic acid to the outside.

A second object of the present invention includes the step of impregnating salicylic acid and tea tree oil in the hollow porous silica and the step of impregnating a pH sensitive material in the hollow porous silica impregnated with the salicylic acid and tea tree oil, the hollow type Porous silica is formed of a core structure consisting of a hollow space and a shell formed with a plurality of through holes connecting the core and the outside, the core is supported with salicylic acid and tea tree oil, at least one of the plurality of through holes The present invention provides a method for preparing a pH-sensitive complex capable of releasing salicylic acid to the outside only in a specific pH region as the pH-sensitive substance is loaded thereon.

The third object of the present invention is to include a pH-sensitive complex for discharging salicylic acid contained in the core to a specific pH region to the outside, thereby providing a cosmetic composition having excellent acne-improving effect and hypoallergenic and stable formulation to the skin. To provide.

The object of the present invention is not limited to the technical problem as described above, another technical problem can be derived from the following description.

In order to achieve the first object, the present invention includes a hollow porous silica, salicylic acid, tea tree oil and a pH sensitive material, the hollow porous silica is made of a hollow core And a shell formed with a plurality of through holes connecting the core and the outside, wherein the core is supported with salicylic acid and tea tree oil, and at least one of the plurality of through holes carries a pH-sensitive material. It relates to a pH sensitive complex.

The pH sensitive composite may include 0.01 to 50.0 wt% of hollow porous silica, 0.01 to 40.0 wt% of salicylic acid, 0.01 to 40.0 wt% of tea tree oil, and 0.01 to 30.0 wt% of pH sensitive material, based on the total weight of the pH sensitive composite. Can be.

The salicylic acid and tea tree oil may be included in a weight ratio of 1: 0.5 to 2.

The pH sensitive material may be meadowfoam delta-lactone.

In order to achieve the second object, the present invention is a hollow porous silica, salicylic acid (Salicylic acid), tea tree oil (Tea tree oil) and a method for producing a pH sensitive composite comprising a pH sensitive material, hollow porous Impregnating salicylic acid and tea tree oil on silica; And impregnating the pH-sensitive material into the hollow porous silica impregnated with the salicylic acid and the tea tree oil, wherein the hollow porous silica has a core formed of an empty space and a plurality of through holes connecting the core and the outside. It is formed in the structure of the shell, the core is supported with salicylic acid and tea tree oil, at least one or more of the plurality of through-holes provides a pH-sensitive composite manufacturing method.

In order to achieve the third object, the present invention includes a hollow porous silica, salicylic acid, tea tree oil and a pH sensitive material, wherein the hollow porous silica is a hollow core And a shell having a plurality of through holes connecting the core and the outside, wherein the core is supported with salicylic acid and tea tree oil, and at least one of the plurality of through holes has a pH sensitive material thereon. It provides a pH sensitive cosmetic composition for acne improvement, including a sensitive complex.

The pH sensitive complex may be included in an amount of 0.01 to 30.0 wt% based on the total weight of the cosmetic composition.

The cosmetic composition may inhibit the activity of acne causing bacteria.

The cosmetic composition is selected from the group consisting of flexible cosmetics, nourishing cosmetics, astringent cosmetics, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water It may be one of the formulation.

The cosmetic composition may be purified water, wrinkle improver, anti-aging agent, antioxidant, elasticity improver, whitening agent, moisturizer, sunscreen, anti-inflammatory agent, atopic dermatitis improver, acne improver, sebum secretion inhibitor, trouble preventing agent, fatty substance, organic solvent, solubilizer, Thickeners, gelling agents, emollients, suspending agents, stabilizers, blowing agents, fragrances, surfactants, emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, flavorings, hydrophilic or It may further include an additive comprising at least one selected from the group consisting of a lipophilic active agent and a lipid vesicle.

The pH sensitive composite of the present invention is a hollow porous silica, salicylic acid, tea tree oil, and pH sensitive shell having a hollow core and a shell structure having a plurality of through holes connecting the core and the outside. Including a material, the core is supported salicylic acid and tea tree oil, at least one or more of the plurality of through-holes are formed in a form that is supported by a pH-sensitive material, external salicylic acid of the core only in a specific pH region Can be discharged.

In addition, a sufficient amount of salicylic acid and tea tree oil may be supported on the core of the hollow porous silica, and a sufficient amount of pH-sensitive material may be supported on the plurality of through holes of the shell.

In addition, while the salicylic acid and tea tree oil is supported on the core of the hollow porous silica, the salicylic acid and tea tree oil is supported in a weight ratio of 1: 0.5 to 2, it is possible to continuously release salicylic acid in a specific pH region, The pH sensitive complex can remain more stable.

According to the method for producing a pH-sensitive composite of the present invention, the step of impregnating salicylic acid and tea tree oil in the hollow porous silica of the shell structure having a core consisting of a hollow space and a plurality of through holes connecting the core and the outside and the salicylic acid And impregnating a pH sensitive material in the hollow porous silica impregnated with tea tree oil, wherein the core of the hollow porous silica is supported with salicylic acid and tea tree oil, and at least one of the plurality of through holes. One or more pH-sensitive substances may be loaded to prepare a pH-sensitive complex capable of releasing salicylic acid from the core to the outside only in a specific pH range.

In addition, a sufficient amount of salicylic acid and tea tree oil may be supported on the core of the hollow porous silica, and a sufficient amount of pH-sensitive material may be supported on the plurality of through holes of the shell.

