KR20170100245A - Cosmetic composition for improving atopic dermatitis comprising steam extracts of Chamaecyparis obtusa and Dendropanax morbifera as active ingredients - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving atopic dermatitis containing an extract of Chamaecyparis obtusa and a water vapor extract of Dendropanax morbifera as an active ingredient. The cosmetic composition is useful for the treatment of atopic dermatitis Therefore, the water extract of Wako wood and the water vapor extract of Wako white can be effectively used as an active ingredient of a cosmetic composition for improving atopic dermatitis.

Description

[0001] The present invention relates to a cosmetic composition for improving atopic dermatitis, which comprises an extract of Chenopodium albumen,

The present invention relates to a cosmetic composition for improving atopic dermatitis containing Chamaecyparis obtusa extract and water extract of Dendropanax morbifera as an active ingredient, and a dermatological external preparation.

Atopic dermatitis is a chronic, recurrent inflammatory skin disease. Skin dryness and pruritus, resulting in scratching, eczema and inflammatory skin lesions, and as it progresses, more severe pruritus and sleep disorders are caused by a vicious cycle is repeated. In addition, if not properly managed at the initial stage, it may progress to disseminated papules and erythema with erythema and exudate, followed by thickening and wrinkling of the skin and lichenification. In infancy, eczema usually appears on the bent part of the neck, limbs, and back of the knee. When chronic, the skin of the eczema appears to be fizzy, and when atopic dermatitis remains until adulthood, it tends to be easily exposed to the inflammatory reaction by specific substances or stimuli And there is a tendency to develop eczema or erythema and flushing around the face or limb rather than the body.

Atopic dermatitis is a complex clinical manifestation due to the interaction of hereditary and environmental factors. Therefore, the cause of the disease can not be explained by any one reason. However, the environmental pollution such as soot, increase of use of food additives, (Allergens) caused by allergies such as house dust mites due to the environmental factors, genetic predisposition, immunological response, skin barrier and family history (genetic influence) is considered to be the main cause.

Staphylococcus aureus is a major cause of atopic dermatitis as well as causing pyogenic inflammatory disease by growing on the skin surface of humans and animals. Staphylococcus aureus is found at high density in most lesions of patients with atopic dermatitis, and Staphylococcus aureus aggravates the deterioration of atopic dermatitis. In fact, the SCORAD score of patients with externally identified Staphylococcus aureus is higher than the others, and accelerates the progression of dry skin, psoriasis, and interstitial erosion.

In general, atopic dermatitis patients have abnormalities of skin barrier, decrease of skin moisture content, increase of skin pH value and increase of transdermal water evaporation, as well as colonization of Staphylococcus aureus in atopic dermatitis lesions high.

Currently, the severity of atopic dermatitis is assessed by SCORAD (Scoring of Atopic Dermatitis) and ADSI (Atopic Dermatitis Severity Index), which are clinical scores of patients with atopic dermatitis. Objectively assess skin damage indicators such as skin barrier function and inflammation status by measuring skin surface hydration (SSH), skin pH, and transepidermal water loss (TEWL).

The basic treatment of atopic dermatitis is the use of a moisturizing agent to prevent skin's cleansing and drying, the use of oral antihistamines, steroids, immunosuppressants, antibiotics, antivirals, antifungals, Although many treatments such as psoralens and ultraviolet light therapy (PUVA) are used, prolonged use of these agents not only causes side effects such as skin atrophy and swelling, enlargement of blood vessels and pores, skin discoloration, , It is chronic or recurring frequently, and there are concerns about the side effects of drugs such as steroids and meetings with the disease, which may result in failure to provide proper treatment, or chronic therapy that relies on unproven treatment methods, There are many cases of disease. Therefore, there is a constant demand for a therapeutic agent for atopic dermatitis derived from natural materials which is free from side effects and safe to human body.

Chamaecyparis obtusa , also known as cypress tree, is an evergreen tree of the ginseng plant, a plant species, and is widely cultivated as a planting species in the southern part of Korea through development, although it is originated in Japan. , Antibacterial agents and the like.

Phytoncide is a self-defense substance of plants. It is a substance that plants excrete or secretes to resist pathogens, insects and fungi, and contains sterilization and insecticides. The constituent material of phytoncide is an organic compound composed of a phenol compound such as terpene, an alkaloid component, a glycoside, etc., and is known to have antimicrobial action, sedative action, deodorizing action and stress relieving action. Such phytoncide is a natural substance, not a chemical synthetic substance, and selectively absorbs bacteria which are absorbed in human body and harmful to human being. Therefore, various researches are being carried out to utilize the white wood.

