KR20180064705A - Portable Virus Detection Device using Mobile Phone - Google Patents

Abstract

A portable virus detection device using a mobile phone is provided. A portable diagnostic apparatus according to an embodiment of the present invention includes a light source that is equipped with a mobile device that photographs a diagnostic device using a photographing function, a diagnostic device is mounted, and a light is irradiated to the diagnostic device. Thus, it is possible to immediately and quantitatively analyze major viruses (MERS, dengue fever, SFTS) that are important for the analysis of the present invention in the field, so that they can immediately judge the infection.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a portable virus detection device,

The present invention relates to molecular detection and immunodiagnostic techniques, and more particularly to a portable platform for detection of infectious viruses.

Conventionally, blood is separated and purified, followed by amplification of the nucleic acid through a thermocycler and then quantitatively analyzed with a detector in order to see whether the virus needs to be detected immediately in the field.

In other methods, it is confirmed by quantitative amplification method mainly using RT PCR arranged in Lab, which requires cumbersome sample transfer operation and additional amplification operation, and there may be problems such as contamination and accuracy reduction due to sample transfer .

Also, in case of immunoassay platform, it is necessary to develop a platform that emphasizes the field of activity because the development of a platform that is equipped with strips and analysis with a separate detection device is popular.

SUMMARY OF THE INVENTION The present invention has been made in order to solve the above-mentioned problems, and it is an object of the present invention to provide a method and system for easily and rapidly quantifying major viruses (mers, dengue fever, SFTS) The present invention provides a portable virus detection device using a mobile phone.

According to an aspect of the present invention, there is provided a portable diagnostic apparatus including: a first mounting unit on which a mobile device for photographing a diagnostic unit is mounted; A second mounting portion on which the diagnostic device is mounted; And light sources for irradiating light to the diagnostic unit.

And, the light sources can irradiate the light toward the diagnostic unit at different angles.

Also, the light sources may be arranged in a shape that surrounds the periphery of the camera lens of the mobile device.

The light sources can irradiate light of different wavelengths toward the diagnostic unit.

Further, the light sources may be selectively driven.

The first mounting portion may be selectively mountable to the optical module of the first type and the optical module of the second type that transmit the light generated from the light sources to the diagnostic unit.

Further, the second mounting portion can be detachable to the optical module.

And, the diagnostic device may include at least one of a strip, a cartridge, and a container.

Further, according to another embodiment of the present invention, the portable diagnostic apparatus may further include a heater for isothermal amplification of the container.

According to another aspect of the present invention, there is provided a portable diagnostic method including: generating light by light sources provided in a portable diagnostic apparatus; And irradiating the light generated by the light sources with a diagnostic device mounted on the portable diagnostic device, wherein the diagnostic device is photographed by a mobile device having a photographing function.

On the other hand, according to another embodiment of the present invention, there is provided a portable diagnostic apparatus to which a diagnostic apparatus is attached, the portable diagnostic apparatus irradiating light to the diagnostic apparatus; And a mobile device detachable to the portable diagnostic device and photographing the diagnostic device with the imaging function at the time of installation.

According to another aspect of the present invention, there is provided a portable diagnostic method comprising the steps of: irradiating a light to a diagnostic device; And a step of the mobile device mounted on the portable diagnostic device photographing the diagnostic device by the photographing function.

As described above, according to the embodiments of the present invention, major viruses (MERS, dengue fever, SFTS) for which the analysis of the present invention is important can be quantitatively analyzed on the spot easily and quickly to determine whether or not the infection has occurred.

In particular, according to embodiments of the present invention, virus quantitative detection is possible by a simple cell phone operation, and immune / fluorescence analysis is possible with a simple form platform without the need for an expensive platform.

1 illustrates a portable molecular detection platform according to one embodiment of the present invention,
2 is a view provided in the description of a mobile phone mounting portion of a portable molecular detection platform,
Figures 3 to 5 are diagrams provided in the description of optical modules of a portable molecular detection platform,
6 is a view provided in the description of a strip mounting portion of a portable molecular detection platform,
Fig. 7 is a photograph of a portable molecular detection platform shown in Fig. 1 actually photographed,
8 is a diagram illustrating a portable immunodiagnostic platform according to another embodiment;
9 is a view provided in the description of the mobile phone mounting portion of the portable immunodiagnostic platform,
10 and 11 are diagrams provided in the description of the optical module of the portable immunodiagnostic platform,
12 is a diagram provided in the description of a light source module of a portable immunodiagnostic platform,
Fig. 13 is a photograph of a portable molecular detection platform shown in Fig.

Hereinafter, the present invention will be described in detail with reference to the drawings.