The pH-sensitive cosmetic composition of the present invention includes a pH-sensitive complex capable of discharging salicylic acid of the core to the outside in a specific pH range, and is a cosmetic composition having an excellent acne-improving effect and a hypoallergenic, stable formulation to the skin. To provide.

In particular, as a pH-sensitive substance, mesoform delta-lactone is dissolved in the oil phase in acid and in the aqueous phase in basic, and blocks the through-hole of the shell in a solid state in weakly acidic healthy skin, and in basic acne or inflammatory skin It can be dissolved in water and released from the through hole. In addition, salicylic acid and tea tree oil supported on the core of the hollow porous silica are released to the outside along the through-hole of the shell, thereby improving acne or inflammatory skin.

In addition, in weakly acidic healthy skin, as salicylic acid is supported on the core of the hollow porous silica, the irritation of the skin may be reduced, and stable formulations and various formulations may be realized.

In addition, since the pH sensitive complex includes salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 2, the salicylic acid may be continuously released in a specific pH range, and thus the persistence of the acne improving effect may be improved. In addition, the pH-sensitive complex may include salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 2, and it is possible to implement a more stable pH-sensitive complex, whereby the formulation stability of the cosmetic composition may be further improved. .

1 is a view showing a hollow porous silica according to an embodiment of the present invention.
2 is a cross-sectional view of the pH sensitive composite according to an embodiment of the present invention.
Figure 3 is a graph showing the amount of salicylic acid released according to the pH change of the pH sensitive complex according to Example 3.
4 is a graph showing the amount of salicylic acid released over time of the pH-sensitive complex according to Examples 1 to 4 exposed to an alkaline environment.
5 is a graph showing the results of evaluating the stability of the pH sensitive composite according to Examples 1 to 4.
6 is a view showing the killing effect of P. acnes bacteria of the pH sensitive complex according to Example 3.

DETAILED DESCRIPTION Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention.

The terms or words used in the specification and claims of the present invention are not to be construed in a conventional or dictionary sense, and the inventors may appropriately define the concept of terms in order to best explain their invention in the best way. Based on the principle, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

Throughout the specification of the present invention, when a part is said to "include" a certain component, it means that it can further include other components, without excluding the other components unless otherwise stated. .

In the specification of the present invention, "A and / or B" means A or B, or A and B.

Throughout the specification of the present invention, "a pH sensitive cosmetic composition for improving acne" may be simply referred to as "cosmetic composition".

Throughout the specification of the present invention, "oil phase" may mean a known oil phase, oil, etc., but is not limited thereto.

In the entire specification of the present invention, "water phase" may mean a known water phase part, water, etc., but is not limited thereto.

In the entire specification of the present invention, "acne bacteria" may mean a bacterium that causes acne, but is not limited thereto.

Hereinafter, the present invention has been described in detail, but the present invention is not limited thereto.

The present invention provides a pH sensitive complex.

In one embodiment of the present invention, the hollow porous silica, salicylic acid (Salicylic acid), tea tree oil (Tea tree oil) and a pH sensitive material, the hollow porous silica is a hollow core core 100 and the The core 100 is formed in a structure of a shell 200 in which a plurality of through holes 210 are connected to the outside, and the core 100 supports salicylic acid and tea tree oil, and the plurality of through holes 210. At least one or more of) is supported by the pH-sensitive material, thereby providing a pH-sensitive complex that discharges salicylic acid of the core 100 to the outside in a specific pH region. Preferably, the pH sensitive composite of the present embodiment may be applied to a pH sensitive cosmetic composition for acne improvement.

1 is a view showing a hollow porous silica according to an embodiment of the present invention. In addition, Figure 2 is a view showing a cross-section of the pH sensitive composite according to an embodiment of the present invention. In FIG. 2, the core 100 of the pH sensitive composite is supported with salicylic acid and tea tree oil, which correspond to a point region, and at least one of the plurality of through holes 210 of the shell 200 has a pH sensitive material. Supported, which corresponds to the hatched area.

The hollow porous silica is formed in the structure of the core 100 formed of the empty space and the shell 200 in which a plurality of through holes 210 connecting the core 100 and the outside are formed. As shown in Figure 1, the hollow porous silica of the present embodiment may be spherical, but is not limited thereto. The hollow porous silica of the present embodiment may have a particle diameter of 7 to 10 micrometers, and a particle diameter of the core 100 may be 5 to 8 micrometers, but is not limited thereto.

Referring to FIG. 2, salicylic acid and tea tree oil are supported on the core 100 of the hollow porous silica of the present embodiment, and at least one or more of the plurality of through-holes 210 carry a pH-sensitive material. Accordingly, salicylic acid is not exposed to the outside, but may be exposed to the outside by deformation of the pH sensitive material in a specific pH region. In particular, when the pH-sensitive complex of the present embodiment is applied to acne skin, as the salicylic acid of the core 100 is discharged to the outside while the pH-sensitive material of the shell 200 is dissolved, acne skin can be improved.

The pH sensitive composite of the present embodiment is 0.01 to 50.0% by weight, preferably 10.0 to 45.0% by weight, more preferably 15.0 to 40.0% by weight, most preferably 20.0 to 35.0% by weight, based on the total weight of the pH sensitive composite It can be included as.