Dendropanax morbifera is an evergreen broad-leaved forest belonging to Araliaceae. It is an endemic species grown and cultivated only in the western and southern coastal regions of Chonnam Province. Huangchil resin is golden color, strong in heat resistance, durability, water resistance, good adhesion and gloss, and has been used as a natural paints and civilian medicine materials in traditional handicrafts since ancient times. In addition, Huangchil contains various components such as arachidonic acid, palmitic acid, and arginine as well as essential oil components such as sesquiterpene, and is effective for atherosclerosis, liver function improvement, antioxidation, bone regeneration promotion, immunity enhancement, However, the effect on atopic dermatitis is not known.

Accordingly, the present inventors have made efforts to develop a cosmetic composition having a safe and adverse effect on the human body and having a remarkable effect of improving atopic dermatitis. As a result, it has been found that the water vapor extract of Huaxia tree and the water vapor extract of Huaxia wood are effective in skin application tests for atopic patients The present invention has been accomplished on the basis of the findings that it can be effectively used as an effective ingredient of a cosmetic composition for improving atopic dermatitis by confirming that the atopic dermatitis improving effect is exhibited.

The object of the present invention is to provide a cosmetic composition for improving atopic dermatitis and an external preparation for skin containing Chamaecyparis obtusa extract and Dendropanax morbifera extract as an active ingredient.

In order to attain the above object, the present invention provides a cosmetic composition for improving atopic dermatitis, which contains Chamaecyparis obtusa extract and Dendropanax morbifera extract as an active ingredient.

In addition, the present invention provides an external preparation for skin for prevention and improvement of atopic dermatitis, which contains an extract of Ungermanychus cinnabarstus and a extract of Hwangchujang tree as an active ingredient.

The present invention relates to a cosmetic composition for improving atopic dermatitis containing Chamaecyparis obtusa extract and Dendropanax morbifera water vapor extract as an active ingredient. The cosmetic composition is useful for skin application tests for atopic patients The atypical antipsychotic extract of the present invention can be effectively used as an active ingredient of a cosmetic composition for improving atopic dermatitis.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing a method for producing the steam extract of the present invention. FIG.

Hereinafter, the present invention will be described in more detail.

The present invention provides a cosmetic composition for improving atopic dermatitis containing Chamaecyparis obtusa extract and Dendropanax morbifera extract as an active ingredient.

The cosmetic composition can improve atopic dermatitis by improving skin moisture retention, stabilizing the pH of the skin, and decreasing the amount of percutaneous water evaporation.

The extract is preferably prepared by the following method, but is not limited thereto:

1) Extracting an extractant from an unplasticized or woody wood; And

2) filtering the extract of step 1)

In the production method of the present invention, the unplasticized or perennial tree of step 1) may be cultivated or commercially available.

The whitening wood or the woody wood can be mixed in a weight ratio of 1: 1 and then extracted with an extraction solvent. .

In the production method of the present invention, it is preferable to use water, an alcohol or a mixture thereof in the extraction solvent in the step 1), but it is most preferable to use water vapor. As the alcohol, C ₁ to C ₂ lower alcohols are preferably used. As the extraction method, it is preferable to use shaking extraction, Soxhelt extraction, reflux extraction, or steam distillation extraction method, and it is most preferable to use steam distillation extraction method. It is preferable that the extraction solvent is added by 1 to 10 times the amount of the dried white or woody wood, and it is more preferable that the extraction solvent is added by 2 to 3 times. The extraction temperature is preferably 20 ° C to 100 ° C, and most preferably 20 ° C to 50 ° C, but is not limited thereto. The extraction time is preferably 1 to 48 hours, more preferably 2 to 10 hours, most preferably 2 to 5 hours, but is not limited thereto. The number of times of extraction is preferably 1 to 5 times, more preferably 3 to 4 times, more preferably 3 times, but is not limited thereto.

In a specific example of the present invention, the inventors of the present invention prepared each of the extracts of P. japonicus and P. japonicus, respectively, and then applied the extracts to patients suffering from atopic dermatitis. As a result, (Table 1). The results are shown in Table 1. [Table 1] < EMI ID = 13.1 > < tb > < TABLE > Id = Table 2 Columns = 2 < tb > .