1 is a view illustrating a portable molecular detection platform according to an embodiment of the present invention. A portable molecular detection platform according to an embodiment of the present invention is a portable virus detection device for detecting an infectious virus using a mobile phone 10. [

The portable molecular detection platform according to the embodiment of the present invention can quantify virus in blood through detection of a fluorescent substance combined with virus using the camera function of the cellular phone 10. [ It is for field / live inspection.

The portable molecular detection platform according to an embodiment of the present invention includes a mobile phone mount 110, an optical module 120, and a strip mount 130, as shown in FIG.

1 shows a state in which the mobile phone 10 is mounted on the mobile phone mounting portion 110 and FIG. 2 shows a state in which the mobile phone 10 is detached from the mobile phone mounting portion 110 Respectively.

The mounted mobile phone 10 is fixed by a fixing pin 111 provided in the mobile phone mounting portion 110. [ 2, a hole is formed in a portion of the mobile phone mounting portion 110 opposite to the camera lens of the mobile phone 10, as shown in FIG.

In this hole, a lens module 121 provided in an optical module 120 coupled to a lower portion of the mobile phone mounting portion 110 is exposed. The exposed lens module 121 is opposed to the camera lens of the cellular phone 10. [ The lens module 121 may protrude into the hole of the mobile phone mounting part 110 according to the zoom adjustment.

FIG. 3 shows a state in which the mobile phone mounting portion 110 is removed from the portable molecular detection platform shown in FIG. As shown in FIG. 3, a lens module 121 is provided on the optical module 120.

FIG. 4 is a view showing a state in which the case of the optical module 120 is removed in FIG. As shown in FIG. 4, four LEDs 122 are provided in the interior of the optical module 120 so as to surround the lens of the cellular phone 10.

These four LEDs 122 generate light of the same wavelength or different wavelengths and irradiate the same downward. Specifically, light is irradiated to the strip mounted on the strip mounting portion 130 provided at the lower portion.

FIG. 5 is a simplified representation of four LEDs 122 in FIG. 5, a hole for transmitting the light emitted from the LEDs 122 to the strip is formed at the center of the lower frame 123 of the optical module 120. As shown in FIG.

FIG. 6 is a view showing a state in which the optical module 120 is removed in FIG. For ease of understanding, the four LEDs 122 are simplified in FIG. As shown in FIG. 6, the four LEDs 122 are arranged in a direction in which light can be irradiated to the central portion of the strip to be mounted on the strip mounting portion 130.

A heater for amplifying the isothermal (65-70 degrees) blood sample contained in the container may be incorporated in the strip mounting portion 130 or the lower portion thereof.

In addition, the optical module 120 and the strip mounting portion 130 can be separated from each other by a user. That is, the user removes the optical module 120 and the strip mounting part 130, mounts the strip on the strip mounting part 130, and attaches the optical module 120 to the strip mounting part 130, It is possible to detect the virus by mounting the mobile phone 10 on the mobile phone mounting portion 110 fixed to the mobile phone 10.

For virus detection, the LEDs 122 of the optical module 120 illuminate the strip mounted on the strip mounting part 130, and the cellular phone 10 can directly analyze the image taken by the camera function, Virus can be quantified by wireless transmission to the server.

Meanwhile, the four LEDs 122 provided in the optical module 120 can be selectively irradiated. This is for the purpose of enabling investigation of different wavelengths suitable for the virus to be detected.

Alternatively, the four LEDs 122 provided in the optical module 120 are successively irradiated one by one, two by three, and then irradiated in all four directions to generate images according to various wavelengths of illumination , And may detect various kinds of viruses.

FIG. 7 is a photograph of a portable molecular detection platform according to an embodiment of the present invention.

8 is a diagram illustrating a portable immunodiagnostic platform according to another embodiment of the present invention. A portable immunodiagnostic platform according to an embodiment of the present invention is a portable virus detection device for detecting an infectious virus in a container or cartridge using a cellular phone 10. [

The portable immunodiagnostic platform according to the embodiment of the present invention can also quantify virus in blood through detection of a fluorescent substance combined with virus using the camera function of the cellular phone 10. [ It is for field / live inspection.

The portable immunodiagnostic platform according to an embodiment of the present invention includes a support 210, a mobile phone mount 220, a light source module 230, and an optical module 240, as shown in FIG.

A light source module 230 and an optical module 240 are provided on the upper part of the support table 210 and a mobile phone mounting part 220 is coupled to one side of the optical module 240. Although not shown, the other side of the optical module 240 is equipped with a cartridge containing a blood sample or a cartridge which has reacted with a blood sample.

Then, a heater for amplifying the isothermal (65 to 70 degrees) blood sample contained in the mounted container or cartridge may be incorporated.

8 shows a state in which the mobile phone 10 is mounted on the mobile phone mounting portion 220 and FIG. 9 shows a state in which the mobile phone 10 is detached from the mobile phone mounting portion 220 Respectively.