If the pH sensitive composite of the present embodiment contains less than 0.01% by weight of hollow porous silica based on the total weight of the pH sensitive composite, salicylic acid, tea tree oil, and the pH sensitive material are the core 100 or the through hole 210. May not be sufficiently loaded. Accordingly, the acne improving effect of the cosmetic composition of the present embodiment may be significantly lowered. On the other hand, when the pH sensitive composite of the present embodiment contains more than 50.0% by weight of the hollow porous silica based on the total weight of the pH sensitive composite, the core 100 or the through hole 210 may not be sufficiently filled to be economical. In addition, there may be a problem that salicylic acid and tea tree oil of the core 100 are easily discharged to the outside.

Salicylic acid is a colorless solid which is an aromatic oxycarboxylic acid. It has direct activity as an anti-inflammatory and antimicrobial agent, and can regenerate skin and promote exfoliation to prevent clogging of pores. In particular, as well as anti-inflammatory and antibacterial activity, it is possible to inhibit the growth or activity of acne bacteria by preventing excess sebum and clogging of pores, which promote the growth of acne bacteria.

In addition, salicylic acid lowers the pH of the alkaline acne skin, so that the skin can be maintained in a slightly acidic state, it is possible to improve the homeostasis, antibacterial action of the skin itself.

The pH-sensitive complex of the present embodiment may include 0.01 to 40.0% by weight of salicylic acid, preferably 10.0 to 37.0% by weight, more preferably 15.0 to 33.0% by weight, most preferably 20.0 to 30.0% by weight, based on the total weight of the pH-sensitive complex. Can be.

If the pH-sensitive complex of the present embodiment contains less than 0.01% by weight of salicylic acid based on the total weight of the pH-sensitive complex, the effects of anti-inflammatory activity, skin regeneration, and clogging of pores of the cosmetic composition to which the pH-sensitive complex is applied are not sufficient. Acne may be a minor improvement. On the other hand, when the pH-sensitive complex of the present embodiment contains more than 40.0% by weight of salicylic acid based on the total weight of the pH-sensitive complex, some of the salicylic acid is not supported in the core 100 of the hollow porous silica or the shell 200 Supported in the through-hole 210 may be discharged to the outside regardless of the pH change. Accordingly, the cosmetic composition to which the pH-sensitive complex of the present embodiment is applied may irritate the skin and may have a problem in that formulation stability is lowered.

Tea tree oil is an essential oil extracted from the leaves and twigs of tea tree. It is an antimicrobial oil that sterilizes bacteria, viruses and fungi, and increases immunity. That is, the tea tree oil of the present embodiment may inhibit the activity of acne bacteria by sterilizing or disinfecting the acne bacteria.

PH sensitive complex of the present embodiment is 0.01 to 40.0% by weight, preferably 10.0 to 37.0% by weight, more preferably 15.0 to 33.0% by weight, most preferably 20.0 to 30.0, based on the total weight of the pH sensitive complex It may be included in weight percent.

If the pH-sensitive complex of the present embodiment contains less than 0.01% by weight of tea tree oil based on the total weight of the pH-sensitive complex, disinfectant disinfection and antimicrobial activity may be lowered, and the acne improvement effect may be insignificant. On the other hand, when the pH sensitive composite of the present embodiment contains more than 40.0% by weight of tea tree oil based on the total weight of the pH sensitive complex, some tea tree oil is not supported on the core 100 of the hollow porous silica or the shell It may be supported in the through hole 210 of the (200). Accordingly, the cosmetic composition of the present embodiment may be irritated to the skin while being discharged to the outside regardless of the pH change, and formulation stability may be lowered.

PH sensitive complex of the present embodiment comprises 0.01 to 40.0% by weight of salicylic acid and 0.01 to 40.0% by weight of tea tree oil, respectively, based on the total weight of the pH-sensitive complex, the salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 2 It may include.

Preferably, the salicylic acid and tea tree oil may be included in a weight ratio of 1: 1 to 1.5.

More preferably, in the present embodiment, the salicylic acid and tea tree oil may be included in a weight ratio of 1: 1.5.

In particular, the pH-sensitive complex of the present embodiment may include 0.01 to 40.0% by weight of salicylic acid and 0.01 to 40.0% by weight of tea tree oil, respectively, based on the total weight, and include salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 1.5. When the salicylic acid is continuously released in a specific pH region, the persistence of the acne improving effect can be improved. In addition, salicylic acid and tea tree oil may be supported in a stable state on the core 100 of the hollow porous silica, so that the pH-sensitive complex may be maintained in a stable state. As a result, the cosmetic composition including the pH sensitive complex may have excellent formulation stability.

pH sensitive material is a material that changes state according to the pH change, the pH sensitive material of the present embodiment is dissolved in oily under acidic conditions according to the pH change and under basic conditions May be dissolved in aqueous.

Preferably, the pH-sensitive material of the present embodiment may be dissolved in oil under acidic conditions of less than pH 4.0, and in aqueous state under basic conditions of pH 7.0 or higher, depending on the pH change.

In this embodiment, at least one or more of the plurality of through-holes 210 to support the above-described pH-sensitive material, in the weak acidic healthy skin, the pH-sensitive material is not dissolved in water and the through-holes of the shell 200 210 may be supported in. On the other hand, in basic acne or inflammatory skin, the pH-sensitive material may be dissolved in water to be discharged from the through hole 210 of the shell 200 so that salicylic acid and tea tree oil of the core 100 may be discharged to the outside. . That is, by supporting the pH-sensitive material dissolved in oil in the acidic condition and in the aqueous condition in the basic condition in the through hole 210 of the shell 200, the salicylic acid can be selectively discharged to the outside according to the pH of the skin.

