KR20110019977A - Pharmaceutical composition for the prevention and treatment of stress and panic disorder - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for the prevention and treatment of stress and panic disorder, and specifically includes heel herb root and lotus root, and may be in the form of an extract from the hydrothermal extract of the heel herb root and lotus root.

The pharmaceutical composition for the prevention and treatment of stress and panic disorder is effective in the prevention and treatment of panic disorders such as anxiety, nervous breakdown, palpitations as well as autonomic ataxia due to insomnia, anxiety, chronic fatigue due to stress. Not only that, but also safe for the human body, including substances of natural origin, there are no side effects.

Heel root, soft muscle, stress, insomnia, panic disorder

Description

Composition for protection and treatment of stress and panic disorder

The present invention relates to a pharmaceutical composition for the prevention and treatment of stress and panic disorder, specifically, symptoms such as anxiety, nervous breakdown, palpitation, as well as autonomic ataxia due to stress, insomnia, anxiety, chronic fatigue. The present invention relates to a pharmaceutical composition effective for preventing and treating panic disorder.

Stress is a social problem in modern society because stress is excessive. In general, when a stimulus affects a certain degree or more, the body shows a general adaptative syndrome, which is non-specific in response to a certain threat regardless of the type of stimulus, which is defined as stress. These reactions occur in various ways in the body, such as tension headaches, migraines, high blood pressure, indigestion, fatigue, pain, menopausal disorders, hair growth, skin roughness, and if chronically persisted, they cause various neurosis, insomnia, stomach ulcers, etc. As the body's physiological activity and immune activity are deteriorated and the body's homeostasis is broken, the body's resistance is weakened and other diseases are caused, which may pose a significant threat to health, reduce mental activity, and unstable emotions, resulting in abnormal activity. It may cause.

Panic disorder is a condition characterized by extreme anxiety symptoms, panic attacks, which appear unexpectedly for no particular reason. Panic attacks are extreme symptoms of anxiety that can lead to death, accompanied by physical symptoms, such as a fast-paced heart bursting or feeling tight, breathing and sweating. Recent studies have shown that biological factors, along with psychosocial factors, are the leading cause of panic disorder. Problems with brain function and structure have been reported, such as abnormalities in neurotransmitter systems such as norepinephrine, serotonin, and GABA (GABA, -aminobutyric acid), and abnormal brain structures such as temporal lobe and frontal lobe. And so on. Many patients with panic disorder are known to experience stress before they develop symptoms.

As a Chinese medicine or a folk remedy, various types of medicines have been developed and sold on the market, mainly containing ginseng, tofu, and thorny ginseng, which are known to have useful effects on stress. However, some of the various changes caused by stress Only effective or insignificant efficacy has been shown, and studies on panic disorders such as herbal medicines are inadequate.

In order to solve the above problems, an object of the present invention is a pharmaceutical that is effective in the prevention and treatment of panic disorders such as anxiety, nervous breakdown, palpitations as well as autonomic ataxia due to insomnia, anxiety, chronic fatigue due to stress To provide a composition.

The present invention to achieve the above object,

Hill Calves and

It provides a pharmaceutical composition for the prevention and treatment of stress and panic disorder, including soft muscle.

The heel herb muscle may be included in an amount of 50 to 95 parts by weight based on the composition.

The soft meat may be included in an amount of 5 to 50 parts by weight based on the composition.

The pharmaceutical composition may be an extract obtained by hot water extraction of the heel chogeun and lotus root meat.

The pharmaceutical composition may be formulated in the form of a weak solution obtained by distilling the composition.

The present invention to achieve another object of the present invention,

It provides a health functional food for preventing and improving stress and panic disorder comprising the pharmaceutical composition as an active ingredient.

The pharmaceutical composition of the present invention exhibits excellent pharmacological effects in the prevention and treatment of stress by relieving stress. In addition, it has an effect on tension headache, fatigue, various neurosis, insomnia, etc. that can be caused by stress.

The pharmaceutical composition of the present invention exhibits excellent pharmacological effects in the prevention and treatment of panic disorders such as anxiety, nervous breakdown and palpitations.

