KR20130060684A - A lipolysis kit - Google Patents
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
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Abstract
본 발명은 저주파 자극기와 지방분해 수단이 함유된 주사액을 포함하는 키트에 관한 것으로, 지방분해 주사가 유래하는 통증, 멍, 홍반, 부종, 경화, 가려움증 등을 완화시키는데 탁월한 효과가 있는 기기와 지방분해 주사의 조합에 관한 것이다. The present invention relates to a kit comprising an injection solution containing a low frequency stimulator and a lipolysis means, and a device and lipolysis that have an excellent effect in alleviating pain, bruising, erythema, edema, hardening, and itching caused by lipolysis injection. To a combination of injections.
Description
본 발명은 지방분해 주사가 유래하는 통증, 멍, 홍반, 부종, 경화, 가려움증 등을 완화시키는데 탁월한 효과가 있는 지방 분해 키트에 관한 것이다.The present invention relates to a lipolysis kit that has an excellent effect on alleviating pain, bruising, erythema, edema, swelling, itching, and the like, from which lipolysis injections are derived.
지방분해(lipolysis)란 지방세포에 포함되어 있는 중성지방이 분해되는 것으로서 호르몬 감수성 리파아제의 작용에 의해서 일어나고 호르몬이나 자율신경에 의해서 조절된다. 최근에는 운동 또는 식이요법보다 손쉬운 체중감량 또는 몸매관리를 위한 방법 중 하나로 이러한 지방분해를 이용한 지방분해주사가 인기를 얻고 있다. Lipolysis is the breakdown of triglycerides contained in fat cells and is caused by the action of hormone-sensitive lipases and is controlled by hormones or autonomic nerves. Recently, lipolysis injection using lipolysis is gaining popularity as one of methods for weight loss or body management that is easier than exercise or diet.
지방분해주사의 경우 원하는 부위의 지방을 분해하여 제거할 수 있으나, 시술 후 통증, 멍, 홍반, 부종, 경화, 가려움증과 같은 부작용이 있어 시술 후에 일상적인 생활로 복귀하는데 있어 어려움이 있어 왔다.Lipolysis injection can remove and remove fat in the desired area, but there are side effects such as pain, bruising, erythema, swelling, sclerosis, and itching after the procedure, and there have been difficulties in returning to normal life after the procedure.
이에 본 발명자들은 상술한 바와 같은 부작용을 저하시키면서도 우수한 지방 분해 효과를 갖는 지방분해 키트를 제공하고자 하는 것이다.The present inventors are to provide a lipolysis kit having excellent lipolysis effect while reducing the side effects as described above.
상기의 목적을 달성하기 위하여, 본 발명은 근육을 이완 및 수축시켜 운동효과와 혈액 순환 효과로 지방분해 주사가 유래하는 통증, 멍, 홍반, 부종, 경화, 가려움증 등을 완화시키는데 탁월한 효과가 있는 저주파 자극기와 지방분해 수단이 함께 조합되어 있는 키트를 제공한다.In order to achieve the above object, the present invention is a low frequency that has an excellent effect in relieving pain, bruising, erythema, swelling, itching, etc. caused by lipolysis injection by relaxing and contracting muscles to exercise and blood circulation effect A kit is provided in which a stimulator and a lipolysis means are combined together.
본 발명의 일 실시예에 따른 저주파 자극기 키트에 의하면, 저주파 자극에 의하여 지방분해 주사 후 지방 분해 작용에 의해 통상적으로 주사부위에서 나타나는 통증, 멍, 홍반, 부종, 경화, 가려움증 등의 지방분해 주사의 특이적인 부작용을 최소화시켜 줄 수 있다.According to the low frequency stimulator kit according to an embodiment of the present invention, a lipolysis injection such as pain, bruising, erythema, swelling, sclerosis, itching, etc., which are usually shown at the injection site by lipolytic action after lipolysis injection by low frequency stimulation, You can minimize specific side effects.
도 1은 PPC 주사와 PPC 주사 + 저주파 자극기의 부종 감소효과를 비교하기 위한 둘레측정 그래프이다.
도 2는 PPC 주사와 PPC 주사 + 저주파 자극기의 멍 감소효과를 비교하기 위한 색도계 측정 비교 그래프이다.