Accordingly, salicylic acid is not in contact with the skin in healthy weakly acidic skin, but salicylic acid is in contact with the skin only in basic skin such as acne, thereby reducing skin irritation and maintaining a stable formulation. In addition, in the prior art, it was difficult to implement various formulations by salicylic acid, but by applying the pH-sensitive complex according to the present embodiment, it may be possible to utilize the various formulations including salicylic acid.

Preferably, the pH-sensitive material of this embodiment may be Meadowfoam delta-lactone.

Meadowfoam delta-lactone is derived from the plant, meadowfoam, and its solubility in oil phase and water phase changes according to pH change, and is an amphoteric compound having isomer accordingly. The medoform delta-lactone has the properties of an intermediate under neutral conditions, but under basic conditions, it changes to the structure of 5-hydroxy fatty acid and has a water phase property and can be dissolved in the water phase. On the other hand, in acidic conditions, the lactone (Lactone) structure is changed to have an oily property and can be dissolved in the oil phase.

That is, in the basic condition of acne skin, medofoam delta-lactone is dissolved in the water phase and discharged from the through hole 210, and the salicylic acid and tea tree oil of the core 100 are discharged to the outside, thereby improving acne skin. .

The pH sensitive composite of the present embodiment is 0.01 to 30.0 wt%, preferably 5.0 to 25.0 wt%, more preferably 10.0 to 23.0 wt%, most preferably 15.0 to 20.0 wt% of the pH sensitive material based on the total weight of the pH sensitive complex. It may be included in weight percent.

If the pH-sensitive complex of the present embodiment contains less than 0.01% by weight of the pH-sensitive material based on the total weight of the pH-sensitive complex, the through-hole 210 is not sufficiently filled and salicylic acid of the core 100 is difficult to be protected. However, there may be a problem that salicylic acid is exposed to the outside regardless of pH change. Accordingly, skin irritation, formulation stability, and acne improving effect of the cosmetic composition including the pH sensitive complex of the present embodiment may be reduced.

On the other hand, when the pH sensitive composite of the present embodiment contains more than 30.0 wt% of the pH sensitive material on the basis of the total weight of the pH sensitive complex, the pH sensitive material is excessively dense on the surface of the hollow porous silica and is removed from the core 100. There may be a problem that makes it difficult to release salicylic acid.

The present invention provides a method for preparing a pH sensitive composite.

In one embodiment of the present invention comprising the step of impregnating salicylic acid and tea tree oil in the hollow porous silica and the step of impregnating the pH sensitive material in the hollow porous silica impregnated with the salicylic acid and tea tree oil, the hollow type The porous silica is formed in the structure of a shell 100 having a core 100 formed of an empty space and a plurality of through holes 210 connecting the core 100 to the outside, and the salicylic acid and the tea are formed in the core 100. Tree oil is supported, and at least any one or more of the plurality of through-holes 210, the pH-sensitive material is supported, the production of a pH-sensitive complex that can discharge the salicylic acid of the core 100 to the outside in a specific pH region Provide a method. Preferably, the pH sensitive composite of the present embodiment may be applied to a pH sensitive cosmetic composition for acne improvement.

(1) impregnating salicylic acid and tea tree oil into the porous porous silica

In the step of impregnating salicylic acid and tea tree oil to the hollow porous silica of the present embodiment, salicylic acid and tea tree oil may be impregnated into the core 100 of the hollow porous silica.

In more detail, in the step (1) impregnating salicylic acid and tea tree oil in the porous porous silica of the present embodiment, the mixture is prepared by dissolving salicylic acid in the tea tree oil (about 40 ° C.) and the hollow porous material in a closed Henschel mixer. After the silica is added, the mixed solution may be sprayed into the spray injector through the inlet while stirring, so that the mixed solution may be impregnated or adsorbed to the core 100 in the hollow porous silica.

Accordingly, the salicylic acid and the tea tree oil may be supported on the core 100 of the hollow porous silica. At this time, separate drying, heating, cooling, ultrasonic, stirring, vibration treatment, etc. may be performed, but is not limited thereto.

As a result, as shown in FIG. 2, salicylic acid and tea tree oil may be supported on the core 100.

(2) impregnating the pH sensitive material in the hollow porous silica impregnated with salicylic acid and tea tree oil

In the step of impregnating the pH-sensitive material in the hollow porous silica impregnated with salicylic acid and tea tree oil of the present embodiment, according to the above, the pH-sensitive material in the hollow porous silica loaded with salicylic acid and tea tree oil in the core 100 Can be impregnated Preferably, at least one or more of the plurality of through holes 210 of the porous porous silica in which the salicylic acid and the tea tree oil are supported on the core 100 may be impregnated with a pH sensitive material.

More specifically, in the step (2) impregnating the pH-sensitive material in the hollow porous silica impregnated with salicylic acid and tea tree oil of the present embodiment, liquid meadow delta-lactone is warmed (about 40 ° C.) to liquefy, and salicylic acid and While stirring the hermetically sealed Hensel mixer containing hollow porous silica loaded with tea tree oil, the liquidized meadow delta-lactone was sprayed through an inlet through a spray injector, so that the meadow delta-lactone was deposited on the shell 200 of the hollow porous silica. Can be impregnated or adsorbed.