The pharmaceutical composition of the present invention is safe for the human body, including components derived from nature, and has no side effects even when used for a long time.

In addition, the pharmaceutical composition of the present invention can be applied to health functional foods and the like that are effective in the prevention and improvement of stress and airport disorders.

It will be described below in detail to be easily carried out by those skilled in the art. The present invention may be variously modified and may take various forms, and only the specific embodiments thereof will be described here. It is to be understood, however, that the present invention is not limited to the specific forms referred to herein, but rather to include all modifications, equivalents and substitutions within the spirit and scope of the invention as defined by the appended claims. .

The pharmaceutical composition for the prevention and treatment of stress and panic disorder of the present invention includes Valeriana faurie . The heel chogeuneun relieve stress, soothing the heart is effective in insomnia or various neurosis.

The heel herb refers to dried roots of Valerian. Valerian grows in a rather humid place, the main stem is 40 ~ 90 cm high, has a vertical line, and the root leaf is 50 cm long, 5 small leaves are feather-shaped and have long stems. Stem leaf is opposite, odd-shaped leaf leaf (奇數 羽狀 複葉) consists of 3 ~ 7 small leaves with serrated edge. Flowers bloom in June-July in inflorescences, light red.

The composition of the present invention may be included after crushing the heel herb root and powdered or may include an extract of the heel herb muscle. The hilcho root extract can be obtained by conventional extraction methods known in the art. Specifically, it can be obtained by organic solvent extraction, water extraction using water or supercritical extraction, preferably by water extraction using water in consideration of safety to the human body. The organic solvent can be used without limitation those known in the art, specifically, lower alcohols such as methanol, ethanol, isopropyl alcohol, butanol; Polyhydric alcohols such as glycerol, ethylene glycol, propylene glycol and 1, 3-butylene glycol; And hydrocarbon solvents such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane, and chloroform may be used alone or in a mixture thereof. It can be mixed with and used as an extraction solvent.

The heel herb muscle may be included in an amount of 50 to 95 parts by weight based on the composition. If less than 50 parts by weight of heel myo muscle may prevent the effect of preventing and treating neurological diseases such as insomnia due to stress or airport disorders, and when included in excess of 95 parts by weight, the increase in efficacy is less than the added amount It may be inefficient, and may not have good taste or flavor at the time of manufacturing as health food.

The pharmaceutical composition for the prevention and treatment of stress and panic disorder of the present invention includes a soft muscle (蓮 子 肉). In addition to the effects of sedation and neurostable, the lotus root is also effective in preventing and improving stress and panic disorder when used in combination with heel choso, and supplementing blood, and is safe for humans and ingestible for food. .

The lotus meat is the lotus of Nelumbo nucifera A seed of Gaertner ), which refers to a dried herb that has been peeled off of the seedling, and in Japan, the same plant is called yukyeon (,), and in China, the same plant seeds are soft-leaved, dried young leaves and young roots in mature seeds. It is called the heart (蓮 子 心). Yeonjagi has almost no smell and taste can be less rejected when included in Chinese medicine or food. The appearance of the lotus root is oval or ball-shaped, one end is rounded off slightly. The outer surface is pale yellowish brown or reddish brown with greyish white powder, thin vertical pattern and relatively clear vein pattern. Seed shells are thin, yellowish brown and hard to peel off. There are two cotyledons in the seed shell and it is thick white with yellowish white.

The pharmaceutical composition of the present invention may be included by pulverizing and softening the soft magnetic meat or may include an extract of the soft magnetic meat. The lotus root extract may include any extract obtained by conventional extraction methods known in the art, such as organic solvent extract, water extract extracted using water, supercritical extract, water extract using water in consideration of the stability of the human body This is preferred. The organic solvent is as described above.

The soft meat may be included in an amount of 5 to 50 parts by weight based on the composition. When the soft lotus meat is included in less than 5 parts by weight, it may be difficult to achieve the object of the present invention because the effects of alleviation of stress and prevention and treatment of airport disorders are insignificant. This can reduce the effects of stress and reduce the prevention and treatment of airport disorders.