도 3은 PPC 주사와 PPC 주사 + 저주파 자극기의 멍 감소효과를 비교하기 위한 사진이다.
도 4는 PPC 주사와 PPC 주사 + 저주파 자극기의 통증 감소효과를 비교하기 위한 피험자 설문 비교 그래프이다.
도 5는 PPC 주사와 PPC 주사 + 저주파 자극기의 멍, 부종, 홍반 감소효과를 비교하기 위한 사진이다.1 is a circumferential graph for comparing the edema reduction effect of PPC injection and PPC injection + low frequency stimulator.
2 is a colorimeter measurement graph for comparing the bruising effect of PPC injection and PPC injection + low frequency stimulator.
3 is a photograph for comparing the bruise reduction effect of PPC injection and PPC injection + low frequency stimulator.
4 is a graph of a subject questionnaire for comparing the pain reduction effect of PPC injection and PPC injection + low frequency stimulator.
5 is a photograph for comparing the effect of bruising, edema, erythema of PPC injection and PPC injection + low frequency stimulator.
본 발명의 일 실시예에 따른 지방분해 키트는 지방분해용 조성물, 이를 지방을 분해하고자 하는 표적 위치로 전달할 수 있는 전달 기구를 포함하는 지방분해 수단과 저주파 발생으로 인한 근육 자극기를 포함할 수 있다.The lipolysis kit according to an embodiment of the present invention may include a lipolysis means including a composition for lipolysis, a delivery mechanism capable of delivering the same to a target position to decompose fat, and a muscle stimulator due to low frequency generation.
본 발명의 일 실시예에 따른 키트에 포함되는 지방 분해 수단은 예를 들어 지방 분해용 활성 성분을 포함하는 지방 분해용 조성물과, 지방의 축적 또는 처진 피부와 같은 표적 부위에 상기 활성 성분을 전달할 수 있는 1개의 니들을 갖는 주사기, 복수개의 니들을 갖는 주사기, 패치, 마이크로 니들 등과 같은 전달 기구를 포함할 수 있다. Lipolysis means included in the kit according to an embodiment of the present invention may deliver the active ingredient to a target site such as, for example, a fat decomposition composition including an active ingredient for lipolysis, and accumulation or sagging skin of fat. And a delivery mechanism, such as a syringe having one needle, a syringe having a plurality of needles, a patch, a micro needle, and the like.
상기 지방 분해용 활성 성분은 표적 부위의 지방을 감소시키는 성분으로서, 예를 들어 지질, 담즙산 혹은 그의 염, 베타 아드레날린 수용체 효능제 및 히아루로니다제 중 적어도 하나를 함유하는 것일 수 있으며, 보다 상세하게는 데옥시콜린산, 콜린산, 체노데옥시콜린산, 7-알파-데히드록실레이트 체노데옥시콜린산, 리쏘콜린산, 우르소데옥시콜린산, 디하이드록시타우린산, 트리히드록시타우린산 및 그의 염, 포스파티딜콜린, 히아루로니다제, 아미노필린, 테오필린, 이소프로테레놀, 살부타몰 및 살메테롤 및 그의 염 중 적어도 하나를 함유하는 것일 수 있다. The lipolytic active ingredient is a component for reducing fat at the target site, and may contain, for example, at least one of lipids, bile acids or salts thereof, beta adrenergic receptor agonists and hyaluronidase, and more specifically, Deoxycholine acid, choline acid, chenodeoxycholine acid, 7-alpha-dehydroxylate chenodeoxycholine acid, lithocholine acid, ursodeoxycholine acid, dihydroxytaurine acid, trihydroxytaurine acid and And salts thereof, phosphatidylcholine, hyaluronidase, aminophylline, theophylline, isoproterenol, salbutamol and salmeterol and salts thereof.