Meanwhile, the meadow delta-lactone may be impregnated or adsorbed to the shell 200 of the hollow porous silica according to the above process. In addition, although salicylic acid and tea tree oil may be impregnated or adsorbed on the empty core 100, salicylic acid or tea tree oil may be impregnated or adsorbed while being wrapped so as not to be exposed to the outside. At this time, separate drying, heating, cooling, ultrasonic, stirring, vibration treatment, etc. may be performed, but is not limited thereto.

As a result, as shown in FIG. 2, at least one or more of the plurality of through holes 210 of the shell 200 of the hollow porous silica of the present embodiment is loaded with a pH sensitive material, whereby a pH sensitive composite may be prepared. Can be.

The preparation method of the pH sensitive complex of the present example includes all the contents of the pH sensitive complex.

The present invention provides a pH sensitive cosmetic composition for improving acne.

In one embodiment of the present invention, the hollow porous silica, salicylic acid (Salicylic acid), tea tree oil (Tea tree oil) and a pH sensitive material, the hollow porous silica is a hollow core core 100 and the The core 100 is formed in a structure of a shell 200 in which a plurality of through holes 210 are connected to the outside, and the core 100 supports salicylic acid and tea tree oil, and the plurality of through holes 210. At least one or more of) provides a pH-sensitive cosmetic composition for acne improvement, including a pH-sensitive complex carrying a pH-sensitive material.

Preferably, the cosmetic composition of the present embodiment can improve acne by inhibiting the activity of acne causing bacteria.

In this embodiment, the pH sensitive complex may be included in an amount of 0.01 to 30.0 wt% based on the total weight of the cosmetic composition. When the pH-sensitive complex is included in less than 0.01% by weight based on the total weight of the cosmetic composition of the present embodiment, the acne improvement effect may be insignificant. On the other hand, when the pH-sensitive complex is contained in more than 30.0% by weight based on the total weight of the cosmetic composition of the present embodiment is not economical, there may be a problem that the skin irritation increases, formulation stability is lowered.

The cosmetic composition of this embodiment is in the group consisting of supple cosmetics, nourishing cosmetics, astringent cosmetics, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water It may be any one of the formulations selected, but is not limited thereto.

The cosmetic composition of the present embodiment may include a cosmetically acceptable carrier or additive in addition to salicylic acid, tea tree oil, pH sensitive material and hollow porous silica. For example, the cosmetic composition is purified water, wrinkle improver, anti-aging agent, antioxidant, elasticity improver, whitening agent, moisturizer, sunscreen, anti-inflammatory agent, atopic dermatitis improver, acne improver, sebum secretion inhibitor, trouble prevention agent, fatty substance, organic Solvents, solubilizers, thickeners, gelling agents, emollients, suspending agents, stabilizers, blowing agents, fragrances, surfactants, emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, It may further include, but is not limited to, an additive comprising one or more selected from the group consisting of fragrances, hydrophilic or lipophilic active agents, and lipid vesicles.

PH sensitive cosmetic composition for acne improvement of the present embodiment includes all the contents of the pH sensitive complex.

The present invention provides a method for producing a pH sensitive cosmetic composition for improving acne.

In one embodiment of the present invention, the hollow porous silica, salicylic acid (Salicylic acid), tea tree oil (Tea tree oil) and a pH sensitive material, the hollow porous silica is a hollow core core 100 and the The core 100 is formed in a structure of a shell 200 in which a plurality of through holes 210 are connected to the outside, and the core 100 supports salicylic acid and tea tree oil, and the plurality of through holes 210. At least one or more of)) to prepare a pH-sensitive composite carrying a pH-sensitive material, and then mixed with the additives, a cosmetic composition can be prepared.

For example, the additive may be purified water, wrinkle improver, anti-aging agent, antioxidant, elasticity improver, whitening agent, moisturizer, sunscreen, anti-inflammatory agent, atopic dermatitis improver, acne improver, sebum secretion inhibitor, trouble prevention agent, fatty substance, organic solvent , Solubilizers, thickeners, gelling agents, emollients, suspending agents, stabilizers, foaming agents, fragrances, surfactants, emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, flavorings , Hydrophilic or lipophilic active agent and lipid vesicles may include one or more selected from the group consisting of, but is not limited thereto.

According to the present embodiment, stirring, heating, cooling, ultrasonic waves, vibration treatment, and the like may be performed in the process of mixing the pH-sensitive complex and the additive, but is not limited thereto.

Hereinafter, the pH-sensitive cosmetic composition for improving acne of the present invention and its preparation method will be described in detail through Examples, Comparative Examples, and Experimental Examples. Since these examples are only for illustrating the present invention, the scope of the present invention is not to be construed as being limited by these examples.

EXAMPLE

Examples 1-4

First, as shown in FIG. 1, a hollow porous silica having a shell structure in which a core consisting of an empty space and a plurality of through holes connecting the core and the outside are formed is prepared. Separately, after the salicylic acid and tea tree oil were mixed, a mixed solution warmed at about 40 ° C. was prepared. Thereafter, the hollow porous silica was added to the hermetically sealed Henschel mixer and the mixture was sprayed with a spray injector while stirring to impregnate the mixture of salicylic acid and tea tree oil in the core of the hollow porous silica.