The hilcho root extract and lotus root extract of the present invention is included in the present invention as long as it exhibits substantially the same effect using the above extraction solvent as well as other extraction solvents, and includes extracts that have undergone the usual purification process. Specifically, the heel chogeun extract or lotus root extract is used as it is or extract the extract by the extraction solvent after purification, for example, membrane separation, size, charge, hydrophobicity or affinity using a filter membrane having a cut-off value at a constant molecular weight Purification process such as separation by a variety of chromatography for separation according to sex can be additionally carried out.

Pharmaceutical compositions for the prevention and treatment of stress and panic disorder of the present invention can be prepared in oral dosage forms such as tablets, powders, pills, granules, capsules, suspensions, emulsions, syrups, aerosols. The solid preparation for oral administration of the pharmaceutical composition for the prevention and treatment of stress and panic disorder of the present invention is a diluent such as a pharmaceutically acceptable carrier, excipient, filler, extender, binder, wetting agent, disintegrant or surfactant. It can be included as. Starch, calcium carbonate (calcium carbonate), sucrose (sucrose) or lactose (lactose), gelatin and the like can be used as the excipient. Specifically, the pill may be prepared by mixing starch root with soft powder of starch as an excipient.

The pharmaceutical composition for the prevention and treatment of stress and panic disorder of the present invention is formulated as a preparation for parenteral administration, such as sterile aqueous solution, solution, non-aqueous solvent, suspension, emulsion, lyophilized preparation, suppository, injection Can be. Formulations for parenteral administration may include vegetable oils such as propylene glycol, polyethylene glycol, olive oil, and the like, injectable esters such as ethyl oleate, and the like. Formulations for parenteral administration can be administered by known methods. For example, it may be administered topically, intramuscularly, subcutaneously or by other suitable means.

Preferably the pharmaceutical composition for the prevention and treatment of stress and panic disorder of the present invention may be prepared as a herbal acupuncture for parenteral administration. The immersion liquid may be obtained by distilling the composition of the present invention, and may be prepared by the following method. Washing and drying the heel grass root and lotus root meat, pulverized and powdered, and immersed in distilled water of 2 to 10 times the dry weight of the heel grass root and lotus root in the form of powder 80 Hot water at a temperature of from 120 ° C. to 120 ° C .; The steam generated during the pouring process is passed through a cooling circuit to liquefy and the supernatant of the liquid is taken. The pH of the supernatant can be adjusted to 7 to 7.5 to obtain a weak immersion liquid.

The acupuncture solution may be administered by a known method, and may be injected intramuscularly or subcutaneously. Preferably, the medicinal acupuncture solution may be injected into the blood level, and more preferably, may be injected into the acupoint blood and tube blood. The acupoint refers to acupuncture points in the middle of the lower part of the seventh cervical spine (the jujube blood) and the acupoint (the deltoid root anterior part of the shoulder joint). It means five points. The medicinal acupuncture solution may be administered at a dose of 0.2-2.0 ml per hemoglobin.

The therapeutically or prophylactically effective amount of the pharmaceutical composition according to the present invention may be appropriately selected depending on the administration target, age, individual difference and disease state. Preferably the pharmaceutical composition of the present invention can be administered in the range of 0.01 to 1000 mg / kg / day, the administration may be administered once a day or divided into several times.

In addition, the present invention provides a health functional food for preventing and improving stress and panic disorder comprising the pharmaceutical composition of the present invention as an active ingredient.

The pharmaceutical composition of the present invention may be added to various foods, dairy products, beverages, gums, teas, vitamin complexes and health supplements such as extracts, and the like, and may be in the form of powders, granules, tablets, capsules or beverages.

The pharmaceutical composition may be included in an amount of 0.1 to 10 parts by weight based on the health functional food. When included in less than 0.1 part by weight may be insignificant effect of the prevention and treatment of stress and panic disorder, when exceeding 10 parts by weight may affect the taste or aroma to the health functional food may decrease the preference.