상기한 바와 같은 지방 분해용 활성 성분은 지방 용해 효과는 물론 셀룰라이트 제거, 피부 탄력 재생 효과까지 우수하며 번거로운 절차 없이 국소부위의 지방층을 비교적 확실하게 파괴하는 성분으로서, 지방세포의 결합을 깨뜨리며 지방질을 파괴시켜 액체 상태로 림프순환을 통해, 소변 등으로 배출하게 한다. The active ingredient for lipolysis as described above is excellent in fat dissolving effect, cellulite removal, skin elasticity regenerating effect and relatively reliably destroys the fat layer of the local area without cumbersome procedures, and breaks the binding of fat cells and makes fat Destroys it in a liquid state and discharges it through the lymph circulation to urine.
이러한 지방 분해용 활성 성분을 포함하는 지방 분해용 조성물은 예를 들어 1개 니들을 갖거나 복수개의 니들을 포함하는 주사기를 통해 지방을 분해하고자 하는 표적 부위로 전달될 수 있고, 예를 들어 패치 등의 형태로 표적 부위에 부착되어 표적 부위로 전달될 수도 있으며, 예를 들어 마이크로 니들을 이용하여 표적 부위로 전달될 수도 있고, 이에 특별히 제한되는 것은 아니다.A lipolytic composition comprising such a lipolytic active ingredient may be delivered to a target site to which fat is to be decomposed via, for example, a syringe having one needle or a plurality of needles, for example a patch or the like. It may be attached to the target site in the form of and delivered to the target site, for example, may be delivered to the target site using a microneedle, but is not particularly limited thereto.
본 발명의 일 실시예에 따른 키트에 포함되는 저주파 자극기는 낮은 주파수, 예를 들어 1Hz~5000Hz의 진동 또는 파동을 발생하여 인체에 자극을 전달하는 기구를 의미한다. 상술한 바와 같은 지방 분해용 활성 성분을 지방을 분해하고자 하는 표적 위치에 전달하게 되면 홍반, 통증, 멍, 홍반, 부종, 경화, 가려움증과 같은 부작용이 발생되는데, 상기한 바와 같은 저주파 자극기를 표적 위치에 적용하여 자극을 전달하게 되면, 상술한 바와 같은 부작용을 저하시킬 수 있다. 이러한 저주파 자극기를 표적 부위에 적용하게 되면, 근육 및 혈관 등에 적당한 자극을 주어, 해당 부위의 체지방을 분해하여 체중 감소에 대한 시너지 효과를 갖는 동시에 부작용을 저하시킬 수 있다.
Low frequency stimulator included in the kit according to an embodiment of the present invention refers to a mechanism for transmitting a stimulus to the human body by generating a vibration or wave of a low frequency, for example 1Hz ~ 5000Hz. When the active ingredient for lipolysis as described above is delivered to the target site to decompose fat, side effects such as erythema, pain, bruising, erythema, edema, hardening and itching occur, and the low frequency stimulator as described above is targeted. When applied to deliver the stimulation, it can reduce the side effects as described above. When the low frequency stimulator is applied to the target site, the body and blood vessels may be appropriately stimulated to decompose body fat of the site, thereby having a synergistic effect on weight loss and reducing side effects.
따라서, 본 발명의 일 실시예에 따른 지방분해 수단과 저주파 자극기를 포함하는 키트를 제공함으로써, 지방분해 조성물의 지방 분해 작용에 의해 표적 부위에 통상적으로 나타나는 부작용인 통증, 멍, 홍반, 부종, 경화, 가려움증 등과 같은 증상을 완화시켜줄 수 있어, 시술 후에도 일상적인 생활로의 복귀를 용이하게 할 수 있다.
Thus, by providing a kit comprising a lipolysis means and a low frequency stimulator according to an embodiment of the present invention, pain, bruising, erythema, edema, stiffness, which are side effects that are commonly seen on the target site by the lipolytic action of the lipolytic composition It can relieve symptoms such as itching, and it can facilitate the return to daily life after the procedure.
이하, 본 발명의 내용을 실시예 및 시험예를 통하여 보다 구체적으로 설명한다. 이들 실시예는 본 발명의 내용을 이해하기 위해 제시되는 것일 뿐 본 발명의 권리범위가 이들 실시예 및 시험예로 한정되는 것은 아니고, 당업계에서 통상적으로 주지된 변형, 치환 및 삽입 등을 수행할 수 있으며, 이에 대한 것도 본 발명의 범위에 포함된다.
Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples are provided only for understanding the contents of the present invention, but the scope of the present invention is not limited to these examples and test examples, and modifications, substitutions, and insertions commonly known in the art may be performed. It may be included in the scope of the present invention.
[시험예 1]PPC 주사에 의한 부종 감소효과 비교 시험Test Example 1 Comparative Test of Edema Reduction Effect by PPC Injection
피험자를 두 그룹으로 나누어 한 그룹은 왼쪽 상완에 PPC 주사(Phosphatidyl Choline, 태평양제약사제)만 주입하고 오른쪽 상완에 PPC 주사와 저주파 자극기(슬렌더톤사제)로 구성된 키트를 사용하였다. 나머지 한 그룹은 왼쪽을 PPC 주사와 저주파 자극기로 구성된 키트를 사용하고 오른쪽을 PPC 주사만 사용하였다.The subjects were divided into two groups, and one group used only a PPC injection (Phosphatidyl Choline (manufactured by Pacific Pharmaceuticals)) in the left upper arm and a kit consisting of PPC injection and a low frequency stimulator (Slenderton) in the right upper arm. The other group used a kit consisting of a PPC injection and a low frequency stimulator on the left and only a PPC injection on the right.
이때, 하나의 팔당 사용한 PPC의 양은 10ml였으며, 4 내지 99Hz 범위의 저주파를 사용하였고, 20분씩 1회 시술하였다.At this time, the amount of PPC used per arm was 10ml, using a low frequency range of 4 to 99Hz, was performed once every 20 minutes.
시험 시작 전 피험자들의 양쪽 상완에 둘레 측정 부위를 표시하고 상완둘레를 측정하였다. 부종이 나타나는 주사 후 1일, 2일, 3일의 상완둘레와 주사 전 상완둘레의 차이값을 Δ상완둘레로 하고 이를 PPC 주사만 주입한 그룹과 PPC 주사와 저주파 자극기로 구성된 키트를 사용한 그룹간의 값을 비교한 후 그 결과를 도 1에 나타내었다.The circumference measurement site was marked on both upper arms of the subjects before the start of the test, and the circumference of the arm was measured. The difference between the humeral circumference of the 1st, 2nd and 3rd day after injection showing edema is Δ upper arm circumference, and the injection of PPC injection only and the group using the kit consisting of PPC injection and low frequency stimulator After comparing the values, the results are shown in FIG. 1.
시험 결과, PPC 주사만을 주입한 경우에 비하여 본원발명인 PPC 주사와 동시에 저주파 자극기로 구성된 키트를 사용한 경우 피험자 팔의 상완둘레가 약 50% 감소한 것으로 보아, 본원발명이 우수한 부종 완화효과를 가짐을 알 수 있었다.
As a result of the test, the arm arm circumference of the subject's arm was reduced by 50% compared to the case of injecting only PPC injection. there was.
[시험예 2]PPC 주사에 의한 멍 감소효과 비교 시험Test Example 2 Comparative Test of Bruising Reduction by PPC Injection
시험예 1과 동일한 방법으로 시험하였다. 멍 감소효과 수치화하여 비교하기 위하여 색차계를 사용하여 피험부위를 측정하였다. 색차계에서 나타나는 L-value, a-value, b-value는 색의 3가지 특성인 명도, 채도, 색상을 표시하기 위한 것이다. L-value는 명도를 나타내고, a-value가 높을수록 붉은색에 가깝고 낮을수록 녹색에 가깝다. b-value가 높으면 노란색에, 낮으면 파란색에 가까운 값을 나타낸다. 멍이 가장 높게 나타나는 주사 후 1일차에 측정한 값에서 주사 후 8일차 측정값의 차이값을 Δ로 나타내었고 색차계 3값인 ΔL-value, Δa-value, Δb-value로 각각 비교하였다. 본 시험에서는 대부분의 피험자가 파란색의 멍보다는 붉은색의 홍반에 가까운 멍을 가지고 있었으므로 a-value 비교를 우선으로 하였다. 시험결과는 도 2 및 도 3에 나타내었다.It tested in the same manner as in Test Example 1. In order to quantify and compare the bruise reduction effect, the subject area was measured using a color difference meter. L-values, a-values, and b-values that appear in the chrominometer are for displaying three characteristics of color: brightness, saturation, and color. L-value indicates brightness, the higher the a-value, the closer to red color, and the lower the closer to green. If the b-value is high, it is yellow, and if it is low, it is blue. The difference between the measured values on the first day after injection where the bruise was the highest was expressed as Δ and compared with the ΔL-value, Δa-value, and Δb-value, respectively. Since most of the subjects had bruises closer to red erythema than blue bruises, a-value comparison was given priority. The test results are shown in FIGS. 2 and 3.