Subsequently, the hollow porous silica loaded with a mixture of salicylic acid and tea tree oil in the core was introduced into a closed Henschel mixer and stirred while spraying a liquid meadowfoam delta-lactone heated at about 40 ° C. with a spray injector, followed by hollow injection. Meadowfoam delta-lactone was impregnated into the voids containing the through-holes of porous silica.

By cooling and drying it to room temperature, a pH sensitive composite was prepared. In this case, silica, salicylic acid, tea tree oil and meadowfoam delta-lactone were mixed in the composition [unit: weight%] as shown in Table 1.

In Table 1, the salicylic acid and tea tree oil of Examples 1 to 4 were mixed so that the total content of the two components to a total of 50% by weight, the mixing ratio of salicylic acid and tea tree oil in Table 2 [unit: weight ratio] Changed to.

Comparative Example

Comparative Examples 1 to 8

Prepared in the same manner as in the above example, silica, salicylic acid, tea tree oil and meadowfoam delta-lactone were mixed in the composition [unit: weight%] as shown in Table 3.

Preparation Example

A cream type cosmetic composition comprising the pH sensitive complex of Example or Comparative Example prepared according to the above was prepared according to a known method.

At this time, the cosmetic composition was prepared in a composition as shown in Table 4 [unit: weight%].

Experimental Example 1

Experimental Example 1 Salicylic Acid Release According to pH Change

(1) Evaluation of Salicylic Acid Release by pH Change

The release amount of salicylic acid according to the pH change of the pH sensitive complexes according to Examples 1 to 4 and Comparative Examples 1 to 8 was analyzed using HPLC (liquid chromatography), and when salicylic acid was released, it was marked as ○, and the salicylic acid was released. If not indicated by X.

At this time, the release of salicylic acid using HPLC is as described below, [functional cosmetic standards and test method : Internal standard method of liquid chromatograph method of general test method].

First, 50% acetonitrile containing 1% phosphoric acid was added to about 2.0 g of the sample, followed by ultrasonic shaking to sufficiently disperse the sample. Then, 1 mL of internal standard solution and 50% acetonitrile containing 1% phosphoric acid were added to make 50 mL. Use the sample solution. The sample means a pH sensitive composite according to Examples 1 to 4 or Comparative Examples 1 to 8.

Apart from the sample solution, add 50% acetonitrile containing 1% phosphoric acid to about 50 mg of salicylic acid standard to make 25 mL. Take 0.63 mL, 1.25 mL, 2.5 mL, 5.0 mL, and 10.0 mL of the standard stock solution, add 1.0 mL of internal standard solution, and add 100% of 50% acetonitrile containing 1% phosphoric acid to make 100 mL.

The internal standard solution was prepared by mixing about 100 mg of acetaminophen and 50% acetonitrile containing 1% phosphoric acid. If necessary, sampling or dilution multiples can be adjusted within the calibration curve of the standard solution.

-Detector (wavelength): ultraviolet absorption photometer (220 nm)

Column: Shiseido, Capcellpak C18 UG 120 (5 μm, 4.6 × 250 mm)

Mobile phase flow rate: 1.0 mL / min, injection volume 20 μL

Looking at Table 5, it can be seen that according to Examples 1 to 4 specifically releases salicylic acid only in the alkaline region of pH 7 or more.

In addition, in Comparative Example 1 in which a very small amount of hollow porous silica was used, salicylic acid, tea tree oil and meadowfoam delta-lactone were not sufficiently supported in the hollow porous silica. It was difficult. On the other hand, in the case of Comparative Example 2 in which a very large amount of hollow porous silica was used, release of salicylic acid was confirmed in all regions between pH 4.5 and 9.0. It is shown that as excess amount of hollow porous silica is used, salicylic acid in the core is not sufficiently protected by medofoam delta-lactone and released to the outside regardless of pH change.

In addition, in the case of Comparative Example 3 in which a very small amount of salicylic acid was used, it was difficult to evaluate whether salicylic acid was released according to the pH change. On the other hand, in the case of Comparative Example 4 in which the salicylic acid was used in an excessive amount, the release of salicylic acid was confirmed in all regions between pH 4.5 and 9.0. It is shown that as salicylic acid is used in excess, salicylic acid in the core is not sufficiently protected by medoform delta-lactone and released to the outside regardless of pH change.

In addition, in the case of Comparative Example 5 in which a small amount of tea tree oil is used, it can be seen that specifically releases salicylic acid only in an alkaline region of pH 7 or higher. On the other hand, in the case of Comparative Example 6 in which an excessive amount of tea tree oil was used, release of salicylic acid was confirmed in all regions between pH 4.5 and 9.0. This is because an excessive amount of tea tree oil is used so that the mixture of tea tree oil and salicylic acid is not sufficiently loaded in the hollow porous silica, so that the material of the core is not protected by the meadowfoam delta-lactone, regardless of the pH change. It is shown to be released to the outside.

In addition, in the case of Comparative Example 7 in which a small amount of meadowfoam delta-lactone was used, the salicylic acid supported in the hollow porous silica was not protected by the meadowfoam delta-lactone, and thus it was released to the outside regardless of the pH change. . On the other hand, in Comparative Example 8 in which an excessive amount of meadowfoam delta-lactone was used, the mesoform delta-lactone formed a film not only in the through hole of the shell of the hollow porous silica but also outside of the hollow porous silica, whereby salicylic acid was released to the outside. It seems to interfere with being.