In addition to the pharmaceutical composition as the active ingredient, the health functional food may be added without limitation the ingredients that may be included in the general health functional food or beverages. Specific examples may include flavoring agents or natural carbohydrates.

Hereinafter, the present invention will be described in detail through Examples and Comparative Examples. This is for the purpose of illustrating the invention only, and thus the scope of the invention is not limited.

< Example  1> Prevention and treatment of stress and panic disorder Pilled  Produce

Heel root muscle and lotus root were trimmed, dried and crushed to powder. 10 g of starch and 50 ml of distilled water were added to 180 g of heel chorus root powder and 20 g of soft-fried meat powder, and the mixture was mixed to prepare a ring having a diameter of about 4 mm.

< Example  2> Prevention and treatment of stress and panic disorder Medicinal  Produce

180 g of hilcho root powder and 20 g of soft-fried meat powder were added to a 2 L reaction tank connected to a cooling circulation device, and 1500 ml of tertiary distilled water was added thereto, followed by pouring at 105 ° C. for 2 hours. The steam generated during the pouring process was passed through the cooling circulation system to collect the liquefied and liquefied steam to separate the supernatant thereof. Soak phosphate (Na ₃ PO ₄ ) was added to the collected supernatant to adjust the pH to 7.25 to 7.35 to prepare a weak solution.

< Example  3> Prevention and treatment of stress and panic disorder Medicinal  Produce

A medicinal acupuncture solution was prepared in the same manner as in Example 2, except that 100 g of heel herb root powder and 100 g of soft gyros powder were used in Example 2.

< Example  4> Health functional drink  Produce

500 mg of heel chondroitin powder, 500 mg of lotus root powder, 1000 mg of citric acid, oligosaccharide, 100 g, 2 g of plum concentrate, 1 g of taurine and purified water were added to make 900 ml of the mixture, and the above ingredients were mixed according to the conventional beverage production method. To prepare a health functional drink for the prevention and improvement of stress and panic disorder.

< Comparative example  1> Prevention and treatment of stress and panic disorder Medicinal  Produce

Into a 2 L reactor connected to the cooling cycle was added 200 g of Hilcho root powder, and the third distilled water 1500 was added, followed by hot water at 105 for 2 hours. The steam generated during the pouring process was passed through the cooling circulation system to collect the liquefied and liquefied steam to separate the supernatant thereof. Soak phosphate was added to the collected supernatant to adjust the pH to 7.25 to 7.35 to prepare a weak solution.

< Experimental Example  1> Inhibitory Effects of Organ Weight Changes on Stress-induced Models

When stress is induced, the adrenal gland increases in weight, and the spleen is known to significantly reduce its weight due to a decrease in immune function. Therefore, in this experiment, the weight of the adrenal and spleen was measured to determine the effect of the composition of the present invention on stress.

For experiments on stress induction, Selye method (Brekhaman, I.I: Llyoydia, Vol. 32, No. p 46 ~ 51, 1965) was used. The starting point of the start point of the neck and the start of the upper extremity of the experimental animal corresponding to the human acupoint blood 2 hours before the stress induced, 6 hours and 21 hours after the stress induced the medicinal acupuncture prepared in Examples 2 to 3 and Comparative Example 1 The medicinal needles prepared in Examples and Comparative Examples were injected into the midpoint. All the animals were anesthetized with ether to extract organs, and the weights of the adrenal and spleen were measured. The results are shown in Table 1 below. In the following Table 1, the normal group refers to the experimental animal group that did not cause stress, and the positive control group refers to the experimental animal group that did not administer the medicinal acupuncture solution of Examples and Comparative Examples after the stress was induced.

 Weight of Spleen (mg) Weight of adrenal gland (mg) Normal 685 30 Positive control group 260 38 Example 2 410 32 Example 3 401 33 Comparative Example 1 328 35

According to Table 1, the medicinal acupuncture solution containing the heel chokeuneun and yeonjak of the present invention did not reduce the weight of the spleen compared to the positive control, it can be seen that the weight of the adrenal gland does not significantly increase the effect of relieving stress Therefore, it can be expected that the effect is also effective in diseases caused by stress. In addition, the herbal medicinal solution of the present invention was superior to the stress relief effect of the herbal medicinal solution of the comparative example using only heel choke root.