도 2에 나타난 바와 같이, 본원발명인 PPC 주사와 저주파 자극기로 구성된 키트를 사용한 경우 PPC 주사만을 사용한 경우보다 명도의 경우 약 19%, 채도의 경우 약 30% 정도로 감소하는 등 멍이 든 정도가 현저히 감소함을 알 수 있었다. 또한, 도 3의 사진으로 알 수 있는 바와 같이 본원발명의 키트를 사용한 경우 홍반에 가까운 멍의 정도가 눈으로 식별 가능할 만큼 현저히 개선되었음을 확인할 수 있었다.
As shown in FIG. 2, the use of a kit consisting of the PPC injection and the low frequency stimulator of the present invention significantly reduces the degree of bruising such as about 19% in lightness and about 30% in saturation than when only PPC injection is used. I could see. In addition, as can be seen in the photo of Figure 3, when using the kit of the present invention it was confirmed that the degree of bruise close to the erythema is remarkably improved as can be seen by the eye.
[시험예 3]PPC 주사에 의한 통증 감소효과 비교 시험Test Example 3 Comparison of Pain Reduction Effect by PPC Injection
시험예 1과 동일한 방법으로 시험하였다. 주사 후 1일, 2일, 3일 그리고 8일차에 피험자 설문을 실시하여 통증을 느끼는 정도를 수치화하여 비교하였다. 통증이 높을수록 5에 가깝게 표시하도록 하였고, 그 결과를 도 4에 나타내었다.It tested in the same manner as in Test Example 1. Subject questionnaire was performed on
도 4에서 나타난 바와 같이, 본원발명인 PPC 주사와 저주파 자극기로 구성된 키트를 사용한 경우 시험 2일차에 통증이 처음보다 50% 이상 감소하여 PPC 주사만을 사용한 경우보다 약 13% 더 신속히 통증 개선효과를 가짐을 알 수 있었다.
As shown in Figure 4, when using the kit consisting of the PPC injection and low frequency stimulator of the present invention, the pain was reduced by more than 50% than the first day on the second day of the test has a pain improvement effect about 13% faster than using only PPC injection Could know.
[시험예 4]PPC 주사에 의한 멍, 부종, 홍반 감소효과 비교 시험Test Example 4 Comparative test of bruising, edema, erythema reduction effect by PPC injection
시험예 1과 동일한 방법으로 시험하였다. 주사 후 8일 차 사진을 비교하였을 때 PPC만 주사한 팔과 PPC 주사와 저주파 근육자극기로 구성된 키트를 사용한 팔을 비교하여 멍의 크기, 부종 정도를 사진으로 비교하여 도 5에 나타내었다. It tested in the same manner as in Test Example 1. When comparing the 8th day post-injection photograph, the arm of the PPC-only injection and the arm using the kit consisting of the PPC injection and the low frequency muscle stimulator were compared with the photograph, and the degree of swelling and the degree of swelling were shown in FIG. 5.
도 5의 사진에서 확인할 수 있듯이, PPC 주사만을 사용한 경우보다 본원발명의 키트를 사용한 경우 멍, 부종, 홍반 등 지방분해 주사의 전반적인 부작용이 눈으로 식별 가능할 정도로 개선되었음을 알 수 있었다.As can be seen in the photo of Figure 5, when using the kit of the present invention than the case of using only PPC injection, it was found that the overall side effects of lipolysis injections such as bruising, edema, erythema improved visually discernible.
Claims (6)
저주파 자극기를 포함하는 부작용이 감소된 지방분해 키트.Lipolysis means comprising a composition for lipolysis, a delivery mechanism for delivering the lipolysis composition to a target site; And
Lipolysis kit with reduced side effects, including low frequency stimulator.