That is, according to the results, pH-sensitive composites containing all of the porous porous silica, salicylic acid, tea tree oil and pH sensitive material, and when containing them in a specific content, can specifically release salicylic acid only in a specific pH range It can be seen that the formation of.

(2) Evaluation of Salicylic Acid Release by pH Change

After analyzing the release amount of salicylic acid according to the pH change of the pH-sensitive complex according to Example 3 using HPLC (liquid chromatography), the results are shown in FIG. 3.

3, it can be seen that the pH sensitive complex according to Example 3 does not release salicylic acid under acidic conditions, but specifically releases salicylic acid only under conditions of pH 7 or higher.

Experimental Example 2: Evaluation of Salicylic Acid Release Rate with Time in Alkali Environment

After the pH-sensitive complexes of Examples 1 to 4 were exposed to an alkaline environment, the amount of salicylic acid released to the outside was measured by time, and the results are shown in FIG. 4.

The amount of salicylic acid released was mixed with potassium hydroxide in purified water to prepare an aqueous solution under alkaline conditions (pH 7.5), and then, after adding a pH sensitive complex and separating a predetermined amount with time while stirring with a magnetic stirrer, Experimental Example 1 and The same was analyzed by HPLC. At this time, in evaluating the salicylic acid release amount of Examples 1 to 4, the same amount of the aqueous solution and the pH-sensitive complex were used in the same conditions.

4, it can be seen that the salicylic acid is released in all of Examples 1 to 4 after the pH-sensitive complex is exposed to an alkaline environment of pH 7.5 or higher.

In more detail, in the case of Examples 1 to 3 in which salicylic acid and tea tree oil are mixed at a weight ratio of 1: 0.5 to 1.5, it can be seen that the release amount of salicylic acid increases with time, which improves acne by salicylic acid. It can be maintained for a long time.

Particularly, in the case of Example 3 in which salicylic acid and tea tree oil are mixed at a weight ratio of 1: 1.5, it can be seen that salicylic acid at a high concentration is continuously released for a long time, compared to Examples 1 and 2, and has the best acne improvement effect. Even though it has the best sustainability of acne improvement effect.

On the other hand, in Example 4 in which salicylic acid and tea tree oil are mixed at a weight ratio of 1: 2, as salicylic acid is rapidly released and the concentration rapidly decreases, the sustainability of the acne improvement effect is higher than that of the pH sensitive complex of Example 3 It can be seen that low.

Experimental Example 3 Evaluation of Stability of pH Sensitive Composites

Using Lumisizer (L.U.M. GmbH, Berlin, Germany), an accelerated stability test of the pH sensitive composites according to Examples 1-4 was carried out. The accelerated stability test is in accordance with the stability evaluation method specified in the ISO guideline (ISO / TR13097).

More specifically, the pH sensitive complex was carried out by measuring the light transmittance (865 nm wavelength) at intervals of about 60 seconds for 12 hours while accelerating at 40 ° C. at 4,000 rpm.

Thereafter, the instability index based on the light transmittance measured according to the above is shown in FIG. At this time, the instability index (Instability index) is represented by 0 ~ 1, the closer to 1 the instability index means that the pH-sensitive complex is unstable, when the pH-sensitive complex is unstable lipophilic component (tea tree oil) ) Is emitted to the outside, resulting in low light transmittance.

Referring to FIG. 5, in the case of Examples 1 to 3, the instability index is low, but in the case of Example 4, it can be seen that the instability index is remarkably high. That is, in the case of Examples 1 to 3 than Example 4 it can be seen that a stable pH-sensitive complex can be implemented.

Experimental Example 4: Acne Improvement

(1) Evaluation of killing effect of p.acne strain

The pH sensitive complex of Example 1 was exposed to an alkaline environment of pH 7.5 for about 6 hours to release salicylic acid, which was then 0.5%, 1.0%, 2.0% in medium cultured with anaerobic p.acne (Propionibacterium acnes). After the addition at the concentration of, the degree of killing (size of growth inhibition ring) was evaluated, and the results are shown in Table 6.

At this time, the p.acne (Propionibacterium acnes) was incubated in an anaerobic condition plate, it was inoculated in broth medium in anaerobic conditions, the culture was used.

In addition, the degree of death of the p.acne strains according to Examples 2 to 4 and Comparative Examples 1 to 8 were evaluated in the same manner as in Example 1, and the results are shown in Table 6 [unit: cm].

Looking at Table 6, it can be seen that the killing effect of the p.acne strain is significantly superior to the Examples according to the present Example than Comparative Examples 1 to 8. In particular, among Examples 1 to 4 it can be seen that the killing effect of the p.acne strain of Example 3 containing salicylic acid and tea tree oil in a weight ratio of 1: 1.5.

In addition, in Comparative Example 1, 3, and 8, in which the release of salicylic acid was not easy in Experimental Example 1, there was almost no killing effect of the p.acne strain.

In addition, the figure of the experiment result of Example 3 is shown in FIG. As shown in FIG. 6, it can be seen that the killing effect of the p.acne strain can be achieved according to the present embodiment.