Experimental Example 2 Evaluation of Effect on Insomnia

50 patients suffering from insomnia due to stress were injected with medicinal acupuncture of Examples 2 to 3 and Comparative Example 1 once a day for 10 days for septic and tuberculosis, and then went to sleep at 10 pm Sleep state was observed. The results are shown in Table 2 below.

in 1 hour
Number of patients asleep 4 hours or more without breaking
Number of patients 6 hours or more without breaking
Number of patients Example 2 43 41 38 Example 3 36 32 28 Comparative Example 1 32 28 23

According to Table 2, the patient receiving the medicinal acupuncture of Example was asleep more than 90% of the patients within 1 hour after going to sleep, most of them were not awake and sleep more than 4 hours. In addition, the medicinal acupuncture solution of Comparative Example, which was prepared only by the heel herb, showed an effect on insomnia, but was less effective than the example. Therefore, the composition of the present invention has been shown to be effective in insomnia due to stress bringing a neurostable effect.

Experimental Example 3 Evaluation of Panic Disorder

In general, if four or more of the 13 symptoms of Table 3, it can be determined that the symptoms of the airport disorder.

One Dyspnea 8 Unreal 2 Feel dizzy or fall 9 Numbness or numbness of the limbs 3 Heart palpitations, the heart is likely to stop 10 Hot or cold 4 Trembling of hands and feet 11 Chest tightness or chest pain 5 Sweating 12 Death, fear that bad things will happen 6 Choking 13 Loss of self-control, mad feeling 7 Nausea, discomfort

After administering the compositions of Examples 2 to 3 and Comparative Example 1 once a day for 2 months to 15 patients having 5 or more of the 13 symptoms of panic disorder, the degree of relief of symptoms In consultation with the following criteria, the results are shown in Table 4 below.

After one month the symptoms go away
Relaxed patients After 2 months the symptoms go away
Relaxed patients Example 2 9 11 Example 3 8 12 Comparative Example 1 5 6

According to Table 4, in the case of the administration of the medicinal acupuncture of the embodiment it can be seen that after about two months, about 70% or more patients improved or disappeared symptoms of panic disorder such as anxiety or seizure symptoms. Moreover, the improvement was quick compared with the composition of the comparative example.

As described above, the composition for the prevention and treatment of stress and panic disorder including the heel root and soft muscle of the present invention is effective in relieving stress and improving diseases such as insomnia due to stress as well as extreme anxiety and seizures. The improvement effect of panic disorder showing back was excellent. In addition, the side effects or rejection is not reported from the patient during the experiment process, the pharmaceutical composition of the present invention is expected to be safe to the human body, including a substance derived from nature, even if used for a long time.

Claims (6)

Hill Calves and Pharmaceutical composition for the prevention and treatment of stress and panic disorder, characterized in that it comprises a soft muscle. The method of claim 1, The heel chogeun the pharmaceutical composition for the prevention and treatment of stress and panic disorder, characterized in that it comprises 50 to 95 parts by weight with respect to the composition. The method of claim 1, The soft muscle is a pharmaceutical composition for the prevention and treatment of stress and panic disorder, characterized in that it comprises 5 to 50 parts by weight with respect to the composition. The method of claim 1, The pharmaceutical composition is a medicinal composition for the prevention and treatment of stress and panic disorder, characterized in that it comprises a heel chogeun extract and yeonjak muscle extract obtained by hydrothermal extraction of heel chogeun and lotus root muscle. The method of claim 1, The pharmaceutical composition for the prevention and treatment of stress and panic disorder, characterized in that the formulation of the pharmaceutical composition is a distillation solution obtained by distilling the composition. A health functional food for preventing and improving stress and panic disorder, comprising the pharmaceutical composition of any one of claims 1 to 5 as an active ingredient.