The mounted mobile phone 10 is fixed by a fixing pin 221 provided in the mobile phone mounting portion 220. 9, a hole is formed in a portion of the mobile phone 10 mounted on the mobile phone mounting portion 220, which portion faces the camera lens.

In this hole, a lens module 241 provided in the optical module 240 coupled to the mobile phone mounting part 220 is exposed. The exposed lens module 241 is opposed to the camera lens of the cellular phone 10. [ The lens module 241 may protrude into the hole of the mobile phone mounting part 220 according to the zoom adjustment.

FIG. 10 shows a state in which the mobile phone mounting part 220 is removed from the portable molecular detection platform shown in FIG. A lens module 241 is provided on a side surface of the optical module 240 as shown in FIG.

11 is a view showing a state in which the case of the light source module 230 and the case of the optical module 240 are removed in FIG. As shown in Fig. 11, the optical module 240 is provided with a lens 241, a polarimeter 242, and a beam splitter 243.

The beam splitter 243 reflects the light emitted from the light source module 230 to the container or the cartridge and transmits the light excited from the container or the cartridge through the polarizing system 242 and the lens 241 and enters the cellular phone 10 .

FIG. 12 is a view illustrating a state in which the outer case of parts is removed for a detailed description of the light source module 230 in FIG. As shown in FIG. 12, the light source module 230 includes seven LEDs 231, a collimator 232, an optical amplifier 233, and a polarimeter 234.

The seven LEDs 122 generate light of the same wavelength or different wavelengths and are amplified by the optical amplifier 233 through the collimator 232 and transmitted through the polarimeter 234 to the beam splitter 243 of the optical module 240 .

The LEDs 231 of the optical module 230 illuminate the container or the cartridge through the beam splitter 243 of the optical module 240 and the cell phone 10 is illuminated by the camera function, It is possible to directly analyze the image of the light transmitted through the beam splitter 243 excited by the fluorescent material in the fluorescence material, or wirelessly transmit the image to a remote server to quantify the virus.

Meanwhile, the seven LEDs 231 provided in the optical module 230 can be selectively irradiated. This is for the purpose of enabling investigation of different wavelengths suitable for the virus to be detected.

Alternatively, the seven LEDs 231 provided in the optical module 230 are successively irradiated one by one, two at a time, three at a time, and then four images are irradiated to generate images according to various wavelengths of illumination , And may detect various kinds of viruses.

12 is a photograph of a portable immunoassay platform according to an embodiment of the present invention.

Up to now, portable virus detection devices using mobile phones have been described in detail with respect to preferred embodiments.

It is possible to implement the mobile phone mounting unit 110 and the mobile phone mounting unit 220 described in the above embodiments in the same manner and in a platform compatible manner. For example, when the mobile phone mounting portion 110 is detached from the optical module 120 and mounted on the optical module 230, and the mobile phone mounting portion 220 is detached from the optical module 230 and mounted on the optical module 120 It can be implemented.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the present invention.

210: Support
110, 220: Mobile phone mounting part
230: Light source module
120, 240: optical module
130:

Claims (12)

A first mounting portion on which a mobile device for photographing a diagnostic device by a photographing function is mounted;
A second mounting portion on which the diagnostic device is mounted;
And a light source for irradiating light to the diagnostic unit.
The method according to claim 1,
The light sources,
And the light is irradiated to the diagnostic unit at different angles.
The method of claim 2,
The light sources,
Wherein the portable device is disposed in a shape that surrounds the periphery of a camera lens of the mobile device.
The method according to claim 1,
The light sources,
And irradiates light of different wavelengths toward the diagnostic unit.
The method according to claim 1,
The light sources,
Wherein the first and second sensors are selectively driven.
The method according to claim 1,
In the first mounting portion,
Wherein the optical module is selectively mountable to a first type optical module and a second type optical module that transmit light generated from the light sources to a diagnostic unit.
The method of claim 6,
In the second mounting portion,
Wherein the portable diagnostic device is detachable to the optical module.
The method according to claim 1,
The diagnostic,
A cartridge, and a container.
The method according to claim 1,
And a heater for isothermally amplifying the container.
The light sources provided in the portable diagnostic apparatus generate light;
And illuminating the light generated by the light sources with a diagnostic device mounted on the portable diagnostic device,
The diagnostic,
The portable diagnostic method according to any one of claims 1 to 3, wherein the image is captured by a mobile device having a photographing function.
A portable diagnostic device equipped with a diagnostic device and irradiating light to the diagnostic device; And
And a mobile device detachably attached to the portable diagnostic device and configured to photograph the diagnostic device using the imaging function when the portable diagnostic device is mounted.
A portable diagnostic apparatus to which a diagnostic apparatus is mounted, the method comprising the steps of: irradiating light to a diagnostic apparatus; And
And a step of photographing the diagnostic device by the photographing function, wherein the mobile device mounted on the portable diagnostic device comprises:

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