(2) Verification of acne improvement effect through panel test

The cosmetic composition comprising the pH sensitive complex according to Example 3 was applied to the subjects evenly on the face twice a day (5 mL) for about 6 weeks, followed by 2 parking, 3 parking, 4 parking and 6 parking Acne severity rating (Investigator's assessment grade) was evaluated and the results are shown in Table 7.

In addition, as a control thereof, acne severity ratings of 2 parking, 3 parking, 4 parking and 6 parking of the test subjects who did not apply the cosmetic composition including the pH sensitive complex according to Example 3 were evaluated and the results are shown in Table 8.

At this time, the experimental group to which the cosmetic composition comprising the pH sensitive complex according to Example 3 and the control group not applied to the subjects are all subjects group consisting of five men and five women having an age of 20 to less than 50 years old Experiment with.

The acne severity rating was measured through a facial measuring device (JANUS equipment), acne severity rating was evaluated according to the following conditions.

-O grade: no lesion

-Grade 1: Almost no lesions (nodules: none, papules / pustules: less than 1, cotton: minority)

-Grade 2: Mild (nodule: none, papule / concentration: 5 or less, cotton cloth: slight)

-Grade 3: Severity (nodule: 1 or less, Papules / Pustules: 6 or more, Cotton: Many)

-Grade 4: Severe (nodule: 5 or less, papules / pustules: many, cotton: many)

In Tables 7 and 8, the acne severity grade was not confirmed in the control group, but when the cosmetic composition including the pH sensitive complex of Example 1 was applied, about 8 out of 10 acne severity grades were improved. You can check it.

That is, according to the present embodiment it can be seen that the acne improvement effect is excellent.

In addition, the degree of improvement of the acne severity grades of Examples 1, 2, and 4 and Comparative Examples 1 to 8 was evaluated in the same manner as in Example 3. The test subjects were composed of 10 people under the same conditions. Table 9 shows the number of people who improved the acne severity level by 1 or more.

Looking at Table 9, in the case of the Example according to the present embodiment it can be seen that the acne improvement effect is significantly superior to the comparative example. In particular, it can be seen that the acne improvement effect of Example 3 is the most excellent.

In addition, in Comparative Example 1, 3 and 8, which was not easy to release the salicylic acid in Experimental Example 1 had little effect of improving acne.

As described above, the description of the present invention is for the purpose of illustration, and those skilled in the art to which the present invention pertains can easily change to other specific forms without changing the technical spirit or essential features of the present invention. I can understand. Therefore, it is to be understood that the embodiments described above are exemplary in all respects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present invention is shown by the following claims rather than the above description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention. do.

100: core
200: shell
210: through hole

Claims (9)

Hollow porous silica, salicylic acid, tea tree oil and pH sensitive materials,
The hollow porous silica is formed of a core structure consisting of an empty space and a shell formed with a plurality of through holes connecting the core and the outside,
The core is supported with salicylic acid and tea tree oil,
At least one or more of the plurality of through-holes, characterized in that the pH-sensitive material is carried, pH sensitive composite.
The method of claim 1,
The pH sensitive complex is
0.01 to 50.0% by weight of the hollow porous silica, 0.01 to 40.0% by weight of salicylic acid, 0.01 to 40.0% by weight of tea tree oil and 0.01 to 30.0% by weight of the pH sensitive material, based on the total weight of the pH sensitive composite, pH sensitive complexes.
The method of claim 1,
The salicylic acid and tea tree oil is characterized in that it is included in a weight ratio of 1: 0.5 to 2, pH sensitive complex.
In the method of producing a pH sensitive composite comprising a hollow porous silica, salicylic acid, tea tree oil and a pH sensitive material,
Impregnating salicylic acid and tea tree oil to the hollow porous silica; And
Impregnating the pH-sensitive material in the hollow porous silica impregnated with the salicylic acid and tea tree oil,
The hollow porous silica is formed of a core structure consisting of an empty space and a shell formed with a plurality of through holes connecting the core and the outside,
The core is supported with salicylic acid and tea tree oil,
At least one or more of the plurality of through-holes, characterized in that the pH-sensitive material is supported, the method for producing a pH-sensitive composite.
Claim 1, characterized in that it comprises a pH sensitive complex, pH sensitive cosmetic composition for acne improvement.
The method of claim 5,
The pH sensitive composite is characterized in that 0.01 to 30.0% by weight based on the total weight of the cosmetic composition, pH sensitive cosmetic composition for acne improvement.
The method of claim 5,
The cosmetic composition is
It is characterized in that to inhibit the activity of acne causing bacteria, pH sensitive cosmetic composition for acne improvement.
The method of claim 5,
The cosmetic composition is
Formulation of any one selected from the group consisting of softening cream, nourishing cream, astringent makeup, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water Characterized in that, pH sensitive cosmetic composition for acne improvement.
The method of claim 5,
The cosmetic composition is
Purified water, wrinkle improver, anti-aging agent, antioxidant, elasticity improver, whitening agent, moisturizer, sunscreen, anti-inflammatory, atopic dermatitis improver, acne improver, sebum secretion inhibitor, trouble prevention agent, fatty substance, organic solvent, solubilizer, thickener, gel Agents, emollients, suspending agents, stabilizers, blowing agents, fragrances, surfactants, emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, perfumes, hydrophilic or lipophilic active agents and A pH-sensitive cosmetic composition for improving acne, characterized in that it further comprises an additive comprising at least one selected from the group consisting of lipid vesicles.

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