상기 지방분해용 조성물은 지질, 담즙산 혹은 그의 염, 베타 아드레날린 수용체 효능제 및 히아루로니다제 중 적어도 하나를 포함하는 지방분해 키트.The method of claim 1,
The lipolysis composition is a lipolysis kit comprising at least one of lipids, bile acids or salts thereof, beta adrenergic receptor agonists and hyaluronidase.
상기 지방분해용 조성물은 데옥시콜린산, 콜린산, 체노데옥시콜린산, 7-알파-데히드록실레이트 체노데옥시콜린산, 리쏘콜린산, 우르소데옥시콜린산, 디하이드록시타우린산, 트리히드록시타우린산 및 그의 염, 포스파티딜콜린, 히아루로니다제, 아미노필린, 테오필린, 이소프로테레놀, 살부타몰 및 살메테롤 및 그의 염 중 적어도 하나를 포함하는 지방분해 키트.3. The method according to claim 1 or 2,
The lipolytic composition is deoxycholine acid, choline acid, chenodeoxycholine acid, 7-alpha-dehydroxylate chenodeoxycholine acid, lithocholine acid, ursodeoxycholine acid, dihydroxytaurine acid, trihydric acid Lipolytic acid and its salt, phosphatidylcholine, hyaluronidase, aminophylline, theophylline, isoproterenol, salbutamol and salmeterol and a lipolysis kit comprising at least one thereof.
상기 전달기구는 1개의 니들을 포함하는 주사기, 복수개의 니들을 포함하는 주사기, 패치 및 마이크로 니들 중 적어도 하나를 포함하는 것인 지방분해 키트.The method of claim 1,
Wherein said delivery mechanism comprises at least one of a syringe comprising one needle, a syringe comprising a plurality of needles, a patch and a micro needle.
상기 저주파 자극기는 저주파의 발생으로 주사 부위의 근육이 이완 또는 수축되도록 하는 지방분해 키트.The method of claim 1,
The low frequency stimulator is a lipolysis kit that allows the muscle of the injection site to relax or contract by the generation of low frequency.
상기 부작용은 통증, 멍, 홍반, 부종, 경화 및 가려움 중 적어도 하나를 포함하는 증상인 지방분해 키트.The method of claim 1,
The side effect is a lipolysis kit that is a symptom comprising at least one of pain, bruising, erythema, edema, sclerosis and itching.
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| KR1020110126881A KR20130060684A (en) | 2011-11-30 | 2011-11-30 | A lipolysis kit |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200092069A (en) * | 2019-01-24 | 2020-08-03 | 유승민 | Apparatus for oscillate jet injecting lipolysis composition |
| US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
| KR20220087967A (en) * | 2020-12-18 | 2022-06-27 | 주식회사 레시텍 | Composition for localized fat reduction comprising lithocholic acid |
| KR20220115413A (en) * | 2021-02-10 | 2022-08-17 | 한국과학기술연구원 | Deoxycholic acid composition with improved lipolytic effect and preparation method thereof |
| EP4159240A4 (en) * | 2020-06-01 | 2024-06-19 | Cosmed Pharmaceutical Co., Ltd. | MICRO-NEEDLE NETWORK FOR AESTHETIC CARE |
-
2011
- 2011-11-30 KR KR1020110126881A patent/KR20130060684A/en not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
| KR20200092069A (en) * | 2019-01-24 | 2020-08-03 | 유승민 | Apparatus for oscillate jet injecting lipolysis composition |
| US11260202B2 (en) | 2019-01-24 | 2022-03-01 | Seung Min YOO | Apparatus for oscillating, jetting, and injecting lipolysis composition |
| EP4159240A4 (en) * | 2020-06-01 | 2024-06-19 | Cosmed Pharmaceutical Co., Ltd. | MICRO-NEEDLE NETWORK FOR AESTHETIC CARE |
| KR20220087967A (en) * | 2020-12-18 | 2022-06-27 | 주식회사 레시텍 | Composition for localized fat reduction comprising lithocholic acid |
| KR20220115413A (en) * | 2021-02-10 | 2022-08-17 | 한국과학기술연구원 | Deoxycholic acid composition with improved lipolytic effect and preparation method thereof |
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