Accordingly, the composition of the present invention comprising a water extract of Clostel wood and a water-white steam extract of the present invention exhibits a significant atopic dermatitis-improving effect in skin application tests for patients with atopic dermatitis, May be useful as an ingredient.

The cosmetic composition according to the present invention may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, ≪ / RTI >

The cosmetic composition according to the present invention may be prepared into any of the formulations conventionally produced in the art, for example, a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, But are not limited to, cleansing, oil, powder foundation, emulsion foundation, wax foundation, and spray. More particularly, when the composition of the present invention is used as a cosmetic composition, a cosmetic preparation is selected from cosmetic lotion, emulsion, cream, essence, gel, pack and cleansing cream; Makeup cosmetics such as foundation, and the like.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

In addition, the cosmetic composition of the present invention may further contain, in addition to the components described above, oil, water, a surfactant, a moisturizer, a lower alcohol, a thickener, a chelating agent, a coloring agent, an antiseptic, And can be appropriately used in combination.

For example, besides the composition according to the present invention, the number of softening agents may be selected so that 1 to 10 wt% of polyhydric alcohols (propylene glycol, glycerin, etc.) and 0.05 to 2 wt% of a surfactant (polyethylene oleyl ether, polyoxyethylene hardened castor oil, etc.) Can be manufactured. The nutritional lotion and nutritional cream may contain 5 to 20% by weight of oils (squalane, petrolatum, octyldodecanol, etc.) and 3 to 15% by weight of wax components (cetanol, stearyl alcohol, And the essence may be prepared by adding 5 to 30% by weight of polyhydric alcohols such as glycerin and propylene glycol in addition to the composition according to the present invention. In addition to the composition according to the present invention, the massage cream contains 30 to 70% by weight of an oil such as liquid paraffin, petrolatum, isononylisononanoate and the like, and the pack contains 5 to 20% by weight of polyvinyl alcohol, A wash off pack containing 5 to 30% by weight of pigment such as kaolin, talc, zinc oxide, titanium dioxide, etc. in addition to the composition according to the present invention in a peel off pack or general emulsion type cosmetic containing Can be manufactured.

In addition, the present invention provides an external preparation for skin for prevention and improvement of atopic dermatitis, which contains an extract of Ungermanychus cinnabarstus and a extract of Hwangchujang tree as an active ingredient.

The composition of the present invention comprising a water extract of Clostel wood and a water-white steam extract of the present invention exhibits a significant atopic dermatitis-improving effect in skin application tests for patients with atopic dermatitis, and thus the composition is effective for the prevention and improvement of atopic dermatitis May be useful as an ingredient.

For prevention and improvement of atopic dermatitis, it is important to select an appropriate external preparation type. Accordingly, the composition of the present invention can be manufactured with an ointment agent so that it can be effectively applied to the affected part. The ointment agent is prepared by compounding the mixture of the present invention with an inorganic material and coating it with a liposoluble base. The inorganic material is preferably a material having excellent antimicrobial activity, anti-inflammatory effect, epidermal regeneration effect, etc. Specific examples thereof include zinc oxide, zinc carbonate, iron oxide and the like. Further, it is preferable to further use a ceramic carrier capable of safely impregnating the composition of the present invention, which is a water-soluble substance. As the ceramic carrier, zeolite, talc, gypsum, mortar and mixtures thereof are preferably used. Such a ceramic carrier is excellent in the impregnation property of the water-soluble component, so that the water-soluble component can be smoothly supplied to the skin.

Hereinafter, the present invention will be described in detail with reference to Examples, Experimental Examples and Preparation Examples.

However, the following Examples, Experimental Examples and Preparation Examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following Examples, Experimental Examples and Production Examples.

Example 1: Preparation of an extract of Prunus mume

≪ 1-1 > Preparation of Ethanol Extract of White Oak

The cottonwood was picked and cleaned to remove the foreign matter and impurities completely, and then dried in a shade maintained at a temperature of 20 to 35 DEG C, sterilized at a temperature of 121 DEG C for 30 minutes, and cooled. Then, the granules were pulverized so that the particle size of the sterilized leaves and branches was 0.5 mm or less. Then, 60 g of the granular white powder was immersed in 1 liter of ethanol and heated to prepare an albino ethanol extract.

<1-2> Preparation of water vapor extract

The cottonwood was picked and cleaned to remove the foreign matter and impurities completely, and then dried in a shade maintained at a temperature of 20 to 35 DEG C, sterilized at a temperature of 121 DEG C for 30 minutes, and cooled. Then, the particles of the sterilized leaves and branches were pulverized to have a particle size of 0.5 mm or less. Then, 60 g of the white powdery wood powder was immersed in 1 L of distilled water, heated, and the water vapor evaporated was collected.

<Example 2> Preparation of extracts

<2-1> Preparation of Ethanol Extract of Yellow Grass Tree

The woods were picked and washed thoroughly to remove impurities and impurities completely, then dried in a shade maintained at a temperature of 20 to 35 ° C, sterilized at a temperature of 121 ° C for 30 minutes, and cooled. Then, the powder was pulverized so that the particle size of the sterilized leaves and branches was 0.5 mm or less. Then, 60 g of the powdered wood powder was immersed in ethanol and heated to prepare an ethanol extract of Yellow Hut tree.

<2-2> Preparation of water vapor extract

The woods were picked and washed thoroughly to remove impurities and impurities completely, then dried in a shade maintained at a temperature of 20 to 35 ° C, sterilized at a temperature of 121 ° C for 30 minutes, and cooled. Then, the powder was pulverized so that the particle size of the sterilized leaves and branches was 0.5 mm or less. Then 60 g of the powdered wood powder was immersed in 1 liter of distilled water and heated. Then, the water vapor evaporated was collected to prepare a steamed watermelon extract.

&Lt; Example 3 > Preparation of Mixed Extracts of Polygonatum and Wiltwood

&Lt; 3-1 > Preparation of a mixture of an ethanol extract of Wanbai and Huaxia tree

100 ml of each of the extracts of the whitening wood and ethanol extract of the whitening woods prepared in Example 1 and Example 2 was mixed to prepare a mixture of an extract of Chenille wood and the extract of Huangchu tree.

<3-2> Preparation of 3: 1 Mixture of Steam Extracts of Polyunsaturated Trees and Yellowtail Trees

The mixture of 150 ml of the white wool water vapor extract and 50 ml of the water extract of Huchilchia tree prepared in Examples 1 and 2 were mixed to prepare a 3: 1 mixture of white walnut tree and Huaxia tree water vapor extract.

&Lt; 3-3 > Preparation of 2: 1 mixture of water-white and woody water extracts

133 ml of the water extract of unshrubby trees and 67 ml of the water extract of Hwangcholguk tree prepared in Example 1 and Example 2 were mixed to prepare a 2: 1 mixture of Waxy wood and Huaxia tree water vapor extract.

<3-4> Preparation of 1: 1 Mixture of Steam Extracts from Prunus mume

The mixture of 100 ml of the water extract of Clark's wood vinegar and 100 ml of the water vapor extract of Hwangcholgak tree prepared in Example 1 and Example 2 were mixed to prepare a 1: 1 mixture of Waxy wood and Huaxia tree water vapor extract.

<Experimental Example 1> Confirmation of anti-atopic effect of extracts

The effect of improving the atopic dermatitis of the mixture containing the extract of Wakaba tree and the extract of Echinochloa crusa prepared in Example 3 was confirmed.

Specifically, among patients diagnosed with atopic dermatitis, 30 patients were selected for treatment of atopic dermatitis within 6 months except for those patients who had received topical and systemic steroids, immunomodulators and inhibitors, antihistamines or similar treatments, The mixture containing the extract of Wakaba tree and the extract of Echinochloa crus-galli prepared in Examples <3-1> to <3-4> was applied to the selected patients once a day for four weeks. Then, we evaluated the results of the questionnaire about the symptom relief such as itching and the grossly visible erythema and rash before the treatment, and evaluated it with the 5 point satisfaction scale.

sample Low skin irritation Skin improvement effect Itching improvement effect Inflammation relieving effect The mixture prepared in < 3-1 > 2.4 2.2 2.4 2.6 The mixture prepared in < 3-2 > 2.8 2.5 2.7 3.0 The mixture prepared in < 3-3 > 3.0 3.1 2.9 3.1 The mixture prepared in < 3-4 > 4.3 4.5 4.8 4.4

As a result, as shown in Table 1, a mixture of 1: 1 mixture of the extract of Waxy wood steam and the extract of Watermelon wood steam showed a significant effect on each symptom of atopic dermatitis The number of scratches due to the improvement of itching and the erythema and rash observed by the human eye were significantly superior to those of the other experimental groups (Table 1).

In conclusion, it has been confirmed that a mixture of a water vapor extract of Waxy wood and a water vapor extract of Hwangchu tree at 1: 1 can be useful as a cosmetic composition for atopic dermatitis.

Production Example 1 Production of Lotion

5.0 wt% of the mixture prepared in Example <3-4>, 5.0 wt% of glycerin, 5.0 wt% of 1,3-butylene glycol, 0.2 wt% of hyaluronic acid, 0.15 wt% of polyoxyethylene hydrogenated castor oil, 5.0 wt %, A preservative 0.1% by weight, a proper amount of perfume, and a remaining amount of purified water were mixed to prepare a lotion.

&Lt; Preparation Example 2 > Preparation of essence

5.0 wt% of the mixture prepared in Example <3-4>, 2.0 wt% of cetostearyl alcohol, 1.5 wt% of self emulsifying monostearic acid, 3.0 wt% of dimethicone, 0.5 wt% of monostearic acid sorbitan, 1.0 wt% 5.0 wt% of mineral oil, 2.0 wt% of jojoba oil, 7.0 wt% of monostearic acid polyethylene glycol, 3.0 wt% of glycerin, 3.0 wt% of 1,3-butylene glycol, 0.15 wt% of carbomer, 0.2 wt% of triethanolamine, A proper amount of preservative, fragrance and remaining amount of purified water were mixed to prepare an essence.

&Lt; Preparation Example 3 > Production of lotion

5.0 wt% of the mixture prepared in Example <3-4>, 2.0 wt% of cetostearyl alcohol, 1.5 wt% of self emulsifying monostearic acid, 3.0 wt% of dimethicone, 0.5 wt% of monostearic acid sorbitan, 1.0 wt% 5.0 wt% of mineral oil, 2.0 wt% of jojoba oil, 7.0 wt% of monostearic acid polyethylene glycol, 3.0 wt% of glycerin, 5.0 wt% of 1,3-butyleneglycol, 0.2 wt% of carbomer, 0.3 wt% of triethanolamine, A lotion was prepared by mixing a proper amount of preservative, fragrance and remaining amount of purified water.

&Lt; Preparation Example 4 > Preparation of cream

7.0 weight% of the mixture prepared in Example <3-4>, 4.0 weight% of cetostearyl alcohol, 3.0 weight% of self emulsifying monostearic acid, 5.0 weight% of dimethicone, 2.0 weight% of monostearic acid sorbitan, 3.0 weight% 5.0 wt% of mineral oil, 4.0 wt% of jojoba oil, 7.0 wt% of monostearic acid polyethylene glycol, 5.0 wt% of glycerin, 5.0 wt% of 1,3-butylene glycol, 0.3 wt% of carbomer, 0.4 wt% of triethanolamine, A cream was prepared by mixing a proper amount of preservative, perfume and remaining amount of purified water.

Claims (9)

A cosmetic composition for improving atopic dermatitis containing an extract of Chamaecyparis obtusa and a extract of Dendropanax morbifera as an active ingredient.
The cosmetic composition for improving atopic dermatitis according to claim 1, wherein the extract of Wakabayashi tree and the extract of Wakayama tree are extracted with water vapor.
[Claim 3] The cosmetic composition for improving atopic dermatitis according to claim 1, wherein the extract is selected from the group consisting of Cryptomeria japonica extract and Horticultural extract.
The cosmetic composition for improving atopic dermatitis according to claim 1, wherein the cosmetic composition enhances the skin moisture content, stabilizes the pH of the skin, and reduces the amount of transdermal moisture evaporation.
The cosmetic composition of claim 1, wherein the cosmetic composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, And at least one compound selected from the group consisting of:
A skin external preparation for prevention and improvement of atopic dermatitis, which contains an extract of Chamaecyparis obtusa and an extract of Hokkaido tree as an active ingredient.
The external preparation for skin as set forth in claim 6, wherein the extract of Wakabayashi tree and the extract of Wakayama tree is extracted with water vapor.
The external preparation for skin as set forth in claim 6, wherein the extract is selected from the group consisting of wheat germ extract and woodworm extract.
[Claim 7] The external preparation for skin prevention and improvement according to claim 6, wherein the external preparation for skin improves the moisture content of the skin, stabilizes the pH of the skin, and reduces the amount of percutaneous water evaporation.

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